المؤلفون: Morgan, AR, Touchard, S, Leckey, C, O'Hagan, C, Nevado-Holgado, AJ, Barkhof, F, Bertram, L, Blin, O, Bos, I, Dobricic, V, Engelborghs, S, Frisoni, G, Frolich, L, Gabel, S, Johannsen, P, Kettunen, P, Koszewska, I, Legido-Quigley, C, Lleo, A, Martinez-Lage, P, Mecocci, P, Meersmans, K, Molinuevo, JL, Peyratout, G, Popp, J, Richardson, J, Sala, I, Scheltens, P, Streffer, J, Soininen, H, Tainta-Cuezva, M, Teunissen, C, Tsolaki, M, Vandenberghe, R, Visser, PJ, Vos, S, Wahlund, LO, Wallin, A, Westwood, S, Zetterberg, H, Lovestone, S, Morgan, BP, Bullmore, ET, Bhatti, J, Chamberlain, SJ, Correia, MM, Crofts, AL, Dickinson, A, Foster, AC, Kitzbichler, MG, Knight, C, Lynall, ME, Maurice, C, O'Donnell, C, Pointon, LJ, Hyslop, PS, Turner, L, Vertes, P, Widmer, B, Williams, GB, Cavanagh, J, Deith, C, Farmer, S, McClean, J, McColl, A, McPherson, A, Scouller, P, Sutherland, M, Boddeke, HWGM, Richardson, JC, Khan, S, Murphy, P, Parker, CA, Patel, J, Jones, D, Boer, P, Kemp, J, Drevets, WC, Nye, JS, Wittenberg, G, Isaac, J, Bhattacharya, A, Carruthers, N, Kolb, H, Pariante, CM, Turkheimer, F, Barker, GJ, Byrom, H, Cash, D, Cattaneo, A, Gee, A, Hastings, C, Mariani, N, McLaughlin, A, Mondelli, V, Nettis, M, Nikkheslat, N, Randall, K, Sheridan, H, Simmons, C, Singh, N, Van Loo, V, Vicente-Rodriguez, M, Wood, TC, Worrell, C, Zajkowska, Z, Plath, N, Egebjerg, J, Eriksson, H, Gastambide, F, Adams, KH, Jeggo, R, Thomsen, C, Pederson, JT, Campbell, B, Moller, T, Nelson, B, Zorn, S, O'Connor, J, Attenburrow, MJ, Baird, A, Benjamin, J, Clare, S, Cowen, P, Huang, IS, Hurley, S, Jones, H, Mada, F, Nevado-Holgado, A, Oladejo, A, Ribe, E, Smith, K, Vyas, A, Hughes, Z, Balice-Gordon, R, Duerr, J, Piro, JR, Sporn, J, Perry, VH, Cleal, M, Fryatt, G, Gomez-Nicola, D, Mancuso, R, Reynolds, R, Harrison, NA, Cercignani, M, Clarke, CL, Hoskins, E, Kohn, C, Murray, R, Wilcock, L, Wlazly, D

المصدر: Alzheimer's & dementia : the journal of the Alzheimer's Association. 15(6):776-787

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:141089094

المؤلفون: Arakawa, R, Takano, A, Nag, S, Jia, ZS, Amini, N, Maresca, KP, Zhang, L, Keliher, EJ, Butler, CR, Piro, JR, Samad, TA, Smith, D, Nason, D, O'Neil, S, Trapa, P, Fonseca, KR, Litchfield, J, McCarthy, T, Carson, RE, Halldin, C

المصدر: EJNMMI research. 12(1):13

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:149047115

المؤلفون: Zhang, L, Butler, CR, Maresca, KP, Takano, A, Nag, S, Jia, Z, Arakawa, R, Piro, JR, Samad, T, Smith, DL, Nason, DM, O'Neil, S, McAllister, L, Schildknegt, K, Trapa, P, McCarthy, TJ, Villalobos, A, Halldin, C

