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1دورية أكاديمية
المؤلفون: James M. Mutunga, Qiao-Hong Chen, Dawn M. Wong, Polo C-H. Lam, Jianyong Li, Maxim M. Totrov, Aaron D. Gross, Paul R. Carlier, Jeffrey R. Bloomquist
المصدر: CHIMIA, Vol 70, Iss 10 (2016)
مصطلحات موضوعية: Anticholinesterase, Catalytic site, Molecular docking, Peripheral site, Chemistry, QD1-999
وصف الملف: electronic resource
Relation: https://www.chimia.ch/chimia/article/view/1829; https://doaj.org/toc/0009-4293; https://doaj.org/toc/2673-2424
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2
المؤلفون: Denise Wootten, Patrick M. Sexton, Laurence J. Miller, Ingrid Mechin, Anil Nair, Andrew Orry, Ruben Abagyan, Karthigeyan Nagarajan, Polo C.-H. Lam, Aditya J. Desai, Celine Valant, Arthur Christopoulos
المصدر: Molecular Pharmacology. 95:245-259
مصطلحات موضوعية: 0301 basic medicine, Agonist, Indoles, Allosteric modulator, medicine.drug_class, Allosteric regulation, Cooperativity, CHO Cells, Cholecystokinin receptor, Cell Line, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Allosteric Regulation, medicine, Animals, Receptor, Pharmacology, Chemistry, Small molecule, Thiazoles, 030104 developmental biology, Docking (molecular), Mutagenesis, Site-Directed, Biophysics, Molecular Medicine, Receptors, Cholecystokinin, Cholecystokinin, Peptides, Allosteric Site, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c9bc25645b7738741cf3ef5e518422
https://doi.org/10.1124/mol.118.114082 -
3دورية أكاديمية
المؤلفون: Dawn M Wong, Jianyong Li, Qiao-Hong Chen, Qian Han, James M Mutunga, Ania Wysinski, Troy D Anderson, Haizhen Ding, Tiffany L Carpenetti, Astha Verma, Rafique Islam, Sally L Paulson, Polo C-H Lam, Maxim Totrov, Jeffrey R Bloomquist, Paul R Carlier
المصدر: PLoS ONE, Vol 7, Iss 10, p e46712 (2012)
وصف الملف: electronic resource
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4Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae
المؤلفون: Paul R. Carlier, Polo C.-H. Lam, Maxim Totrov, Dawn M. Wong, Howard Robinson, Qian Han, Haizhen Ding, Jianyong Li
المصدر: Insect Science. 25:721-724
مصطلحات موضوعية: 0301 basic medicine, biology, Anopheles gambiae, biology.organism_classification, Acetylcholinesterase, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Malaria transmission, chemistry, Biochemistry, Insect Science, Hydrolase, Malaria vector, Agronomy and Crop Science, 030217 neurology & neurosurgery, Ecology, Evolution, Behavior and Systematics, Pichia
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المؤلفون: Maxim Totrov, Dawn M. Wong, Qiao-Hong Chen, Jianyong Li, Polo C-H. Lam, Paul R. Carlier, James M. Mutunga, Jeffrey R. Bloomquist, Aaron D. Gross
المصدر: CHIMIA, Vol 70, Iss 10 (2016)
مصطلحات موضوعية: 0106 biological sciences, Peripheral site, Carbamate, Insecticides, Mosquito Control, medicine.medical_treatment, Anopheles gambiae, Catalytic site, 010402 general chemistry, 01 natural sciences, Bivalent (genetics), Anticholinesterase, Insecticide Resistance, chemistry.chemical_compound, Anopheles, parasitic diseases, medicine, Potency, Animals, QD1-999, Cross-resistance, biology, General Medicine, General Chemistry, medicine.disease, biology.organism_classification, Acetylcholinesterase, 0104 chemical sciences, Malaria, 010602 entomology, Chemistry, Biochemistry, chemistry, Active compound, Drug Design, Molecular docking, Carbamates, Cholinesterase Inhibitors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b442afdebb71ff23cfd3e3c5413c99f1
https://www.chimia.ch/chimia/article/view/1829 -
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المؤلفون: Polo C.-H. Lam, Erin E. Cawston, Ruben Abagyan, Arthur Christopoulos, Brad R. Henke, Achyut Patil, Andrew Orry, Kaleeckal G. Harikumar, Laurence J. Miller, Patrick M. Sexton
المصدر: Journal of Biological Chemistry. 288:21082-21095
