المؤلفون: Plewe MB; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego 92121, CA, United States., Gantla VR; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego 92121, CA, United States., Sokolova NV; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego 92121, CA, United States., Shin YJ; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego 92121, CA, United States., Naik S; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego 92121, CA, United States., Brown ER; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego 92121, CA, United States., Fetsko A; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego 92121, CA, United States., Zhang L; Department of Pathology, and Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston 77555, TX, United States., Kalveram B; Department of Pathology, and Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston 77555, TX, United States., Freiberg AN; Department of Pathology, and Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston 77555, TX, United States., Henkel G; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego 92121, CA, United States., McCormack K; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego 92121, CA, United States. Electronic address: kenm@arisanthera.com.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Jun 01; Vol. 41, pp. 127983. Date of Electronic Publication: 2021 May 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Antiviral Agents/*pharmacology , Arenavirus/*drug effects , Heterocyclic Compounds/*pharmacology , Viral Envelope Proteins/*antagonists & inhibitors, Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Arenavirus/metabolism ; Dose-Response Relationship, Drug ; Heterocyclic Compounds/chemical synthesis ; Heterocyclic Compounds/chemistry ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship ; Viral Envelope Proteins/metabolism

المؤلفون: Plewe MB; Arisan Therapeutics, 11189 Sorrento Valley Road, Suite 104, San Diego, California 92121, United States., Sokolova NV; Arisan Therapeutics, 11189 Sorrento Valley Road, Suite 104, San Diego, California 92121, United States., Gantla VR; Arisan Therapeutics, 11189 Sorrento Valley Road, Suite 104, San Diego, California 92121, United States., Brown ER; Arisan Therapeutics, 11189 Sorrento Valley Road, Suite 104, San Diego, California 92121, United States., Naik S; Arisan Therapeutics, 11189 Sorrento Valley Road, Suite 104, San Diego, California 92121, United States., Fetsko A; Arisan Therapeutics, 11189 Sorrento Valley Road, Suite 104, San Diego, California 92121, United States., Lorimer DD; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98105, United States.; UCB Pharma, 7869 NE Day Road West, Bainbridge Island, Washington 98110, United States., Dranow DM; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98105, United States.; UCB Pharma, 7869 NE Day Road West, Bainbridge Island, Washington 98110, United States., Smutney H; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98105, United States.; UCB Pharma, 3 Preston Court, Bedford, Massachusetts 01730, United States., Bullen J; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98105, United States.; UCB Pharma, 7869 NE Day Road West, Bainbridge Island, Washington 98110, United States., Sidhu R; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98105, United States.; UCB Pharma, 3 Preston Court, Bedford, Massachusetts 01730, United States., Master A; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98105, United States.; UCB Pharma, 3 Preston Court, Bedford, Massachusetts 01730, United States., Wang J; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98105, United States.; UCB Pharma, 3 Preston Court, Bedford, Massachusetts 01730, United States., Kallel EA; Victrix, 12631 Bendito Drive, San Diego, California 92128, United States., Zhang L; Department of Pathology andCenter for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, Texas 77555, United States., Kalveram B; Department of Pathology andCenter for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, Texas 77555, United States., Freiberg AN; Department of Pathology andCenter for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, Texas 77555, United States.; Department of Pathology andCenter for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, Texas 77555, United States., Henkel G; Arisan Therapeutics, 11189 Sorrento Valley Road, Suite 104, San Diego, California 92121, United States., McCormack K; Arisan Therapeutics, 11189 Sorrento Valley Road, Suite 104, San Diego, California 92121, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 May 01; Vol. 11 (6), pp. 1160-1167. Date of Electronic Publication: 2020 May 01 (Print Publication: 2020).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Han XR; Cullgen Inc., 12671 High Bluff Drive, Suite 130, San Diego, California 92130, United States.; Cullgen (Shanghai) Inc., Building 6, 230 ChuanHong Road, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Chen L; Cullgen (Shanghai) Inc., Building 6, 230 ChuanHong Road, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Wei Y; Cullgen (Shanghai) Inc., Building 6, 230 ChuanHong Road, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Yu W; Cullgen (Shanghai) Inc., Building 6, 230 ChuanHong Road, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Chen Y; Cullgen (Shanghai) Inc., Building 6, 230 ChuanHong Road, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Zhang C; Cullgen (Shanghai) Inc., Building 6, 230 ChuanHong Road, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Jiao B; Cullgen (Shanghai) Inc., Building 6, 230 ChuanHong Road, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Shi T; Cullgen (Shanghai) Inc., Building 6, 230 ChuanHong Road, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Sun L; Cullgen (Shanghai) Inc., Building 6, 230 ChuanHong Road, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Zhang C; Cullgen (Shanghai) Inc., Building 6, 230 ChuanHong Road, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Xu Y; Cullgen (Shanghai) Inc., Building 6, 230 ChuanHong Road, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Lee MR; Cullgen Inc., 12671 High Bluff Drive, Suite 130, San Diego, California 92130, United States., Luo Y; Cullgen Inc., 12671 High Bluff Drive, Suite 130, San Diego, California 92130, United States., Plewe MB; Cullgen Inc., 12671 High Bluff Drive, Suite 130, San Diego, California 92130, United States., Wang J; Cullgen Inc., 12671 High Bluff Drive, Suite 130, San Diego, California 92130, United States.; Cullgen (Shanghai) Inc., Building 6, 230 ChuanHong Road, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Apr 23; Vol. 63 (8), pp. 4069-4080. Date of Electronic Publication: 2020 Apr 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery/*methods , Protein Kinase Inhibitors/*chemistry , Protein Kinase Inhibitors/*metabolism , Proteolysis/*drug effects , Proto-Oncogene Proteins B-raf/*metabolism, Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Humans ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Vemurafenib/chemistry ; Vemurafenib/metabolism ; Vemurafenib/pharmacology