المصدر: Journal of medicinal chemistry. 62(18):8532-8543

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:141988006

المؤلفون: Leckey, C, Nevado-Holgado, AJ, Barkhof, F, Bertram, L, Blin, O, Bos, I, Dobricic, V, Engelborghs, S, Frisoni, G, Frolich, L, Gabel, S, Johannsen, P, Kettunen, P, Koszewska, I, Legido-Quigley, C, Lleo, A, Martinez-Lage, P, Mecocci, P, Meersmans, K, Molinuevo, JL, Peyratout, G, Popp, J, Richardson, J, Sala, I, Scheltens, P, Streffer, J, Soininen, H, Tainta-Cuezva, M, Teunissen, C, Tsolaki, M, Vandenberghe, R, Visser, PJ, Vos, S, Wahlund, LO, Wallin, A, Westwood, S, Zetterberg, H, Bullmore, ET, Bhatti, J, Chamberlain, SJ, Correia, MM, Crofts, AL, Dickinson, A, Foster, AC, Kitzbichler, MG, Knight, C, Lynall, ME, Maurice, C, O'Donnell, C, Pointon, LJ, Hyslop, PS, Turner, L, Vertes, P, Widmer, B, Williams, GB, Morgan, BP, Morgan, AR, O'Hagan, C, Touchard, S, Cavanagh, J, Deith, C, Farmer, S, McClean, J, McColl, A, McPherson, A, Scouller, P, Sutherland, M, Boddeke, HWGM, Richardson, JC, Khan, S, Murphy, P, Parker, CA, Patel, J, Jones, D, Boer, P, Kemp, J, Drevets, WC, Nye, JS, Wittenberg, G, Isaac, J, Bhattacharya, A, Carruthers, N, Kolb, H, Pariante, CM, Turkheimer, F, Barker, GJ, Byrom, H, Cash, D, Cattaneo, A, Gee, A, Hastings, C, Mariani, N, McLaughlin, A, Mondelli, V, Nettis, M, Nikkheslat, N, Randall, K, Sheridan, H, Simmons, C, Singh, N, Van Loo, V, Vicente-Rodriguez, M, Wood, TC, Worrell, C, Zajkowska, Z, Plath, N, Egebjerg, J, Eriksson, H, Gastambide, F, Adams, KH, Jeggo, R, Thomsen, C, Pederson, JT, Campbell, B, Moller, T, Nelson, B, Zorn, S, O'Connor, J, Attenburrow, MJ, Baird, A, Benjamin, J, Clare, S, Cowen, P, Huang, IS, Hurley, S, Jones, H, Lovestone, S, Mada, F, Nevado-Holgado, A, Oladejo, A, Ribe, E, Smith, K, Vyas, A, Hughes, Z, Balice-Gordon, R, Duerr, J, Piro, JR, Sporn, J, Perry, VH, Cleal, M, Fryatt, G, Gomez-Nicola, D, Mancuso, R, Reynolds, R, Harrison, NA, Cercignani, M, Clarke, CL, Hoskins, E, Kohn, C, Murray, R, Wilcock, L, Wlazly, D, NIMA Consortium, NIMA-Wellcome Trust Consortium

المصدر: Alzheimers & Dementia
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

مصطلحات موضوعية: Inflammation, Plasma, Complement, Biomarker, Alzheimer's disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::eeaa0152773020a55e475b800720dc99
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2650

المؤلفون: Butler, CR, Takano, A, Nag, S, Arakawa, R, Maresca, KP, Piro, JR, Samad, T, Smith, D, Nason, D, O'Neil, S, McAllister, L, Grimwood, S, Trapa, P, McCarthy, T, Villalobos, A, Halldin, C, Zhang, L

المصدر: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 44:S366-S367

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:140019158

المؤلفون: Biber K; AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Ludwigshafen, Germany., Bhattacharya A; Janssen Research & Development LLC, San Diego, CA, United States., Campbell BM; Sage Therapeutics, Cambridge, MA, United States., Piro JR; AbbVie Foundational Neuroscience Center, Cambridge, MA, United States., Rohe M; AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Ludwigshafen, Germany., Staal RGW; Paracelsus Neuroscience, Metuchen, NJ, United States., Talanian RV; AbbVie Foundational Neuroscience Center, Cambridge, MA, United States., Möller T; AbbVie Foundational Neuroscience Center, Cambridge, MA, United States.

