المؤلفون: Zsoldos B; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary., Nagy N; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary., Donkó-Tóth V; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary., Keglevich P; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary., Weber M; Spectroscopic Research Department, Gedeon Richter Plc., P.O. Box 27, H-1475 Budapest, Hungary., Dékány M; Spectroscopic Research Department, Gedeon Richter Plc., P.O. Box 27, H-1475 Budapest, Hungary., Nehr-Majoros A; Department of Pharmacology and Pharmacotherapy, Medical School & Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.; National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.; HUN-REN PTE Chronic Pain Research Group, H-7624 Pécs, Hungary., Szőke É; Department of Pharmacology and Pharmacotherapy, Medical School & Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.; National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.; HUN-REN PTE Chronic Pain Research Group, H-7624 Pécs, Hungary., Helyes Z; Department of Pharmacology and Pharmacotherapy, Medical School & Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.; National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.; HUN-REN PTE Chronic Pain Research Group, H-7624 Pécs, Hungary., Hazai L; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 19; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Cricetulus* , Piperazines*/pharmacology , Piperazines*/chemistry , Piperazines*/chemical synthesis , Cell Proliferation*/drug effects , Piperazine*/chemistry , Piperazine*/pharmacology, Humans ; Cell Line, Tumor ; CHO Cells ; Animals ; Vinblastine/analogs & derivatives ; Vinblastine/pharmacology ; Vinblastine/chemistry ; Vinblastine/chemical synthesis ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship ; Cell Survival/drug effects

المؤلفون: Shin Y; Department of Global Innovative Drugs, The Graduate School of Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, 06974, Republic of Korea., Kim M; Department of Global Innovative Drugs, The Graduate School of Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, 06974, Republic of Korea., Kim C; Department of Global Innovative Drugs, The Graduate School of Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, 06974, Republic of Korea., Jeon H; Department of Global Innovative Drugs, The Graduate School of Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, 06974, Republic of Korea., Koo J; Department of Global Innovative Drugs, The Graduate School of Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, 06974, Republic of Korea., Oh J; Department of Global Innovative Drugs, The Graduate School of Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, 06974, Republic of Korea., Shin S; Department of Global Innovative Drugs, The Graduate School of Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, 06974, Republic of Korea.; College of Pharmacy, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, 06974, Republic of Korea., Youn YS; School of Pharmacy, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi-Do, 16419, Republic of Korea., Lim C; College of Pharmacy, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi-do, 13488, Republic of Korea. chaemin@cha.ac.kr., Oh KT; Department of Global Innovative Drugs, The Graduate School of Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, 06974, Republic of Korea. kyungoh@cau.ac.kr.; College of Pharmacy, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, 06974, Republic of Korea. kyungoh@cau.ac.kr.

المصدر: AAPS PharmSciTech [AAPS PharmSciTech] 2024 Sep 24; Vol. 25 (7), pp. 221. Date of Electronic Publication: 2024 Sep 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 100960111 Publication Model: Electronic Cited Medium: Internet ISSN: 1530-9932 (Electronic) Linking ISSN: 15309932 NLM ISO Abbreviation: AAPS PharmSciTech Subsets: MEDLINE

مواضيع طبية MeSH: Piperazines*/chemistry , Piperazines*/administration & dosage , Piperazines*/pharmacokinetics , Phthalazines*/chemistry , Phthalazines*/administration & dosage , Phthalazines*/pharmacokinetics , Phthalazines*/pharmacology , Solubility* , Emulsions*/chemistry , Drug Delivery Systems*/methods , Biological Availability*, Humans ; Cell Line, Tumor ; Drug Stability ; Chemistry, Pharmaceutical/methods ; Particle Size ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Surface-Active Agents/chemistry ; Drug Carriers/chemistry ; Polyethylene Glycols/chemistry ; MCF-7 Cells ; Drug Liberation ; Nanoparticles/chemistry ; Drug Compounding/methods

المؤلفون: Koziej S; II Department of Psychiatry and Psychiatric Rehabilitation, Student Scientific Circle, Faculty of Medicine, Medical University of Lublin, Lublin, Poland., Kowalczyk E; II Department of Psychiatry and Psychiatric Rehabilitation, Student Scientific Circle, Faculty of Medicine, Medical University of Lublin, Lublin, Poland., Soroka E; II Department of Psychiatry and Psychiatric Rehabilitation, Faculty of Medicine, Medical University of Lublin, Lublin, Poland.

