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المؤلفون: Carla Ghelardini, Antonio Giordani, Andrea Cappelli, Giovanna Poce, Mariangela Biava, Alma Martelli, Gianfranco Caselli, Maurizio Anzini, Sara Consalvi, L. Sautebin, A. Di Capua, Vincenzo Calderone, Maria Cristina Breschi, P. Patrignani, Lucio Claudio Rovati, Lara Testai
المساهمون: Martelli, A, Testai, L, Anzini, M, Cappelli, A, Di Capua, A, Biava M., A, Poce, G., Consalvi, S, Giordani, A, Caselli, G, Rovati, L, Ghelardini, C, Patrignani, P, Sautebin, Lidia, Breschi, Mc, Calderone, V.
المصدر: Pharmacological Research. 78:1-9
مصطلحات موضوعية: 2-[2-[1-(4-Fluorophenyl)-2-methyl-5-(4-methylsulfonylphenyl)pyrrol-3-yl]ethoxy]ethyl nitrate, Male, resuspending buffer, systolic blood pressure, Vascular smooth muscle, Wistar, Blood Pressure, Prostacyclin, Pharmacology, Rats, Inbred SHR, 2-[2-[1-(4-Fluorophenyl)-2-methyl-5-(4-methylsulfonylphenyl)pyrrol-3-yl]ethoxy]ethyl nitrate (PubChem CID: 56929588), HR, left ventricular developed pressure, heart rate, COX-inhibiting nitric oxide donor, GC, NO-naproxen (PubChem CID: 9884642), sodium nitroprusside, ANOVA, VIGOR, Pharmacodynamic hybrids, cardiovascular, APPROVe, Nitric oxide-releasing drugs, COX2-inhibitors, Inbred SHR, Endothelium, SHRs, Endothelium-Dependent Relaxing Factors, Nitric Oxide, traditional non-steroidal anti-inflammatory drugs, COX(2), BP, VA692, In vivo, VA694, Pyrroles, Rats, Wistar, SBP, COX(2)-selective inhibitors, Cyclooxygenase 2 Inhibitors, 2-[2-[1-(4-Fluorophenyl)-2-methyl-5-(4-methylsulfonylphenyl)pyrrol-3-yl]ethoxy]ethanol, LVDP, medicine.disease, 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one, 2-[2-[1-(4-Fluorophenyl)-2-methyl-5-(4-methylsulfonylphenyl)pyrrol-3-yl]ethoxy]ethanol (PubChem CID: 56929591), ACh, Adenomatous Polyp PRevention On Vioxx study, Anti-inflammatory drugs, CINOD, COX(2)-inhibitors, COXIBs, CV, DMSO, Endothelial dysfunction, Hypertension, IL-1β, NA, NO, NR, NSAIDs, ODQ, RB, SEM, SNP, Vioxx Gastrointestinal Outcome studies, acetylcholine, analysis of variance, blood pressure, cyclooxygenase-2, dimethylsulphoxide, guanylate cyclase, interleukine-1β, nitrate reductase bars, nitric oxide, non-steroidal anti-inflammatory drugs, noradrenaline, spontaneously hypertensive rats, standard error of the mean, tNSAIDs, Animals, Anti-Inflammatory Agents, Non-Steroidal, Coronary Vessels, Nitrates, Nitrites, Rats, Regional Blood Flow, Blood pressure, Cyclooxygenase, Anti-Inflammatory Agents, biology, Chemistry, Anti-inflammatory drugs, Pharmacodynamic hybrids, COX2-inhibitors, Nitric oxide-releasing drugs, Hypertension, Endothelial dysfunction, medicine.anatomical_structure, Non-Steroidal, medicine.drug, 4]Oxadiazolo[4, medicine, 1H-[1, biology.protein, 3-a]quinoxalin-1-one
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المؤلفون: Carla Ghelardini, Antonio Giordani, Lidia Sautebin, Antonietta Rossi, S. Alfonso, Maurizio Anzini, Claudio Battilocchio, Angela Di Capua, Vincenzo Calderone, Sara Consalvi, Lorenzo Di Cesare Mannelli, Mariangela Biava, Stefano Persiani, Paola Patrignani, Milena Colovic, Melania Dovizio, Giovanna Poce, Alma Martelli, Lara Testai
المساهمون: Biava, M, Battilocchio, C, Poce, G, Alfonso, S, Consalvi, S, Di Capua, A, Calderone, V, Martelli, A, Testai, L, Sautebin, Lidia, Rossi, Antonietta, Ghelardini, C, Di Cesare Mannelli, L, Giordani, A, Persiani, S, Colovic, M, Dovizio, M, Patrignani, P, Anzini, M.
