المؤلفون: Bleriot, C, Barreby, E, Dunsmore, G, Ballaire, R, Chakarov, S, Ficht, X, De Simone, G, Andreata, F, Fumagalli, V, Guo, W, Wan, GC, Gessain, G, Khalilnezhad, A, Zhang, XM, Ang, N, Chen, P, Morgantini, C, Azzimato, V, Kong, WT, Liu, ZY, Pai, R, Lum, J, Shihui, F, Low, I, Xu, C, Malleret, B, Kairi, MFM, Balachander, A, Cexus, O, Larbi, A, Lee, B, Newell, EW, Ng, LG, Phoo, WW, Sobota, RM, Sharma, A, Howland, SW, Chen, JM, Bajenoff, M, Yvan-Charvet, L, Venteclef, N, Iannacone, M, Aouadi, M, Ginhoux, F

المصدر: Immunity. 54(9):2101

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:147687957

المؤلفون: Chew BLA; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, Singapore., Ngoh ANQ; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Phoo WW; Functional Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Chan KWK; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Ser Z; Functional Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Tulsian NK; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.; Singapore Centre for Life Sciences, Department of Biochemistry, National University of Singapore, Singapore, Singapore., Lim SS; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Weng MJG; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, Singapore., Watanabe S; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Choy MM; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Low J; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore., Ooi EE; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Ruedl C; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Sobota RM; Functional Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Vasudevan SG; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.; Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Institute for Glycomics (G26), Griffith University Gold Coast Campus, Southport, Australia., Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, Singapore.

المصدر: ELife [Elife] 2024 May 24; Vol. 12. Date of Electronic Publication: 2024 May 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Viral Nonstructural Proteins*/metabolism , Viral Nonstructural Proteins*/chemistry , Viral Nonstructural Proteins*/genetics , Dengue Virus*/genetics , Dengue Virus*/metabolism , Lipoproteins, HDL*/metabolism , Dengue*/virology , Dengue*/metabolism, Animals ; Chlorocebus aethiops ; Mice ; Humans ; Vero Cells ; Apolipoprotein A-I/metabolism ; Apolipoprotein A-I/chemistry ; Protein Multimerization ; Cryoelectron Microscopy

المؤلفون: Park DS; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Kozaki T; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Tiwari SK; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Moreira M; INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France., Khalilnezhad A; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Torta F; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore., Olivié N; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University, Paris, France., Thiam CH; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Liani O; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Silvin A; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.; INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France., Phoo WW; Functional Proteomics Laboratory, SingMass National Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Gao L; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore., Triebl A; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore., Tham WK; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore., Gonçalves L; INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France., Kong WT; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.; INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France., Raman S; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Zhang XM; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Dunsmore G; INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France., Dutertre CA; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.; INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France., Lee S; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Ong JM; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Balachander A; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Khalilnezhad S; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.; Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore., Lum J; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Duan K; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Lim ZM; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Tan L; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Low I; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Utami KH; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research, Singapore, Singapore., Yeo XY; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research, Singapore, Singapore., Di Tommaso S; Oncoprot Platform, TBM-Core US 005, Bordeaux, France., Dupuy JW; Bordeaux Protéome, University of Bordeaux, Bordeaux, France., Varga B; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Karadottir RT; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Madathummal MC; A*STAR Microscopy Platform Electron Microscopy, Research Support Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Bonne I; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Malleret B; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; A*STAR Microscopy Platform Electron Microscopy, Research Support Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Binte ZY; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Wei Da N; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Tan Y; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Wong WJ; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhang J; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research, Singapore, Singapore., Chen J; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Sobota RM; Functional Proteomics Laboratory, SingMass National Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Howland SW; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore., Ng LG; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Saltel F; Oncoprot Platform, TBM-Core US 005, Bordeaux, France., Castel D; INSERM U981, Molecular Predictors and New Targets in Oncology & Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Grill J; INSERM U981, Molecular Predictors and New Targets in Oncology & Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Minard V; INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France., Albani S; Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore., Chan JKY; Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore., Thion MS; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University, Paris, France., Jung SY; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research, Singapore, Singapore.; Department of Medical Science, College of Medicine, CHA University, Seongnam, Republic of Korea., Wenk MR; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore., Pouladi MA; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research, Singapore, Singapore.; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada., Pasqualini C; INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France., Angeli V; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Cexus ONF; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research, Singapore, Singapore.; School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK., Ginhoux F; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore. florent_ginhoux@immunol.a-star.edu.sg.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. florent_ginhoux@immunol.a-star.edu.sg.; INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France. florent_ginhoux@immunol.a-star.edu.sg.; Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore. florent_ginhoux@immunol.a-star.edu.sg.; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. florent_ginhoux@immunol.a-star.edu.sg.

