المؤلفون: Plotnik JP; Oncology Discovery Research, AbbVie Inc., North Chicago, Illinois., Zha Z; Genomic Research Center, AbbVie Inc., North Chicago, Illinois., Feng W; Genomic Research Center, AbbVie Inc., North Chicago, Illinois., Lee I; Precision Medicine, Translational Oncology, AbbVie Inc., North Chicago, Illinois., Riehm J; Precision Medicine, Translational Oncology, AbbVie Inc., North Chicago, Illinois., McClure RA; Physical Chemistry, Discovery, AbbVie Inc., North Chicago, Illinois., Sandoval S; Physical Chemistry, Discovery, AbbVie Inc., North Chicago, Illinois., Uziel T; Precision Medicine, Translational Oncology, AbbVie Inc., North Chicago, Illinois., Murphy E; Genomic Research Center, AbbVie Inc., North Chicago, Illinois., Lu X; Genomic Research Center, AbbVie Inc., North Chicago, Illinois., Lam LT; Precision Medicine, Translational Oncology, AbbVie Inc., North Chicago, Illinois.

المصدر: Molecular cancer research : MCR [Mol Cancer Res] 2024 Aug 02; Vol. 22 (8), pp. 689-698.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101150042 Publication Model: Print Cited Medium: Internet ISSN: 1557-3125 (Electronic) Linking ISSN: 15417786 NLM ISO Abbreviation: Mol Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Small Cell Lung Carcinoma*/genetics , Small Cell Lung Carcinoma*/drug therapy , Small Cell Lung Carcinoma*/pathology , Small Cell Lung Carcinoma*/metabolism , Lung Neoplasms*/genetics , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism, Humans ; Cell Line, Tumor ; Gene Amplification ; Proto-Oncogene Proteins c-myc/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; N-Myc Proto-Oncogene Protein/genetics ; N-Myc Proto-Oncogene Protein/metabolism ; Bromodomain Containing Proteins ; Proteins ; Pyridones ; Sulfonamides

المؤلفون: Plotnik JP; AbbVie Inc., North Chicago, Illinois., Richardson AE; AbbVie Inc., North Chicago, Illinois., Yang H; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Rojas E; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Bontcheva V; AbbVie Inc., North Chicago, Illinois., Dowell C; AbbVie Inc., North Chicago, Illinois., Parsons S; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Wilson A; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Ravanmehr V; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Will C; AbbVie Inc., North Chicago, Illinois., Jung P; AbbVie Inc., North Chicago, Illinois., Zhu H; AbbVie Inc., North Chicago, Illinois., Partha SK; AbbVie Inc., North Chicago, Illinois., Panchal SC; AbbVie Inc., North Chicago, Illinois., Mali RS; AbbVie Bay Area, South San Francisco, California., Kohlhapp FJ; AbbVie Inc., North Chicago, Illinois., McClure RA; AbbVie Inc., North Chicago, Illinois., Ramathal CY; AbbVie Inc., North Chicago, Illinois., George MD; AbbVie Inc., North Chicago, Illinois., Jhala M; AbbVie Inc., North Chicago, Illinois., Elsen NL; AbbVie Inc., North Chicago, Illinois., Qiu W; AbbVie Inc., North Chicago, Illinois., Judge RA; AbbVie Inc., North Chicago, Illinois., Pan C; AbbVie Bay Area, South San Francisco, California., Mastracchio A; AbbVie Inc., North Chicago, Illinois., Henderson J; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Meulbroek JA; AbbVie Inc., North Chicago, Illinois., Green MR; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas., Pappano WN; AbbVie Inc., North Chicago, Illinois.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2024 Jul 02; Vol. 23 (7), pp. 949-960.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein*/antagonists & inhibitors , Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein*/metabolism , Proto-Oncogene Proteins c-bcl-2*/antagonists & inhibitors , Proto-Oncogene Proteins c-bcl-2*/metabolism , Proto-Oncogene Proteins c-bcl-2*/genetics , Drug Synergism* , Xenograft Model Antitumor Assays*, Humans ; Animals ; Mice ; Cell Line, Tumor ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Cell Proliferation/drug effects ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Disease Models, Animal

