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1
المؤلفون: Kuniko Katagiri, Miku Ishizawa, Mari Kannagi, Yoshiko Nagano, Nobuyo Kondo, Atsuhiko Hasegawa, Takeru Yoneda, Takao Masuda
المصدر: Biochemical and Biophysical Research Communications. 574:104-109
مصطلحات موضوعية: Biophysics, Microbial Sensitivity Tests, macromolecular substances, Antiviral Agents, Biochemistry, Cell Line, immune system diseases, hemic and lymphatic diseases, medicine, Humans, Enhancer of Zeste Homolog 2 Protein, Lenalidomide, Molecular Biology, Multiple myeloma, Cell Proliferation, Human T-lymphotropic virus 1, Chemistry, EZH2, Cell Biology, Protein Cereblon, Pomalidomide, medicine.disease, HTLV-I Infections, Thalidomide, Leukemia, Apoptosis, Cell culture, Cancer research, medicine.drug
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2
المؤلفون: Heung Kyoung Lee, Ara Go, Jong Yeon Hwang, Sung Goo Park, Young Uk Jeon, Jae Du Ha, Sung Yun Cho, Chi Hoon Park, Pilho Kim, Sun Jun Park, Ji-Eun Kim, Jeong Hoon Kim, Seung-Hyun Jo, Byoung Chul Park, Chong-Ock Lee, Sung Ah Kim, Sunhong Kim
المصدر: European Journal of Medicinal Chemistry. 166:65-74
مصطلحات موضوعية: Ubiquitin-Protein Ligases, Protein degradation, 01 natural sciences, BET inhibitor, Mice, 03 medical and health sciences, Transcription (biology), Cell Line, Tumor, Drug Discovery, Animals, Humans, Immunologic Factors, Piperidones, Adaptor Proteins, Signal Transducing, 030304 developmental biology, Pharmacology, 0303 health sciences, biology, 010405 organic chemistry, Cell growth, Chemistry, Cereblon, Organic Chemistry, Proteolysis targeting chimera, General Medicine, Protein Cereblon, Xenograft Model Antitumor Assays, 0104 chemical sciences, Ubiquitin ligase, Cell biology, Proteolysis, biology.protein, Female, Peptide Hydrolases
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3
المؤلفون: Reinhard Albrecht, Kerstin Bär, Hartmann, Christopher Heim, B. Hernandez Alvarez, Andrei N. Lupas, I. Boichenko, Silvia Deiss
المصدر: ACS Omega, Vol 3, Iss 9, Pp 11163-11171 (2018)
ACS Omegaمصطلحات موضوعية: 0301 basic medicine, General Chemical Engineering, lenalidomide, Clinical settings, substrate, Computational biology, Protein degradation, 01 natural sciences, Article, lcsh:Chemistry, 03 medical and health sciences, thalidomide, molecular graphics, e3 ubiquitin ligase, 010405 organic chemistry, Chemistry, Effector, Cereblon, General Chemistry, Protein Cereblon, molscript, Ligand (biochemistry), protein-degradation, crl4(crbn), Chemical space, 0104 chemical sciences, 030104 developmental biology, lcsh:QD1-999, Ubiquitin ligase complex, identification, complex
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المؤلفون: Cinzia Fionda, Marco Cippitelli, Silvia Ruggeri, Andrea Kosta, Angela Gismondi, Giovanna Peruzzi, Cristina Capuano, Helena Stabile, Alessandra Zingoni, Angela Santoni, Rossella Paolini, Alessandra Soriani, Rosa Molfetta
مصطلحات موضوعية: Cytotoxicity, Immunologic, rac1 GTP-Binding Protein, Chemokine, Ubiquitin-Protein Ligases, Immunology, lenalidomide, RAC1, cereblon, E3 ubiquitin ligase, natural killer cells, rac1, Biology, Immunological synapse, Immunomodulating Agents, Cell Movement, Humans, Immunology and Allergy, Adaptor Proteins, Signal Transducing, Cereblon, Cell migration, Protein Cereblon, Actin cytoskeleton, Ubiquitin ligase, Cell biology, Killer Cells, Natural, biology.protein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f838d274c9e66c837ca983835d81529b
http://hdl.handle.net/11573/1569443 -
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المؤلفون: Neil Vargesson, Nigel H. Greig, Marc C. Nicklaus, Matthew K Collins, Christian Steinebach, Weiming Luo, Michael Gütschow, Suzana Markolovic, David Tweedie, Shaunna L. Beedie, Cindy H. Chau, William D. Figg, Megan L. Peach
المصدر: Molecules
Volume 25
Issue 23
