المؤلفون: Todesca S; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany., Sandmeir F; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany sandmeir@biochem.mpg.de conti@biochem.mpg.de., Keidel A; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany., Conti E; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany sandmeir@biochem.mpg.de conti@biochem.mpg.de.

المصدر: RNA (New York, N.Y.) [RNA] 2024 Jun 17; Vol. 30 (7), pp. 795-806. Date of Electronic Publication: 2024 Jun 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE

مواضيع طبية MeSH: Cryoelectron Microscopy* , mRNA Cleavage and Polyadenylation Factors*/metabolism , mRNA Cleavage and Polyadenylation Factors*/chemistry , mRNA Cleavage and Polyadenylation Factors*/genetics , Polynucleotide Adenylyltransferase*/metabolism , Polynucleotide Adenylyltransferase*/genetics , Polynucleotide Adenylyltransferase*/chemistry, Humans ; Protein Binding ; Polyadenylation ; Models, Molecular ; RNA Precursors/metabolism ; RNA Precursors/genetics ; RNA Precursors/chemistry ; Cleavage And Polyadenylation Specificity Factor/metabolism ; Cleavage And Polyadenylation Specificity Factor/genetics ; Cleavage And Polyadenylation Specificity Factor/chemistry

المؤلفون: Yang K; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China; Liangzhu Laboratory, Zhejiang University, Hangzhou, Zhejiang 311121, China; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 311121, China; The State Key Laboratory for Complex, Severe, and Rare Diseases, Haihe Laboratory of Cell Ecosystem, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China. Electronic address: yangk_92@163.com., Zhu T; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China; Liangzhu Laboratory, Zhejiang University, Hangzhou, Zhejiang 311121, China; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 311121, China., Yin J; The State Key Laboratory for Complex, Severe, and Rare Diseases, Haihe Laboratory of Cell Ecosystem, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China., Zhang Q; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China; Liangzhu Laboratory, Zhejiang University, Hangzhou, Zhejiang 311121, China; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 311121, China., Li J; The State Key Laboratory for Complex, Severe, and Rare Diseases, Haihe Laboratory of Cell Ecosystem, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China., Fan H; The State Key Laboratory for Complex, Severe, and Rare Diseases, Haihe Laboratory of Cell Ecosystem, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China., Han G; The State Key Laboratory for Complex, Severe, and Rare Diseases, Haihe Laboratory of Cell Ecosystem, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China., Xu W; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China; Liangzhu Laboratory, Zhejiang University, Hangzhou, Zhejiang 311121, China; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 311121, China., Liu N; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China; Liangzhu Laboratory, Zhejiang University, Hangzhou, Zhejiang 311121, China; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 311121, China. Electronic address: liun@zju.edu.cn., Lv X; The State Key Laboratory for Complex, Severe, and Rare Diseases, Haihe Laboratory of Cell Ecosystem, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Medical Epigenetics Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China. Electronic address: lvxiang@pumc.edu.cn.

المصدر: Journal of genetics and genomics = Yi chuan xue bao [J Genet Genomics] 2024 Jun; Vol. 51 (6), pp. 594-607. Date of Electronic Publication: 2024 Feb 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Science press Country of Publication: China NLM ID: 101304616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1673-8527 (Print) Linking ISSN: 16738527 NLM ISO Abbreviation: J Genet Genomics Subsets: MEDLINE

مواضيع طبية MeSH: Erythropoiesis*/genetics , Polynucleotide Adenylyltransferase*/genetics , Polynucleotide Adenylyltransferase*/metabolism, Humans ; Animals ; Mice ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Genome-Wide Association Study ; Mitochondria/genetics ; Mitochondria/metabolism ; Cell Differentiation/genetics ; Lysosomes/metabolism ; Lysosomes/genetics ; Erythrocytes/metabolism ; Transcriptome/genetics

المؤلفون: Min K; Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China., Li Y, Wu Z, Dai Z, Feng Z, Qian Z, Sun X, Qiu Y, Xu L, Zhu Z

