المؤلفون: Pinkas, DM, Sanvitale, CE, Bufton, JC, Sorrell, FJ, Solcan, N, Chalk, R, Doutch, J, Bullock, AN

المصدر: Biochemical Journal

مصطلحات موضوعية: Cullin-RING ligase, BTB, Ubiquitin-Protein Ligases, Nuclear Proteins, ubiquitination, Crystallography, X-Ray, Cullin Proteins, Protein Structure, Secondary, Protein Structure, Tertiary, Cul3, protein–protein interaction, Potassium Channels, Voltage-Gated, Humans, Amino Acid Sequence, crystallography, Research Articles, Research Article, Adaptor Proteins, Signal Transducing, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::94bd7c75ceec9c133689783424735aa4
http://europepmc.org/articles/PMC5664961

المؤلفون: Lepore, R, Kryshtafovych, A, Alahuhta, M, Bufton, JC, Bullock, AN, Pinkas, DM

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______1064::6364479dbfa401c06a32bca55444dd23
https://ora.ox.ac.uk/objects/uuid:26bf2cc3-5e4f-459e-b8ba-ece756c73305

المؤلفون: Pinkas DM; Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK. Electronic address: danpinkas@hotmail.com., Bufton JC; Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Hunt AE; Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Manning CE; Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Richardson W; Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Bullock AN; Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK. Electronic address: alex.bullock@cmd.ox.ac.uk.

المصدر: Structure (London, England : 1993) [Structure] 2024 Aug 20. Date of Electronic Publication: 2024 Aug 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

المؤلفون: Miller KA; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Cruz Walma DA; Centre for Medicines Discovery, University of Oxford, Oxford, UK.; Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Pinkas DM; Centre for Medicines Discovery, University of Oxford, Oxford, UK.; Department of Biological Sciences, Universidad Loyola Andalucía, Seville, Spain., Tooze RS; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Bufton JC; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Richardson W; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Manning CE; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Hunt AE; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Cros J; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Hartill V; Leeds Institute of Medical Research, University of Leeds, Leeds, UK.; Yorkshire Regional Genetics Service, Leeds Teaching Hospitals NHS Trust, Chapel Allerton Hospital, Leeds, UK., Parker MJ; Sheffield Clinical Genomics Service, Sheffield Children's Hospital NHS Foundation Trust, Sheffield, UK., McGowan SJ; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Twigg SRF; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Chalk R; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Staunton D; Department of Biochemistry, University of Oxford, Oxford, UK., Johnson D; Craniofacial Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Wilkie AOM; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Craniofacial Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Bullock AN; Centre for Medicines Discovery, University of Oxford, Oxford, UK alex.bullock@cmd.ox.ac.uk.

المصدر: Journal of medical genetics [J Med Genet] 2024 Apr 19; Vol. 61 (5), pp. 490-501. Date of Electronic Publication: 2024 Apr 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: British Medical Association Country of Publication: England NLM ID: 2985087R Publication Model: Electronic Cited Medium: Internet ISSN: 1468-6244 (Electronic) Linking ISSN: 00222593 NLM ISO Abbreviation: J Med Genet Subsets: MEDLINE

مواضيع طبية MeSH: BTB-POZ Domain* , Craniofacial Abnormalities*/genetics , Face*/abnormalities, Humans ; Abnormalities, Multiple ; Co-Repressor Proteins/genetics ; Ectodermal Dysplasia ; Mutation, Missense/genetics ; Syndrome

SCR Disease Name: Frontonasal dysplasia

المؤلفون: Röhm S; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Berger BT; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Schröder M; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Chatterjee D; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Mathea S; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Joerger AC; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Pinkas DM; Centre for Medicines Discovery, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, U.K., Bufton JC; Centre for Medicines Discovery, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, U.K., Tjaden A; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Kovooru L; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.; Institute of Biochemistry II, Faculty of Medicine, Johann Wolfgang Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Kudolo M; Department of Pharmaceutical/Medicinal Chemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Pohl C; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.; Institute of Biochemistry II, Faculty of Medicine, Johann Wolfgang Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Bullock AN; Centre for Medicines Discovery, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, U.K., Müller S; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Laufer S; Department of Pharmaceutical/Medicinal Chemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Knapp S; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Sep 23; Vol. 64 (18), pp. 13451-13474. Date of Electronic Publication: 2021 Sep 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Benzamides/*pharmacology , Discoidin Domain Receptor 1/*metabolism , Discoidin Domain Receptor 2/*metabolism , Sulfonamides/*pharmacology , p38 Mitogen-Activated Protein Kinases/*metabolism, Allosteric Site ; Animals ; Benzamides/chemical synthesis ; Benzamides/metabolism ; Cell Line, Tumor ; Discoidin Domain Receptor 1/chemistry ; Discoidin Domain Receptor 2/chemistry ; Dogs ; HEK293 Cells ; Humans ; Madin Darby Canine Kidney Cells ; Microsomes, Liver/metabolism ; Protein Binding ; Sulfonamides/chemical synthesis ; Sulfonamides/metabolism ; p38 Mitogen-Activated Protein Kinases/chemistry

