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1دورية أكاديمية
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2دورية أكاديمية
المؤلفون: Jung Sun Park, In Ae Jung, Hong Sang Choi, Dong-Hyun Kim, Hoon In Choi, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
المصدر: Biomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112402- (2022)
مصطلحات موضوعية: 6-bromo-indirubin-3’-oxime (6-BIO), Transforming growth factor β (TGFβ), Fibrosis, Plasminogen activator inhibitor type-1 (PAI-1), Activator protein-1 (AP-1), Specificity protein 1 (SP-1), Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: O. O. Potapov, O. P. Kmyta, O. O. Tsyndrenko, M. P. Khavro, T. V. Bereznyi, I. O. Karpeko
المصدر: Zaporožskij Medicinskij Žurnal, Vol 21, Iss 1, Pp 44-48 (2019)
مصطلحات موضوعية: O. P. Kmyta, O. O. Tsyndrenko, M. P. Khavro, T. V. Bereznyi, I. O. Karpeko Abstract Purpose. To study the association between the plasma level of plasminogen activator inhibitor type-1 (PAI-1) and both body weight and PAI-1 -675 4G/5G gene polymorphism in patients with cranio-cerebral trauma (CCT) over the treatment course. Materials and methods. The hemostasis system state was analyzed in 200 patients with CCT by studying the association between the plasma level of PAI-1 and both body weight and -675 4G/5G polymorphism of the PAI-1 gene. For statistical processing of the obtained study results, a licensed version of the SPSS STATISTICA 17 program was used. K-means cluster analysis was also performed, the Euclidean distance was used as the distance measure. Results. Clustering of patients was performed depending on the plasma PAI-1 content on days 1, 7 and 14 after trauma. All patients were distributed into 3 clusters. Thus, the first cluster included patients with the average PAI-1 concentration within the normal range during the study. The second cluster included patients who presented significantly increased PAI-1 concentration at the time of an injury, which tended to decrease rapidly and almost normalized by day 14. The third cluster consisted of patients with significantly increased plasma concentration of PAI-1 following an injury with the tendency to remain at a high level for 14 days. Due to statistical processing of the study results, an association between an increase in PAI-1 level and both the 4G/4G, 4G/5G genotypes and overweight or obesity in patients was found. Increased levels of PAI-1 were observed in overweight or obese patients with the 4G/4G and 4G/5G genotypes over the course of treatment. Conclusions. The association between both overweight and -675 4G/5G polymorphism of the PAI-1 gene and plasma level of plasminogen activator inhibitor type-1 in patients with traumatic brain injury has been proven. Keywords CCT, PAI-1, the -675 4G/5G polymorphism of PAI-1 gene, obesity, CCT, Medicine
وصف الملف: electronic resource
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4كتاب إلكتروني
المساهمون: Choi, Sangdun, editorAff1
المصدر: Encyclopedia of Signaling Molecules. :4054-4054
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5دورية أكاديمية
المؤلفون: Ozgen, Merih, Cosan, Didem Turgut, Doganer, Fulya, Soyocak, Ahu, Armagan, Onur, Gunes, Hasan Veysi, Degirmenci, Irfan, Ozkara, Gulsah Ogutler, Mutlu, Fezan Sahin
المصدر: Clinics. November 2012 67(11)
مصطلحات موضوعية: Osteoporosis, Polymorphism, Plasminogen Activator Inhibitor Type-1 (PAI-1) Gene, Bone Mineral Density, Turkish Women
وصف الملف: text/html
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المؤلفون: Hoon In Choi, Hong Sang Choi, Soo Wan Kim, In Ae Jung, Seong Kwon Ma, Eun Hui Bae, Dong-Hyun Kim, Jung Sun Park
المصدر: Biomedicine & Pharmacotherapy, Vol 145, Iss, Pp 112402-(2022)
مصطلحات موضوعية: MAPK/ERK pathway, Male, Cell signaling, Indoles, Sp1 Transcription Factor, SMAD, RM1-950, Cell Line, Kidney Tubules, Proximal, Rats, Sprague-Dawley, Fibrosis, Specificity protein 1 (SP-1), Oximes, Plasminogen Activator Inhibitor 1, medicine, Animals, Humans, Enzyme Inhibitors, Transcription factor, Pharmacology, Kidney, Glycogen Synthase Kinase 3 beta, integumentary system, Chemistry, Connective Tissue Growth Factor, General Medicine, Activator protein-1 (AP-1), medicine.disease, Cell biology, Rats, Plasminogen activator inhibitor type-1 (PAI-1), CTGF, Transcription Factor AP-1, medicine.anatomical_structure, Transforming growth factor β (TGFβ), Kidney Diseases, Therapeutics. Pharmacology, Signal transduction, Signal Transduction, 6-bromo-indirubin-3’-oxime (6-BIO)
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7دورية أكاديمية
المؤلفون: Merih Ozgen, Didem Turgut Cosan, Fulya Doganer, Ahu Soyocak, Onur Armagan, Hasan Veysi Gunes, Irfan Degirmenci, Gulsah Ogutler Ozkara, Fezan Sahin Mutlu
المصدر: Clinics, Vol 67, Iss 11, Pp 1299-1302 (2012)
مصطلحات موضوعية: Osteoporosis, Polymorphism, Plasminogen Activator Inhibitor Type-1 (PAI-1) Gene, Bone Mineral Density, Turkish Women, Medicine (General), R5-920
وصف الملف: electronic resource
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8دورية أكاديمية
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9دورية أكاديمية
المؤلفون: Yixun, Liu, Yijun, Chen, Qiang, Feng, Zhaoyun, Hu
المصدر: Chinese Science Bulletin. 42(23):1994-2000
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10دورية أكاديمية
المؤلفون: Liu, Yixun, Hu, Zhaoyuan, Zou, Rujin, Ockleford, C. D.
المصدر: Chinese Science Bulletin. 42(12):1030-1033