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المؤلفون: Mao C; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: m_c@foxmail.com., Lei G; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Horbath A; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wang M; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Lu Z; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Yan Y; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Liu X; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Kondiparthi L; Kadmon Corporation, LLC (A Sanofi Company), New York, NY 10016, USA., Chen X; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Cheng J; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Li Q; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Xu Z; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Zhuang L; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Fang B; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Marszalek JR; Translational Research to AdvanCe Therapeutics and Innovation in Oncology (TRACTION), The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Poyurovsky MV; Kadmon Corporation, LLC (A Sanofi Company), New York, NY 10016, USA., Olszewski K; Kadmon Corporation, LLC (A Sanofi Company), New York, NY 10016, USA., Gan B; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA. Electronic address: bgan@mdanderson.org.

المصدر: Molecular cell [Mol Cell] 2024 May 16; Vol. 84 (10), pp. 1964-1979.e6.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: AMP-Activated Protein Kinases*/metabolism , AMP-Activated Protein Kinases*/genetics , Electron Transport Complex I*/metabolism , Electron Transport Complex I*/genetics , Ferroptosis*/genetics , Ferroptosis*/drug effects, Animals ; Female ; Humans ; Mice ; AMP-Activated Protein Kinase Kinases/genetics ; Cell Line, Tumor ; Mitochondria/metabolism ; Mitochondria/genetics ; Mitochondria/drug effects ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/metabolism ; Neoplasms/drug therapy ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Signal Transduction ; Xenograft Model Antitumor Assays

المؤلفون: Lee H; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Horbath A; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Kondiparthi L; Kadmon Corporation, New York, NY, 10016, USA.; Sanofi US, Cambridge, MA, 02139, USA., Meena JK; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA., Lei G; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Dasgupta S; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Liu X; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Zhuang L; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Koppula P; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, 77030, USA., Li M; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Mahmud I; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Wei B; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Lorenzi PL; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Keyomarsi K; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, 77030, USA., Poyurovsky MV; Kadmon Corporation, New York, NY, 10016, USA.; PMV Pharmaceuticals, Princeton, NJ, 08540, USA., Olszewski K; Kadmon Corporation, New York, NY, 10016, USA.; Carl Icahn Labs, Princeton University, Princeton, NJ, 08544, USA., Gan B; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. bgan@mdanderson.org.; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, 77030, USA. bgan@mdanderson.org.; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. bgan@mdanderson.org.

المصدر: Nature communications [Nat Commun] 2024 Jan 02; Vol. 15 (1), pp. 79. Date of Electronic Publication: 2024 Jan 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Ferroptosis* , Neoplasms*/metabolism, Humans ; Lipid Droplets/metabolism ; Fatty Acids, Unsaturated/metabolism ; Lipid Peroxidation ; Triglycerides/metabolism ; Cell Cycle Checkpoints ; Diacylglycerol O-Acyltransferase/metabolism ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use

المؤلفون: Mooring M; Department of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Yale School of Medicine, New Haven, CT 06514, USA., Yeung GA; Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Yale School of Medicine, New Haven, CT 06514, USA., Luukkonen P; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06514, USA., Liu S; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Akbar MW; Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Yale School of Medicine, New Haven, CT 06514, USA., Zhang GJ; Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Yale School of Medicine, New Haven, CT 06514, USA., Balogun O; Department of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Yu X; Kadmon Corporation LLC, 450 East 29th Street, New York, NY 10016, USA., Mo R; Kadmon Corporation LLC, 450 East 29th Street, New York, NY 10016, USA., Nejak-Bowen K; Department of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Poyurovsky MV; Kadmon Corporation LLC, 450 East 29th Street, New York, NY 10016, USA., Booth CJ; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06514, USA., Konnikova L; Section of Neonatology, Department of Pediatrics, Yale School of Medicine, New Haven, CT 06514, USA., Shulman GI; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06514, USA.; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06514, USA., Yimlamai D; Department of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Yale School of Medicine, New Haven, CT 06514, USA.; Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; Yale Liver Center, Yale School of Medicine, New Haven, CT 06514, USA.

المصدر: Science translational medicine [Sci Transl Med] 2023 Sep 27; Vol. 15 (715), pp. eade3157. Date of Electronic Publication: 2023 Sep 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Non-alcoholic Fatty Liver Disease*/pathology , Diabetes Mellitus, Type 2*/metabolism, Mice ; Animals ; Interleukin-1 Receptor-Associated Kinases/metabolism ; NF-kappa B/metabolism ; Disease Models, Animal ; Liver/metabolism ; Hepatocytes/metabolism ; Fibrosis ; Macrophages/metabolism ; Mice, Knockout ; Mice, Inbred C57BL

المؤلفون: Yan Y; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Teng H; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Hang Q; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Kondiparthi L; Kadmon Corporation, LLC (A Sanofi Company), New York, NY, 10016, USA.; Sanofi US Services Inc, 270 Albany St, Cambridge, MA, 02139, USA., Lei G; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Horbath A; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Liu X; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Mao C; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Wu S; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Zhuang L; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., James You M; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Poyurovsky MV; Kadmon Corporation, LLC (A Sanofi Company), New York, NY, 10016, USA., Ma L; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, 77030, USA., Olszewski K; Kadmon Corporation, LLC (A Sanofi Company), New York, NY, 10016, USA.; The Barer Institute, Philadelphia, PA, 19104, USA., Gan B; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. bgan@mdanderson.org.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, 77030, USA. bgan@mdanderson.org.

