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المؤلفون: Helen Carnaghan, Joanne Bal, Rab K. Prinjha, Jackie C. Bloomer, Jack A. Brown, Peter Ernest Soden, Palwinder K. Mander, Sarah J Hopkins, João Joaquim Oliveira, Lars Erwig, William A. Fahy, Yi Cui, Shruti Daga, Bill Davis, Monica Simeoni, Disala Fernando, Peter Williams, Gabriel K. Wong, Edward Banham-Hall
المصدر: British Journal of Clinical Pharmacology. 88:2140-2155
مصطلحات موضوعية: Male, Pharmacology, Cross-Over Studies, Dose-Response Relationship, Drug, business.industry, Metabolite, Placebo, Crossover study, Healthy Volunteers, chemistry.chemical_compound, Regimen, Double-Blind Method, chemistry, Pharmacokinetics, Area Under Curve, Pharmacodynamics, Humans, Medicine, Pharmacology (medical), business, Adverse effect, Ex vivo
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المؤلفون: Peter Ernest Soden, Massimo Petretich, Robert J. Watson, Laurie J. Gordon, Chun-wa Chung, Paola Grandi, Alex Phillipou, Paul Bamborough, Emmanuel Hubert Demont, Rab K. Prinjha, Inmaculada Rioja, Thilo Werner, Robert E. Davis, Heather A. Barnett
المصدر: Journal of Medicinal Chemistry. 63:9045-9069
مصطلحات موضوعية: Cellular activity, Anti-Inflammatory Agents, Cell Cycle Proteins, chemical and pharmacologic phenomena, Molecular Dynamics Simulation, Quinolones, Pharmacology, Crystallography, X-Ray, 01 natural sciences, 03 medical and health sciences, Protein Domains, In vivo, Cell Line, Tumor, Drug Discovery, Humans, Naphthyridines, Cell Proliferation, 030304 developmental biology, 0303 health sciences, Binding Sites, Chemistry, hemic and immune systems, Highly selective, In vitro, 0104 chemical sciences, Bromodomain, DNA-Binding Proteins, 010404 medicinal & biomolecular chemistry, ATPases Associated with Diverse Cellular Activities, Molecular Medicine, Half-Life, Transcription Factors
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المؤلفون: Peter Ernest Soden, Emma J. Roberts, Danette L. Daniels, Chun-wa Chung, Stephen John Atkinson, Paul Bamborough, Anne Marie Michon, Johanna Vappiani, Andrea C. Haynes, Massimo Petretich, Marcus Bantscheff, Miriam M. Yeung, Matthew J Bell, Sarah-Jane Dawson, Paola Grandi, Dane Vassiliadis, Simon Taylor, James Gray, Omer Gilan, Kathy Knezevic, Marjeta Urh, Matthew J Lindon, Marian L. Burr, Rab K. Prinjha, Alex Preston, Inmaculada Rioja, Mark A. Dawson, Gerard Drewes, Thilo Werner, Christopher Roland Wellaway, Emmanuel Hubert Demont, Anna K. Bassil, Nicola Harker, Thomas Gobbetti, Enid Y.N. Lam, David F. Tough, Vinod Kumar
المصدر: Science
مصطلحات موضوعية: Regulation of gene expression, Male, BRD4, Multidisciplinary, Chromatin binding, HEK 293 cells, Prostatic Neoplasms, Proteins, Biology, Article, Chromatin, Bromodomain, Protein Domains, Gene expression, Cancer research, Humans, Transcription factor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f230e3011891f1a84ffe803aee2fab
https://europepmc.org/articles/PMC7610820/ -
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المؤلفون: Chun-wa Chung, Rab K. Prinjha, Rejbinder Kaur, Peter Ernest Soden, Ann Louise Walker, Van Loc Nguyen, Christophe Simon, Simon Taylor, Romain Luc Marie Gosmini, Jean-Marie Brusq, Antonia J. Lewis, Mark B. Schilling, Lionel Trottet, Matthew D. Walker, Leanne Cutler, Olivier Mirguet, Emmanuel Hubert Demont, Edwige Nicodeme, Eric Boursier, Jérôme Toum, Alizon M. Riou-Eymard, Gael Krysa, Hugh Clark, Paul Bamborough
المصدر: Journal of Medicinal Chemistry. 57:8111-8131
مصطلحات موضوعية: Anti-Inflammatory Agents, Regulator, Cell Cycle Proteins, Inflammation, Protein Serine-Threonine Kinases, Benzoates, Mice, Structure-Activity Relationship, Transcription (biology), Neuroblastoma, Drug Discovery, medicine, Animals, Humans, Histone code, Epigenetics, Gene, Genetics, Apolipoprotein A-I, Chemistry, Nuclear Proteins, medicine.disease, Bromodomain, Aminoquinolines, Quinolines, Cancer research, Molecular Medicine, medicine.symptom, Transcription Factors
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المؤلفون: Stephen John Atkinson, Chun-wa Chung, Peter Ernest Soden, Laurie J. Gordon, Rab K. Prinjha, Nicholas Smithers, Rebecca C. Furze, Kathryn A. Giblin, Davina C. Angell, Marcus Bantscheff, Nigel J. Parr, Inmaculada Rioja, Jason Witherington, Gerard Drewes
المصدر: MedChemComm. 5:342-351
مصطلحات موضوعية: Pharmacology, Hydroxamic acid, Organic Chemistry, Pharmaceutical Science, hemic and immune systems, chemical and pharmacologic phenomena, Biology, Biochemistry, Small molecule, In vitro, Bromodomain, chemistry.chemical_compound, chemistry, Transcription (biology), Drug Discovery, Cancer cell, Molecular Medicine, Histone deacetylase, Epigenetics