المؤلفون: Suebsuwong C; Department of Chemistry, University of Houston, Health Building 2, Houston, TX, 77204, USA., Dai B; Department of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111, USA., Pinkas DM; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7DQ, UK., Duddupudi AL; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Health Building 2, Houston, TX, 77204, USA., Li L; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Health Building 2, Houston, TX, 77204, USA., Bufton JC; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7DQ, UK., Schlicher L; Nuffield Department of Medicine, Ludwig Institute for Cancer Research, University of Oxford, Old Road Campus, Roosevelt Drive, OX3 7DQ, UK., Gyrd-Hansen M; Nuffield Department of Medicine, Ludwig Institute for Cancer Research, University of Oxford, Old Road Campus, Roosevelt Drive, OX3 7DQ, UK., Hu M; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Health Building 2, Houston, TX, 77204, USA., Bullock AN; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7DQ, UK., Degterev A; Department of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111, USA. Electronic address: alexei.degterev@tufts.edu., Cuny GD; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Health Building 2, Houston, TX, 77204, USA. Electronic address: gdcuny@central.uh.edu.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2020 Aug 15; Vol. 200, pp. 112417. Date of Electronic Publication: 2020 May 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Aminopyridines/*chemistry , Nod Signaling Adaptor Proteins/*chemistry , Receptor-Interacting Protein Serine-Threonine Kinase 2/*chemistry , Signal Transduction/*drug effects, Binding Sites ; Crystallography, X-Ray ; Humans ; Inflammation ; Structure-Activity Relationship

المؤلفون: Lepore R; BSC-CNS Barcelona Supercomputing Center, Barcelona, Spain., Kryshtafovych A; Genome Center, University of California, Davis, California., Alahuhta M; Biosciences Center, National Renewable Energy Laboratory, Golden, Colorado., Veraszto HA; Department of Protein Evolution, Max Planck Institute for Developmental Biology, Tübingen, Germany., Bomble YJ; Biosciences Center, National Renewable Energy Laboratory, Golden, Colorado., Bufton JC; Nuffield Department of Medicine; Structural Genomics Consortium, University of Oxford, Oxford, UK.; School of Biochemistry, University of Bristol, Bristol, UK., Bullock AN; Nuffield Department of Medicine; Structural Genomics Consortium, University of Oxford, Oxford, UK., Caba C; Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada., Cao H; Department of BioSciences, Rice University, Houston, Texas.; Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin., Davies OR; Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Desfosses A; School of Biological Sciences, University of Auckland, Auckland, New Zealand.; Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS, Grenoble, France., Dunne M; Institute of Food, Nutrition and Health, Zurich, Switzerland., Fidelis K; Genome Center, University of California, Davis, California., Goulding CW; Department of Molecular Biology and Biochemistry; Pharmaceutical Sciences, University of California Irvine, Irvine, California., Gurusaran M; Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Gutsche I; Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS, Grenoble, France., Harding CJ; School of Biosciences, University of Birmingham, Birmingham, UK., Hartmann MD; Department of Protein Evolution, Max Planck Institute for Developmental Biology, Tübingen, Germany., Hayes CS; Department of Molecular, Cellular and Developmental Biology, Biomolecular Science and Engineering Program, University of California, Santa Barbara, California., Joachimiak A; Structural Biology Center, Biosciences Division, Midwest Center for Structural Genomics, Argonne.; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois., Leiman PG; Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas., Loppnau P; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada., Lovering AL; School of Biosciences, University of Birmingham, Birmingham, UK., Lunin VV; Biosciences Center, National Renewable Energy Laboratory, Golden, Colorado., Michalska K; Structural Biology Center, Biosciences Division, Midwest Center for Structural Genomics, Argonne., Mir-Sanchis I; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois., Mitra AK; School of Biological Sciences, University of Auckland, Auckland, New Zealand., Moult J; Institute for Bioscience and Biotechnology Research, Department of Cell Biology and Molecular genetics, University of Maryland, Rockville, Maryland, USA., Phillips GN Jr; Department of BioSciences, Rice University, Houston, Texas.; Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin., Pinkas DM; Nuffield Department of Medicine; Structural Genomics Consortium, University of Oxford, Oxford, UK., Rice PA; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois., Tong Y; Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada., Topf M; Institute of Structural and Molecular Biology, Birkbeck, University College London, London, UK., Walton JD; Great Lakes Bioenergy Research Center and Department of Plant Biology, Michigan State University, East Lansing, Michigan., Schwede T; Biozentrum University of Basel, Basel, Switzerland.; SIB Swiss Institute of Bioinformatics, Biozentrum University of Basel, Basel, Switzerland.

