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1دورية أكاديمية
المؤلفون: Jutta Glock, Peter D. J. Grootenhuis, Steven Bondy, Daniel D. Comer, Soan Cheng, Arthur Steiger, Martin Zeller, Grit Laue, Adrian Friedmann, Olivier Jacob, Mafalda Nina, Hans-Jürg Widmer, Klaus Kreuz, Julie E. Penzotti, Hans Brunner, James Allen, Thierry Niderman, Hans Ulrich Haas, Renold Chollet, Martin Eberle, Peter Renold, William Lutz, Jürg Ehrler, Marian Valentini, Markus Walti, Evelyne Sieger, Thomas Vettiger, G. Wayne Craig
المصدر: CHIMIA, Vol 62, Iss 1-2 (2008)
مصطلحات موضوعية: Agrochemicals, Alkyne template, Combinatorial chemistry, Discovery, Sonogashira coupling, Chemistry, QD1-999
وصف الملف: electronic resource
Relation: https://chimia.ch/chimia/article/view/4428; https://doaj.org/toc/0009-4293; https://doaj.org/toc/2673-2424
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المصدر: 2018 Medicinal Chemistry Reviews ISBN: 9780996293266
2018 Medicinal Chemistry Reviewsمصطلحات موضوعية: medicine.medical_specialty, business.industry, Lumacaftor, medicine.disease, Gastroenterology, Cystic fibrosis, Ivacaftor, chemistry.chemical_compound, chemistry, Internal medicine, Mutation (genetic algorithm), medicine, F508del cftr, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::deee7cefe7ba8d46db26c255719b5c87
https://doi.org/10.29200/acsmedchemrev-v53.ch25 -
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المؤلفون: Jan N. M. Commandeur, Daan P. Geerke, Flemming Jørgensen, Ernst ter Haar, Arun K. Mohanty, Lars Olsen, Luigi Capoferri, Rasmus Leth, Peter D. J. Grootenhuis, Eduardo Vottero, Nico P. E. Vermeulen
المصدر: Proteins: Structure, Function, and Bioinformatics. 84:383-396
مصطلحات موضوعية: 0301 basic medicine, Mefenamic acid, biology, Chemistry, Stereochemistry, Mutant, Regioselectivity, Cytochrome P450, Biochemistry, Hydroxylation, Enzyme binding, 03 medical and health sciences, chemistry.chemical_compound, Crystallography, 030104 developmental biology, Structural Biology, Docking (molecular), medicine, biology.protein, Molecular Biology, Heme, medicine.drug
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المؤلفون: Luigi, Capoferri, Rasmus, Leth, Ernst, ter Haar, Arun K, Mohanty, Peter D J, Grootenhuis, Eduardo, Vottero, Jan N M, Commandeur, Nico P E, Vermeulen, Flemming Steen, Jørgensen, Lars, Olsen, Daan P, Geerke
المصدر: Proteins. 84(3)
مصطلحات موضوعية: Mutation, Missense, Hydrogen Bonding, Heme, Molecular Dynamics Simulation, Crystallography, X-Ray, Protein Structure, Secondary, Molecular Docking Simulation, Mefenamic Acid, Bacterial Proteins, Cytochrome P-450 Enzyme System, Catalytic Domain, Bacillus megaterium, Thermodynamics, Protein Binding
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المؤلفون: John Saunders, Jan N. M. Commandeur, Peter D. J. Grootenhuis, Nico P. E. Vermeulen, Jelle Reinen, Caroline Decker, Yongmin Li, Jolanda van Leeuwen, Lifang Sun
المصدر: Drug Metabolism and Disposition. 39:1568-1576
مصطلحات موضوعية: Drug, media_common.quotation_subject, Mutant, Pharmaceutical Science, Biology, Mass Spectrometry, Substrate Specificity, Bacterial Proteins, Cytochrome P-450 Enzyme System, Humans, Genomic library, Gene Library, media_common, Pharmacology, Molecular mass, Cytochrome P450, Chemical space, Pharmaceutical Preparations, Biochemistry, Drug development, Inactivation, Metabolic, Microsomes, Liver, Mutagenesis, Site-Directed, biology.protein, Drug metabolism, Chromatography, Liquid
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0984d93607f7640bd35fa142122525a
https://doi.org/10.1124/dmd.111.039461 -
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المصدر: Recueil des Travaux Chimiques des Pays-Bas. 112:161-168