مصطلحات موضوعية: Models, Molecular, Agonist, medicine.drug_class, Molecular Sequence Data, Allosteric regulation, CHO Cells, digestive system, Biochemistry, Cholecystokinin receptor, Benzodiazepines, Cricetulus, Cricetinae, medicine, Animals, Amino Acid Sequence, Receptor, Molecular Biology, Cholecystokinin, Chemistry, digestive, oral, and skin physiology, Biological activity, Cell Biology, Small molecule, Receptor, Cholecystokinin B, Recombinant Proteins, Receptor, Cholecystokinin A, ROC Curve, Docking (molecular), Mutant Proteins, Sequence Alignment, hormones, hormone substitutes, and hormone antagonists, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d265c95a3ccb3114d9f9a7b212eb17
https://doi.org/10.1074/jbc.m113.480715 -
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المؤلفون: Kevin B. Temeyer, Jeffrey R. Bloomquist, Fan Tong, Adalberto A. Pérez de León, Polo C-H. Lam, Daniel R. Swale, Paul R. Carlier, Maxim Totrov, Andrew Y. Li
المصدر: Pesticide Biochemistry and Physiology. 106:85-92
مصطلحات موضوعية: chemistry.chemical_classification, Carbamate, biology, Stereochemistry, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Anopheles gambiae, Thio, Active site, General Medicine, biology.organism_classification, Acetylcholinesterase, Toxicology, chemistry.chemical_compound, Enzyme, chemistry, Tacrine, parasitic diseases, biology.protein, medicine, Potency, Agronomy and Crop Science, medicine.drug
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المؤلفون: James M. Mutunga, Dhana Raj Boina, Jeffrey R. Bloomquist, Troy D. Anderson, Paul R. Carlier, Polo C.-H. Lam, Maxim Totrov, Dawn M. Wong
المصدر: Archives of Insect Biochemistry and Physiology. 83:180-194
مصطلحات موضوعية: biology, Physiology, Aché, Stereochemistry, General Medicine, biology.organism_classification, Biochemistry, Acetylcholinesterase, language.human_language, Bivalent (genetics), chemistry.chemical_compound, chemistry, Insect Science, Tacrine, language, medicine, Melanogaster, Potency, Homology modeling, Drosophila melanogaster, medicine.drug
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المؤلفون: Patrick M. Sexton, Andrew Orry, Laurence J. Miller, Polo C.-H. Lam, Ruben Abagyan, Maoqing Dong, Arthur Christopoulos
المصدر: The Journal of biological chemistry, vol 291, iss 10
مصطلحات موضوعية: 0301 basic medicine, Amino Acid Motifs, cell surface receptor, Peptide, Plasma protein binding, Ligand Binding Protein, Biochemistry, Medical and Health Sciences, Receptors, G-Protein-Coupled, gel electrophoresis, Cricetinae, Receptors, Chlorocebus aethiops, Cyclic AMP, membrane protein, Peptide sequence, chemistry.chemical_classification, Gastrointestinal Hormone, Biological Sciences, Ligand (biochemistry), ligand-binding protein, Protein Structure and Folding, COS Cells, mutagenesis, Protein Binding, Biochemistry & Molecular Biology, Stereochemistry, 1.1 Normal biological development and functioning, Molecular Sequence Data, CHO Cells, Receptors, Gastrointestinal Hormone, 03 medical and health sciences, G-Protein-Coupled, Cricetulus, Secretin, Underpinning research, Animals, Humans, Cysteine, Amino Acid Sequence, G protein-coupled receptor, Binding site, Molecular Biology, Binding selectivity, Binding Sites, 030102 biochemistry & molecular biology, molecular modeling, Cell Biology, 030104 developmental biology, chemistry, Chemical Sciences, peptides, Alpha helix
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9342d62d935f94dae62ad922b0385583
https://escholarship.org/uc/item/86g3x66n -
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المؤلفون: Polo C.-H. Lam, Jeffrey R. Bloomquist, Joshua A. Hartsel, Jianyong Li, Paul R. Carlier, Sally L. Paulson, Eric A. Wong, Rafique Islam, Ming Ma, Maxim Totrov, Dawn M. Wong, Troy D. Anderson, James M. Mutunga, Ania Wysinski
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:4593-4598
مصطلحات موضوعية: Models, Molecular, Quantitative structure–activity relationship, Carbamate, Aché, Stereochemistry, Anopheles gambiae, medicine.medical_treatment, Clinical Biochemistry, Quantitative Structure-Activity Relationship, Pharmaceutical Science, Biochemistry, Article, chemistry.chemical_compound, Anopheles, parasitic diseases, Drug Discovery, medicine, Animals, Humans, Re engineering, Molecular Biology, Molecular Structure, biology, Chemistry, Aryl, Organic Chemistry, biology.organism_classification, Acetylcholinesterase, language.human_language, language, Molecular Medicine, Carbamates, Cholinesterase Inhibitors, Selectivity