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المؤلفون: Ryzhakov, G, West, N, Franchini, F, Clare, S, Ilott, N, Sansom, S, Bullers, S, Pearson, C, Costain, A, Vaughan-Jackson, A, Goettel, J, Ermann, J, Horwitz, B, Buti, L, Lu, X, Mukhopadhyay, S, Snapper, S, Powrie, FM
المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Ryzhakov, G, West, N R, Franchini, F, Clare, S, Ilott, N E, Sansom, S N, Bullers, S J, Pearson, C, Costain, A, Vaughan-Jackson, A, Goettel, J A, Ermann, J, Horwitz, B H, Buti, L, Lu, X, Mukhopadhyay, S, Snapper, S B & Powrie, F 2018, ' Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis ', Nature Communications, vol. 9, no. 1, 3797 . https://doi.org/10.1038/s41467-018-06085-5مصطلحات موضوعية: Male, Colon, Science, Primary Cell Culture, Bone Marrow Cells, Interleukin-23, Helicobacter Infections, Mice, Animals, Humans, lcsh:Science, Bone Marrow Transplantation, Mice, Knockout, Mice, Inbred BALB C, Macrophages, Th1 Cells, Colitis, Inflammatory Bowel Diseases, Interleukin-12, Mice, Inbred C57BL, Disease Models, Animal, Radiation Chimera, lcsh:Q, Female, Helicobacter hepaticus, Protein Kinases
وصف الملف: application/pdf
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3دورية أكاديمية
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4دورية أكاديمية
المؤلفون: Heuberger CE; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom., Janney A; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom., Ilott N; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom., Bertocchi A; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom., Pott S; Department of Human Genetics, University of Chicago, Chicago, United States., Gu Y; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom., Pohin M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom., Friedrich M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Mann EH; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom., Pearson C; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom., Powrie FM; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom., Pott J; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom., Thornton E; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Maloy KJ; School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom. Electronic address: Kevin.maloy@glasgow.ac.uk.
المصدر: Mucosal immunology [Mucosal Immunol] 2024 Jun; Vol. 17 (3), pp. 416-430. Date of Electronic Publication: 2023 May 19.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101299742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-3456 (Electronic) Linking ISSN: 19330219 NLM ISO Abbreviation: Mucosal Immunol Subsets: MEDLINE
مواضيع طبية MeSH: Histocompatibility Antigens Class II*/metabolism , Histocompatibility Antigens Class II*/immunology , Antigen Presentation* , Citrobacter rodentium*/immunology , Intestinal Mucosa*/immunology , Intestinal Mucosa*/microbiology , CD4-Positive T-Lymphocytes*/immunology, Animals ; Mice ; Helicobacter hepaticus/immunology ; Enterobacteriaceae Infections/immunology ; Helicobacter Infections/immunology ; Epithelial Cells/immunology ; Lymphocyte Activation ; Coculture Techniques ; Mice, Inbred C57BL ; Disease Models, Animal ; Mice, Knockout
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5دورية أكاديمية
المؤلفون: Friedrich M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Pohin M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Jackson MA; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Korsunsky I; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Bullers SJ; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Rue-Albrecht K; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Christoforidou Z; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Sathananthan D; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Thomas T; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Ravindran R; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Tandon R; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Peres RS; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Sharpe H; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Wei K; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Watts GFM; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Mann EH; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Geremia A; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Attar M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., McCuaig S; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Thomas L; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Collantes E; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Uhlig HH; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.; Department of Paediatrics, John Radcliffe Hospital, Oxford, UK., Sansom SN; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Easton A; Old Road Campus Research Building, Department of Oncology, Medical Sciences Division, University of Oxford, Oxford, UK., Raychaudhuri S; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Centre for Genetics and Genomics Versus Arthritis, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Travis SP; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Powrie FM; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. fiona.powrie@kennedy.ox.ac.uk.
مؤلفون مشاركون: Oxford IBD Cohort Investigators, Roche Fibroblast Network Consortium
المصدر: Nature medicine [Nat Med] 2021 Nov; Vol. 27 (11), pp. 1970-1981. Date of Electronic Publication: 2021 Oct 21.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
مواضيع طبية MeSH: Inflammatory Bowel Diseases/*pathology , Interleukin-1/*metabolism , Neutrophil Infiltration/*immunology , Neutrophils/*immunology , Stromal Cells/*immunology, Adult ; Aged ; Female ; Fibroblasts/metabolism ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/genetics ; Male ; Middle Aged ; Receptors, Interleukin-1/metabolism ; Signal Transduction/physiology ; Vascular Remodeling/physiology
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6دورية أكاديمية
المؤلفون: Mendoza JL; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States., Fischer S; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States., Gee MH; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States., Lam LH; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.; Translational Gastroenterology Unit, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom., Brackenridge S; Nuffield Department of Medicine, University of Oxford, NDM Research Building, Old Road Campus, Headington, Oxford, United Kingdom., Powrie FM; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.; Translational Gastroenterology Unit, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom., Birnbaum M; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.; Koch Institute at MIT, Cambridge, United States., McMichael AJ; Nuffield Department of Medicine, University of Oxford, NDM Research Building, Old Road Campus, Headington, Oxford, United Kingdom., Garcia KC; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, United States., Gillespie GM; Nuffield Department of Medicine, University of Oxford, NDM Research Building, Old Road Campus, Headington, Oxford, United Kingdom.
