المؤلفون: Pirrone GF; Merck & Co., Inc., Analytical Research & Development, 33 Avenue Louis Pasteur, Boston, MA, USA. Electronic address: gregory.pirrone@merck.com., Munsell EV; Merck & Co., Inc., Discovery Pharmaceutical Sciences, 33 Avenue Louis Pasteur, Boston, MA, USA., Ferguson HM; Merck & Co., Inc., Discovery Pharmaceutical Sciences, 33 Avenue Louis Pasteur, Boston, MA, USA., Al-Sayah MA; Merck & Co., Inc., Analytical Research & Development, 33 Avenue Louis Pasteur, Boston, MA, USA., Luthra SA; Merck & Co., Inc., Discovery Pharmaceutical Sciences, 33 Avenue Louis Pasteur, Boston, MA, USA., Makarov AA; Merck & Co., Inc., Analytical Research & Development, 33 Avenue Louis Pasteur, Boston, MA, USA. Electronic address: alexey.makarov@merck.com.

المصدر: Journal of pharmaceutical sciences [J Pharm Sci] 2023 Nov; Vol. 112 (11), pp. 2778-2782. Date of Electronic Publication: 2023 Jul 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

المؤلفون: Makarov AA; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA. Electronic address: alexey.makarov@merck.com., Jiang Y; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Sondey C; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Zhang M; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Mansueto MS; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Pirrone GF; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Huang C; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Biswas K; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Duggal R; Merck & Co. Inc., MRL, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Al-Sayah MA; Merck & Co. Inc., MRL, 213 E. Grand Avenue, So. San Francisco, CA, 94080, USA., Regalado EL; Merck & Co. Inc., MRL, 126 E. Lincoln Avenue, Rahway, NJ, 07065, USA., Mangion I; Merck & Co. Inc., MRL, 126 E. Lincoln Avenue, Rahway, NJ, 07065, USA.

المصدر: Analytica chimica acta [Anal Chim Acta] 2022 Sep 08; Vol. 1225, pp. 340234. Date of Electronic Publication: 2022 Aug 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE

مواضيع طبية MeSH: Deuterium Exchange Measurement*/methods , Hydrogen Deuterium Exchange-Mass Spectrometry*, Cell Membrane Permeability ; Deuterium/chemistry ; Hydrogen/chemistry ; Peptides ; Permeability ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods

المؤلفون: Mukherjee D; Merck & Co. Inc., Merck Research Laboratories, Analytical Research & Development, Boston, Massachusetts, USA., Trigo-Mouriño P; Merck & Co. Inc., Merck Research Laboratories, Analytical Research & Development, Boston, Massachusetts, USA., Jiang Y; Merck & Co. Inc., Merck Research Laboratories, Analytical Research & Development, Boston, Massachusetts, USA., Nowak T; Merck & Co. Inc., Merck Research Laboratories, Analytical Research & Development, Boston, Massachusetts, USA., Shchurik V; Merck & Co. Inc., Merck Research Laboratories, Analytical Research & Development, Boston, Massachusetts, USA., Adpressa DA; Merck & Co. Inc., Merck Research Laboratories, Analytical Research & Development, Boston, Massachusetts, USA., Louie MT; Absci Corp, Vancouver, Washington, USA., Reynolds SR; Absci Corp, Vancouver, Washington, USA., Hohn MJ; Merck & Co. Inc., Merck Research Laboratories, Bioprocess Research & Development, Boston, Massachusetts, USA., Al-Sayah MA; Merck & Co. Inc., Merck Research Laboratories, Analytical Research & Development, Boston, Massachusetts, USA., Pirrone GF; Merck & Co. Inc., Merck Research Laboratories, Analytical Research & Development, Boston, Massachusetts, USA., Makarov AA; Merck & Co. Inc., Merck Research Laboratories, Analytical Research & Development, Boston, Massachusetts, USA.