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3bdb6f43d6b09b952d7c8ccd1e8cfa40
https://doi.org/10.1039/c3md00285c -
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المؤلفون: Lena Shukla, Nermina Lamadema, Stephen John Atkinson, Elena Yiannaki, N. Shaun B. Thomas, Peter Ernest Soden, Charles M. Marson, Christopher J Matthews
المصدر: Journal of Medicinal Chemistry. 56:6156-6174
مصطلحات موضوعية: Pyrimidine, Stereochemistry, Antineoplastic Agents, Apoptosis, Histone Deacetylases, Cell Line, Histones, HeLa, Structure-Activity Relationship, chemistry.chemical_compound, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Humans, Benzamide, Aniline Compounds, biology, Histone deacetylase 2, Thiazoline, Acetylation, Stereoisomerism, HDAC8, biology.organism_classification, Histone Deacetylase Inhibitors, Isoenzymes, Molecular Docking Simulation, chemistry, Benzamides, Molecular Medicine, Histone deacetylase, Drug Screening Assays, Antitumor, Protein Binding
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المؤلفون: Emma J. Roberts, Peter Ernest Soden, Ruud Delwel, Dave Lugo, Brian J. P. Huntly, Samuel Robson, Olivier Mirguet, Chun-wa Chung, Soren Beinke, Rab K. Prinjha, Mikhail M. Savitski, Trevor D. Chapman, Carola Huthmacher, Emma Gudgin, Alan Kenneth Burnett, Gerard Drewes, Mark A. Dawson, Tony Kouzarides, Wai-In Chan, Konstanze Doehner, Kevin Lee, Phillip Jeffrey, Carsten Hopf, Antje Dittmann, Marcus Bantscheff, George Giotopoulos, Kurt R. Auger
المساهمون: Hematology
المصدر: Nature, 478(7370), 529-533. Nature Publishing Group
مصطلحات موضوعية: Models, Molecular, Proteomics, Chromatin Immunoprecipitation, BRD4, Oncogene Proteins, Fusion, Transcription, Genetic, Biology, Heterocyclic Compounds, 4 or More Rings, Article, BET inhibitor, Mice, Cell Line, Tumor, hemic and lymphatic diseases, Animals, Humans, Transcription factor, neoplasms, Multidisciplinary, Gene Expression Profiling, Molecular biology, Pediatric cancer, Chromatin, Cell biology, Bromodomain, Gene Expression Regulation, Neoplastic, Disease Models, Animal, Leukemia, Myeloid, Acute, Multiprotein Complexes, biology.protein, Cyclin-dependent kinase 6, Chromatin immunoprecipitation, Myeloid-Lymphoid Leukemia Protein, Protein Binding, Transcription Factors
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المؤلفون: Stephen D. Skaper, Nicholas A. Evans, Jill C. Richardson, Peter Ernest Soden, Claudia Rosin, Laura Facci
المصدر: Neurochemical Research. 34:2243-2250
مصطلحات موضوعية: BACE1-AS, Tau protein, Thiazines, Biochemistry, Amyloid beta-Protein Precursor, Cellular and Molecular Neuroscience, Alzheimer Disease, mental disorders, medicine, Amyloid precursor protein, Animals, Senile plaques, Amyloid beta-Peptides, biology, Chemistry, Neurodegeneration, P3 peptide, General Medicine, medicine.disease, Peptide Fragments, Rats, Biochemistry of Alzheimer's disease, Cell biology, Oligodendroglia, biology.protein, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase
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المؤلفون: Jill C. Richardson, Ainsley A. Culbert, Peter Ernest Soden, Nicholas A. Evans, David R. Howlett, Laura Facci, Florence Guillot, Stephen D. Skaper, Zoe Seymour, Matthias Gaestel
المصدر: Journal of Biological Chemistry. 281:23658-23667
مصطلحات موضوعية: Genetically modified mouse, Microglia, p38 mitogen-activated protein kinases, Cell Biology, Biology, Biochemistry, medicine.anatomical_structure, Interferon, Immunology, medicine, Cancer research, Amyloid precursor protein, biology.protein, Protein kinase A, Molecular Biology, Macrophage inflammatory protein, Neuroinflammation, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::65c8d261c95a7fb5ac7d480ff532d41f
https://doi.org/10.1074/jbc.m513646200 -
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المؤلفون: Nicholas Smithers, Susan Korenchuk, Charles F. McHugh, Olena Barbash, Jeanne J. Matteo, Peter Ernest Soden, Anastasia Wyce, Daniel J. Felitsky, Christopher L. Carpenter, Kathryn Keenan, Gary Thripp, Rab K. Prinjha
المصدر: Cancer Research. 76:4693-4693
مصطلحات موضوعية: NUT midline carcinoma, Cancer Research, BRD4, Pathology, medicine.medical_specialty, Cell growth, Cancer, Biology, medicine.disease, medicine.disease_cause, Bromodomain, Oncology, Cancer cell, medicine, Cancer research, Nuclear protein, Carcinogenesis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d57da5e415834aef51bcccd340c269f8
https://doi.org/10.1158/1538-7445.am2016-4693
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