المصدر: Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2024 Sep 20; Vol. 30, pp. e945411. Date of Electronic Publication: 2024 Sep 20.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: International Scientific Information, Inc Country of Publication: United States NLM ID: 9609063 Publication Model: Electronic Cited Medium: Internet ISSN: 1643-3750 (Electronic) Linking ISSN: 12341010 NLM ISO Abbreviation: Med Sci Monit Subsets: MEDLINE

مواضيع طبية MeSH: Piperazines*/therapeutic use , Piperazines*/pharmacology , Piperazines*/adverse effects , Antipsychotic Agents*/therapeutic use , Antipsychotic Agents*/adverse effects , Antipsychotic Agents*/pharmacology , Schizophrenia*/drug therapy, Humans ; Bipolar Disorder/drug therapy ; Mental Disorders/drug therapy ; Psychiatry/methods ; Receptors, Dopamine D2/metabolism

المؤلفون: Kobayashi T; Department of Breast Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan. tkobayashi.g@gmail.com., Nishimura M; Department of Breast Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan., Hosonaga M; Department of Breast Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan., Kizawa R; Department of Breast Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan., Kawai S; Department of Breast Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan., Aoyama Y; Department of Breast Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan., Ozaki Y; Department of Breast Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan., Fukada I; Department of Breast Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan., Hara F; Department of Breast Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan., Takano T; Department of Breast Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan., Ueno T; Department of Breast Surgical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan.

المصدر: BMC cancer [BMC Cancer] 2024 Sep 17; Vol. 24 (1), pp. 1156. Date of Electronic Publication: 2024 Sep 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Piperazines*/therapeutic use , Piperazines*/administration & dosage , Pyridines*/therapeutic use , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/mortality, Humans ; Female ; Middle Aged ; Retrospective Studies ; Aged ; Adult ; Lymphocyte Count ; Prognosis ; Aged, 80 and over ; Receptors, Estrogen/metabolism ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Neoplasm Metastasis

المؤلفون: Tian Y; National Institutes for Food and Drug Control, Beijing 102600, China. Electronic address: tianye@nifdc.org.cn., Tao X; National Institutes for Food and Drug Control, Beijing 102600, China., Feng Y; National Institutes for Food and Drug Control, Beijing 102600, China., Yin L; National Institutes for Food and Drug Control, Beijing 102600, China. Electronic address: yinlihui@nifdc.org.cn., Ning B; National Institutes for Food and Drug Control, Beijing 102600, China. Electronic address: ningbm@nifdc.org.cn.

المصدر: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2024 Sep 15; Vol. 248, pp. 116303. Date of Electronic Publication: 2024 Jun 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

مواضيع طبية MeSH: Rifampin*/chemistry , Rifampin*/analysis , Drug Contamination*/prevention & control , Piperazines*/chemistry , Piperazines*/analysis, Mutagens/chemistry ; Mutagens/analysis ; Oxidation-Reduction ; Capsules ; China ; Antioxidants/chemistry ; Antioxidants/analysis

المؤلفون: Sambandan E; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology (VIT), Vellore 632014, India., Thenmozhi K; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology (VIT), Vellore 632014, India., Santosh G; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology (VIT), Chennai 600127, India., Wang CC; School of Pharmacy, Kaohsiung Medical University, Kaohsiung City 807, Taiwan., Tsai PC; Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung City 807, Taiwan; Department of Computational Biology, Institute of Bioinformatics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai 602105, Tamil Nadu, India., Gurrani S; Department of Applied Science and Humanities, Invertis University, Bareilly, Uttar Pradesh, India., Senthilkumar S; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology (VIT), Vellore 632014, India. Electronic address: senthilkumar.s@vit.ac.in., Chen YH; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan. Electronic address: jayshung1985@gmail.com., Ponnusamy VK; Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung City 807, Taiwan; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung City 807, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan; Department of Chemistry, National Sun Yat-sen University (NSYSU), Kaohsiung City 804, Taiwan; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung City 807, Taiwan. Electronic address: kumar@kmu.edu.tw.

المصدر: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2024 Sep 15; Vol. 1245, pp. 124275. Date of Electronic Publication: 2024 Aug 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE

مواضيع طبية MeSH: Heterocyclic Compounds, 3-Ring*/chemistry , Heterocyclic Compounds, 3-Ring*/analysis , Piperazines*/chemistry , Piperazines*/analysis , Pyridones*/chemistry , Pyridones*/analysis , Gas Chromatography-Mass Spectrometry*/methods , Oxazines*/chemistry , Limit of Detection* , Drug Contamination*, Reproducibility of Results ; Linear Models ; Mutagens/analysis ; Anti-HIV Agents/analysis ; Anti-HIV Agents/chemistry ; Liquid-Liquid Extraction/methods ; Sonication/methods ; Computer Simulation ; Humans

