المؤلفون: Pfister, SX, Ahrabi, S, Zalmas, LP, Sarkar, S, Aymard, F, Bachrati, CZ, Helleday, T, Legube, G, La Thangue, NB, Porter, ACG, Humphrey, TC

المصدر: Cell reports. 7(6):2006-2018

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:129305173

المؤلفون: Pfister SX; Sophia X. Pfister is the director of research science at Varian, a Siemens Healthineers company in Palo Alto, California. Send your career story to SciCareerEditor@aaas.org.

المصدر: Science (New York, N.Y.) [Science] 2022 Jul 22; Vol. 377 (6604), pp. 442. Date of Electronic Publication: 2022 Jul 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Stairiker CJ; Cancer Immunology Discovery, Worldwide Research, Development Medical, Pfizer Inc., San Diego, CA, United States., Pfister SX; Cancer Immunology Discovery, Worldwide Research, Development Medical, Pfizer Inc., San Diego, CA, United States., Hendrickson E; Translational Sciences, Worldwide Research, Development Medical, Pfizer Inc., San Diego, CA, United States., Yang W; Computational Biology, Worldwide Research, Development Medical, Pfizer Inc., San Diego, CA, United States., Xie T; Computational Biology, Worldwide Research, Development Medical, Pfizer Inc., San Diego, CA, United States., Lee C; Translational Sciences, Worldwide Research, Development Medical, Pfizer Inc., San Diego, CA, United States., Zhang H; Translational Sciences, Worldwide Research, Development Medical, Pfizer Inc., San Diego, CA, United States., Dillon C; Translational Sciences, Worldwide Research, Development Medical, Pfizer Inc., San Diego, CA, United States., Thomas GD; Cancer Immunology Discovery, Worldwide Research, Development Medical, Pfizer Inc., San Diego, CA, United States., Salek-Ardakani S; Cancer Immunology Discovery, Worldwide Research, Development Medical, Pfizer Inc., San Diego, CA, United States.

المصدر: Frontiers in immunology [Front Immunol] 2021 Nov 24; Vol. 12, pp. 770080. Date of Electronic Publication: 2021 Nov 24 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*pharmacology , CD8-Positive T-Lymphocytes/*drug effects , Enhancer of Zeste Homolog 2 Protein/*antagonists & inhibitors , Enzyme Inhibitors/*pharmacology , Neoplasms, Experimental/*prevention & control , Tumor Necrosis Factor Receptor Superfamily, Member 9/*agonists, Animals ; Antibodies, Monoclonal/immunology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; Cell Survival/immunology ; Enhancer of Zeste Homolog 2 Protein/immunology ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/immunology ; Humans ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/immunology ; Tumor Burden/drug effects ; Tumor Burden/genetics ; Tumor Burden/immunology ; Tumor Necrosis Factor Receptor Superfamily, Member 9/immunology ; Tumor Necrosis Factor Receptor Superfamily, Member 9/metabolism ; Mice

المؤلفون: Zhang Y; Global Translational Science, Varian, a Siemens Healthineers Company, Palo Alto, California, USA., Ding Z; Global Translational Science, Varian, a Siemens Healthineers Company, Palo Alto, California, USA., Perentesis JP; Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Khuntia D; Global Translational Science, Varian, a Siemens Healthineers Company, Palo Alto, California, USA., Pfister SX; Global Translational Science, Varian, a Siemens Healthineers Company, Palo Alto, California, USA., Sharma RA; Global Translational Science, Varian, a Siemens Healthineers Company, Palo Alto, California, USA; UCL Cancer Institute, University College London, London, UK. Electronic address: ricky.sharma@ucl.ac.uk.

المصدر: Clinical oncology (Royal College of Radiologists (Great Britain)) [Clin Oncol (R Coll Radiol)] 2021 Nov; Vol. 33 (11), pp. 713-722. Date of Electronic Publication: 2021 Sep 20.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: W.B. Saunders Country of Publication: England NLM ID: 9002902 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-2981 (Electronic) Linking ISSN: 09366555 NLM ISO Abbreviation: Clin Oncol (R Coll Radiol) Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/radiotherapy , Radiation Oncology*, Clinical Protocols ; Humans ; Immunotherapy ; Radiotherapy ; Radiotherapy Dosage

المؤلفون: Singh J; Global Translational Science, Varian, a Siemens Healthineers company, Palo Alto, California, USA., Hatcher S; Global Translational Science, Varian, a Siemens Healthineers company, Palo Alto, California, USA., Ku AA; Global Translational Science, Varian, a Siemens Healthineers company, Palo Alto, California, USA., Ding Z; Global Translational Science, Varian, a Siemens Healthineers company, Palo Alto, California, USA., Feng FY; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA; Department of Radiation Oncology, University of California, San Francisco, California, USA; Department of Urology, University of California, San Francisco, California, USA., Sharma RA; Global Translational Science, Varian, a Siemens Healthineers company, Palo Alto, California, USA; UCL Cancer Institute, University College London, London, UK., Pfister SX; Global Translational Science, Varian, a Siemens Healthineers company, Palo Alto, California, USA. Electronic address: sophia.pfister@varian.com.

