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المؤلفون: Nina Tunariu, Raquel Perez-Lopez, Maria Jose de Miguel Luken, Brian Hare, Udai Banerji, Daniel Nava Rodrigues, Katherine McDermott, Timothy A. Yap, Juanita Lopez, Stephen J. Pettitt, Ines Figueiredo, Chris T. Williamson, Johann S. de Bono, Jessica S. Brown, Ruth Riisnaes, Rachael Natrajan, Brent O’Carrigan, Saira Khalique, Joline S. Lim, John Pollard, Marina Penney, Christopher J. Lord, Suzanne Carreira
المصدر: Journal of Clinical Oncology
مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Maximum Tolerated Dose, DNA damage, Antineoplastic Agents, Ataxia Telangiectasia Mutated Proteins, Synthetic lethality, Carboplatin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Humans, Medicine, In patient, Phosphorylation, Protein Kinase Inhibitors, Response Evaluation Criteria in Solid Tumors, Aged, business.industry, Isoxazoles, ORIGINAL REPORTS, Middle Aged, Phase I and Clinical Pharmacology, Clinical trial, 030104 developmental biology, Oncology, chemistry, Pyrazines, 030220 oncology & carcinogenesis, Maximum tolerated dose, Checkpoint Kinase 1, Cancer cell, Cancer research, Female, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fafbda8307c6411cd060dfe44ae18e
https://doi.org/10.1200/jco.19.02404 -
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المؤلفون: Alessandro D. Santin, George R. Blumenschein, Raffit Hassan, Johanna C. Bendell, John Nemunaitis, Dirk Laurent, Nenad Sarapa, Annette O. Walter, Stella K. Kim, Shelly Seward, Barrett H. Childs, Kathleen N. Moore, Anish Thomas, Cem Elbi, Hedy L. Kindler, Prabhu Rajagopalan
المصدر: Journal of Clinical Oncology
مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Cancer Research, medicine.medical_specialty, Immunoconjugates, Maximum Tolerated Dose, Nausea, GPI-Linked Proteins, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Antineoplastic Agents, Immunological, Pharmacokinetics, Internal medicine, Neoplasms, medicine, Humans, Mesothelin, Maytansine, Progression-free survival, Mesothelioma, Neoplasm Metastasis, Adverse effect, Aged, biology, business.industry, ORIGINAL REPORTS, Middle Aged, medicine.disease, Progression-Free Survival, Phase I and Clinical Pharmacology, 030104 developmental biology, Oncology, Tolerability, 030220 oncology & carcinogenesis, Vomiting, biology.protein, Female, medicine.symptom, Neoplasm Recurrence, Local, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6a9246f60875f9ed7bf5d6a9c85ab9
https://pubmed.ncbi.nlm.nih.gov/32213105 -
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المؤلفون: John Wu, Andrew G. Hill, Michael Millward, Catherine Barrow, Christopher Jackson, Michael P. Brown, William F. Patterson, Wendy Huang, Zhiyu Tang, Victoria Atkinson, Gary Richardson, Hui K Gan, Ben Tran, Yunxin Chen, Dewan Zeng, Lisa G. Horvath, Lusong Luo, Andrew Haydon, Michael B. Jameson, Lai Wang, Ben Markman, Jayesh Desai, Stephen Begbie, Phillip Parente, Adnan Nagrial, Benjamin Solomon, Michael Friedlander
المصدر: Journal of Clinical Oncology
مصطلحات موضوعية: 0301 basic medicine, Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Maximum Tolerated Dose, 03 medical and health sciences, 0302 clinical medicine, Text mining, Internal medicine, Neoplasms, medicine, Dose escalation, Humans, In patient, Naphthyridines, Protein Kinase Inhibitors, Aged, Kinase, business.industry, ORIGINAL REPORTS, Middle Aged, Phase I and Clinical Pharmacology, Clinical trial, 030104 developmental biology, 030220 oncology & carcinogenesis, Maximum tolerated dose, Benzimidazoles, Female, Open label, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa38a9282a29d6a2a9c38e6fe237bfe
https://pubmed.ncbi.nlm.nih.gov/32182156 -
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المصدر: Journal of Clinical Oncology
مصطلحات موضوعية: Ethics, Comments and Controversies, Clinical Trials, Policy Analysis, Phase I and Clinical Pharmacology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::374c64d9f131b003e83d590091b64f47
https://pubmed.ncbi.nlm.nih.gov/27893329 -
5
