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المؤلفون: Maria L. Webb, Ilana L. Stroke, Laurie J. Sturzenbecker, David W. Hilbert, Brett A. Marinelli, Joan E. Sabalski, Linh Ma, David J. Diller, Philip D. Stein, Jeffrey J. Letourneau, Jorge Quintero
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:756-761
مصطلحات موضوعية: Bacterial Toxins, Clinical Biochemistry, Pharmaceutical Science, Apoptosis, Clostridium difficile toxin B, CHO Cells, Microbial Sensitivity Tests, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Biochemistry, Microbiology, In silico docking, Enterotoxins, Mice, Structure-Activity Relationship, Cricetulus, Bacterial Proteins, Drug Stability, Nucleotidases, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Molecular Structure, Clostridioides difficile, 010405 organic chemistry, Chemistry, Toxin, Organic Chemistry, Stereoisomerism, Clostridium difficile, C difficile, Anti-Bacterial Agents, High-Throughput Screening Assays, 0104 chemical sciences, Molecular Docking Simulation, Microsomes, Liver, Molecular Medicine
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المؤلفون: Yanfang Li, Jeffrey J. Letourneau, Laurie J. Sturzenbecker, Maria L. Webb, Brett A. Marinelli, Philip D. Stein, Ilana L. Stroke, Linh Ma, Andrew G. Cole, Igor Pechik, Jorge Quintero, David W. Hilbert, Joan E. Sabalski
المصدر: Bioorganicmedicinal chemistry letters. 28(23-24)
مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Bacterial Toxins, Pharmaceutical Science, Hamster, Administration, Oral, Clostridium difficile toxin B, CHO Cells, medicine.disease_cause, 01 natural sciences, Biochemistry, Microbiology, 03 medical and health sciences, Benzodiazepines, Mice, Structure-Activity Relationship, Cricetulus, Bacterial Proteins, Cricetinae, Drug Discovery, medicine, Animals, Molecular Biology, 010405 organic chemistry, Chemistry, Toxin, Clostridioides difficile, Organic Chemistry, Clostridium difficile, C difficile, 0104 chemical sciences, Anti-Bacterial Agents, 030104 developmental biology, Clostridium Infections, Molecular Medicine, Half-Life
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المؤلفون: Joan E. Sabalski, Yan Xu, Philip D. Stein, Laurie J. Sturzenbecker, Jeffrey J. Letourneau, Teresa Miller, Ilana L. Stroke, Maria L. Webb, Diana R. Savoly, David W. Hilbert, Linh Ma, Igor Pechik
المصدر: Antimicrobial agents and chemotherapy. 62(5)
مصطلحات موضوعية: 0301 basic medicine, Uridine Diphosphate Glucose, genetic structures, Cell Survival, Colon, 030106 microbiology, Bacterial Toxins, Hamster, Inflammation, Gut flora, medicine.disease_cause, Microbiology, Cell Line, 03 medical and health sciences, Mice, Bacterial Proteins, Cricetinae, medicine, Animals, Humans, Pharmacology (medical), Experimental Therapeutics, Pharmacology, biology, Toxin, business.industry, Clostridioides difficile, Hydrolysis, Clostridium difficile, biology.organism_classification, Antimicrobial, Anti-Bacterial Agents, Diarrhea, 030104 developmental biology, Infectious Diseases, Clostridium Infections, Vancomycin, medicine.symptom, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ab694a3cd02b2c6aab3e9bb9ef4ccd
https://pubmed.ncbi.nlm.nih.gov/29483125 -
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المؤلفون: Steve Castro, Julie Clark, Amy Matheny, David M. Floyd, Philip D. Stein, Spencer Knapp, Gloria Holbrook, Martina Sigal, Fangyi Zhu, Senthil Krishnan, Michele Connelly, Jian Liu, Zheng Wang, Sridevi Bashyum, Rajkumar Dhinakaran, Jaeki Min, R. Kiplin Guy
المصدر: Journal of medicinal chemistry. 59(17)