المصدر: Clinical oncology (Royal College of Radiologists (Great Britain)) [Clin Oncol (R Coll Radiol)] 2021 Nov; Vol. 33 (11), pp. 694-704. Date of Electronic Publication: 2021 Aug 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: W.B. Saunders Country of Publication: England NLM ID: 9002902 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-2981 (Electronic) Linking ISSN: 09366555 NLM ISO Abbreviation: Clin Oncol (R Coll Radiol) Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/drug therapy , Neoplasms*/radiotherapy , Pharmaceutical Preparations* , Radiation Oncology*, Combined Modality Therapy ; Humans

المؤلفون: Pai CC; CRUK-MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, ORCRB, Roosevelt Drive, Oxford, OX3 7DQ, UK chen-chun.pai@oncology.ox.ac.uk timothy.humphrey@oncology.ox.ac.uk., Hsu KF; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3TA, UK.; Department of Surgery, Tri-Service General Hospital, National Defense Medical Centre, Taipei 114, Taiwan., Durley SC; CRUK-MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, ORCRB, Roosevelt Drive, Oxford, OX3 7DQ, UK., Keszthelyi A; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, Sussex, BN1 9RQ, UK., Kearsey SE; Department of Zoology, University of Oxford, Zoology Research & Administration Building, Mansfield Road, Oxford, OX1 3PS, UK., Rallis C; Research Department of Genetics, Evolution & Environment, University College London, London, WC1E 6BT, UK.; School of Health, Sport and Bioscience, University of East London, Stratford Campus, E15 4LZ, London, UK., Folkes LK; CRUK-MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, ORCRB, Roosevelt Drive, Oxford, OX3 7DQ, UK., Deegan R; CRUK-MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, ORCRB, Roosevelt Drive, Oxford, OX3 7DQ, UK., Wilkins SE; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3TA, UK., Pfister SX; CRUK-MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, ORCRB, Roosevelt Drive, Oxford, OX3 7DQ, UK., De León N; Department of Zoology, University of Oxford, Zoology Research & Administration Building, Mansfield Road, Oxford, OX1 3PS, UK., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3TA, UK., Bähler J; Research Department of Genetics, Evolution & Environment, University College London, London, WC1E 6BT, UK., Carr AM; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, Sussex, BN1 9RQ, UK., Humphrey TC; CRUK-MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, ORCRB, Roosevelt Drive, Oxford, OX3 7DQ, UK chen-chun.pai@oncology.ox.ac.uk timothy.humphrey@oncology.ox.ac.uk.

المصدر: Journal of cell science [J Cell Sci] 2019 Mar 25; Vol. 132 (6). Date of Electronic Publication: 2019 Mar 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE

مواضيع طبية MeSH: Cell Cycle Proteins/*metabolism , Cyclin-Dependent Kinases/*metabolism , Nucleotides/*metabolism , Protein-Tyrosine Kinases/*metabolism , Schizosaccharomyces pombe Proteins/*metabolism, Cell Cycle Checkpoints ; DNA Damage ; DNA Replication ; Histone Code ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/metabolism ; Homeostasis ; Methylation ; Schizosaccharomyces/metabolism ; Synthetic Lethal Mutations ; Transcription Factors/metabolism

المؤلفون: Pfister SX; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, USA., Ashworth A; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, USA.

المصدر: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2017 Apr; Vol. 16 (4), pp. 241-263. Date of Electronic Publication: 2017 Mar 10.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1784 (Electronic) Linking ISSN: 14741776 NLM ISO Abbreviation: Nat Rev Drug Discov Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Epigenesis, Genetic/*drug effects , Epigenesis, Genetic/*genetics , Molecular Targeted Therapy/*methods , Neoplasms/*drug therapy , Neoplasms/*genetics, Drug Discovery/methods ; Drug Discovery/trends ; Enzyme Inhibitors/therapeutic use ; Humans ; Models, Genetic

المؤلفون: Ahrabi S; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK., Sarkar S; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK., Pfister SX; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK., Pirovano G; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK., Higgins GS; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK., Porter AC; Gene Targeting Group, Centre for Haematology, Imperial College Faculty of Medicine, London W12 0NN, UK., Humphrey TC; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK timothy.humphrey@oncology.ox.ac.uk.

