-
1
المؤلفون: Donald Nelson, Gary G. Chicchi, James Dellureficio, Ravi P. Nargund, Peter H. Dobbelaar, Liangqin Guo, Kwei-Lan Tsao, Janet S. Kerr, Bei Zhang, Zhong Lai, Patricia R. Bunting, Shrenik K. Shah, Raman K. Bakshi, Qingmei Hong, Hongbo Qi, Guillermo Fernandez, Mikhail Reibarkh, Qing Shao, Quang Truong, Koppara Samuel, Jian Liu, Sylvia Volksdorf, Zhixiong Ye, Yun-Ping Zhou, Margaret Wu, Cai Li, Stan Mitelman, Andrew D. Howard, Wu Du, Maria E. Trujillo, George J. Eiermann, Shuwen He, Vijay Bhasker G. Reddy, Tianying Jian, Pierre Morissette, Patrick Fitzgerald, Dorina Trusca, Sharon Tong, William K. Hagmann
المصدر: ACS Medicinal Chemistry Letters. 5:748-753
مصطلحات موضوعية: biology, business.industry, Organic Chemistry, hERG, Antagonist, In vitro toxicology, Type 2 diabetes, Pharmacology, medicine.disease, Biochemistry, QT interval, Somatostatin, Drug Discovery, biology.protein, Medicine, cardiovascular diseases, Receptor, business, Antagonism
-
2
المؤلفون: Janet Kerr, Gary G. Chicchi, Margaret Wu, Cai Li, Shuwen He, Vijay Bhasker G. Reddy, Sharon Tong, William K. Hagmann, Patrick Fitzgerald, Guillermo Fernandez, Andrew D. Howard, Tianying Jian, Zhe Feng, Raman K. Bakshi, Dorina Trusca, Peter H. Dobbelaar, Donald Nelson, Mikhail Reibarkh, Qing Shao, Liangqin Guo, Yun-Ping Zhou, Ravi P. Nargund, Kwei-Lan Tsao, Edward C. Sherer, Stan Mitelman, Pierre Morissette, Maria E. Trujillo, Quang Truong, Zhixiong Ye, James D. Dellureficio, Hongbo Qi, Melissa Lin, Shrenik K. Shah, Sylvia Volksdorf, Jian Liu, Qingmei Hong, Koppara Samuel, Alexander Pasternak, George J. Eiermann, Patricia B. Bunting, Wu Du, Bei B. Zhang
المصدر: Bioorganicmedicinal chemistry letters. 26(6)
مصطلحات موضوعية: QTC PROLONGATION, congenital, hereditary, and neonatal diseases and abnormalities, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, 010402 general chemistry, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, Animals, Humans, cardiovascular diseases, Receptors, Somatostatin, Molecular Biology, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Antagonist, 0104 chemical sciences, Rats, biology.protein, Molecular Medicine, Antagonism, Carbolines
-
3
المؤلفون: Cecilia H. Marzabadi, Peter H. Dobbelaar
المصدر: Tetrahedron. 67:9273-9282
مصطلحات موضوعية: Organic Chemistry, Quinoline, Moderate activity, Biochemistry, Combinatorial chemistry, Boron trichloride, Leukemia cell line, chemistry.chemical_compound, chemistry, Drug Discovery, Organic chemistry, Stereoselectivity, Lewis acids and bases, Povarov reaction, Cytotoxicity
-
4
المؤلفون: C. Scott Shultz, Peter H. Dobbelaar, Ravi P. Nargund, Ronsar Eid, Zhong Lai, Zhixiong Ye, Shuwen He
المصدر: Tetrahedron Letters. 52:3621-3624
مصطلحات موضوعية: Organic Chemistry, Asymmetric hydrogenation, Enantioselective synthesis, chemistry.chemical_element, Biochemistry, Catalysis, Ruthenium, Acetic acid, chemistry.chemical_compound, chemistry, Yield (chemistry), Drug Discovery, Acetone, Organic chemistry, Enantiomer
-
5
المؤلفون: Yingjie Lai, Ralph A. Stearns, Qianping Peng, Ravi P. Nargund, Qingmei Hong, Jian Liu, Rui Tang, Matthew J. Wyvratt, Raman K. Bakshi, Randy R. Miller, Tianying Jian, Alison M. Strack, Tanya MacNeil, Liangqin Guo, Howard Y. Chen, James Dellureficio, Iyassu K. Sebhat, Peter H. Dobbelaar, Airu S. Chen, Constantin Tamvakopoulos, David H. Weinberg, Tung M. Fong, Christopher L. Franklin, Shuwen He, Zhixiong Ye
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4399-4405
