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1دورية أكاديمية
المؤلفون: Nicholas A. Moore, Bruce J. Sargent, Peter R. Guzzo, Matthew D. Surman
المصدر: Neurobiology of Disease, Vol 61, Iss , Pp 47-54 (2014)
مصطلحات موضوعية: Melanin concentrating hormone, MCH, MCH1, ALB-127158(a), CSF, Human, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
وصف الملف: electronic resource
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2
المؤلفون: Kevin C. Felt, Letty Leslie Ann A. Salas Estrada, Madeleine Stauffer, Peter R. Guzzo, Dejian Xie, Jinkun Huang, Marta Filizola, Sudha Chakrapani
المصدر: Biophysical Journal. 122:460a
مصطلحات موضوعية: Biophysics
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المؤلفون: Dejian Xie, Gillian Grafton, Alexander Roberts, Nicholas A. Moore, Jinkun Huang, Nicholas M. Barnes, Catherine A. Brady, Kristian Brock, Shuang Liu, Andrew D. Powell, Zania Stamataki, Omar S. Qureshi, A.J Cooper, Chunlin Chen, Peter R. Guzzo, Sargent Bruce J, David D. Manning
المصدر: Journal of Pharmacology and Experimental Therapeutics. 373:122-134
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, biology, Intrinsic activity, business.industry, medicine.disease, Symptomatic relief, Partial agonist, 5-HT3 receptor, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Alosetron, biology.protein, Molecular Medicine, Medicine, business, Receptor, 030217 neurology & neurosurgery, Carcinoid syndrome, Irritable bowel syndrome, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b618e2e0df8d6f7865236dcca51d463b
https://doi.org/10.1124/jpet.119.261008 -
4
المؤلفون: Christopher L. Cioffi, Peter R. Guzzo
المصدر: Current Topics in Medicinal Chemistry. 16:3404-3437
مصطلحات موضوعية: biology, 010405 organic chemistry, Glutamic Acid, General Medicine, Glycine Plasma Membrane Transport Proteins, Neurotransmission, Pharmacology, Inhibitory postsynaptic potential, 01 natural sciences, Neuroprotection, 0104 chemical sciences, 03 medical and health sciences, 0302 clinical medicine, Central Nervous System Diseases, Glycine transporter 1, Drug Discovery, Glycine, Schizophrenia, biology.protein, Humans, NMDA receptor, Glycine receptor, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04eb3b5787dfb4220742cb663e07dfa
https://doi.org/10.2174/1568026616666160405113340 -
5
المؤلفون: Alexander, Roberts, Gillian, Grafton, Andrew D, Powell, Kristian, Brock, Chunlin, Chen, Dejian, Xie, Jinkun, Huang, Shuang, Liu, Alison J, Cooper, Catherine A, Brady, Omar, Qureshi, Zania, Stamataki, David D, Manning, Nicholas A, Moore, Bruce J, Sargent, Peter R, Guzzo, Nicholas M, Barnes
المصدر: The Journal of pharmacology and experimental therapeutics. 373(1)
مصطلحات موضوعية: Male, Dose-Response Relationship, Drug, Serotonin 5-HT3 Receptor Agonists, Rats, Drug Partial Agonism, Irritable Bowel Syndrome, Rats, Sprague-Dawley, Dogs, HEK293 Cells, Treatment Outcome, Animals, Humans, Heterocyclic Compounds, 3-Ring, Malignant Carcinoid Syndrome
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::8976e875566eed48c13427941cd64f5d
https://pubmed.ncbi.nlm.nih.gov/32102919 -
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المؤلفون: Gary R. Eldridge, Peter R. Guzzo, James P. Harding, Mark O’Neil-Johnson, John E. Mangette, Courtney M. Starks, Shuang Liu, Steven M. Martin, Julie A. Lawrence, Zhongping Huang, Russell B. Williams, Vanessa L. Norman
المصدر: Journal of medicinal chemistry. 61(15)