المصدر: ELife [Elife] 2020 Jul 27; Vol. 9. Date of Electronic Publication: 2020 Jul 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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7دورية أكاديمية
المؤلفون: Corbin AL; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Gomez-Vazquez M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Berthold DL; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Attar M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Arnold IC; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Institut für Molekulare Krebsforschung, University of Zurich, Zurich, Switzerland., Powrie FM; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Sansom SN; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. irina.udalova@kennedy.ox.ac.uk stephen.sansom@kennedy.ox.ac.uk., Udalova IA; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. irina.udalova@kennedy.ox.ac.uk stephen.sansom@kennedy.ox.ac.uk.
المصدر: Science immunology [Sci Immunol] 2020 May 22; Vol. 5 (47).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
مواضيع طبية MeSH: CD11 Antigens/*immunology , Inflammation/*immunology , Interferon Regulatory Factors/*immunology , Macrophages/*immunology , Monocytes/*immunology, Animals ; Helicobacter hepaticus/immunology ; Inflammation/pathology ; Interferon Regulatory Factors/deficiency ; Macrophages/pathology ; Mice ; Mice, Knockout ; Monocytes/pathology ; Phenotype
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8دورية أكاديمية
المؤلفون: Bollrath J; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK., Powrie FM
المصدر: Seminars in immunology [Semin Immunol] 2013 Nov 30; Vol. 25 (5), pp. 352-7. Date of Electronic Publication: 2013 Oct 31.
نوع المنشور: Journal Article; Review
بيانات الدورية: Publisher: Academic Press Country of Publication: England NLM ID: 9009458 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3618 (Electronic) Linking ISSN: 10445323 NLM ISO Abbreviation: Semin Immunol Subsets: MEDLINE
مواضيع طبية MeSH: Bacteria/*immunology , Intestines/*immunology , Intestines/*microbiology , T-Lymphocytes, Regulatory/*immunology, Animals ; Homeostasis ; Humans ; Microbiota/immunology ; Thymus Gland/immunology
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9دورية أكاديمية
المؤلفون: Harrison OJ; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom., Powrie FM
المصدر: Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2013 Jul 01; Vol. 5 (7). Date of Electronic Publication: 2013 Jul 01.
نوع المنشور: Journal Article; Review
بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101513680 Publication Model: Electronic Cited Medium: Internet ISSN: 1943-0264 (Electronic) Linking ISSN: 19430264 NLM ISO Abbreviation: Cold Spring Harb Perspect Biol Subsets: MEDLINE
مواضيع طبية MeSH: Immune Tolerance* , Models, Immunological*, Intestines/*immunology , T-Lymphocytes, Regulatory/*immunology, Antigen-Presenting Cells/immunology ; Gastrointestinal Tract/cytology ; Gastrointestinal Tract/immunology ; Humans ; Immunity, Cellular ; Interleukin-10/immunology ; Intestines/cytology ; Microbiota/physiology ; Transforming Growth Factor beta/physiology
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10دورية أكاديمية
المؤلفون: Boulard O; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, England, UK., Kirchberger S, Royston DJ, Maloy KJ, Powrie FM
المصدر: The Journal of experimental medicine [J Exp Med] 2012 Jul 02; Vol. 209 (7), pp. 1309-24. Date of Electronic Publication: 2012 Jun 25.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
مواضيع طبية MeSH: Colitis/*genetics , Colorectal Neoplasms/*genetics , Genetic Loci/*genetics , Genetic Predisposition to Disease/*genetics , Helicobacter Infections/*genetics, Animals ; Azoxymethane/toxicity ; Carcinogens/toxicity ; Chromosome Mapping ; Chromosomes, Mammalian/genetics ; Colitis/immunology ; Colitis/microbiology ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/microbiology ; Disease Resistance/drug effects ; Disease Resistance/genetics ; Disease Resistance/immunology ; Helicobacter Infections/immunology ; Helicobacter Infections/microbiology ; Helicobacter hepaticus/immunology ; Helicobacter hepaticus/physiology ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate/genetics ; Immunity, Innate/immunology ; Inflammation/genetics ; Inflammation/immunology ; Mice ; Mice, 129 Strain ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Knockout ; Polymorphism, Single Nucleotide ; Telomere/genetics