المصدر: Spine [Spine (Phila Pa 1976)] 2023 Sep 01; Vol. 48 (17), pp. 1253-1258. Date of Electronic Publication: 2023 May 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7610646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1159 (Electronic) Linking ISSN: 03622436 NLM ISO Abbreviation: Spine (Phila Pa 1976) Subsets: MEDLINE

مواضيع طبية MeSH: Kyphosis* , Scoliosis*/diagnosis , Scoliosis*/genetics , Scoliosis*/epidemiology , Polynucleotide Adenylyltransferase*/genetics, Humans ; Case-Control Studies ; East Asian People ; Genetic Predisposition to Disease ; Genotype ; Polymorphism, Single Nucleotide

المؤلفون: Brouze M; Laboratory of RNA Biology, International Institute of Molecular and Cell Biology, Warsaw, 02-109, Poland.; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 02-106, Poland., Czarnocka-Cieciura A; Laboratory of RNA Biology, International Institute of Molecular and Cell Biology, Warsaw, 02-109, Poland., Gewartowska O; Laboratory of RNA Biology, International Institute of Molecular and Cell Biology, Warsaw, 02-109, Poland.; Genome Engineering Facility, International Institute of Molecular and Cell Biology, Warsaw, 02-109, Poland.; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, 02-106, Poland., Kusio-Kobiałka M; Laboratory of RNA Biology, International Institute of Molecular and Cell Biology, Warsaw, 02-109, Poland., Jachacy K; Laboratory of RNA Biology, International Institute of Molecular and Cell Biology, Warsaw, 02-109, Poland.; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, 02-106, Poland., Szpila M; Genome Engineering Facility, International Institute of Molecular and Cell Biology, Warsaw, 02-109, Poland.; Laboratory of Embryology, Institute of Developmental Biology and Biomedical Research, Faculty of Biology, University of Warsaw, Warsaw, 02-096, Poland., Tarkowski B; Laboratory of RNA Biology, International Institute of Molecular and Cell Biology, Warsaw, 02-109, Poland.; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 02-106, Poland., Gruchota J; Laboratory of RNA Biology, International Institute of Molecular and Cell Biology, Warsaw, 02-109, Poland.; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 02-106, Poland., Krawczyk P; Laboratory of RNA Biology, International Institute of Molecular and Cell Biology, Warsaw, 02-109, Poland.; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 02-106, Poland., Mroczek S; Laboratory of RNA Biology, International Institute of Molecular and Cell Biology, Warsaw, 02-109, Poland.; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, 02-106, Poland., Borsuk E; Laboratory of RNA Biology, International Institute of Molecular and Cell Biology, Warsaw, 02-109, Poland.; Laboratory of Embryology, Institute of Developmental Biology and Biomedical Research, Faculty of Biology, University of Warsaw, Warsaw, 02-096, Poland., Dziembowski A; Laboratory of RNA Biology, International Institute of Molecular and Cell Biology, Warsaw, 02-109, Poland. adziembowski@iimcb.gov.pl.; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 02-106, Poland. adziembowski@iimcb.gov.pl.; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, 02-106, Poland. adziembowski@iimcb.gov.pl.; Laboratory of Embryology, Institute of Developmental Biology and Biomedical Research, Faculty of Biology, University of Warsaw, Warsaw, 02-096, Poland. adziembowski@iimcb.gov.pl.

المصدر: Nature communications [Nat Commun] 2024 Jun 22; Vol. 15 (1), pp. 5331. Date of Electronic Publication: 2024 Jun 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Polyadenylation* , RNA, Messenger*/metabolism , RNA, Messenger*/genetics , Mice, Knockout* , Spermatogenesis*/genetics , Gametogenesis*/genetics, Animals ; Female ; Male ; Mice ; Oogenesis/genetics ; Polynucleotide Adenylyltransferase/metabolism ; Polynucleotide Adenylyltransferase/genetics ; Oocytes/metabolism ; Fertility/genetics ; Mice, Inbred C57BL