المصدر: Journal of separation science [J Sep Sci] 2022 Jun; Vol. 45 (12), pp. 2055-2063. Date of Electronic Publication: 2022 Feb 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101088554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-9314 (Electronic) Linking ISSN: 16159306 NLM ISO Abbreviation: J Sep Sci Subsets: MEDLINE

مواضيع طبية MeSH: Deuterium Exchange Measurement*/methods , Hydrogen*/chemistry, Deuterium/chemistry ; Deuterium/metabolism ; Lasers ; Proteins/chemistry ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

المؤلفون: Bennett R; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ, 07065, USA. Electronic address: raffeal.bennett@merck.com., Pirrone GF; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ, 07065, USA. Electronic address: gregory.pirrone@merck.com., Nowak T; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ, 07065, USA., Mukherjee D; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ, 07065, USA., Shchurik V; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ, 07065, USA., Mapelli C; Merck & Co., Inc., MRL, Chemistry Capabilities for Accelerating Therapeutics, Discovery Chemistry, Kenilworth, NJ, 07033, USA., Hickey JL; Merck & Co., Inc., MRL, Chemistry Capabilities for Accelerating Therapeutics, Discovery Chemistry, Kenilworth, NJ, 07033, USA., Regalado EL; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ, 07065, USA. Electronic address: erik.regalado@merck.com., Mangion I; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ, 07065, USA., Makarov AA; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ, 07065, USA.

المصدر: Analytica chimica acta [Anal Chim Acta] 2021 Jan 15; Vol. 1142, pp. 10-18. Date of Electronic Publication: 2020 Oct 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE

مواضيع طبية MeSH: Peptide Library* , Peptides*, High-Throughput Screening Assays ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Workflow

المؤلفون: Makarov AA; Merck & Co., Inc., Process Research & Development, Rahway, NJ 07065, USA. Electronic address: alexey.makarov@merck.com., Iacob RE; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA., Pirrone GF; Merck & Co., Inc., Process Research & Development, Rahway, NJ 07065, USA., Rodriguez-Granillo A; Merck & Co., Inc., Computational and Structural Chemistry, Rahway, NJ 07065, USA., Joyce L; Merck & Co., Inc., Process Research & Development, Rahway, NJ 07065, USA., Mangion I; Merck & Co., Inc., Process Research & Development, Rahway, NJ 07065, USA., Moore JC; Merck & Co., Inc., Process Research & Development, Rahway, NJ 07065, USA., Sherer EC; Merck & Co., Inc., Computational and Structural Chemistry, Rahway, NJ 07065, USA., Engen JR; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.

المصدر: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2020 Apr 15; Vol. 182, pp. 113141. Date of Electronic Publication: 2020 Feb 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

مواضيع طبية MeSH: Hydrogen Deuterium Exchange-Mass Spectrometry/*methods , Peptides/*chemistry , Proteins/*chemistry , Solvents/*chemistry, Circular Dichroism ; Computer Simulation ; Enzymes/chemistry ; Molecular Dynamics Simulation ; Protein Conformation ; Protein Unfolding ; Stereoisomerism

المؤلفون: Makarov AA; Merck & Co., Inc., MRL, Analytical Research & Development /Process Research & Development, 126 E. Lincoln Ave., Rahway, NJ, 07065, USA. Electronic address: alexey.makarov@merck.com., Pirrone GF; Merck & Co., Inc., MRL, Analytical Research & Development /Process Research & Development, 126 E. Lincoln Ave., Rahway, NJ, 07065, USA., Shchurik V; Merck & Co., Inc., MRL, Analytical Research & Development /Process Research & Development, 126 E. Lincoln Ave., Rahway, NJ, 07065, USA., Regalado EL; Merck & Co., Inc., MRL, Analytical Research & Development /Process Research & Development, 126 E. Lincoln Ave., Rahway, NJ, 07065, USA., Mangion I; Merck & Co., Inc., MRL, Analytical Research & Development /Process Research & Development, 126 E. Lincoln Ave., Rahway, NJ, 07065, USA.

