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المؤلفون: Shah R; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands., Aslam MA; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.; Department/Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Bosan Road, 60800 Multan, Pakistan., Spanjaard A; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands., de Groot D; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands., Zürcher LM; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands., Altelaar M; Proteomics Facility, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands.; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht Institute for Pharmaceutical Sciences, Utrecht University and Netherlands Proteomics Centre, Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands., Hoekman L; Proteomics Facility, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands., Pritchard CEJ; Mouse Clinic for Cancer and Aging Transgenic Facility, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands., Pilzecker B; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands., van den Berk PCM; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands., Jacobs H; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

المصدر: PNAS nexus [PNAS Nexus] 2024 Jun 18; Vol. 3 (7), pp. pgae242. Date of Electronic Publication: 2024 Jun 18 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press on behalf of the National Academy of Sciences Country of Publication: England NLM ID: 9918367777906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2752-6542 (Electronic) Linking ISSN: 27526542 NLM ISO Abbreviation: PNAS Nexus Subsets: PubMed not MEDLINE

المؤلفون: Shah R; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., van den Berk PCM; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Pritchard CEJ; Mouse Clinic for Cancer and Aging Transgenic Facility, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Song JY; Department of Experimental Animal Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Kreft M; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Pilzecker B; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Jacobs H; Department of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Jul 05; Vol. 24 (13). Date of Electronic Publication: 2023 Jul 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Cisplatin*/metabolism , Fanconi Anemia*/genetics , Fanconi Anemia*/metabolism, Humans ; Animals ; Mice ; Mice, Inbred C57BL ; CRISPR-Cas Systems ; DNA-Binding Proteins/metabolism ; Fibroblasts/metabolism ; Mitomycin ; Phenotype ; Fanconi Anemia Complementation Group G Protein/genetics

المؤلفون: Morgner J; Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, 1066 CX, the Netherlands. Electronic address: j.morgner@nki.nl., Bornes L; Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, 1066 CX, the Netherlands., Hahn K; Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, 1066 CX, the Netherlands., López-Iglesias C; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, 6229 ER, the Netherlands., Kroese L; Mouse Clinic for Cancer and Aging, the Netherlands Cancer Institute, Amsterdam, 1066 CX, the Netherlands., Pritchard CEJ; Mouse Clinic for Cancer and Aging, the Netherlands Cancer Institute, Amsterdam, 1066 CX, the Netherlands., Vennin C; Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, 1066 CX, the Netherlands., Peters PJ; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, 6229 ER, the Netherlands., Huijbers I; Mouse Clinic for Cancer and Aging, the Netherlands Cancer Institute, Amsterdam, 1066 CX, the Netherlands., van Rheenen J; Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, 1066 CX, the Netherlands. Electronic address: j.v.rheenen@nki.nl.

المصدر: Developmental cell [Dev Cell] 2023 Apr 10; Vol. 58 (7), pp. 535-549.e5. Date of Electronic Publication: 2023 Mar 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms*/pathology , Laminin*, Animals ; Female ; Humans ; Mice ; Basement Membrane ; Endothelial Cells ; Epithelial Cells ; Disease Models, Animal

المؤلفون: Buoninfante OA; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Pilzecker B; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Spanjaard A; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., de Groot D; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Prekovic S; Division of Oncogenomics, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.; Center for Molecular Medicine, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands., Song JY; Division of Experimental Animal Pathology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Lieftink C; Division of Molecular Carcinogenesis, The Netherlands Cancer Institute Robotics and Screening Center, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Ayidah M; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Pritchard CEJ; Mouse Clinic for Cancer and Aging Research, Transgenic Facility, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Vivié J; Hubrecht Institute-Royal Netherlands Academy of Arts and Sciences, 3584 CT Utrecht, The Netherlands., Mcgrath KE; Department of Pediatrics, University of Rochester Medical Center School of Medicine and Dentistry, Rochester, NY 14642., Huijbers IJ; Mouse Clinic for Cancer and Aging Research, Transgenic Facility, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Philipsen S; Department of Cell Biology, Erasmus Medical Center, 3015CN Rotterdam, The Netherlands., von Lindern M; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratories, 1066CX Amsterdam, The Netherlands., Zwart W; Division of Oncogenomics, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Beijersbergen RL; Division of Molecular Carcinogenesis, The Netherlands Cancer Institute Robotics and Screening Center, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Palis J; Department of Pediatrics, University of Rochester Medical Center School of Medicine and Dentistry, Rochester, NY 14642., van den Berk PCM; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Jacobs H; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 24; Vol. 120 (4), pp. e2216055120. Date of Electronic Publication: 2023 Jan 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: DNA Damage*, Animals ; DNA Repair ; DNA Replication ; Hematopoietic Stem Cells/metabolism ; Mammals/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Ubiquitination

المؤلفون: Trabjerg MS; Laboratory of Molecular Pharmacology, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Andersen DC; Laboratory of Molecular Pharmacology, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Huntjens P; Laboratory of Molecular Pharmacology, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Mørk K; Laboratory of Molecular Pharmacology, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Warming N; Laboratory of Molecular Pharmacology, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Kullab UB; Laboratory of Molecular Pharmacology, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Skjønnemand MN; Laboratory of Molecular Pharmacology, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Oklinski MK; Laboratory of Molecular Pharmacology, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Oklinski KE; Laboratory of Molecular Pharmacology, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Bolther L; Laboratory of Molecular Pharmacology, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Kroese LJ; Mouse Clinic for Cancer and Aging (MCCA) Transgenic Facility, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands., Pritchard CEJ; Mouse Clinic for Cancer and Aging (MCCA) Transgenic Facility, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands., Huijbers IJ; Mouse Clinic for Cancer and Aging (MCCA) Transgenic Facility, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands., Corthals A; Department of Science, John Jay College of Criminal Justice, City University of New York, New York, NY, 10019, USA., Søndergaard MT; DNASense, Aalborg, Denmark., Kjeldal HB; DNASense, Aalborg, Denmark., Pedersen CFM; Laboratory of Molecular Pharmacology, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Nieland JDV; Laboratory of Molecular Pharmacology, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark. Jdn@hst.aau.dk.