المؤلفون: Soni K; Heidelberg University Biochemistry Center (BZH), INF 328, D-69120, Heidelberg, Germany., Sivadas A; The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia., Horvath A; The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia., Dobrev N; Heidelberg University Biochemistry Center (BZH), INF 328, D-69120, Heidelberg, Germany., Hayashi R; The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia., Kiss L; Heidelberg University Biochemistry Center (BZH), INF 328, D-69120, Heidelberg, Germany., Simon B; European Molecular Biology Laboratory (EMBL), Meyerhofstr, 1, D-69117, Heidelberg, Germany., Wild K; Heidelberg University Biochemistry Center (BZH), INF 328, D-69120, Heidelberg, Germany., Sinning I; Heidelberg University Biochemistry Center (BZH), INF 328, D-69120, Heidelberg, Germany. irmi.sinning@bzh.uni-heidelberg.de., Fischer T; The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia. tamas.fischer@anu.edu.au.

المصدر: Nature communications [Nat Commun] 2023 Feb 11; Vol. 14 (1), pp. 772. Date of Electronic Publication: 2023 Feb 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Polynucleotide Adenylyltransferase*/genetics , Polynucleotide Adenylyltransferase*/metabolism , Schizosaccharomyces*/genetics , Schizosaccharomyces*/metabolism , Schizosaccharomyces pombe Proteins*/genetics , Schizosaccharomyces pombe Proteins*/metabolism, Carrier Proteins/metabolism ; Cell Nucleus/metabolism ; RNA/metabolism ; RNA Precursors/metabolism

المؤلفون: Mohanan NK; Cardiovascular and Diabetes Biology Group, Rajiv Gandhi Centre for Biotechnology, Trivandrum 695014, India; Manipal Academy of Higher Education, Manipal 576104, India., Shaji F; Cardiovascular and Diabetes Biology Group, Rajiv Gandhi Centre for Biotechnology, Trivandrum 695014, India; Regional Centre for Biotechnology, Faridabad 121001, India., Sudheesh AP; Cardiovascular and Diabetes Biology Group, Rajiv Gandhi Centre for Biotechnology, Trivandrum 695014, India., Bangalore Prabhashankar A; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India., Sundaresan NR; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India., Laishram RS; Cardiovascular and Diabetes Biology Group, Rajiv Gandhi Centre for Biotechnology, Trivandrum 695014, India. Electronic address: laishram@rgcb.res.in.

المصدر: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Apr; Vol. 1870 (4), pp. 167080. Date of Electronic Publication: 2024 Feb 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-260X (Electronic) Linking ISSN: 09254439 NLM ISO Abbreviation: Biochim Biophys Acta Mol Basis Dis Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms*/pathology , MicroRNAs*/genetics , MicroRNAs*/metabolism, Animals ; Female ; Humans ; Mice ; Cell Proliferation/genetics ; Oncogenes ; Polynucleotide Adenylyltransferase/genetics ; Polynucleotide Adenylyltransferase/metabolism ; RNA, Messenger/metabolism

المؤلفون: Le Boulch M; Eukarÿs SAS, Pépinière Genopole, 4 rue Pierre Fontaine, Genopole Entreprises Campus 3, 4 Rue Pierre Fontaine, 91000, Evry-Courcouronnes, France., Jacquet E; Institut de Chimie des Substances Naturelles, CNRS UPR2301, Université Paris-Saclay, Avenue de la Terrasse, 91198, Gif-Sur-Yvette, France., Nhiri N; Institut de Chimie des Substances Naturelles, CNRS UPR2301, Université Paris-Saclay, Avenue de la Terrasse, 91198, Gif-Sur-Yvette, France., Shmulevitz M; Medical Microbiology and Immunology, Li Ka Shing Institute of Virology, University of Alberta, 6-142J Katz Group Centre for Pharmacy and Health Research, 114 Street NW, Edmonton, AB, T6G 2E1, Canada., Jaïs PH; Eukarÿs SAS, Pépinière Genopole, 4 rue Pierre Fontaine, Genopole Entreprises Campus 3, 4 Rue Pierre Fontaine, 91000, Evry-Courcouronnes, France. philippe.jais@eukarys.com.