مصطلحات موضوعية: Microgram, Antineoplastic Agents, 01 natural sciences, Lignans, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 0302 clinical medicine, Pharmacokinetics, Tubulin, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Animals, Humans, Protein Structure, Quaternary, Cell Proliferation, 010405 organic chemistry, Chemistry, Bifidenone, Xenograft Model Antitumor Assays, In vitro, 0104 chemical sciences, Paclitaxel, Cell culture, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Protein Multimerization, Human cancer
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المؤلفون: Andrew J. Mhyre, Cheng Guo, Russell J. DeOrazio, Kevin Fitzpatrick, Yuri L. Khmelnitsky, Zhenjun Zhang, Min Hu, Peter R. Guzzo, Susan Tom, Jun-Ho Maeng, Douglas B. Kitchen, Michele Luche, Shuang Liu, Alexander Usyatinsky
المصدر: Bioorganic & Medicinal Chemistry. 22:3414-3422
مصطلحات موضوعية: C glycosides, Pyridones, Stereochemistry, Clinical Biochemistry, High selectivity, Pharmaceutical Science, Hydantoin, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Sodium-Glucose Transporter 2, Glucoside, Drug Discovery, Humans, Structure–activity relationship, Glycosides, Sodium-Glucose Transporter 2 Inhibitors, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Glycoside, Triazoles, In vitro, Aglycone, chemistry, Drug Design, Phenytoin, Molecular Medicine
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المصدر: Neurobiology of Disease, Vol 61, Iss, Pp 47-54 (2014)
مصطلحات موضوعية: Male, Melanin concentrating hormone, Indazoles, Pyridones, medicine.drug_class, Drug Evaluation, Preclinical, CSF, Pharmacology, Bioinformatics, Inflammatory bowel disease, lcsh:RC321-571, Mediator, Weight loss, Drug Discovery, Animals, Humans, Medicine, Obesity, Receptors, Pituitary Hormone, Receptor, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Clinical Trials as Topic, business.industry, Mechanism (biology), Antagonist, Receptor antagonist, medicine.disease, MCH, Rats, Neurology, Go/no go, Anti-Obesity Agents, medicine.symptom, business, MCH1, ALB-127158(a), Human
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المصدر: ACS Chemical Neuroscience. 4:43-47
مصطلحات موضوعية: medicine.medical_specialty, Abdominal pain, Constipation, Physiology, medicine.drug_class, Cognitive Neuroscience, Population, Biochemistry, Partial agonist, Gastroenterology, 5-HT3 receptor, Irritable Bowel Syndrome, Internal medicine, medicine, Humans, Serotonin 5-HT3 Receptor Antagonists, education, Irritable bowel syndrome, education.field_of_study, biology, business.industry, Serotonin 5-HT3 Receptor Agonists, Cell Biology, General Medicine, Ligand-Gated Ion Channels, Receptor antagonist, medicine.disease, Alosetron, Anesthesia, biology.protein, Receptors, Serotonin, 5-HT3, medicine.symptom, business, medicine.drug
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المؤلفون: Zhu Qiang, Shailaja Panduga, Kassoum Nacro, Rashmi Pathak, Venkateswara R. Narreddula, Alan J. Henderson, Kai Xiang, Ming Min Hsia, Bharat Shimpukade, Matthew Isherwood, Jagjit Kaur, Animesh Ghosh, Valentina Tan, Peter R. Guzzo
المصدر: Isherwood, M, Guzzo, P R, Henderson, A J, Hsia, M M, Kaur, J, Nacro, K, Narreddula, V R, Panduga, S, Pathak, R, Shimpukade, B, Tan, V, Xiang, K, Qiang, Z & Ghosh, A 2012, ' An efficient synthesis of (7S,10R)-2-bromo-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole: application in the preparation and structural confirmation of a potent 5-HT6 antagonist ', Tetrahedron: Asymmetry, vol. 23, no. 22, pp. 1522-1527 . https://doi.org/10.1016/j.tetasy.2012.10.012
مصطلحات موضوعية: Indole test, Sulfonyl, chemistry.chemical_classification, Chiral auxiliary, Trifluoromethyl, Chemistry, Stereochemistry, Organic Chemistry, 5-HT6, Enantioselective synthesis, Diastereomer, Catalysis, Chiral resolution, Inorganic Chemistry, chemistry.chemical_compound, GPCR, Physical and Theoretical Chemistry, Enantiomer, Asymmetric Synthesis