المؤلفون: Rivera-Acevedo RE, Pless SA, Ahern CA, Schwarz SK, Rivera-Acevedo, Ricardo E, Pless, Stephan A, Ahern, Christopher A, Schwarz, Stephan K W

المصدر: Anesthesiology; 2011 Jun, Vol. 114 Issue 6, p1425-1434, 10p

المؤلفون: Holm CM; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Topaktas AB; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Dannesboe J; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Pless SA; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Heusser SA; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. Electronic address: stephanie.heusser@sund.ku.dk.

المصدر: Biophysical journal [Biophys J] 2024 Jul 16; Vol. 123 (14), pp. 2122-2135. Date of Electronic Publication: 2024 Mar 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

مواضيع طبية MeSH: Acid Sensing Ion Channels*/chemistry , Acid Sensing Ion Channels*/metabolism , Acid Sensing Ion Channels*/genetics, Animals ; Mice ; Hydrogen-Ion Concentration ; Ion Channel Gating ; Protein Conformation ; Mutation ; Protein Domains ; Xenopus laevis

المؤلفون: Schott K; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark., Usher SG; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark., Serra O; Department of Biology, Temple University, Philadelphia, PA 19122.; Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122.; Institute of Computational Molecular Science, Temple University, Philadelphia, PA 19122., Carnevale V; Department of Biology, Temple University, Philadelphia, PA 19122.; Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122.; Institute of Computational Molecular Science, Temple University, Philadelphia, PA 19122., Pless SA; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark., Chua HC; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 May 28; Vol. 121 (22), pp. e2401591121. Date of Electronic Publication: 2024 May 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Phenytoin*/metabolism , Phenytoin*/pharmacology, Binding Sites ; Humans ; Boron Compounds/chemistry ; Boron Compounds/pharmacology ; Boron Compounds/metabolism ; Ion Channels/metabolism ; Ion Channels/genetics ; HEK293 Cells ; Animals ; Nerve Tissue Proteins/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/chemistry ; Membrane Proteins

المؤلفون: Sarkar D; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark., Galleano I; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark; Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, the Netherlands., Heusser SA; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark., Ou SY; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark., Uzun GR; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark., Khoo KK; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark., van der Heden van Noort GJ; Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, the Netherlands., Harrison JS; Department of Chemistry, University of the Pacific, Stockton, CA, USA., Pless SA; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark. Electronic address: stephan.pless@sund.ku.dk.

المصدر: Cell chemical biology [Cell Chem Biol] 2024 May 16; Vol. 31 (5), pp. 1000-1010.e6. Date of Electronic Publication: 2023 Dec 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Acid Sensing Ion Channels*/metabolism , Acid Sensing Ion Channels*/chemistry , Acid Sensing Ion Channels*/genetics , Lysine*/chemistry , Lysine*/metabolism, Humans ; Animals ; Models, Molecular ; Protein Splicing

المؤلفون: Magni L; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen Ø, Denmark., Yu H; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen Ø, Denmark., Christensen NM; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen Ø, Denmark., Poulsen MH; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Frueh A; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen Ø, Denmark., Deshar G; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen Ø, Denmark., Johansen AZ; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte Hospital, Herlev, Denmark., Johansen JS; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte Hospital, Herlev, Denmark.; Department of Medicine, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark., Pless SA; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Jørgensen NR; Department of Clinical Biochemistry, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Novak I; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen Ø, Denmark. inovak@bio.ku.dk.

المصدر: Cancer cell international [Cancer Cell Int] 2024 Apr 25; Vol. 24 (1), pp. 148. Date of Electronic Publication: 2024 Apr 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101139795 Publication Model: Electronic Cited Medium: Print ISSN: 1475-2867 (Print) Linking ISSN: 14752867 NLM ISO Abbreviation: Cancer Cell Int Subsets: PubMed not MEDLINE

المؤلفون: Schott K, Usher SG, Serra O, Carnevale V, Pless SA, Chua HC

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 28. Date of Electronic Publication: 2024 Jan 28.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Gasparri F; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Sarkar D; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Bielickaite S; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Poulsen MH; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Hauser AS; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Pless SA; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

المصدر: British journal of pharmacology [Br J Pharmacol] 2022 Jul; Vol. 179 (14), pp. 3859-3874. Date of Electronic Publication: 2022 Mar 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Ion Channel Gating* , Mutation, Missense* , Receptors, Purinergic P2X2*/genetics, Adenosine Triphosphate/metabolism ; Humans ; Mutation