المصدر: Proteins [Proteins] 2019 Dec; Vol. 87 (12), pp. 1037-1057. Date of Electronic Publication: 2019 Sep 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8700181 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0134 (Electronic) Linking ISSN: 08873585 NLM ISO Abbreviation: Proteins Subsets: MEDLINE

مواضيع طبية MeSH: Computational Biology* , Protein Conformation*, Proteins/*ultrastructure, Arabidopsis/chemistry ; Arabidopsis/ultrastructure ; Bacterial Proteins/chemistry ; Bacterial Proteins/ultrastructure ; Crystallography, X-Ray ; Humans ; Models, Molecular ; Proteins/chemistry ; Proteins/genetics

المؤلفون: Zhu D; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy , Jinan University , 601 Huangpu Avenue West , Guangzhou 510632 , China.; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China., Huang H; Division of Surgical Oncology, Department of Surgery and Hamon Center for Therapeutic Oncology Research , UT Southwestern , Dallas , Texas 75390-8593 , United States., Pinkas DM; Structural Genomics Consortium , University of Oxford , Old Road Campus Research Building, Roosevelt Drive , Oxford OX3 7DQ , U.K., Luo J; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China., Ganguly D; Division of Surgical Oncology, Department of Surgery and Hamon Center for Therapeutic Oncology Research , UT Southwestern , Dallas , Texas 75390-8593 , United States., Fox AE; Structural Genomics Consortium , University of Oxford , Old Road Campus Research Building, Roosevelt Drive , Oxford OX3 7DQ , U.K., Arner E; Division of Surgical Oncology, Department of Surgery and Hamon Center for Therapeutic Oncology Research , UT Southwestern , Dallas , Texas 75390-8593 , United States., Xiang Q; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China., Tu ZC; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China., Bullock AN; Structural Genomics Consortium , University of Oxford , Old Road Campus Research Building, Roosevelt Drive , Oxford OX3 7DQ , U.K., Brekken RA; Division of Surgical Oncology, Department of Surgery and Hamon Center for Therapeutic Oncology Research , UT Southwestern , Dallas , Texas 75390-8593 , United States., Ding K; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy , Jinan University , 601 Huangpu Avenue West , Guangzhou 510632 , China., Lu X; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy , Jinan University , 601 Huangpu Avenue West , Guangzhou 510632 , China.

المصدر: Journal of medicinal chemistry [J Med Chem] 2019 Aug 22; Vol. 62 (16), pp. 7431-7444. Date of Electronic Publication: 2019 Aug 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Discoidin Domain Receptor 1/*antagonists & inhibitors , Neoplasms, Experimental/*prevention & control , Pancreatic Neoplasms/*prevention & control , Xenograft Model Antitumor Assays/*methods, Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Cell Line, Tumor ; Discoidin Domain Receptor 1/metabolism ; Drug Design ; Epithelial-Mesenchymal Transition/drug effects ; Humans ; Male ; Mice, Inbred C57BL ; Neoplasms, Experimental/metabolism ; Pancreatic Neoplasms/metabolism ; Rats, Sprague-Dawley ; Tumor Stem Cell Assay

