نتائج البحث - "Pertti J. Neuvonen"

المساهمون: Medicum, Department of Clinical Pharmacology, University of Helsinki, HUS Helsinki and Uusimaa Hospital District, HUS Perioperative, Intensive Care and Pain Medicine, Department of Diagnostics and Therapeutics, Anestesiologian yksikkö

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f3dfcfa12953670807dfc9351bb3e3

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Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction

المؤلفون: Janne T. Backman, Tuija Tapaninen, Erkki Elonen, Aleksi M. Olkkola, Pertti J. Neuvonen, Mikko Niemi, Aleksi Tornio, Mikko Neuvonen

المساهمون: HUSLAB, Department of Clinical Pharmacology, University of Helsinki, INDIVIDRUG - Individualized Drug Therapy, Research Programs Unit, Faculty of Medicine, HUS Comprehensive Cancer Center, Hematologian yksikkö, Department of Oncology, Medicum, Janne Backman / Principal Investigator

المصدر: Clinical and Translational Science, Vol 13, Iss 2, Pp 345-351 (2020)
Clinical and Translational Science

مصطلحات موضوعية: Male, 030213 general clinical medicine, CYP3A4, Administration, Oral, Pharmacology, 030226 pharmacology & pharmacy, PROPHYLAXIS, chemistry.chemical_compound, 0302 clinical medicine, Piperidines, Agammaglobulinaemia Tyrosine Kinase, Medicine, Cytochrome P-450 CYP3A, Drug Interactions, General Pharmacology, Toxicology and Pharmaceutics, Cross-Over Studies, General Neuroscience, lcsh:Public aspects of medicine, General Medicine, Articles, Healthy Volunteers, 3. Good health, itraconazole, 317 Pharmacy, Ibrutinib, Area Under Curve, TYROSINE KINASE INHIBITOR, medicine.drug, Adult, Itraconazole, Cmax, Biological Availability, Placebo, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Young Adult, Pharmacokinetics, ibrutinib, pharmacokinetic booster, Humans, Dosing, business.industry, Research, Adenine, lcsh:RM1-950, lcsh:RA1-1270, Crossover study, Bioavailability, lcsh:Therapeutics. Pharmacology, chemistry, Biological Variation, Population, Cytochrome P-450 CYP3A Inhibitors, 3111 Biomedicine, business, drug-drug interaction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d00f8fe9003c881ddd35025d799c2f
https://doaj.org/article/701e1cf86da34400937cd534eb0f5ba8

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Lifetime antimicrobial use is associated with weight status in early adolescence-A register-based cohort study

المؤلفون: Pertti J. Neuvonen, Trine B. Rounge, Rejane Augusta de Oliveira Figueiredo, Heli Viljakainen, Elisabete Weiderpass, Eero Kajantie

المساهمون: Medicum, Helsinki Institute of Urban and Regional Studies (Urbaria), Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, HUS Children and Adolescents, Lastentautien yksikkö, Clinicum, Children's Hospital, Helsinki University Hospital Area, Department of Clinical Pharmacology, Department of Food and Nutrition

المصدر: Pediatric Obesity

مصطلحات موضوعية: 0301 basic medicine, Male, Pediatric Obesity, register study, CHILDREN, Overweight, Body Mass Index, Cohort Studies, 0302 clinical medicine, Anti-Infective Agents, Prevalence, Registries, adolescents, Child, Finland, Multinomial logistic regression, Original Research, 2. Zero hunger, Nutrition and Dietetics, ANTIBIOTIC USE, Health Policy, GUT MICROBIOTA, 3. Good health, Cohort, INFANCY, Female, medicine.symptom, 3143 Nutrition, Cohort study, 030209 endocrinology & metabolism, antimicrobials, 03 medical and health sciences, Thinness, medicine, Humans, EXPOSURE, 030109 nutrition & dietetics, OVERWEIGHT, business.industry, Public Health, Environmental and Occupational Health, Odds ratio, medicine.disease, Obesity, Confidence interval, weight status, BODY-MASS INDEX, 3121 General medicine, internal medicine and other clinical medicine, Pediatrics, Perinatology and Child Health, business, Body mass index, RESISTANCE, Demography

