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المؤلفون: Philip G. Humphreys, Niall A. Anderson, Paul Bamborough, Andrew Baxter, Chun-wa Chung, Rosa Cookson, Peter D. Craggs, Toryn Dalton, Julie C. L. Fournier, Laurie J. Gordon, Heather F. Gray, Matthew W. Gray, Richard Gregory, David J. Hirst, Craig Jamieson, Katherine L. Jones, Hripsimee Kessedjian, David Lugo, Grant McGonagle, Vipulkumar K. Patel, Christopher Patten, Darren L. Poole, Rab K. Prinjha, Cesar Ramirez-Molina, Inmaculada Rioja, Gail Seal, Kayleigh A. J. Stafford, Rishi R. Shah, Daniel Tape, Natalie H. Theodoulou, Laura Tomlinson, Sabri Ukuser, Ian D. Wall, Natalie Wellaway, Gemma White
المصدر: Journal of Medicinal Chemistry. 65:15174-15207
مصطلحات موضوعية: Histones, Protein Domains, Lysine, Drug Discovery, Humans, Molecular Medicine, Ligands, Transcription Factors
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المؤلفون: Patricia F Medeiros, Mythily Vimal, Vipulkumar Kantibhai Patel, John Evans, Neil R Carlson, Antonia J. Lewis, Paul Bamborough, Katherine L Jones, Jane E Smith, Michael O'Sullivan, Scott McCleary, Darren J. Mitchell, Heather Barnett, Chun-wa Chung, Gang Yao, Anthony W. J. Cooper, Rab K. Prinjha, Laurie Gordon, Mahnoor Mahmood, Peter D. Craggs, Isobel L Harada, Rino A Bit, Natalie Wellaway, Armelle Le Gall, Robert J. Watson, Tony W Dean, Dominique Amans, Ian D. Wall, Kayleigh A J Stafford, Dave Lugo, Matthew J Lindon, Rishi R Shah, David Jonathan Hirst, Chris Patten, Darren L Poole, Jack A Brown, Philip G Humphreys, Robert P Davis, Christopher Roland Wellaway, Pamela J Thomas
المصدر: Journal of Medicinal Chemistry. 63:714-746
مصطلحات موضوعية: Male, Models, Molecular, Benzimidazole, Lysine, Drug Evaluation, Preclinical, Computational biology, Crystallography, X-Ray, Small Molecule Libraries, Mice, chemistry.chemical_compound, In vivo, Histone tails, Drug Discovery, Leukocytes, Animals, Humans, Chemokine CCL2, Therapeutic strategy, Interleukin-6, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Proteins, Drug Synergism, Epigenome, Small molecule, High-Throughput Screening Assays, Bromodomain, Molecular Medicine, Benzimidazoles, Protein Processing, Post-Translational
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المؤلفون: Nicholas C. O. Tomkinson, Jonathan M. Curle, Alan R. Kennedy, Marina C. Perieteanu, Philip G. Humphreys
المصدر: Organic Letters
مصطلحات موضوعية: chemistry.chemical_classification, Carbamate, Letter, 010405 organic chemistry, Alkene, medicine.medical_treatment, Organic Chemistry, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Biochemistry, Medicinal chemistry, Peroxide, Nitrogen, 0104 chemical sciences, QD450, chemistry.chemical_compound, chemistry, Nucleophile, Reagent, Yield (chemistry), medicine, Trifluoroacetic acid, Physical and Theoretical Chemistry
وصف الملف: application/pdf
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المؤلفون: Emmanuel Hubert Demont, Philip G. Humphreys, Alex Phillipou, Michael A. Clegg, Paul Bamborough, Peter D. Craggs, Chun-wa Chung, Rab K. Prinjha, Gemma Michele Liwicki, Nicholas C. O. Tomkinson, Natalie Hope Theodoulou, Laurie J. Gordon
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: biology, Chemistry, Organic Chemistry, Target engagement, Computational biology, Biochemistry, Small molecule, Bromodomain, TAF1, TA164, Drug Discovery, biology.protein, QD, Epigenetics, TATA-binding protein
وصف الملف: application/pdf
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المصدر: ChemMedChem. 14:362-385
مصطلحات موضوعية: Nerve Tissue Proteins, chemical and pharmacologic phenomena, Chemical probe, Computational biology, 01 natural sciences, Biochemistry, Protein Domains, Drug Discovery, Humans, QD, p300-CBP Transcription Factors, General Pharmacology, Toxicology and Pharmaceutics, Phylogeny, Adaptor Proteins, Signal Transducing, Pharmacology, 010405 organic chemistry, Chemistry, Organic Chemistry, Nuclear Proteins, Proteins, Antigens, Nuclear, hemic and immune systems, 0104 chemical sciences, Bromodomain, DNA-Binding Proteins, 010404 medicinal & biomolecular chemistry, Molecular Probes, Molecular Medicine, Transcription Factors
وصف الملف: application/pdf
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المؤلفون: Corentine M C, Laurin, Joseph P, Bluck, Anthony K N, Chan, Michelle, Keller, Andrew, Boczek, Amy R, Scorah, K F Larissa, See, Laura E, Jennings, David S, Hewings, Fern, Woodhouse, Jessica K, Reynolds, Matthias, Schiedel, Philip G, Humphreys, Philip C, Biggin, Stuart J, Conway