المؤلفون: Wang Z; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy , Jinan University , 601 Huangpu Avenue West , Guangzhou 510632 , China.; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China., Zhang Y, Pinkas DM; Structural Genomics Consortium , University of Oxford , Old Road Campus Research Building, Roosevelt Drive , Oxford OX3 7DQ , U.K., Fox AE; Structural Genomics Consortium , University of Oxford , Old Road Campus Research Building, Roosevelt Drive , Oxford OX3 7DQ , U.K., Luo J; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China., Huang H; Nancy B. and Jake L. Hamon Centre for Therapeutic Oncology Research, Departments of Surgery and Pharmacology , University of Texas Southwestern Medical Center at Dallas , 5323 Harry Hines Boulevard , Dallas , Texas 75390 , United States., Cui S; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China., Xiang Q; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China., Xu T, Xun Q; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China., Zhu D; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China., Tu Z; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China., Ren X; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy , Jinan University , 601 Huangpu Avenue West , Guangzhou 510632 , China., Brekken RA; Nancy B. and Jake L. Hamon Centre for Therapeutic Oncology Research, Departments of Surgery and Pharmacology , University of Texas Southwestern Medical Center at Dallas , 5323 Harry Hines Boulevard , Dallas , Texas 75390 , United States., Bullock AN; Structural Genomics Consortium , University of Oxford , Old Road Campus Research Building, Roosevelt Drive , Oxford OX3 7DQ , U.K., Liang G, Ding K; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy , Jinan University , 601 Huangpu Avenue West , Guangzhou 510632 , China., Lu X; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy , Jinan University , 601 Huangpu Avenue West , Guangzhou 510632 , China.

المصدر: Journal of medicinal chemistry [J Med Chem] 2018 Sep 13; Vol. 61 (17), pp. 7977-7990. Date of Electronic Publication: 2018 Aug 20.

نوع المنشور: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Acute Lung Injury/*drug therapy , Anti-Inflammatory Agents/*chemical synthesis , Anti-Inflammatory Agents/*pharmacology , Discoidin Domain Receptor 1/*antagonists & inhibitors , Discoidin Domain Receptor 2/*antagonists & inhibitors , Pneumonia/*drug therapy, Acute Lung Injury/chemically induced ; Acute Lung Injury/metabolism ; Animals ; Humans ; Lipopolysaccharides/toxicity ; Male ; Mice ; Mice, Inbred C57BL ; Pneumonia/chemically induced ; Pneumonia/metabolism ; Rats ; Rats, Sprague-Dawley

المؤلفون: Hrdinka M; Nuffield Department of Clinical Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK., Schlicher L; Nuffield Department of Clinical Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK., Dai B; Department of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine, Boston, MA, USA., Pinkas DM; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford, UK., Bufton JC; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford, UK., Picaud S; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford, UK., Ward JA; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford, UK.; Nuffield Department of Clinical Medicine, Target Discovery Institute, University of Oxford, Oxford, UK., Rogers C; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford, UK.; Nuffield Department of Clinical Medicine, Target Discovery Institute, University of Oxford, Oxford, UK., Suebsuwong C; Department of Chemistry, University of Houston, Houston, TX, USA., Nikhar S; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA., Cuny GD; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA., Huber KV; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford, UK.; Nuffield Department of Clinical Medicine, Target Discovery Institute, University of Oxford, Oxford, UK., Filippakopoulos P; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford, UK., Bullock AN; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford, UK., Degterev A; Department of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine, Boston, MA, USA alexei.degterev@tufts.edu mads.gyrd-hansen@ludwig.ox.ac.uk., Gyrd-Hansen M; Nuffield Department of Clinical Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK alexei.degterev@tufts.edu mads.gyrd-hansen@ludwig.ox.ac.uk.

المصدر: The EMBO journal [EMBO J] 2018 Sep 03; Vol. 37 (17). Date of Electronic Publication: 2018 Jul 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

مواضيع طبية MeSH: Nod2 Signaling Adaptor Protein/*metabolism , Protein Kinase Inhibitors/*pharmacology , Receptor-Interacting Protein Serine-Threonine Kinase 2/*antagonists & inhibitors , Receptor-Interacting Protein Serine-Threonine Kinases/*antagonists & inhibitors , Signal Transduction/*drug effects, Animals ; Cell Line, Tumor ; Female ; Humans ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitor of Apoptosis Proteins/metabolism ; Mice ; Nod2 Signaling Adaptor Protein/genetics ; Receptor-Interacting Protein Serine-Threonine Kinase 2/genetics ; Receptor-Interacting Protein Serine-Threonine Kinase 2/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Signal Transduction/genetics ; X-Linked Inhibitor of Apoptosis Protein/genetics ; X-Linked Inhibitor of Apoptosis Protein/metabolism