المؤلفون: Noland CL; Department of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA.; Department of Computational and Structural Chemistry, Merck Research Labs, South San Francisco, CA, 94080, USA., Chua HC; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DK 2100, Denmark., Kschonsak M; Department of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA., Heusser SA; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DK 2100, Denmark., Braun N; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DK 2100, Denmark.; Department of Drug Discovery Sciences, Boehringer Ingelheim RCV, Vienna, AU, 1121, Austria., Chang T; Department of BioMolecular Resources, Genentech Inc., South San Francisco, CA, 94080, USA., Tam C; Department of BioMolecular Resources, Genentech Inc., South San Francisco, CA, 94080, USA., Tang J; Department of Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, 94080, USA., Arthur CP; Department of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA., Ciferri C; Department of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA. ciferri.claudio@gene.com., Pless SA; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DK 2100, Denmark. stephan.pless@sund.ku.dk., Payandeh J; Department of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA. jpayandeh@interlinetx.com.; Department of Proteomics and Bioinformatics, Interline Therapeutics, South San Francisco, CA, 94080, USA. jpayandeh@interlinetx.com.

المصدر: Nature communications [Nat Commun] 2022 Mar 17; Vol. 13 (1), pp. 1416. Date of Electronic Publication: 2022 Mar 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Calcium*/metabolism , Sodium*/metabolism, Cations ; Humans ; Tetrodotoxin/pharmacology

المؤلفون: Kschonsak M; Department of Structural Biology, Genentech Inc., South San Francisco, CA, USA., Chua HC; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Weidling C; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Chakouri N; Department Physiology and Cellular Biophysics, Columbia University, New York, NY, USA., Noland CL; Department of Structural Biology, Genentech Inc., South San Francisco, CA, USA.; Department of Computational and Structural Chemistry, Merck & Co., Inc., South San Francisco, CA, USA., Schott K; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Chang T; Department of BioMolecular Resources, Genentech Inc., South San Francisco, CA, USA., Tam C; Department of BioMolecular Resources, Genentech Inc., South San Francisco, CA, USA., Patel N; Department of BioMolecular Resources, Genentech Inc., South San Francisco, CA, USA., Arthur CP; Department of Structural Biology, Genentech Inc., South San Francisco, CA, USA., Leitner A; Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zurich, Switzerland. leitner@imsb.biol.ethz.ch., Ben-Johny M; Department Physiology and Cellular Biophysics, Columbia University, New York, NY, USA. mbj2124@cumc.columbia.edu., Ciferri C; Department of Structural Biology, Genentech Inc., South San Francisco, CA, USA. ciferri.claudio@gene.com., Pless SA; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. stephan.pless@sund.ku.dk., Payandeh J; Department of Structural Biology, Genentech Inc., South San Francisco, CA, USA. jpayandeh@interlinetx.com.; Department of Proteomics and Bioinformatics, Interline Therapeutics, South San Francisco, CA, USA. jpayandeh@interlinetx.com.

المصدر: Nature [Nature] 2022 Mar; Vol. 603 (7899), pp. 180-186. Date of Electronic Publication: 2021 Dec 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Ion Channels*/chemistry , Ion Channels*/metabolism , Membrane Proteins*/chemistry , Membrane Proteins*/metabolism, Amino Acid Motifs ; Calmodulin ; Carrier Proteins/chemistry ; Carrier Proteins/metabolism ; Humans ; Ion Channel Gating ; Membrane Potentials ; Neurons/metabolism ; Sodium/metabolism

المؤلفون: Heusser SA; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Borg CB; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Colding JM; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Pless SA; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

المصدر: ELife [Elife] 2022 Feb 14; Vol. 11. Date of Electronic Publication: 2022 Feb 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Acid Sensing Ion Channels/*chemistry , Acid Sensing Ion Channels/*metabolism , Peptides/*chemistry , Peptides/*metabolism , Spider Venoms/*chemistry , Spider Venoms/*metabolism, Animals ; Binding Sites ; Cysteine/metabolism ; Fluorometry/methods ; Hydrogen-Ion Concentration ; Molecular Conformation ; Mutation ; Neuropeptides/chemistry ; Neuropeptides/metabolism ; Peptides/genetics ; Protein Binding ; Protons ; Spider Venoms/genetics