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3612063e5689932f4a70c608e7dd504
http://hdl.handle.net/10138/326275

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Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans

المؤلفون: Matti K. Itkonen, Mikko Niemi, Mikko Neuvonen, Janne T. Backman, Pertti J. Neuvonen, Aleksi Tornio

المساهمون: HUSLAB, Department of Clinical Pharmacology, Medicum, University of Helsinki, Clinicum, Janne Backman / Principal Investigator

المصدر: Drug Metabolism and Disposition. 47:377-385

مصطلحات موضوعية: Adult, Male, CYP2C8, PHARMACOKINETICS, PLASMA-CONCENTRATIONS, Genotype, TRANSPORTING POLYPEPTIDE 1B1, Glucuronidation, Cmax, Pharmaceutical Science, MARKEDLY INCREASES, METABOLISM, Pharmacology, 030226 pharmacology & pharmacy, UGT2B10 GENOTYPE, Cytochrome P-450 CYP2C8, Young Adult, 03 medical and health sciences, Glucuronides, 0302 clinical medicine, Pharmacokinetics, medicine, Humans, Gemfibrozil, Drug Interactions, Biotransformation, Hypolipidemic Agents, GLUCURONIDATION, DRUG-DRUG INTERACTION, Desloratadine, Cross-Over Studies, Chemistry, Loratadine, Clopidogrel, Crossover study, 3. Good health, Cytochrome P-450 CYP2C8 Inhibitors, 317 Pharmacy, Area Under Curve, 030220 oncology & carcinogenesis, Female, Aryl Hydrocarbon Hydroxylases, 3111 Biomedicine, DEPENDENT INHIBITOR, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3feef04e577c0368de75157b976c99
https://doi.org/10.1124/dmd.118.084665

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Voriconazole greatly increases the exposure to oral buprenorphine

المؤلفون: Jouko Laitila, Teijo I. Saari, Kari Laine, Tuija Hemmilä, Mari Fihlman, Klaus T. Olkkola, Nora Hagelberg, Janne T. Backman, Pertti J. Neuvonen

المساهمون: Department of Clinical Pharmacology, Janne Backman / Principal Investigator, Medicum, University of Helsinki, Department of Diagnostics and Therapeutics, Anestesiologian yksikkö, Clinicum, HUS Perioperative, Intensive Care and Pain Medicine, HUSLAB

المصدر: European Journal of Clinical Pharmacology. 74:1615-1622

مصطلحات موضوعية: Male, Antifungal Agents, CYP3A4, HUMAN LIVER-MICROSOMES, Pharmacology, 030226 pharmacology & pharmacy, chemistry.chemical_compound, 0302 clinical medicine, Cytochrome P-450 CYP3A, Medicine, Drug Interactions, Pharmacology (medical), Norbuprenorphine, Biotransformation, SUBLINGUAL BUPRENORPHINE, Cross-Over Studies, OPIOID DEPENDENCE, P-GLYCOPROTEIN, General Medicine, Healthy Volunteers, SYSTEMIC ANTIMYCOTICS, Buprenorphine, 3. Good health, Analgesics, Opioid, IN-VITRO METABOLISM, Transporters, CYTOCHROME-P450 3A4, 317 Pharmacy, Area Under Curve, Female, CLINICAL PHARMACOKINETICS, Half-Life, Drug-drug interaction, medicine.drug, Adult, MAINTENANCE THERAPY, Adolescent, Cmax, Placebo, Dizziness, Sublingual administration, Young Adult, 03 medical and health sciences, Pharmacokinetics, Humans, Voriconazole, business.industry, Drug interaction, N-DEALKYLATION, chemistry, 3111 Biomedicine, business, 030217 neurology & neurosurgery