المصدر: Frontiers in pharmacology [Front Pharmacol] 2019 Aug 23; Vol. 10, pp. 840. Date of Electronic Publication: 2019 Aug 23 (Print Publication: 2019).

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE

المؤلفون: Piro JR; Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA. JPiro1000@gmail.com.; Present Address: Abbvie Inc., 200 Sidney St., Cambridge, MA, 02139, USA. JPiro1000@gmail.com., Suidan GL; Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA.; Present Address: Biogen, 225 Binney St., Cambridge, MA, 02142, USA., Quan J; Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA., Pi Y; Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA.; Present Address: Biogen, 225 Binney St., Cambridge, MA, 02142, USA., O'Neill SM; Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA.; Present Address: Biogen, 225 Binney St., Cambridge, MA, 02142, USA., Ilardi M; Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA.; Present Address: NYU School of Medicine, 550 1st Ave., New York, NY, 10016, USA., Pozdnyakov N; Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA., Lanz TA; Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA.; Present Address: Biogen, 225 Binney St., Cambridge, MA, 02142, USA., Xi H; Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA.; Present Address: Abbvie Inc., 200 Sidney St., Cambridge, MA, 02139, USA., Bell RD; Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA., Samad TA; Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA. samad.tarek@gmail.com.; Present Address: Sanofi R&D, 49 New York Ave., Framingham, MA, 01701, USA. samad.tarek@gmail.com.

المصدر: Journal of neuroinflammation [J Neuroinflammation] 2018 May 14; Vol. 15 (1), pp. 142. Date of Electronic Publication: 2018 May 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE

مواضيع طبية MeSH: Arachidonic Acids/*antagonists & inhibitors , Arachidonic Acids/*metabolism , Blood-Brain Barrier/*metabolism , Brain Injuries/*drug therapy , Brain Injuries/*metabolism , Capillary Permeability/*physiology , Endocannabinoids/*antagonists & inhibitors , Endocannabinoids/*metabolism , Glycerides/*antagonists & inhibitors , Glycerides/*metabolism, Animals ; Blood-Brain Barrier/drug effects ; Brain Injuries/chemically induced ; Capillary Permeability/drug effects ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Hydrolysis/drug effects ; Lipopolysaccharides ; Male ; Mice ; Mice, Inbred C57BL ; Monoacylglycerol Lipases/antagonists & inhibitors ; Monoacylglycerol Lipases/metabolism

المؤلفون: McAllister LA; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Butler CR; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Mente S; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., O'Neil SV; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Fonseca KR; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Piro JR; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Cianfrogna JA; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Foley TL; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Gilbert AM; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Harris AR; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Helal CJ; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Johnson DS; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Montgomery JI; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Nason DM; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Noell S; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Pandit J; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Rogers BN; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Samad TA; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Shaffer CL; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., da Silva RG; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Uccello DP; Pfizer Worldwide Research and Development , 445 Eastern Point Road , Groton , Connecticut 06340 , United States., Webb D; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States., Brodney MA; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2018 Apr 12; Vol. 61 (7), pp. 3008-3026. Date of Electronic Publication: 2018 Mar 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Inflammatory Agents, Non-Steroidal/*chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal/*pharmacology , Carbamates/*chemical synthesis , Carbamates/*pharmacology , Enzyme Inhibitors/*chemical synthesis , Enzyme Inhibitors/*pharmacology , Monoacylglycerol Lipases/*antagonists & inhibitors , Neuritis/*drug therapy, Amidohydrolases/antagonists & inhibitors ; Animals ; Arachidonic Acids/metabolism ; Biomarkers ; Brain Chemistry/drug effects ; Dogs ; Drug Design ; Drug Discovery ; Endocannabinoids/metabolism ; Glycerides/metabolism ; Humans ; Macaca mulatta ; Models, Molecular ; Rats ; Rats, Wistar ; Structure-Activity Relationship