المصدر: Nucleic acids research [Nucleic Acids Res] 2016 Jul 08; Vol. 44 (12), pp. 5743-57. Date of Electronic Publication: 2016 Apr 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: DNA Breaks, Double-Stranded* , DNA End-Joining Repair* , Recombinational DNA Repair*, BRCA1 Protein/*genetics , BRCA2 Protein/*genetics , DNA/*metabolism , Replication Protein A/*genetics, BRCA1 Protein/antagonists & inhibitors ; BRCA1 Protein/metabolism ; BRCA2 Protein/antagonists & inhibitors ; BRCA2 Protein/metabolism ; Base Sequence ; Biological Assay ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Line, Tumor ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; Endodeoxyribonucleases ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Humans ; MRE11 Homologue Protein ; Mutation ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Replication Protein A/antagonists & inhibitors ; Replication Protein A/metabolism ; Sequence Alignment ; Sequence Homology, Nucleic Acid ; DNA Polymerase theta

المؤلفون: Ramcharan R; Department of Oncology, Old Road Campus Research Building, Oxford, UK., Aleksic T; Department of Oncology, Old Road Campus Research Building, Oxford, UK., Kamdoum WP; Department of Oncology, Old Road Campus Research Building, Oxford, UK., Gao S; Department of Oncology, Old Road Campus Research Building, Oxford, UK., Pfister SX; Department of Oncology, Old Road Campus Research Building, Oxford, UK., Tanner J; Biomedical Services, John Radcliffe Hospital, Oxford, UK., Bridges E; Department of Oncology, Old Road Campus Research Building, Oxford, UK., Asher R; Department of Pathology, John Radcliffe Hospital, Oxford, UK., Watson AJ; Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK., Margison GP; Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK., Woodcock M; Department of Oncology, Old Road Campus Research Building, Oxford, UK., Repapi E; Computational Biology Research Group, Weatherall Institute of Molecular Medicine, Oxford, UK., Li JL; Department of Oncology, Old Road Campus Research Building, Oxford, UK., Middleton MR; Oxford Cancer Centre, Churchill Hospital, Oxford, UK., Macaulay VM; Department of Oncology, Old Road Campus Research Building, Oxford, UK.; Oxford Cancer Centre, Churchill Hospital, Oxford, UK.

المصدر: Oncotarget [Oncotarget] 2015 Nov 24; Vol. 6 (37), pp. 39877-90.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: Print Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: MEDLINE

مواضيع طبية MeSH: Xenograft Model Antitumor Assays*, Antineoplastic Combined Chemotherapy Protocols/*pharmacology , Melanoma/*drug therapy , Receptor, IGF Type 1/*antagonists & inhibitors, Animals ; Apoptosis/drug effects ; Blotting, Western ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA Breaks, Double-Stranded/drug effects ; Dacarbazine/administration & dosage ; Dacarbazine/analogs & derivatives ; Dacarbazine/pharmacology ; Drug Administration Schedule ; Drug Resistance, Neoplasm/drug effects ; Drug Synergism ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Imidazoles/administration & dosage ; Imidazoles/pharmacology ; Melanoma/genetics ; Melanoma/metabolism ; Mice, Inbred BALB C ; Mice, Nude ; Mutation ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/metabolism ; Pyrazines/administration & dosage ; Pyrazines/pharmacology ; Receptor, IGF Type 1/metabolism ; Survival Analysis ; Temozolomide ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism

المؤلفون: Pfister SX; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Markkanen E; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK; Institute of Pharmacology and Toxicology, Vetsuisse Faculty, Winterthurerstrasse 260, 8057 Zürich, Switzerland., Jiang Y; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Sarkar S; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Woodcock M; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Orlando G; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Mavrommati I; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Pai CC; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Zalmas LP; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Drobnitzky N; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Dianov GL; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK; Institute of Cytology and Genetics RAS, Novosibirsk 630090, Russia., Verrill C; Department of Cellular Pathology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK., Macaulay VM; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK; Oxford Cancer and Haematology Centre, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford OX3 7LJ, UK., Ying S; Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital and Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China., La Thangue NB; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., D'Angiolella V; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Ryan AJ; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Humphrey TC; CRUK MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK. Electronic address: timothy.humphrey@oncology.ox.ac.uk.

المصدر: Cancer cell [Cancer Cell] 2015 Nov 09; Vol. 28 (5), pp. 557-568.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Cell Cycle Proteins/*metabolism , Histones/*metabolism , Neoplasms/*metabolism , Nuclear Proteins/*metabolism , Nucleotides/*metabolism , Protein-Tyrosine Kinases/*metabolism, Amino Acid Sequence ; Animals ; Base Sequence ; Blotting, Western ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/genetics ; Humans ; Lysine/genetics ; Lysine/metabolism ; Methylation/drug effects ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Sequence Data ; Neoplasms/genetics ; Neoplasms/prevention & control ; Nuclear Proteins/antagonists & inhibitors ; Nuclear Proteins/genetics ; Nucleotides/genetics ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/genetics ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Pyrimidinones ; RNA Interference ; Reverse Transcriptase Polymerase Chain Reaction ; Ribonucleoside Diphosphate Reductase/genetics ; Ribonucleoside Diphosphate Reductase/metabolism ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid ; Xenograft Model Antitumor Assays