المصدر: Nature [Nature] 2023 Nov; Vol. 623 (7986), pp. 397-405. Date of Electronic Publication: 2023 Nov 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Brain*/cytology , Brain*/metabolism , Induced Pluripotent Stem Cells*/cytology , Microglia*/cytology , Microglia*/metabolism , Neurogenesis* , Organoids*/cytology , Organoids*/metabolism , Cholesterol*/metabolism , Neural Stem Cells*/cytology , Neural Stem Cells*/metabolism, Animals ; Humans ; Mice ; Cell Differentiation ; Axons ; Cell Proliferation ; Esters/metabolism ; Lipid Droplets/metabolism

المؤلفون: Bifani AM; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore., Chan KWK; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore., Borrenberghs D; Janssen Global Public Health, Janssen Pharmaceutica NV, Beerse, Belgium., Tan MJA; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore., Phoo WW; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore., Watanabe S; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore., Goethals O; Janssen Global Public Health, Janssen Pharmaceutica NV, Beerse, Belgium., Vasudevan SG; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore; Institute of Glycomics, Griffith University, Gold Coast Campus, QLD, 4222, Australia., Choy MM; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, 169857, Singapore. Electronic address: milly.choy@duke-nus.edu.sg.

المصدر: Antiviral research [Antiviral Res] 2023 Feb; Vol. 210, pp. 105517. Date of Electronic Publication: 2022 Dec 31.

نوع المنشور: Review; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

مواضيع طبية MeSH: Flavivirus Infections* , Flavivirus*/genetics , Zika Virus*/genetics , Zika Virus Infection*/drug therapy , Zika Virus Infection*/prevention & control , Viral Vaccines*, Humans

المؤلفون: Quek JP; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore., Ser Z; Functional Proteomics Laboratory, SingMass National Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 61 Biopolis Drive, #07-03, Singapore 138673, Singapore., Chew BLA; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore.; NTU Institute of Health Technologies, Interdisciplinary Graduate School, Nanyang Technological University, RTP 02-07, 50 Nanyang Drive, Singapore 637553, Singapore., Li X; SingMass National Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Blk S2, #02, Singapore 117543, Singapore., Wang L; SingMass National Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Blk S2, #02, Singapore 117543, Singapore., Sobota RM; Functional Proteomics Laboratory, SingMass National Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 61 Biopolis Drive, #07-03, Singapore 138673, Singapore., Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore.; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore., Phoo WW; Functional Proteomics Laboratory, SingMass National Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 61 Biopolis Drive, #07-03, Singapore 138673, Singapore.

المصدر: Viruses [Viruses] 2022 Jun 30; Vol. 14 (7). Date of Electronic Publication: 2022 Jun 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

مواضيع طبية MeSH: Flavivirus*/metabolism , Zika Virus*/metabolism , Zika Virus Infection*, Catalytic Domain ; Humans ; Peptide Hydrolases/metabolism ; RNA Helicases/metabolism ; Serine Endopeptidases/metabolism ; Viral Nonstructural Proteins/genetics

المؤلفون: Phoo WW; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 636921, Singapore., El Sahili A; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 636921, Singapore., Zhang Z; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, 636921, Singapore., Chen MW; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, 636921, Singapore., Liew CW; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 636921, Singapore., Lescar J; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 636921, Singapore. Electronic address: julien@ntu.edu.sg., Vasudevan SG; Emerging Infectious Diseases, DUKE NUS Graduate Medical School, 8 College Road, 09, Singapore; Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Institute fof Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia. Electronic address: subhash.vasudevan@duke-nus.edu.sg., Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 636921, Singapore. Electronic address: luodahai@ntu.edu.sg.

المصدر: Antiviral research [Antiviral Res] 2020 Oct; Vol. 182, pp. 104900. Date of Electronic Publication: 2020 Aug 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

مواضيع طبية MeSH: Dengue Virus/*chemistry , Viral Nonstructural Proteins/*chemistry , Viral Nonstructural Proteins/*metabolism, Crystallography, X-Ray ; Dengue Virus/enzymology ; Protein Conformation ; Protein Interaction Domains and Motifs ; RNA Helicases/chemistry ; RNA Helicases/metabolism ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/metabolism ; Virus Replication

المؤلفون: Phoo WW; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore., Zhang Z; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore., Wirawan M; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore., Chew EJC; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore., Chew ABL; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Health Technologies, Interdisciplinary Graduate School, Nanyang Technological University, RTP 02-07, 50 Nanyang Drive, Singapore 637553, Singapore., Kouretova J; Institute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, Marburg 35032, Germany., Steinmetzer T; Institute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, Marburg 35032, Germany. Electronic address: luodahai@ntu.edu.sg., Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore. Electronic address: steinmetzer@uni-marburg.de.