المؤلفون: Terrone G; Department of Neuroscience, IRCCS-Mario Negri Institute for Pharmacological Research, Milano, Italy., Pauletti A; Department of Neuroscience, IRCCS-Mario Negri Institute for Pharmacological Research, Milano, Italy., Salamone A; Department of Neuroscience, IRCCS-Mario Negri Institute for Pharmacological Research, Milano, Italy., Rizzi M; Department of Neuroscience, IRCCS-Mario Negri Institute for Pharmacological Research, Milano, Italy., Villa BR; Department of Neuroscience, IRCCS-Mario Negri Institute for Pharmacological Research, Milano, Italy., Porcu L; Department of Oncology, IRCCS-Mario Negri Institute for Pharmacological Research, Milano, Italy., Sheehan MJ; Internal Medicine Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, USA., Guilmette E; Internal Medicine Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, USA., Butler CR; Medicinal Chemistry, Pfizer Worldwide Research & Development, Cambridge, MA, USA., Piro JR; Internal Medicine Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, USA., Samad TA; Internal Medicine Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, USA., Vezzani A; Department of Neuroscience, IRCCS-Mario Negri Institute for Pharmacological Research, Milano, Italy.

المصدر: Epilepsia [Epilepsia] 2018 Jan; Vol. 59 (1), pp. 79-91. Date of Electronic Publication: 2017 Nov 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE

مواضيع طبية MeSH: Status Epilepticus*/chemically induced , Status Epilepticus*/complications , Status Epilepticus*/enzymology , Status Epilepticus*/therapy, Carbamates/*therapeutic use , Monoacylglycerol Lipases/*antagonists & inhibitors , Piperidines/*therapeutic use , Sulfonamides/*therapeutic use, Animals ; Brain/metabolism ; Brain/pathology ; Brain Waves/drug effects ; Brain Waves/physiology ; Carbamates/chemistry ; Carbamates/pharmacokinetics ; Cognition Disorders/drug therapy ; Cognition Disorders/etiology ; Diazepam/adverse effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Resistant Epilepsy/chemically induced ; Drug Resistant Epilepsy/enzymology ; Drug Resistant Epilepsy/therapy ; Electroencephalography ; Excitatory Amino Acid Agonists/toxicity ; Fluoresceins/metabolism ; Kainic Acid/toxicity ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Monoacylglycerol Lipases/metabolism ; Neurons/drug effects ; Neurons/pathology ; Piperidines/chemistry ; Piperidines/pharmacology ; Random Allocation ; Receptor, Cannabinoid, CB1/deficiency ; Receptor, Cannabinoid, CB1/genetics ; Recognition, Psychology/drug effects ; Sulfonamides/chemistry ; Sulfonamides/pharmacokinetics ; Time Factors

المؤلفون: Butler CR; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Beck EM; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Harris A; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States., Huang Z; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States., McAllister LA; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Am Ende CW; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States., Fennell K; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States., Foley TL; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States., Fonseca K; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Hawrylik SJ; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States., Johnson DS; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Knafels JD; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States., Mente S; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Noell GS; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States., Pandit J; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States., Phillips TB; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States., Piro JR; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Rogers BN; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States., Samad TA; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States., Wang J; WuXi AppTec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Wan S; WuXi AppTec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Brodney MA; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2017 Dec 14; Vol. 60 (23), pp. 9860-9873. Date of Electronic Publication: 2017 Dec 05.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Azetidines/*pharmacology , Carbamates/*pharmacology , Enzyme Inhibitors/*pharmacology , Monoacylglycerol Lipases/*antagonists & inhibitors , Piperidines/*pharmacology, Animals ; Azetidines/chemistry ; Azetidines/pharmacokinetics ; Carbamates/chemistry ; Carbamates/pharmacokinetics ; Cell Line ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacokinetics ; Humans ; Mice, Inbred C57BL ; Models, Molecular ; Monoacylglycerol Lipases/metabolism ; Piperidines/chemistry ; Piperidines/pharmacokinetics ; Recombinant Proteins/metabolism