المصدر: Bioorganicmedicinal chemistry. 22(2)
مصطلحات موضوعية: Male, Clinical Biochemistry, Pharmaceutical Science, Constriction, Pathologic, Pharmacology, Carrageenan, Biochemistry, chemistry.chemical_compound, Mice, Amide, CINODs, Cyclooxygenases, Coxibs, 1,5-Diarylpyrroles, Pharmacodynamic hybrids, Nitric oxide, Drug Discovery, Moiety, Edema, Acetic Acid, coxibs, 5-diarylpyrroles, cyclooxygenases, Liver, Hyperalgesia, cinods, nitric oxide, pharmacodynamic hybrids, Molecular Medicine, 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide, medicine.symptom, Glycine, Nitric Oxide, Cell Line, Structure-Activity Relationship, In vivo, medicine, Animals, Humans, Rats, Wistar, Molecular Biology, Nitrites, Nitrates, Cyclooxygenase 2 Inhibitors, CINODs, Cyclooxygenases, Coxibs, 1,5-Diarylpyrroles, Pharmacodynamic hybrids, Nitric oxide, Organic Chemistry, Amides, Rats, PyBOP, chemistry, Cyclooxygenase 2
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3دورية أكاديمية
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المؤلفون: Vincenzo Calderone, Antonio Giordani, Gianluca Giorgi, Angela Di Capua, Andrea Cappelli, Germano Giuliani, Maurizio Anzini, Paola Patrignani, Carla Ghelardini, Luisa Chiasserini, Giovanna Poce, Lara Testai, Melania Dovizio, Lorenzo Di Cesare Mannelli, Antonietta Rossi, Mariangela Biava, Alma Martelli, V. Benetti, Salvatore Valenti, Salvatore Vomero, Paola Anzellotti, Simone Brogi, Alessandro Sega, Simona Pace, Michele Rovini, Lidia Sautebin
المساهمون: Anzini, M, Di Capua, A, Valenti, S, Brogi, S, Rovini, M, Giuliani, G, Cappelli, A, Vomero, S, Chiasserini, L, Sega, A, Poce, G, Giorgi, G, Calderone, V, Martelli, A, Testai, L, Sautebin, Lidia, Rossi, Antonietta, Pace, Simona, Ghelardini, C, Di Cesare Mannelli, L, Benetti, V, Giordani, A, Anzellotti, P, Dovizio, M, Patrignani, P, Biava, M.
المصدر: Journal of medicinal chemistry. 56(8)
مصطلحات موضوعية: MONOSSIDO D'AZOTO, cicloossigenasi, Molecular model, Stereochemistry, medicine.drug_class, Ether, BLOOD-PRESSURE, Anti-inflammatory, Nitric oxide, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, In vivo, Drug Discovery, Osteoarthritis, Side chain, medicine, Animals, Humans, inibitori, Nitric Oxide Donors, Pyrroles, NUCLEAR-MAGNETIC-RESONANCE, BIOLOGICAL EVALUATION, Analgesics, biology, Cyclooxygenase 2 Inhibitors, Chemistry, INDUCED EXPERIMENTAL OSTEOARTHRITIS, GLYCERYL TRINITRATE, Anti-Inflammatory Agents, Non-Steroidal, CARTILAGE EXPLANTS, Active site, PHARMACODYNAMIC HYBRIDS, IN-VITRO, In vitro, Rats, Cyclooxygenase 2, PHARMACOLOGICAL CHARACTERIZATION, FORCE-FIELD, biology.protein, Cyclooxygenase 1, Molecular Medicine, Ethers
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5دورية أكاديمية
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6دورية أكاديمية
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7دورية أكاديمية
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8دورية أكاديمية
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9دورية أكاديمية
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10دورية أكاديمية
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