المؤلفون: Brudon A; Thoracic Oncology Department, Université Paris Cité, CIC INSERM 1425, Institut du Cancer AP-HP.Nord, Hôpital Bichat-Claude Bernard, 46 Rue Henri Huchard, Paris, 75108, France. alexandre.brudon01@chu-lyon.fr., Fournier D; Service de Pharmacologie Médicale, Centre Régional de Pharmacovigilance Pitié-Saint-Antoine, Groupe Hospitalier AP-HP-Sorbonne Université, Paris, 75013, France., Selle F; Department of Medical Oncology, Hôpital Diaconesses Croix Saint Simon, Paris, 75020, France., Seront E; Department of Medical Oncology, Hôpital Jolimont, Haine-Saint-Paul, La Louvière, 7100, Belgique., Conforti R; Department of Medical Oncology, Sorbonne UniversitéHôpital Pitié Salpêtrière, APHP, Paris, 75011, France., Veyrac G; Clinical Pharmacology Department, CHU Nantes, Nantes, France., Gouraud A; Service Hospitalo-Universitaire de Pharmaco-Toxicologie (SHUPT), Hospices Civils de Lyon, 162, Avenue Lacassagne, Lyon, 69424, France., Lebrun-Vignes B; Service de Pharmacologie Médicale, Centre Régional de Pharmacovigilance Pitié-Saint-Antoine, Groupe Hospitalier AP-HP-Sorbonne Université, Paris, 75013, France., Khalil A; Department of Radiology, Université Paris Cité, Hôpital Bichat-Claude Bernard, Institut du Cancer Paris Nord, APHP, Université Paris Cité, Paris, 75018, France., Zalcman G; Thoracic Oncology Department, Université Paris Cité, CIC INSERM 1425, Institut du Cancer AP-HP.Nord, Hôpital Bichat-Claude Bernard, 46 Rue Henri Huchard, Paris, 75108, France., Gounant V; Thoracic Oncology Department, Université Paris Cité, CIC INSERM 1425, Institut du Cancer AP-HP.Nord, Hôpital Bichat-Claude Bernard, 46 Rue Henri Huchard, Paris, 75108, France.

المصدر: BMC pulmonary medicine [BMC Pulm Med] 2024 Sep 13; Vol. 24 (1), pp. 448. Date of Electronic Publication: 2024 Sep 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968563 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2466 (Electronic) Linking ISSN: 14712466 NLM ISO Abbreviation: BMC Pulm Med Subsets: MEDLINE

مواضيع طبية MeSH: Lung Diseases, Interstitial*/chemically induced , Lung Diseases, Interstitial*/diagnostic imaging , Phthalazines*/adverse effects , Phthalazines*/therapeutic use , Piperazines*/adverse effects , Piperazines*/therapeutic use , Pharmacovigilance* , Poly(ADP-ribose) Polymerase Inhibitors*/adverse effects , Poly(ADP-ribose) Polymerase Inhibitors*/therapeutic use, Humans ; Female ; Retrospective Studies ; Aged ; Middle Aged ; Adult ; Breast Neoplasms/drug therapy ; Tomography, X-Ray Computed ; Ovarian Neoplasms/drug therapy ; France ; Belgium

المؤلفون: Reinmuth N; Department of Thoracic Oncology, Asklepios Lung Clinic Munich-Gauting, Gauting, Germany.; German Center of Lung Research, LMU Munich, Munich, Germany., Juan-Vidal O; Department of Medical Oncology, La Fe University Hospital, Valencia, Spain., Kowalski D; Department of Lung Cancer and Thoracic Tumours, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Bryl M; Oncology Department, E.J. Zeyland Wielkopolska Center of Pulmonology and Thoracic Surgery, Poznan, Poland., Kryzhanivska A; Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine., Vicente D; Hospital Universitario Virgen Macarena, Seville, Spain., Horváth Z; Bacs-Kiskun County Teaching Hospital, Kecskemét, Hungary., Gálffy G; Pulmonology Hospital Törökbálint, Törökbálint, Hungary., Csánky E; Department of Pulmonology, Semmelweis Hospital, Miskolc, Hungary., Pápai Székely Z; St George Hospital of Fejér County, Szekesfehervar, Hungary., Vynnychenko I; Sumy State University, Sumy, Ukraine., Armstrong J; AstraZeneca, Cambridge, United Kingdom., Dalvi T; AstraZeneca, Gaithersburg, Maryland., Xie M; AstraZeneca, Waltham, Massachusetts., Iyer S; AstraZeneca, Waltham, Massachusetts., Shrestha Y; AstraZeneca, Gaithersburg, Maryland., Jiang H; AstraZeneca, Gaithersburg, Maryland., Bondarenko I; Dnipropetrovsk State Medical Academy, Dnipropetrovsk, Ukraine.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Sep 13; Vol. 30 (18), pp. 4055-4067.