المصدر: Analytica chimica acta [Anal Chim Acta] 2020 Feb 22; Vol. 1099, pp. 111-118. Date of Electronic Publication: 2019 Sep 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE

مواضيع طبية MeSH: Alamethicin/*analysis , Aprotinin/*analysis , Gramicidin/*analysis , Melitten/*analysis , Ubiquitin/*analysis, Hydrogen Deuterium Exchange-Mass Spectrometry ; Liposomes/chemistry ; Membranes, Artificial ; Permeability

المؤلفون: Kabaria SR; Merck & Co., Inc., Merck Research Laboratories, Process Research & Development, Rahway, NJ, 07065, USA; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, 120 Olin Hall, Ithaca, NY, 14853, USA., Mangion I; Merck & Co., Inc., Merck Research Laboratories, Process Research & Development, Rahway, NJ, 07065, USA., Makarov AA; Merck & Co., Inc., Merck Research Laboratories, Process Research & Development, Rahway, NJ, 07065, USA. Electronic address: alexey.makarov@merck.com., Pirrone GF; Merck & Co., Inc., Merck Research Laboratories, Process Research & Development, Rahway, NJ, 07065, USA. Electronic address: gregory.pirrone@merck.com.

المصدر: Analytica chimica acta [Anal Chim Acta] 2019 Apr 25; Vol. 1054, pp. 114-121. Date of Electronic Publication: 2019 Jan 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE

مواضيع طبية MeSH: Deuterium Exchange Measurement/*methods , Peptides/*chemistry , Proteins/*chemistry , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods, Automation ; Freeze Drying ; Models, Molecular ; Protein Conformation, alpha-Helical ; Protein Folding ; Protein Stability

المؤلفون: Haidar Ahmad IA; Process Research and Development, MRL, Merck & Co., Inc., Rahway, NJ 07065, USA. erik.regalado@merck.com., Chen W, Halsey HM, Klapars A, Limanto J, Pirrone GF, Nowak T, Bennett R, Hartman R, Makarov AA, Mangion I, Regalado EL

المصدر: The Analyst [Analyst] 2019 Apr 23; Vol. 144 (9), pp. 2872-2880.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 0372652 Publication Model: Print Cited Medium: Internet ISSN: 1364-5528 (Electronic) Linking ISSN: 00032654 NLM ISO Abbreviation: Analyst Subsets: MEDLINE

مواضيع طبية MeSH: Carbamates/*isolation & purification , Chromatography, High Pressure Liquid/*methods , Heterocyclic Compounds, 2-Ring/*isolation & purification, Chromatography, High Pressure Liquid/instrumentation ; Computer Simulation

المؤلفون: Schiavone NM; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ 07065, USA., Bennett R; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ 07065, USA., Hicks MB; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ 07065, USA., Pirrone GF; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ 07065, USA., Regalado EL; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ 07065, USA., Mangion I; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ 07065, USA., Makarov AA; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ 07065, USA. Electronic address: alexey.makarov@merck.com.

المصدر: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2019 Mar 15; Vol. 1110-1111, pp. 94-100. Date of Electronic Publication: 2019 Feb 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE

مواضيع طبية MeSH: Chromatography, Supercritical Fluid/*methods , Peptides/*analysis , Peptides/*isolation & purification , Proteins/*analysis , Proteins/*isolation & purification, Circular Dichroism ; Models, Chemical ; Peptides/chemistry ; Protein Conformation ; Proteins/chemistry

المؤلفون: Schiavone NM; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ 07065, USA. Electronic address: nicole.schiavone@merck.com., Pirrone GF; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ 07065, USA., Guetschow ED; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ 07065, USA., Mangion I; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ 07065, USA., Makarov AA; Merck & Co., Inc., MRL, Analytical Research & Development, Rahway, NJ 07065, USA. Electronic address: alexey.makarov@merck.com.

المصدر: Talanta [Talanta] 2019 Mar 01; Vol. 194, pp. 177-182. Date of Electronic Publication: 2018 Sep 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

مواضيع طبية MeSH: Chromatography, Gel* , Circular Dichroism* , Deuterium Exchange Measurement* , Mass Spectrometry*, Peptides/*chemistry, Humans ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Folding ; Solutions ; Trifluoroethanol/chemistry