مصطلحات موضوعية: Agonist, medicine.medical_specialty, Pyrrolidines, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Anti-Obesity Agents, Internal medicine, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Spiro Compounds, Obesity, Molecular Biology, Mice, Knockout, Chemistry, Body Weight, Organic Chemistry, Amides, Rats, Endocrinology, Drug development, Anorectic, Receptor, Melanocortin, Type 4, Molecular Medicine
-
6
المؤلفون: Howard Y. Chen, William J. Martin, D. Euan MacIntyre, Zhixiong Ye, Raman K. Bakshi, Alison M. Strack, Doreen E. Cashen, Jian Liu, Yingjie Lai, Tianying Jian, Constantin Tamvakopoulos, Nancy N. Tsou, Shuwen He, James Dellureficio, Tung M. Fong, Peter H. Dobbelaar, David H. Weinberg, Airu S. Chen, Qingmei Hong, Iyassu K. Sebhat, Tanya MacNeil, Christopher L. Franklin, Ravi P. Nargund, Ralph A. Stearns, Rui Tang, Richard G. Ball, Matthew J. Wyvratt, Randy R. Miller, Liangqin Guo, Qianping Peng
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2106-2110
مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, CHO Cells, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, Cricetulus, Dogs, Erectile Dysfunction, Cricetinae, Drug Discovery, medicine, Animals, Humans, Spiro Compounds, Receptor, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Haplorhini, Rats, Bioavailability, Indans, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin, Protein Binding
-
7
المؤلفون: Marc L. Reitman, Cheng Guo, Theresa M. Kelly, Constantin Tamvakopoulos, Joseph M. Metzger, Tianying Jian, Howard Y. Chen, Arthur A. Patchett, Oksana C. Palyha, Alison M. Strack, Allan J. Goodman, Ravi P. Nargund, Peter H. Dobbelaar, Yanqing Kan, Mark Hadden, Larry Yet, Peter R. Guzzo, Qianping Peng, Linus S. Lin, Shuwen He, Lauren P. Shearman, Alan J. Henderson, Carina P. Tan, Sargent Bruce J, Xiao-Ming Guan, Scott D. Feighner, Iyassu K. Sebhat, Jie Pan, Jian Liu, Donald J. Marsh, Matthew J. Wyvratt, Andrew D. Howard, Megan Ruenz
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1913-1917
مصطلحات موضوعية: Agonist, medicine.drug_class, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Molecular Biology, Biphenyl, Chemistry, Drug discovery, fungi, Organic Chemistry, Imidazoles, Rats, Bombesin receptor, Bioavailability, Receptors, Bombesin, Molecular Medicine, Bombesin Receptor Subtype-3
-
8
المؤلفون: Cecilia H. Marzabadi, Peter H. Dobbelaar
المصدر: Tetrahedron Letters. 51:201-204
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Yield (chemistry), Organic Chemistry, Drug Discovery, Quinoline, Organic chemistry, Lewis acids and bases, Biochemistry, Catalysis
-
9
المؤلفون: Yang Yu, Gary G. Chicchi, Frederick Wong, Janet S. Kerr, Sharon Tong, Zhe Feng, Guillermo Fernandez, Edward C. Sherer, Kwei-Lan Tsao, Qing Shao, Bei B. Zhang, Yun-Ping Zhou, Pierre Morissette, Shuwen He, Shrenik K. Shah, Vijay Bhasker G. Reddy, Liangqin Guo, Ravi P. Nargund, Margaret Wu, Cai Li, Zhixiong Ye, Alexander Pasternak, George J. Eiermann, Patricia R. Bunting, Hongbo Qi, Michele Pachanski, Stan Mitelman, Maria E. Trujillo, Quang Truong, Maria Madiera, Andrew D. Howard, Donald Nelson, Qingmei Hong, Zhong Lai, Yue Feng, Bindhu V. Karanam, Jian Liu, Koppara Samuel, Wu Du, William K. Hagmann, Tianying Jian, Dorina Trusca, Sylvia Volksdorf, Peter H. Dobbelaar
المصدر: ACS medicinal chemistry letters. 6(5)
مصطلحات موضوعية: business.industry, Murine model, Organic Chemistry, Drug Discovery, Antagonist, Qtc interval prolongation, medicine, Type 2 diabetes, Glucose excursion, Pharmacology, medicine.disease, business, Biochemistry
-
10
المؤلفون: Peter H. Dobbelaar, Cecilia H. Marzabadi
المصدر: ChemInform. 43
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Quinoline, Organic chemistry, General Medicine, Sugar