المصدر: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2023 Jan 21; Vol. 9 (1), pp. 6. Date of Electronic Publication: 2023 Jan 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE

المؤلفون: Widmer CA; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Klebic I; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.; COMPATH, Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Domanitskaya N; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Decollogny M; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Howald D; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Siffert M; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Essers P; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Nowicka Z; Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland., Stokar-Regenscheit N; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., van de Ven M; Mouse Clinic for Cancer and Aging Research (MCCA), Preclinical Intervention Unit, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., de Korte-Grimmerink R; Mouse Clinic for Cancer and Aging Research (MCCA), Preclinical Intervention Unit, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Galván JA; Translational Research Unit, Institute of Pathology, University of Bern, Bern, Switzerland., Pritchard CEJ; Mouse Clinic for Cancer and Aging Research (MCCA), Transgenic Facility, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Huijbers IJ; Mouse Clinic for Cancer and Aging Research (MCCA), Transgenic Facility, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Fendler W; Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland.; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Vens C; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Rottenberg S; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.; Division of Molecular Pathology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.; Bern Center for Precision Medicine, University of Bern, 3012 Bern, Switzerland.; Cancer Therapy Resistance Cluster, Department for BioMedical Research, University of Bern, 3012 Bern, Switzerland.

المصدر: Cancer research communications [Cancer Res Commun] 2022 Oct 26; Vol. 2 (10), pp. 1266-1281.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun

مواضيع طبية MeSH: Cisplatin*/pharmacology , Platinum*/metabolism, Mice ; Animals ; Carboplatin/pharmacology ; Tumor Suppressor Protein p53/genetics ; Prospective Studies ; Membrane Proteins/genetics ; Anions/metabolism

المؤلفون: Harmsen TJW; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Plant Sciences and Natural Products, Institute of Biology Leiden (IBL), Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands., Pritchard CEJ; Mouse Clinic for Cancer and Aging Research, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Riepsaame J; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK., van de Vrugt HJ; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Department of Clinical Genetics, Section Oncogenetics, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands., Huijbers IJ; Mouse Clinic for Cancer and Aging Research, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Te Riele H; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. h.t.riele@nki.nl.

المصدر: Scientific reports [Sci Rep] 2022 Jun 10; Vol. 12 (1), pp. 9606. Date of Electronic Publication: 2022 Jun 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems* , Gene Editing*/methods, Animals ; DNA Breaks, Double-Stranded ; Endonucleases/genetics ; Mice ; RNA, Guide, CRISPR-Cas Systems/genetics

المؤلفون: Antoszewski M; Ecole Polytechnique Fédérale de Lausanne (EPFL), School of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), Lausanne, Switzerland.; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland., Fournier N; Ecole Polytechnique Fédérale de Lausanne (EPFL), School of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), Lausanne, Switzerland.; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland.; Bioinformatics Core Facility, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland., Ruiz Buendía GA; Bioinformatics Core Facility, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland., Lourenco J; Bioinformatics Core Facility, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland., Liu Y; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland.; Department of Computational Biology, University of Lausanne (UNIL), Lausanne, Switzerland.; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland., Sugrue T; Ecole Polytechnique Fédérale de Lausanne (EPFL), School of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), Lausanne, Switzerland.; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland.; Botnar Research Centre for Child Health, University of Basel & ETH Zürich, Basel, Switzerland., Dubey C; Ecole Polytechnique Fédérale de Lausanne (EPFL), School of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), Lausanne, Switzerland.; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland.; INSELSPITAL, Universitätsspital Bern, Universitätsklinik für Thoraxchirurgie, Forschungsabteilung Thoraxchirurgie, Bern, Switzerland., Nkosi M; Ecole Polytechnique Fédérale de Lausanne (EPFL), School of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), Lausanne, Switzerland.; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland., Pritchard CEJ; Mouse Clinic for Cancer & Aging (MCCA)/Transgenic Core Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Huijbers IJ; Mouse Clinic for Cancer & Aging (MCCA)/Transgenic Core Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands., Segat GC; Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada., Alonso-Moreno S; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain., Serracanta E; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain., Belver L; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.; Catalan Institute of Oncology-Immuno  Procure, Barcelona, Spain; and., Ferrando AA; Institute for Cancer Genetics, Columbia University Medical Center, New York, NY., Ciriello G; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland.; Department of Computational Biology, University of Lausanne (UNIL), Lausanne, Switzerland.; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland., Weng AP; Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada., Koch U; Ecole Polytechnique Fédérale de Lausanne (EPFL), School of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), Lausanne, Switzerland.; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland., Radtke F; Ecole Polytechnique Fédérale de Lausanne (EPFL), School of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), Lausanne, Switzerland.; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland.

المصدر: Blood [Blood] 2022 Apr 21; Vol. 139 (16), pp. 2483-2498.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/genetics, Carcinogenesis/genetics ; Cell Line, Tumor ; Chromatin/genetics ; Humans ; Oncogenes ; Receptor, Notch1/genetics