المؤلفون: Zhang L; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Cai T; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Lin X; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Huang X; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Bui MH; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Plotnik JP; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Bellin RJ; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Faivre EJ; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Kuruvilla VM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Lam LT; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Lu X; Genomic Research Center, AbbVie Inc., North Chicago, Illinois., Zha Z; Cyteir Therapeutics, 128 Spring Street, Lexington, Massachusetts., Feng W; Genomic Research Center, AbbVie Inc., North Chicago, Illinois., Hessler P; 190 Lisk Drive, Hainesville, Illinois., Uziel T; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Zhang Q; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Cavazos A; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Han L; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Ferguson DC; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Mehta G; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Shanmugavelandy SS; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Magoc TJ; Cyteir Therapeutics, 128 Spring Street, Lexington, Massachusetts., Rowe J; Charles River Laboratories, Wilmington, Massachusetts., Goodwin NC; Champions Oncology, Rockville, Maryland., Dorritie KA; Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania., Boyiadzis M; Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania., Albert DH; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., McDaniel KF; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Kati WM; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Konopleva M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas. yu.shen@abbvie.com mkonople@mdanderson.org., Shen Y; Oncology Discovery, AbbVie Inc., North Chicago, Illinois. yu.shen@abbvie.com mkonople@mdanderson.org.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2021 Oct; Vol. 20 (10), pp. 1809-1819. Date of Electronic Publication: 2021 Jul 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Bridged Bicyclo Compounds, Heterocyclic/*pharmacology , Leukemia, Myeloid, Acute/*drug therapy , Proteins/*antagonists & inhibitors , Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors , Pyridines/*pharmacology , Pyrroles/*pharmacology , Sulfonamides/*pharmacology, Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; Cell Proliferation ; Drug Therapy, Combination ; Female ; Humans ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays

المؤلفون: Plotnik JP; Oncology Discovery at AbbVie Inc, North Chicago, IL, USA. joshua.plotnik@abbvie.com.

المصدر: Nature chemical biology [Nat Chem Biol] 2021 Jul; Vol. 17 (7), pp. 753-754.

نوع المنشور: Journal Article; Comment

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Histones* , Polycomb Repressive Complex 1*/metabolism

المؤلفون: Greulich BM; Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA., Plotnik JP; Biology Department, Indiana University, Bloomington, IN 47405, USA., Jerde TJ; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Hollenhorst PC; Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA.

المصدر: NAR cancer [NAR Cancer] 2021 Jan 27; Vol. 3 (1), pp. zcaa046. Date of Electronic Publication: 2021 Jan 27 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101769553 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8674 (Electronic) Linking ISSN: 26328674 NLM ISO Abbreviation: NAR Cancer Subsets: PubMed not MEDLINE

المؤلفون: Faivre EJ; Oncology Discovery, AbbVie, North Chicago, IL, USA., McDaniel KF; Oncology Discovery, AbbVie, North Chicago, IL, USA., Albert DH; Oncology Discovery, AbbVie, North Chicago, IL, USA., Mantena SR; Preclinical Safety, Development Sciences, AbbVie, North Chicago, IL, USA., Plotnik JP; Oncology Discovery, AbbVie, North Chicago, IL, USA., Wilcox D; Oncology Discovery, AbbVie, North Chicago, IL, USA., Zhang L; Oncology Discovery, AbbVie, North Chicago, IL, USA., Bui MH; Oncology Discovery, AbbVie, North Chicago, IL, USA., Sheppard GS; Oncology Discovery, AbbVie, North Chicago, IL, USA., Wang L; Oncology Discovery, AbbVie, North Chicago, IL, USA., Sehgal V; Oncology Discovery, AbbVie, North Chicago, IL, USA., Lin X; Oncology Discovery, AbbVie, North Chicago, IL, USA., Huang X; Oncology Discovery, AbbVie, North Chicago, IL, USA., Lu X; Oncology Discovery, AbbVie, North Chicago, IL, USA., Uziel T; Oncology Discovery, AbbVie, North Chicago, IL, USA., Hessler P; Oncology Discovery, AbbVie, North Chicago, IL, USA., Lam LT; Oncology Discovery, AbbVie, North Chicago, IL, USA., Bellin RJ; Oncology Discovery, AbbVie, North Chicago, IL, USA., Mehta G; Oncology Discovery, AbbVie, North Chicago, IL, USA., Fidanze S; Oncology Discovery, AbbVie, North Chicago, IL, USA., Pratt JK; Oncology Discovery, AbbVie, North Chicago, IL, USA., Liu D; Oncology Discovery, AbbVie, North Chicago, IL, USA., Hasvold LA; Oncology Discovery, AbbVie, North Chicago, IL, USA., Sun C; Oncology Discovery, AbbVie, North Chicago, IL, USA., Panchal SC; Oncology Discovery, AbbVie, North Chicago, IL, USA., Nicolette JJ; Preclinical Safety, Development Sciences, AbbVie, North Chicago, IL, USA., Fossey SL; Preclinical Safety, Development Sciences, AbbVie, North Chicago, IL, USA., Park CH; Oncology Discovery, AbbVie, North Chicago, IL, USA., Longenecker K; Oncology Discovery, AbbVie, North Chicago, IL, USA., Bigelow L; Oncology Discovery, AbbVie, North Chicago, IL, USA., Torrent M; Oncology Discovery, AbbVie, North Chicago, IL, USA., Rosenberg SH; Oncology Discovery, AbbVie, North Chicago, IL, USA., Kati WM; Oncology Discovery, AbbVie, North Chicago, IL, USA., Shen Y; Oncology Discovery, AbbVie, North Chicago, IL, USA. yu.shen@abbvie.com.