مصطلحات موضوعية: Chemistry, business.industry, General Chemistry, Predictive value, Sequence identity, Molecular dynamics, Crystallography, Thrombin, Software, Protein structure, medicine, Human Thrombin, Homology modeling, Biological system, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::303052a4a8bee55a552bac45f48eca44
https://doi.org/10.1002/recl.19931120214 -
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المؤلفون: Tom Knapp, Victor Panchenko, Paul A. Negulescu, Ashvani K. Singh, Roger D. Tung, James A. Rader, Timothy Neuberger, Fredrick Van Goor, Kimberly Straley, Jeffrey H. Stack, Jesus E. Gonzalez, Eric R. Olson, John Joubran, Dong Cao, Mark Miller, Peter D. J. Grootenhuis, Sabine Hadida, Anna R. Hazlewood, Lewis R. Makings
المصدر: American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L1117-L1130
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Cystic Fibrosis, Physiology, Thyroid Gland, Cystic Fibrosis Transmembrane Conductance Regulator, Gating, Biology, medicine.disease_cause, Cystic fibrosis, 3T3 cells, Cell Line, Cresols, Mice, Chlorides, Physiology (medical), medicine, Animals, Humans, Biotinylation, Gene, Cells, Cultured, Sequence Deletion, Mutation, 3T3 Cells, Cell Biology, respiratory system, Potentiator, medicine.disease, Recombinant Proteins, Rats, respiratory tract diseases, medicine.anatomical_structure, Cell culture, Immunology, Cancer research, Pyrazoles, Ion Channel Gating
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbd5a9130d1b6a77b6165a012ea7fa0
https://doi.org/10.1152/ajplung.00169.2005 -
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المؤلفون: Mccartney Jason, Vijayalaksmi Arumugam, Peter D. J. Grootenhuis, Sabine Hadida, Caroline Decker, Paul A. Negulescu, Anna R. Hazlewood, Fredrick Van Goor, Jinglan Zhou
المصدر: Journal of medicinal chemistry. 57(23)
مصطلحات موضوعية: Male, Investigational drug, Cystic Fibrosis, medicine.drug_class, Cystic Fibrosis Transmembrane Conductance Regulator, Carboxamide, Pharmacology, Quinolones, Aminophenols, Ivacaftor, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Dogs, Pharmacokinetics, Drug Discovery, medicine, Potency, Animals, Humans, Child, CFTR Potentiator, Tert butyl, Chemistry, Bioavailability, Macaca fascicularis, NIH 3T3 Cells, Molecular Medicine, medicine.drug
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المؤلفون: Peter D. J. Grootenhuis, Gregor Zlokarnik, William J. Egan
المصدر: Drug Discovery Today: Technologies. 1:381-387
مصطلحات موضوعية: Drug, Cardiotoxicity, Liver toxicity, business.industry, media_common.quotation_subject, In silico, Drug Discovery, Molecular Medicine, Medicine, Pharmacology, business, Bioinformatics, media_common
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062622488445d5d77e7f9140b1a2ef99
https://doi.org/10.1016/j .ddtec.2004.11.002 -
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المؤلفون: Angelo J. Castellino, Peter D. J. Grootenhuis, Bondy Steven Scott, Mark J. Suto, Erin K. Bradley, Graham Beaton, Paul A. Gibbons, Michelle Lamb
المساهمون: Molecular and Computational Toxicology
المصدر: Journal of Molecular Graphics and Modelling, 23(1), 15-21. Elsevier Inc.
Lamb, M L, Bradley, E K, Beaton, G, Bondy, S S, Castellino, A J, Gibbons, P A, Suto, M J & Grootenhuis, P D J 2004, ' Design of a gene family screening library targeting G-protein coupled receptors ', Journal of Molecular Graphics and Modelling, vol. 23, no. 1, pp. 15-21 . https://doi.org/10.1016/j.jmgm.2004.03.001مصطلحات موضوعية: Prioritization, Molecular Structure, Computer science, Computational biology, Ligands, Bioinformatics, Computer Graphics and Computer-Aided Design, Receptors, G-Protein-Coupled, Drug Design, Multigene Family, Materials Chemistry, Iterative analysis, Combinatorial Chemistry Techniques, Gene family, Physical and Theoretical Chemistry, Pharmacophore, Receptor, Gene, Spectroscopy, Gene Library, G protein-coupled receptor
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