المؤلفون: Plewe MB; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States., Whitby LR; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States., Naik S; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States., Brown ER; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States., Sokolova NV; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States., Gantla VR; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States., York J; Montana Biotechnology Center, The University of Montana, Missoula, MT 59812, United States., Nunberg JH; Montana Biotechnology Center, The University of Montana, Missoula, MT 59812, United States., Zhang L; Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, United States., Kalveram B; Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, United States., Freiberg AN; Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, United States; Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, TX 77555, United States., Boger DL; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States., Henkel G; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States., McCormack K; Arisan Therapeutics, 11189 Sorrento Valley Rd, Suite 104, San Diego, CA 92054, United States. Electronic address: kenm@arisanthera.com.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Nov 15; Vol. 29 (22), pp. 126620. Date of Electronic Publication: 2019 Aug 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents/*pharmacology , Arenavirus/*drug effects , Piperazines/*pharmacology , Viral Envelope Proteins/*antagonists & inhibitors, Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Arenavirus/metabolism ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Molecular Structure ; Piperazines/chemical synthesis ; Piperazines/chemistry ; Structure-Activity Relationship ; Viral Envelope Proteins/metabolism

المؤلفون: Johnson TW; Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, United States. ted.w.johnson@pfizer.com, Tanis SP, Butler SL, Dalvie D, Delisle DM, Dress KR, Flahive EJ, Hu Q, Kuehler JE, Kuki A, Liu W, McClellan GA, Peng Q, Plewe MB, Richardson PF, Smith GL, Solowiej J, Tran KT, Wang H, Yu X, Zhang J, Zhu H

المصدر: Journal of medicinal chemistry [J Med Chem] 2011 May 12; Vol. 54 (9), pp. 3393-417. Date of Electronic Publication: 2011 Apr 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: HIV Integrase Inhibitors/*chemical synthesis , HIV-1/*drug effects , Heterocyclic Compounds, 3-Ring/*chemical synthesis , Naphthyridines/*chemical synthesis, Administration, Oral ; Animals ; Biological Availability ; Cell Membrane Permeability ; Cells, Cultured ; Dogs ; Drug Design ; HIV Integrase Inhibitors/pharmacokinetics ; HIV Integrase Inhibitors/pharmacology ; HIV-1/enzymology ; Hepatocytes/metabolism ; Heterocyclic Compounds, 3-Ring/pharmacokinetics ; Heterocyclic Compounds, 3-Ring/pharmacology ; Humans ; Liver/metabolism ; Molecular Conformation ; Naphthyridines/pharmacokinetics ; Naphthyridines/pharmacology ; Structure-Activity Relationship

المؤلفون: Tanis SP; Global Research and Development, Pfizer Inc., San Diego, CA 92121, USA. sptanis@sbcglobal.net, Plewe MB, Johnson TW, Butler SL, Dalvie D, DeLisle D, Dress KR, Hu Q, Huang B, Kuehler JE, Kuki A, Liu W, Peng Q, Smith GL, Solowiej J, Tran KT, Wang H, Yang A, Yin C, Yu X, Zhang J, Zhu H

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Dec 15; Vol. 20 (24), pp. 7429-34. Date of Electronic Publication: 2010 Oct 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: HIV Integrase/*chemistry , HIV Integrase Inhibitors/*chemistry , HIV-1/*enzymology , Hydroxamic Acids/*chemistry , Indoles/*chemistry, Administration, Oral ; Animals ; Dogs ; HIV Integrase/metabolism ; HIV Integrase Inhibitors/pharmacokinetics ; HIV Integrase Inhibitors/toxicity ; Half-Life ; Hepatocytes/drug effects ; Humans ; Hydroxamic Acids/pharmacokinetics ; Hydroxamic Acids/toxicity ; Structure-Activity Relationship

المؤلفون: Zhu H, Plewe MB, Rheingold AL, Moore C, Yanovsky A

المصدر: Acta crystallographica. Section E, Structure reports online [Acta Crystallogr Sect E Struct Rep Online] 2009 Dec 16; Vol. 66 (Pt 1), pp. o175-6. Date of Electronic Publication: 2009 Dec 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101089178 Publication Model: Electronic Cited Medium: Print ISSN: 1600-5368 (Print) Linking ISSN: 16005368 NLM ISO Abbreviation: Acta Crystallogr Sect E Struct Rep Online Subsets: PubMed not MEDLINE

المؤلفون: Plewe MB; Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, USA. michael.plewe@pfizer.com, Butler SL, Dress KR, Hu Q, Johnson TW, Kuehler JE, Kuki A, Lam H, Liu W, Nowlin D, Peng Q, Rahavendran SV, Tanis SP, Tran KT, Wang H, Yang A, Zhang J

المصدر: Journal of medicinal chemistry [J Med Chem] 2009 Nov 26; Vol. 52 (22), pp. 7211-9.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: HIV Integrase/*metabolism , HIV Integrase Inhibitors/*chemistry , HIV Integrase Inhibitors/*pharmacology , HIV-1/*enzymology , Hydroxamic Acids/*chemistry , Hydroxamic Acids/*pharmacology, Drug Evaluation, Preclinical ; HIV Integrase Inhibitors/chemical synthesis ; HIV-1/drug effects ; Hydroxamic Acids/chemical synthesis ; Inhibitory Concentration 50 ; Ligands ; Magnesium/metabolism ; Picolines/chemistry