نوع المنشور: Journal Article; Clinical Trial, Phase II; Multicenter Study

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/adverse effects , Small Cell Lung Carcinoma*/drug therapy , Small Cell Lung Carcinoma*/pathology , Small Cell Lung Carcinoma*/genetics , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , Lung Neoplasms*/mortality , Phthalazines*/administration & dosage , Phthalazines*/therapeutic use , Piperazines*/administration & dosage , Piperazines*/therapeutic use , Carboplatin*/administration & dosage , Drug Resistance, Neoplasm*, Humans ; Male ; Female ; Middle Aged ; Aged ; DNA Repair/drug effects ; Adult ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/therapeutic use ; Immunotherapy/methods ; Aged, 80 and over ; Neoplasm Staging ; Biomarkers, Tumor ; Antibodies, Monoclonal ; Pyrazoles ; Pyrimidinones

المؤلفون: Zheng J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China., Zhou L; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China., Gong X; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China., Yang F; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China., Cheng J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China., Ma R; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China., Wu C; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China., Xu Z; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China., Zhu W; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: wlzhu@simm.ac.cn., He Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: heyang@simm.ac.cn., Shen J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116564. Date of Electronic Publication: 2024 Jun 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antidepressive Agents*/pharmacology , Antidepressive Agents*/chemical synthesis , Antidepressive Agents*/chemistry , Piperazines*/chemistry , Piperazines*/pharmacology , Piperazines*/chemical synthesis , Molecular Docking Simulation*, Animals ; Mice ; Structure-Activity Relationship ; Humans ; Molecular Structure ; Male ; Dose-Response Relationship, Drug ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Depression/drug therapy ; Receptor, Serotonin, 5-HT1A/metabolism

المؤلفون: da Silva Oliveira DD; Laboratório de Síntese de Candidatos a Fármacos, Institute of Chemistry, Federal University of Uberlândia (UFU), Uberlândia, MG, 38400-902, Brazil., Paz F; Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Brito NPF; Laboratório de Síntese de Candidatos a Fármacos, Institute of Chemistry, Federal University of Uberlândia (UFU), Uberlândia, MG, 38400-902, Brazil., Krüger A; Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Martinho ACC; Laboratório de Síntese de Candidatos a Fármacos, Institute of Chemistry, Federal University of Uberlândia (UFU), Uberlândia, MG, 38400-902, Brazil., Lapierre TJWJD; Laboratório de Síntese de Candidatos a Fármacos, Institute of Chemistry, Federal University of Uberlândia (UFU), Uberlândia, MG, 38400-902, Brazil., de Oliveira Souza F; Laboratório de Biomoléculas e Espectrometria de Massas (LaBioMass), State University of Maringá (UEM), Maringá, PR, 807020-900, Brazil., Maltarollo VG; Department of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil., Kronenberger T; German Center for Infection Research (DZIF), Partner-site Tübingen, 72076, Tübingen, Germany; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, 70211, Finland., Mendes MS; Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, 14040-903, Brazil; Center for the Research and Advancement of Fragments and Molecular Targets, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, 14040-903, Brazil., Nonato MC; Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, 14040-903, Brazil; Center for the Research and Advancement of Fragments and Molecular Targets, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, 14040-903, Brazil., Pilau EJ; Laboratório de Biomoléculas e Espectrometria de Massas (LaBioMass), State University of Maringá (UEM), Maringá, PR, 807020-900, Brazil., Wrenger C; Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Wunderlich G; Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Rezende Júnior CO; Laboratório de Síntese de Candidatos a Fármacos, Institute of Chemistry, Federal University of Uberlândia (UFU), Uberlândia, MG, 38400-902, Brazil. Electronic address: celso@ufu.br.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116621. Date of Electronic Publication: 2024 Jun 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials*/pharmacology , Antimalarials*/chemical synthesis , Antimalarials*/chemistry , Plasmodium falciparum*/drug effects , Piperazines*/chemistry , Piperazines*/pharmacology , Piperazines*/chemical synthesis , Drug Design* , Parasitic Sensitivity Tests*, Structure-Activity Relationship ; Humans ; Molecular Structure ; Dose-Response Relationship, Drug ; Animals