المصدر: Antiviral research [Antiviral Res] 2018 Dec; Vol. 160, pp. 17-24. Date of Electronic Publication: 2018 Oct 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

مواضيع طبية MeSH: Peptidomimetics/*chemistry , Protease Inhibitors/*chemistry , Viral Nonstructural Proteins/*chemistry , Zika Virus/*enzymology, Crystallography, X-Ray ; Models, Molecular ; Peptidomimetics/metabolism ; Protease Inhibitors/metabolism ; Protein Binding ; Protein Conformation ; RNA Helicases/chemistry ; RNA Helicases/metabolism ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/metabolism ; Viral Nonstructural Proteins/metabolism

المؤلفون: Li Y; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore., Zhang Z; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore., Phoo WW; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 636921, Singapore., Loh YR; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore., Li R; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore., Yang HY; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore., Jansson AE; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore., Hill J; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore., Keller TH; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore., Nacro K; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore. Electronic address: knacro@etc.a-star.edu.sg., Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore. Electronic address: luodahai@ntu.edu.sg., Kang C; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore. Electronic address: cbkang@etc.a-star.edu.sg.

المصدر: Structure (London, England : 1993) [Structure] 2018 Apr 03; Vol. 26 (4), pp. 555-564.e3. Date of Electronic Publication: 2018 Mar 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents/*chemistry , Protease Inhibitors/*chemistry , Small Molecule Libraries/*chemistry , Viral Nonstructural Proteins/*chemistry , Zika Virus/*chemistry, Amino Acid Sequence ; Antiviral Agents/metabolism ; Binding Sites ; Cloning, Molecular ; Crystallography, X-Ray ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Kinetics ; Models, Molecular ; Protease Inhibitors/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; RNA Helicases/antagonists & inhibitors ; RNA Helicases/chemistry ; RNA Helicases/genetics ; RNA Helicases/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Serine/chemistry ; Serine/metabolism ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Small Molecule Libraries/metabolism ; Substrate Specificity ; Viral Nonstructural Proteins/antagonists & inhibitors ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism ; Zika Virus/enzymology ; Zika Virus/genetics

المؤلفون: Swarbrick CMD; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore., Basavannacharya C; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore., Chan KWK; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore.; Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, 117545, Singapore., Chan SA; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore., Singh D; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore., Wei N; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore., Phoo WW; Lee Kong Chian School of Medicine, Nanyang Technological University, 138673, Singapore.; Nanyang Institute for Structural Biology, School of Biological Sciences, Nanyang Technological University, 138673, Singapore., Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, 138673, Singapore., Lescar J; Nanyang Institute for Structural Biology, School of Biological Sciences, Nanyang Technological University, 138673, Singapore., Vasudevan SG; Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore.; Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, 117545, Singapore.

المصدر: Nucleic acids research [Nucleic Acids Res] 2017 Dec 15; Vol. 45 (22), pp. 12904-12920.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: Virus Replication*, Dengue Virus/*metabolism , RNA, Viral/*metabolism , Viral Nonstructural Proteins/*metabolism, Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Animals ; Cell Line ; Dengue Virus/genetics ; Kinetics ; Models, Molecular ; Mutation ; Nucleic Acid Conformation ; Protein Binding ; Protein Domains ; RNA Helicases/chemistry ; RNA Helicases/genetics ; RNA Helicases/metabolism ; RNA, Viral/chemistry ; RNA, Viral/genetics ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Thermodynamics ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/genetics

المؤلفون: Li Y; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore., Zhang Z; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore., Phoo WW; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 636921, Singapore., Loh YR; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore., Wang W; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore., Liu S; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore., Chen MW; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore., Hung AW; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore., Keller TH; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore., Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore. Electronic address: luodahai@ntu.edu.sg., Kang C; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore. Electronic address: cbkang@etc.a-star.edu.sg.

المصدر: Structure (London, England : 1993) [Structure] 2017 Aug 01; Vol. 25 (8), pp. 1242-1250.e3. Date of Electronic Publication: 2017 Jul 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents/*pharmacology , Dipeptides/*pharmacology , Protease Inhibitors/*pharmacology , Viral Nonstructural Proteins/*chemistry, Antiviral Agents/chemistry ; Catalytic Domain ; Dipeptides/chemistry ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protease Inhibitors/chemistry ; Protein Binding ; RNA Helicases/chemistry ; RNA Helicases/metabolism ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/metabolism ; Viral Nonstructural Proteins/metabolism ; Zika Virus/enzymology