المصدر: Nature [Nature] 2020 Feb; Vol. 578 (7794), pp. 306-310. Date of Electronic Publication: 2020 Jan 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cell Cycle Proteins/*antagonists & inhibitors , Cell Cycle Proteins/*chemistry , Prostatic Neoplasms/*drug therapy , Prostatic Neoplasms/*metabolism , Protein Domains/*drug effects , Pyridines/*pharmacology , Pyrroles/*pharmacology , Transcription Factors/*antagonists & inhibitors , Transcription Factors/*chemistry, Animals ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Enhancer Elements, Genetic/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Male ; Mice ; Pyridines/adverse effects ; Pyridines/toxicity ; Pyrroles/adverse effects ; Pyrroles/toxicity ; Rats ; Receptors, Androgen/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic/drug effects ; Xenograft Model Antitumor Assays

المؤلفون: Tomar S; Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, United States., Plotnik JP; Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, United States., Haley J; Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, United States., Scantland J; Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, United States., Dasari S; Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, United States., Sheikh Z; Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, United States., Emerson R; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, United States., Lenz D; Urology, IU Health Southern Indiana Physicians, Bloomington, IN, United States., Hollenhorst PC; Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, United States; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, United States; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, United States., Mitra AK; Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, United States; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, United States; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address: anmitra@indiana.edu.

المصدر: Cancer letters [Cancer Lett] 2018 Feb 01; Vol. 414, pp. 190-204. Date of Electronic Publication: 2017 Nov 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic*, Focal Adhesion Kinase 1/*genetics , Ovarian Neoplasms/*genetics , Proto-Oncogene Protein c-ets-1/*genetics , Tumor Microenvironment/*genetics, Animals ; Cell Line, Tumor ; Cell Movement/genetics ; Female ; Focal Adhesion Kinase 1/metabolism ; Humans ; Kaplan-Meier Estimate ; Mice, Nude ; Neoplasm Metastasis ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Proto-Oncogene Protein c-ets-1/metabolism ; RNA Interference ; Transplantation, Heterologous

المؤلفون: Plotnik JP; Biology Department, Indiana University, Bloomington, IN 47405, USA., Hollenhorst PC; Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA.

المصدر: Nucleic acids research [Nucleic Acids Res] 2017 May 05; Vol. 45 (8), pp. 4452-4462.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma/*genetics , Carcinoma, Non-Small-Cell Lung/*genetics , Carrier Proteins/*genetics , Lung Neoplasms/*genetics , Prostatic Neoplasms/*genetics , Proto-Oncogene Protein c-ets-1/*genetics , Proto-Oncogene Protein c-ets-2/*genetics, A549 Cells ; Adenocarcinoma/metabolism ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Carrier Proteins/metabolism ; Cell Cycle Proteins ; Cell Line, Tumor ; Co-Repressor Proteins ; DNA-Binding Proteins ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Male ; Mitogen-Activated Protein Kinases/genetics ; Mitogen-Activated Protein Kinases/metabolism ; Organ Specificity ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Protein Binding ; Proto-Oncogene Protein c-ets-1/metabolism ; Proto-Oncogene Protein c-ets-2/metabolism ; Signal Transduction ; Survival Analysis ; Transcription, Genetic ; ras Proteins/genetics ; ras Proteins/metabolism

المؤلفون: Plotnik JP; Department of Biology, Indiana University, Bloomington, IN, USA., Hollenhorst PC; Medical Sciences, Indiana University School of Medicine, 1001 E 3rd St., Jordan Hall 104, Bloomington, IN, 47405, USA. pchollen@indiana.edu.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1487, pp. 277-288.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Genome-Wide Association Study*/methods , Signal Transduction*, Extracellular Signal-Regulated MAP Kinases/*metabolism , ras Proteins/*metabolism, Computational Biology/methods ; Gene Expression Profiling ; High-Throughput Nucleotide Sequencing ; Humans ; Transcriptome

المؤلفون: Kedage V; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA., Selvaraj N; Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA., Nicholas TR; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Budka JA; Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA., Plotnik JP; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Jerde TJ; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Hollenhorst PC; Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA. Electronic address: pchollen@indiana.edu.

المصدر: Cell reports [Cell Rep] 2016 Oct 25; Vol. 17 (5), pp. 1289-1301.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Oncogenes*, Gene Rearrangement/*genetics , Prostatic Neoplasms/*genetics , Prostatic Neoplasms/*pathology , Proto-Oncogene Protein c-ets-1/*metabolism , RNA-Binding Protein EWS/*metabolism , Sarcoma, Ewing/*pathology, Animals ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice, Nude ; Phenotype ; Promoter Regions, Genetic/genetics ; Protein Binding ; Protein Interaction Domains and Motifs ; Transcription Factors/metabolism