المصدر: Scientific reports [Sci Rep] 2024 Mar 02; Vol. 14 (1), pp. 5156. Date of Electronic Publication: 2024 Mar 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Polyadenylation* , DNA-Directed RNA Polymerases*/genetics, Animals ; Humans ; Mice ; RNA, Messenger/metabolism ; Polynucleotide Adenylyltransferase/genetics ; Polynucleotide Adenylyltransferase/metabolism ; Poly A/genetics ; Poly A/metabolism

المؤلفون: Yang A; RNA Mediated Gene Regulation Section; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA., Bofill-De Ros X; RNA Mediated Gene Regulation Section; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA., Stanton R; RNA Mediated Gene Regulation Section; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA., Shao TJ; RNA Mediated Gene Regulation Section; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA.; School of Basic Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, China., Villanueva P; RNA Mediated Gene Regulation Section; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA., Gu S; RNA Mediated Gene Regulation Section; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA. shuo.gu@nih.gov.

المصدر: Nature communications [Nat Commun] 2022 Sep 07; Vol. 13 (1), pp. 5260. Date of Electronic Publication: 2022 Sep 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: DNA-Binding Proteins*/genetics , MicroRNAs*/genetics , Polynucleotide Adenylyltransferase*/genetics , RNA Nucleotidyltransferases*/genetics , mRNA Cleavage and Polyadenylation Factors*/genetics, HEK293 Cells ; Humans ; Uridine Monophosphate/metabolism

المؤلفون: Vo JM; Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA., Mulroney L; Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA., Quick-Cleveland J; Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA., Jain M; Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA., Akeson M; Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA., Ares M Jr; Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA.

المصدر: RNA (New York, N.Y.) [RNA] 2021 Dec; Vol. 27 (12), pp. 1497-1511. Date of Electronic Publication: 2021 Aug 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE

مواضيع طبية MeSH: Nanopores*, Nucleotides/*chemistry , Nucleotidyltransferases/*metabolism , Polymers/*chemistry , Polynucleotide Adenylyltransferase/*metabolism , Saccharomyces cerevisiae/*enzymology , Schizosaccharomyces/*enzymology , Schizosaccharomyces pombe Proteins/*metabolism , Sequence Analysis, RNA/*methods, Nucleotidyltransferases/genetics ; Polynucleotide Adenylyltransferase/genetics ; Schizosaccharomyces pombe Proteins/genetics

المؤلفون: Gao Z; State Key Laboratory for Animal Disease Control and Prevention, Ministry of Agriculture Key Laboratory of Veterinary Public Health, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China., He X; State Key Laboratory for Animal Disease Control and Prevention, Ministry of Agriculture Key Laboratory of Veterinary Public Health, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China., Chen G; State Key Laboratory for Animal Disease Control and Prevention, Ministry of Agriculture Key Laboratory of Veterinary Public Health, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China., Fang Y; State Key Laboratory for Animal Disease Control and Prevention, Ministry of Agriculture Key Laboratory of Veterinary Public Health, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China., Meng Z; School of Public Health, Lanzhou University, Lanzhou 730000, China., Tian H; State Key Laboratory for Animal Disease Control and Prevention, Ministry of Agriculture Key Laboratory of Veterinary Public Health, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China., Zhang H; State Key Laboratory for Animal Disease Control and Prevention, Ministry of Agriculture Key Laboratory of Veterinary Public Health, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China., Jing Z; State Key Laboratory for Animal Disease Control and Prevention, Ministry of Agriculture Key Laboratory of Veterinary Public Health, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.; School of Public Health, Lanzhou University, Lanzhou 730000, China.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 30; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Ectromelia virus*/genetics , Ectromelia, Infectious*, Animals ; Mice ; Humans ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Polynucleotide Adenylyltransferase/metabolism ; Catalytic Domain ; Antiviral Agents/pharmacology