المصدر: ACS infectious diseases. 7(8)
مصطلحات موضوعية: Trypanosoma cruzi, Escherichia coli, Humans, Chagas Disease, Ligands, Epigenesis, Genetic
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المؤلفون: Ishna N. Mistry, Philip G. Humphreys, Panagis Filippakopoulos, Amy Hicks, Pavel Guzanov, Laura E. Jennings, Larissa See, Jessica K. Reynolds, Amy R. Scorah, Matthias Schiedel, Anna K. Mapp, James Clayton, David S. Hewings, Paul A. Bruno, Mustafa Moroglu, Charles N. G. Evans, Corentine M.C. Laurin, Stuart J. Conway, Joseph P. Bluck, Ester M. Hammond, Giulia Stazi, Sarah Picaud, Philip C. Biggin
المصدر: Bioorganic & Medicinal Chemistry
مصطلحات موضوعية: 0301 basic medicine, BRD4, Protein subunit, Blotting, Western, Clinical Biochemistry, Pharmaceutical Science, Cell Cycle Proteins, Molecular Dynamics Simulation, Crystallography, X-Ray, Ligands, Heterocyclic Compounds, 4 or More Rings, Biochemistry, Histone H4, Inhibitory Concentration 50, Structure-Activity Relationship, 03 medical and health sciences, Drug Stability, Drug Discovery, Humans, Structure–activity relationship, Molecule, Luciferases, Molecular Biology, Molecular Structure, Chemistry, Ligand, Hydrogen bond, Organic Chemistry, Nuclear Proteins, Combinatorial chemistry, 3. Good health, Bromodomain, 030104 developmental biology, MCF-7 Cells, Molecular Medicine, Biological Assay, Transcription Factors
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المؤلفون: Kirsty E Waddington, Céline Gongora, Lauren C. Davis, Valentino Parravicini, Zuni I. Bassi, Emma J. Roberts, Philip G. Humphreys, Darcy E. Lewis, Abigail L. Macmillan-Jones, Ian Churcher, Afjal Hussain Miah, Claire Maller, Martin Christian Fillmore, David F. Tough, Rab K. Prinjha, Trevor D. Chapman, Nicholas Galwey
المساهمون: Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
المصدر: ACS Chemical Biology
ACS Chemical Biology, American Chemical Society, 2018, 13 (10), pp.2862-2867. ⟨10.1021/acschembio.8b00705⟩مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Lipopolysaccharide, Ubiquitin-Protein Ligases, Context (language use), [SDV.CAN]Life Sciences [q-bio]/Cancer, Biochemistry, Benzoates, Monocytes, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Immune system, Piperidines, Protein Domains, Animals, Humans, p300-CBP Transcription Factors, Adaptor Proteins, Signal Transducing, Inflammation, Macrophages, Proteolysis targeting chimera, Signal transducing adaptor protein, Cell Differentiation, Stereoisomerism, General Medicine, Dendritic Cells, 3. Good health, Cell biology, Bromodomain, Pyridazines, enzymes and coenzymes (carbohydrates), 030104 developmental biology, chemistry, PCAF, 030220 oncology & carcinogenesis, Acetyltransferase, Proteolysis, Molecular Medicine, Cytokines, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Peptide Hydrolases
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المصدر: Current Opinion in Chemical Biology. 33:58-66
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Clinical Trials as Topic, Drug discovery, Proteins, chemical and pharmacologic phenomena, hemic and immune systems, Pharmacology, Biology, Biochemistry, Small molecule, RS, Analytical Chemistry, Bromodomain, Small Molecule Libraries, 03 medical and health sciences, 030104 developmental biology, Molecular Probes, Drug Discovery, Humans, QD
وصف الملف: application/pdf
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المؤلفون: Rab K. Prinjha, Anne Rueger, Neil Stuart Garton, Dirk Eberhard, David Matthew Wilson, Marcus Bantscheff, Robert J. Sheppard, Kevin Lee, Jack A. Brown, Nigel Ramsden, Susan Marie Westaway, Gerard Drewes, Philip G. Humphreys, Toby Mathieson, Gerard Joberty, Marcel Muelbaier, Valerie Reader, Markus Boesche
المصدر: ACS Chemical Biology. 11:2002-2010
مصطلحات موضوعية: Proteomics, 0301 basic medicine, chemistry.chemical_classification, Cofactor binding, biology, Drug discovery, Druggability, Active site, General Medicine, Biochemistry, Small molecule, Dioxygenases, 03 medical and health sciences, 030104 developmental biology, Enzyme, chemistry, Dioxygenase, biology.protein, Ketoglutaric Acids, Molecular Medicine, Chemoproteomics
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