مصطلحات موضوعية: Erythrocytes, Plasmodium falciparum, Drug resistance, Pharmacology, 010402 general chemistry, 01 natural sciences, Article, Antimalarials, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Potency, Animals, Humans, Anilides, Cytotoxicity, biology, 010405 organic chemistry, Chemistry, Stereoisomerism, Hit to lead, biology.organism_classification, Isoquinolines, In vitro, Coculture Techniques, 0104 chemical sciences, Solubility, Microsomes, Liver, Molecular Medicine, Enantiomer
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المؤلفون: Zheming Ruan, S. M. Seiler, Herbert E. Klei, Jing Zhang, Jeffrey A. Robl, Stephen P. O'connor, Mengxiao Shi, Liang Schweizer, John E. Macor, R. Michael Lawrence, Karnail S. Atwal, William A. Schumacher, Eddie C.-K. Liu, Sharon N. Bisaha, Doree F. Sitkoff, Ying Wang, Chi Li, Thomas E. Steinbacher, Yan Shi, Philip D. Stein, Kevin Kish
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:7516-7521
مصطلحات موضوعية: Serine Proteinase Inhibitors, Lactams, medicine.drug_mechanism_of_action, Stereochemistry, Clinical Biochemistry, Factor Xa Inhibitor, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Enzyme activator, Drug Discovery, medicine, Humans, Structure–activity relationship, Binding site, Molecular Biology, Piperidones, Binding Sites, Aryl, Organic Chemistry, Anticoagulants, Combinatorial chemistry, Protein Structure, Tertiary, Enzyme Activation, chemistry, Factor Xa, Molecular Medicine, Bioisostere, Pharmacophore, Factor Xa Inhibitors
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المؤلفون: Joseph Yanchunas, Eddie C.-K. Liu, Christine Huang, S. M. Seiler, Yan Shi, Ying Wang, Karnail S. Atwal, Thomas E. Steinbacher, Doree F. Sitkoff, Andrew T. Pudzianowski, William A. Schumacher, Karen S. Hartl, Sharon N. Bisaha, Chi Li, Stephen P. O'connor, Kevin Kish, Mengxiao Shi, Philip D. Stein, Herbert E. Klei, Jing Zhang
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6882-6889
مصطلحات موضوعية: Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Factor Xa Inhibitor, Pharmaceutical Science, Carboxamide, Guanidines, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Cytochrome P-450 CYP3A, Humans, Structure–activity relationship, Guanidine, Molecular Biology, Cytochrome P-450 CYP3A Inhibitors, biology, Chemistry, Organic Chemistry, Anticoagulants, Enzyme inhibitor, biology.protein, Lactam, Molecular Medicine, Factor Xa Inhibitors
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المؤلفون: Doree F. Sitkoff, Ming Chang, Carolyn A Cuff, Bang-Chi Chen, Cort S. Madsen, Xiaohong Yin, Saleem Ahmad, Evan B. Janovitz, Richard A. Reeves, Thomas Harrity, Lawrence J. Kennedy, Carol S. Ryan, Hossain Monshizadegan, Van Nguyen-Tran, Tong Li, Robert Zahler, Michael A. Blanar, Khehyong Ngu, Philip D. Stein, Rongan Zhang, Sharon N. Bisaha, Christine Huang, Joel C. Barrish, Eileen Bird, Debra Search, Celia D’Arienzo, Mary Giancarli, Robert Setters, Rulin Zhao, Jeffrey A. Robl, Xing Chen, Shaobin Zhuang
المصدر: Journal of Medicinal Chemistry. 51:2722-2733
مصطلحات موضوعية: Models, Molecular, Guinea Pigs, Administration, Oral, Biological Availability, In Vitro Techniques, Reductase, Crystallography, X-Ray, Chemical synthesis, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Oral administration, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, chemistry.chemical_classification, Muscle Cells, biology, Chemistry, Stereoisomerism, Haplorhini, Triazoles, Hydroxymethylglutaryl-CoA reductase, Rats, Cholesterol, Pyrimidines, Enzyme, Liver, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Female, Hydroxymethylglutaryl CoA Reductases, Chemical and Drug Induced Liver Injury, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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المؤلفون: Wei Han, Patrick Y.S. Lam, Philip D. Stein, John E. Macor, Jing Zhang, Robert Zahler, Eddie C.-K. Liu, Karnail S. Atwal, Yan Shi, Ying Wang, Saleem Ahmad, Lawrence J. Kennedy, Stephen P. O'connor, S. M. Seiler, Jeffrey A. Robl, Zilun Hu, Doree F. Sitkoff