المصدر: Nature communications [Nat Commun] 2023 Jun 21; Vol. 14 (1), pp. 3673. Date of Electronic Publication: 2023 Jun 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Cystine*/metabolism , Neoplasms*/genetics, Cell Line, Tumor ; Hydrogen Peroxide/pharmacology ; Hydrogen Peroxide/metabolism ; Oxidative Stress ; Disulfides/metabolism ; Amino Acid Transport System y+/genetics ; Amino Acid Transport System y+/metabolism

المؤلفون: Liu X; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Nie L; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhang Y; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yan Y; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang C; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Colic M; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Olszewski K; Kadmon Corporation (A Sanofi Company), LLC, New York, NY, USA.; The Barer Institute, Philadelphia, PA, USA., Horbath A; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chen X; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lei G; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mao C; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wu S; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhuang L; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Poyurovsky MV; Kadmon Corporation (A Sanofi Company), LLC, New York, NY, USA., James You M; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hart T; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Billadeau DD; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, USA., Chen J; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jchen8@mdanderson.org.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. jchen8@mdanderson.org., Gan B; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. bgan@mdanderson.org.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. bgan@mdanderson.org.

المصدر: Nature cell biology [Nat Cell Biol] 2023 Mar; Vol. 25 (3), pp. 404-414. Date of Electronic Publication: 2023 Feb 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: Disulfides* , Neoplasms*/metabolism, Humans ; Apoptosis ; Actin Cytoskeleton/metabolism ; Glucose/metabolism

المؤلفون: Han M; Pulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA., Bushong EA; Department of Neurosciences, University of California San Diego (UCSD), San Diego, CA, USA.; National Center for Microscopy and Imaging Research, UCSD, San Diego, CA, USA., Segawa M; University of Cambridge, Cambridge, UK., Tiard A; Department of Computer Science, UCLA, Los Angeles, CA, USA., Wong A; Department of Computer Science, Yale University, New Haven, CT, USA., Brady MR; Pulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA., Momcilovic M; Pulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA., Wolf DM; University of Cambridge, Cambridge, UK.; Imperial College, London, UK., Zhang R; Pulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA., Petcherski A; Department of Endocrinology, DGSOM UCLA, Los Angeles, CA, USA., Madany M; Department of Neurosciences, University of California San Diego (UCSD), San Diego, CA, USA.; National Center for Microscopy and Imaging Research, UCSD, San Diego, CA, USA., Xu S; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.; Crump Institute for Molecular Imaging, UCLA, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA., Lee JT; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.; Crump Institute for Molecular Imaging, UCLA, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.; Molecular Imaging Program, Department of Radiology, Stanford University, Stanford, CA, USA., Poyurovsky MV; Kadmon Corporation, New York, NY, USA., Olszewski K; Kadmon Corporation, New York, NY, USA., Holloway T; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA., Gomez A; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA., John MS; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.; Department of Head and Neck Surgery, DGSOM UCLA, Los Angeles, CA, USA., Dubinett SM; Pulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA.; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, DGSOM UCLA, Los Angeles, CA, USA.; VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA., Koehler CM; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA.; Department of Biological Chemistry, UCLA, Los Angeles, CA, USA., Shirihai OS; Department of Endocrinology, DGSOM UCLA, Los Angeles, CA, USA.; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA., Stiles L; Department of Endocrinology, DGSOM UCLA, Los Angeles, CA, USA.; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA., Lisberg A; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.; Department Hematology and Oncology, DGSOM UCLA, Los Angeles, CA, USA., Soatto S; Department of Computer Science, UCLA, Los Angeles, CA, USA., Sadeghi S; Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada., Ellisman MH; Department of Neurosciences, University of California San Diego (UCSD), San Diego, CA, USA.; National Center for Microscopy and Imaging Research, UCSD, San Diego, CA, USA., Shackelford DB; Pulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA. dshackelford@mednet.ucla.edu.; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA. dshackelford@mednet.ucla.edu.

المصدر: Nature [Nature] 2023 Mar; Vol. 615 (7953), pp. 712-719. Date of Electronic Publication: 2023 Mar 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Non-Small-Cell Lung*/metabolism , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/ultrastructure , Energy Metabolism* , Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology , Lung Neoplasms*/ultrastructure , Mitochondria*/metabolism , Mitochondria*/ultrastructure, Humans ; Fatty Acids/metabolism ; Glucose/metabolism ; Lipid Droplets/metabolism ; Microscopy, Electron ; Oxidative Phosphorylation ; Phenotype ; Positron-Emission Tomography