المؤلفون: Heather A. Jacene, Michelle A. Rudek, Antonio Jimeno, Ming Zhao, Sharyn D. Baker, Daniel A. Laheru, Peter Kulesza, Ross C. Donehower, Manuel Hidalgo, Wells A. Messersmith, Jenna Wheelhouse, Anna Howard, Yasmin Khan, Elizabeth Garrett-Mayer, Wen Wee Ma
المصدر: Journal of Clinical Oncology. 26:4172-4179
مصطلحات موضوعية: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Maximum Tolerated Dose, Pharmacology, Drug Administration Schedule, Dose finding, Pharmacokinetics, Neoplasms, Internal medicine, medicine, Humans, Aged, Aged, 80 and over, Sirolimus, Antibiotics, Antineoplastic, Dose-Response Relationship, Drug, medicine.diagnostic_test, Adult patients, business.industry, Middle Aged, Phase I and Clinical Pharmacology, Clinical trial, Positron emission tomography, Positron-Emission Tomography, Pharmacodynamics, Toxicity, Leukocytes, Mononuclear, Female, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dcf93edeccc653c1c35cd2ed31ce9e8
https://doi.org/10.1200/jco.2008.16.2347 -
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المؤلفون: John A. Worrell, Vicki L. Keedy, David H. Johnson, Wei Wang, Lyn A. Thet, Joan H. Schiller, Keith Coffee, David P. Carbone, Sunil Chada, Bonnie S. Slovis
المصدر: Journal of Clinical Oncology. 26:4166-4171
مصطلحات موضوعية: Adult, Male, Cancer Research, medicine.medical_specialty, Pathology, Lung Neoplasms, Pulmonary toxicity, Pilot Projects, Bronchoalveolar Lavage, Gastroenterology, Adenoviridae, Internal medicine, medicine, Carcinoma, Humans, Lung cancer, Aged, Lung, medicine.diagnostic_test, business.industry, Respiratory disease, Gene Transfer Techniques, Genetic Therapy, Adenocarcinoma, Bronchiolo-Alveolar, Middle Aged, Genes, p53, medicine.disease, Phase I and Clinical Pharmacology, Treatment Outcome, medicine.anatomical_structure, Bronchoalveolar lavage, Oncology, Toxicity, Adenocarcinoma, Female, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a72c77dfd09a244f6dafe94fbe73c3
https://doi.org/10.1200/jco.2007.15.6927 -
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المؤلفون: Michelle A. Rudek, Manoj Maniar, Ross C. Donehower, Sharyn D. Baker, Manuel Hidalgo, Jing Li, Antonio Jimeno, Wells A. Messersmith, Daniel A. Laheru
المصدر: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 26(34)
مصطلحات موضوعية: Oncology, G2 Phase, Male, Cancer Research, medicine.medical_specialty, Time Factors, Glycine, Antineoplastic Agents, Cell Cycle Proteins, Protein Serine-Threonine Kinases, Pharmacokinetics, Refractory, Internal medicine, Neoplasms, Proto-Oncogene Proteins, Medicine, Humans, Sulfones, Aged, Dose-Response Relationship, Drug, business.industry, Kinase, Rigosertib, Cancer, Middle Aged, medicine.disease, Phase I and Clinical Pharmacology, Clinical trial, Gene Expression Regulation, Neoplastic, Dose–response relationship, Treatment Outcome, Cancer cell, Immunology, Female, business, Cell Division
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b158621d9df3edbedbb1dc74c8989b7b
https://pubmed.ncbi.nlm.nih.gov/18955441 -
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المؤلفون: Anne Keating, Pamela Bartels, E. Till, Chris Takimoto, Scott Antonia, Amita Patnaik, Adil Daud, Lionel D. Lewis, Alain Mita, Anthony W. Tolcher, Kyri Papadopoulos, Christopher R. Garrett
المصدر: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 26(32)
مصطلحات موضوعية: Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Maximum Tolerated Dose, Nausea, Survivin, Antineoplastic Agents, Apoptosis, Pilot Projects, Pharmacology, Drug Administration Schedule, Inhibitor of Apoptosis Proteins, Excretion, chemistry.chemical_compound, Pharmacokinetics, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Infusions, Intravenous, Stomatitis, Acute tubular necrosis, Aged, Volume of distribution, Creatinine, Dose-Response Relationship, Drug, business.industry, Imidazoles, Middle Aged, medicine.disease, Phase I and Clinical Pharmacology, Neoplasm Proteins, Treatment Outcome, Oncology, chemistry, Female, medicine.symptom, business, Microtubule-Associated Proteins, Signal Transduction, Naphthoquinones
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3d3412f07ad6cc29fceab35f4bf3d5
https://pubmed.ncbi.nlm.nih.gov/18824700