Molecules, Vol 25, Iss 5683, p 5683 (2020)مصطلحات موضوعية: Male, Ubiquitin-Protein Ligases, In silico, Neovascularization, Physiologic, Pharmaceutical Science, Angiogenesis Inhibitors, Pharmacology, Article, Analytical Chemistry, Rats, Sprague-Dawley, lcsh:QD241-441, 03 medical and health sciences, angiogenesis, 0302 clinical medicine, lcsh:Organic chemistry, thalidomide, Drug Discovery, medicine, Animals, Humans, Computer Simulation, Physical and Theoretical Chemistry, Aorta, Adaptor Proteins, Signal Transducing, 030304 developmental biology, 0303 health sciences, Chemistry, Cereblon, Organic Chemistry, cereblon, Protein Cereblon, Rats, Molecular Docking Simulation, Thalidomide, Chemistry (miscellaneous), Docking (molecular), 030220 oncology & carcinogenesis, docking, Molecular Medicine, structure–activity relationships, Pharmacophore, Ex vivo, medicine.drug
وصف الملف: application/pdf
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المؤلفون: Yoshitaka Satoh, Gilles Carmel, Frans Baculi, Peter H. Schafer, Laurie LeBrun, Matt Hickman, Thomas O. Daniel, Brian E. Cathers, James Carmichael, Godrej Khambatta, Hon-Wah Man, Mary E Matyskiela, Philip P Chamberlain, Weihong Zhang, Mariko Riley, George W. Muller, Barbra Pagarigan, Gang Lu, Chin-Chun Lu
المصدر: Journal of Medicinal Chemistry. 61:535-542
مصطلحات موضوعية: 0301 basic medicine, Morpholines, Ubiquitin-Protein Ligases, Phthalimides, Crystallography, X-Ray, Heterocyclic Compounds, 4 or More Rings, Ikaros Transcription Factor, 03 medical and health sciences, DDB1, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, Fluorescence Resonance Energy Transfer, medicine, Humans, Binding site, Lenalidomide, Transcription factor, Piperidones, Adaptor Proteins, Signal Transducing, chemistry.chemical_classification, DNA ligase, biology, Cereblon, Protein Cereblon, Pomalidomide, Molecular biology, Ubiquitin ligase, Cell biology, DNA-Binding Proteins, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Proteolysis, biology.protein, Molecular Medicine, Multiple Myeloma, Peptide Hydrolases, Protein Binding, medicine.drug
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المؤلفون: Philip P Chamberlain, Brian E. Cathers
المصدر: Drug discovery today. Technologies. 31
مصطلحات موضوعية: Protein family, Ubiquitin-Protein Ligases, Protein degradation, 01 natural sciences, 03 medical and health sciences, Drug Discovery, Humans, 030304 developmental biology, Adaptor Proteins, Signal Transducing, 0303 health sciences, biology, 010405 organic chemistry, Chemistry, Drug discovery, Cereblon, Signal transducing adaptor protein, Protein Cereblon, Small molecule, 0104 chemical sciences, Ubiquitin ligase, Molecular Weight, Biochemistry, Proteolysis, biology.protein, Molecular Medicine, Peptide Hydrolases
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المؤلفون: O. Fuchs, R. Bokorova
المصدر: Drugs of the Future. 45:305
مصطلحات موضوعية: business.industry, Cancer research, Medicine, Protein Cereblon, business, Cancer treatment
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::403a6d6d027fa461cdbee704dda13c8d
https://doi.org/10.1358/dof.2020.45.5.3116300 -
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المؤلفون: Tadao Ishida, Yu Abe
المصدر: Japanese journal of clinical oncology. 49(8)
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, medicine.drug_class, Monoclonal antibody, 03 medical and health sciences, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Immunologic Factors, Radiology, Nuclear Medicine and imaging, Adverse effect, Multiple myeloma, Lenalidomide, Randomized Controlled Trials as Topic, business.industry, General Medicine, Protein Cereblon, Pomalidomide, medicine.disease, IKZF3, Thalidomide, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, business, Multiple Myeloma, Proteasome Inhibitors, medicine.drug, Stem Cell Transplantation
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabaa62dc81c963a65a951f24cc3cade
https://pubmed.ncbi.nlm.nih.gov/31187860 -
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المؤلفون: Andrei N. Lupas, Murray Coles, Marcus D. Hartmann, Fabio Zanini, Birte Hernandez Alvarez, I. Boichenko
المصدر: Journal of Structural Biology. 188:225-232
مصطلحات موضوعية: Stereochemistry, Pomalyst, Antineoplastic Agents, Biology, chemistry.chemical_compound, Structural Biology, In vivo, Escherichia coli, medicine, IMiD, Uridine, Immunomodulatory drug, Binding Sites, Ligand, Cereblon, Tryptophan, Protein Cereblon, Pomalidomide, Thalidomide, chemistry, Biochemistry, Revlimid, Peptide Hydrolases, medicine.drug