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:5952-5958
مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Serine Proteinase Inhibitors, Molecular model, medicine.drug_mechanism_of_action, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Factor Xa Inhibitor, Pharmaceutical Science, Carboxamide, Biochemistry, Pyrrolidine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Sulfonamide, Piperazine, Enzyme inhibitor, biology.protein, Molecular Medicine, Bioisostere, Factor Xa Inhibitors
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المؤلفون: Adele M. Lehane, Anupam Pradhan, David A. Fidock, Dennis E. Kyle, Gloria Holbrook, Amy Matheny, Martina Sigal, Anang A. Shelat, David Waterson, Iñigo Angulo-Barturen, Kathleen O’Loughlin, Jian Liu, Laura M. Sanz, Philip D. Stein, Daniel H. Ebert, Kiaran Kirk, Hongshen Ma, Marcus C. S. Lee, Jon C. Mirsalis, W. Armand Guiguemde, Xiaoyan Deng, Greg Fedewa, Ane Rodríguez-Alejandre, María Belén Jiménez-Díaz, María G. Gómez, Angela K. Carrillo, Mariana Justino de Almeida, Yandira G. Salinas, Vicky M. Avery, David M. Shackleford, Sandra Duffy, Marie-Eve Myrand-Lapierre, Gregory M. Miller, María Santos Martínez, Adelaide S. M. Dennis, Charles C. Kim, R. Kiplin Guy, Julie Clark, Jeremy A. Horst, Aaron N. Endsley, Joseph L. DeRisi, Zheng Wang, Spencer Knapp, Fangyi Zhu, David M. Floyd, Santiago Ferrer, Jonathon Diep, Francisco-Javier Gamo, Susan A. Charman, Natalie J. Spillman
المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 50
مصطلحات موضوعية: Models, Molecular, Plasmodium, Erythrocytes, Drug Resistance, Drug resistance, Pharmacology, Corrections, chemistry.chemical_compound, Models, Heterocyclic Compounds, Drug Discovery, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, Cellular Senescence, PfATP4, Multidisciplinary, Molecular Structure, Drug discovery, Flow Cytometry, Cell biology, Infectious Diseases, PNAS Plus, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Cell aging, Intracellular, Phenotypic screening, malaria, Calcium-Transporting ATPases, Biology, Heterocyclic Compounds, 4 or More Rings, drug discovery, Antimalarials, Rare Diseases, In vivo, Prevention, Molecular, Plasmodium falciparum, 4 or More Rings, biology.organism_classification, Isoquinolines, Cipargamin, High-Throughput Screening Assays, Malaria, Vector-Borne Diseases, Orphan Drug, Good Health and Well Being, chemistry
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd38753b4b27787a1d271647ca26a4f8
https://europepmc.org/articles/PMC4273362/ -
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المؤلفون: Jack Z. Gougoutas, Karen S. Hartl, R. Michael Lawrence, Doree F. Sitkoff, Gregory S. Bisacchi, Steven M. Seiler, Andrew T. Pudzianowski, William A. Schumacher, Philip D. Stein, Eddie C.-K. Liu, Thomas E. Steinbacher, Zhaoxiao Zhang, James C. Sutton
المصدر: Letters in Drug Design & Discovery. 2:625-630
مصطلحات موضوعية: Series (mathematics), medicine.drug_mechanism_of_action, Stereochemistry, Factor Xa Inhibitor, Caprolactam, Pharmaceutical Science, Combinatorial chemistry, chemistry.chemical_compound, Lead (geology), chemistry, Drug Discovery, medicine, Molecular Medicine, Identification (biology)
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a7cee05c3fc0caebfd7b297901137ea0
https://doi.org/10.2174/157018005774717316