المؤلفون: Anastasiou P; Oncogene Biology Laboratory, Francis Crick Institute, London, UK., Moore C; Oncogene Biology Laboratory, Francis Crick Institute, London, UK., Rana S; Oncogene Biology Laboratory, Francis Crick Institute, London, UK., Tomaschko M; Oncogene Biology Laboratory, Francis Crick Institute, London, UK., Pillsbury CE; Oncogene Biology Laboratory, Francis Crick Institute, London, UK., de Castro A; Oncogene Biology Laboratory, Francis Crick Institute, London, UK., Boumelha J; Oncogene Biology Laboratory, Francis Crick Institute, London, UK., Mugarza E; Oncogene Biology Laboratory, Francis Crick Institute, London, UK., de Carné Trécesson S; Oncogene Biology Laboratory, Francis Crick Institute, London, UK., Mikolajczak A; Experimental Histopathology, Francis Crick Institute, London, UK., Blaj C; Revolution Medicines, Inc., Redwood City, CA, USA., Goldstone R; Bioinformatics & Biostatistics Science Technology Platform, Francis Crick Institute, London, UK., Smith JAM; Revolution Medicines, Inc., Redwood City, CA, USA., Quintana E; Revolution Medicines, Inc., Redwood City, CA, USA., Molina-Arcas M; Oncogene Biology Laboratory, Francis Crick Institute, London, UK. miriam.molina@crick.ac.uk., Downward J; Oncogene Biology Laboratory, Francis Crick Institute, London, UK. julian.downward@crick.ac.uk.

المصدر: Nature communications [Nat Commun] 2024 Sep 25; Vol. 15 (1), pp. 8146. Date of Electronic Publication: 2024 Sep 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Protein Tyrosine Phosphatase, Non-Receptor Type 11*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism , Lung Neoplasms*/drug therapy , Lung Neoplasms*/immunology , Lung Neoplasms*/pathology , Immune Checkpoint Inhibitors*/pharmacology , Immune Checkpoint Inhibitors*/therapeutic use , Proto-Oncogene Proteins p21(ras)*/genetics , Proto-Oncogene Proteins p21(ras)*/metabolism, Animals ; Mice ; Humans ; Cell Line, Tumor ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Mice, Inbred C57BL ; Female ; Signal Transduction/drug effects ; Mutation

المؤلفون: Taylor JD; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK. jonathan.taylor@astrazeneca.com., Barrett N; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Martinez Cuesta S; Data Sciences and Quantitative Biology, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge, CB2 0AA, UK., Cassidy K; Protein Sciences, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Waltham, MA, 02451, USA., Pachl F; Protein Sciences, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Waltham, MA, 02451, USA., Dodgson J; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Patel R; Centre for Genomics Research, Dynamic Omics, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge, CB2 0AA, UK., Eriksson TM; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Riley A; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Burrell M; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Bauer C; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Rees DG; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Cimbro R; Centre for Genomics Research, Dynamic Omics, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge, CB2 0AA, UK., Zhang AX; Protein Sciences, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Waltham, MA, 02451, USA., Minter RR; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK., Hunt J; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK. james.hunt1@astrazeneca.com., Legg S; Biologics Engineering, R&D Oncology, AstraZeneca, Cambridge, CB2 0AA, UK.

المصدر: Communications biology [Commun Biol] 2024 Sep 19; Vol. 7 (1), pp. 1179. Date of Electronic Publication: 2024 Sep 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

مواضيع طبية MeSH: Ubiquitin-Conjugating Enzymes*/metabolism , Ubiquitin-Conjugating Enzymes*/genetics , Proteolysis* , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/genetics, Humans ; Ubiquitination ; Proto-Oncogene Proteins p21(ras)/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics ; Recombinant Fusion Proteins/metabolism ; Recombinant Fusion Proteins/genetics ; HEK293 Cells ; Proteomics/methods ; Protein Binding

المؤلفون: Wang L; Department of Orthopaedic Surgery, Brown University Alpert Medical School, Rhode Island Hospital, Providence, Rhode Island, USA., Yang H; Department of Orthopaedic Surgery, Brown University Alpert Medical School, Rhode Island Hospital, Providence, Rhode Island, USA., Wang C; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Wang M; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Huang J; Department of Orthopaedic Surgery, Brown University Alpert Medical School, Rhode Island Hospital, Providence, Rhode Island, USA., Nyunt T; Department of Orthopaedic Surgery, Brown University Alpert Medical School, Rhode Island Hospital, Providence, Rhode Island, USA., Osorio C; Department of Orthopaedic Surgery, Brown University Alpert Medical School, Rhode Island Hospital, Providence, Rhode Island, USA., Sun SY; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Pacifici M; Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Lefebvre V; Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Moore DC; Department of Orthopaedic Surgery, Brown University Alpert Medical School, Rhode Island Hospital, Providence, Rhode Island, USA., Wang S; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Yang W; Department of Orthopaedic Surgery, Brown University Alpert Medical School, Rhode Island Hospital, Providence, Rhode Island, USA.

المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2024 Sep 15; Vol. 38 (17), pp. e70013.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

مواضيع طبية MeSH: SOX9 Transcription Factor*/metabolism , SOX9 Transcription Factor*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/genetics , Chondrocytes*/metabolism , Chondrocytes*/pathology , Cartilage, Articular*/metabolism , Cartilage, Articular*/pathology , Osteoarthritis*/metabolism , Osteoarthritis*/pathology, Animals ; Mice ; Cell Proliferation ; Cells, Cultured ; Mice, Inbred C57BL ; Mice, Knockout ; Male

المؤلفون: Guo Z; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China., Duan Y; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China., Sun K; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China., Zheng T; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China., Liu J; Department of Organic Chemistry, School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China. Electronic address: cpu-jill@163.com., Xu S; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China. Electronic address: cpuxst@163.com., Xu J; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China. Electronic address: jinyixu@china.com.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116579. Date of Electronic Publication: 2024 Jun 13.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Protein Tyrosine Phosphatase, Non-Receptor Type 11*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis, Humans ; Allosteric Regulation/drug effects ; Molecular Structure ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Neoplasms/drug therapy ; Neoplasms/pathology ; Structure-Activity Relationship ; Animals

المؤلفون: Xue F; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China.; Department of Obstetrics and Gynecology, The Fourth Hospital of Baotou, Baotou, China., Liu L; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China., Tao X; Department of Spinal Surgery, The Fourth Hospital of Baotou, Baotou, China., Zhu W; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China. zhuweipeivip@126.com.

المصدر: Journal of gynecologic oncology [J Gynecol Oncol] 2024 Sep; Vol. 35 (5), pp. e64. Date of Electronic Publication: 2024 Feb 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Asian Society of Gynecologic Oncology Country of Publication: Korea (South) NLM ID: 101483150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2005-0399 (Electronic) Linking ISSN: 20050380 NLM ISO Abbreviation: J Gynecol Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/genetics , ErbB Receptors*/metabolism , ErbB Receptors*/genetics , Endometrial Neoplasms*/pathology , Endometrial Neoplasms*/genetics , Endometrial Neoplasms*/metabolism , Dioxygenases*/metabolism , MAP Kinase Signaling System*/physiology , Disease Progression* , DNA Demethylation*, Female ; Humans ; Animals ; Cell Line, Tumor ; Mice ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins/genetics ; Mice, Nude ; Gene Expression Regulation, Neoplastic ; Promoter Regions, Genetic ; Mice, Inbred BALB C

المؤلفون: Huang M; Department of Oncology, The First People's Hospital Affiliated to Yangtze University, Jingzhou City, Hubei Province 434000, China., Zhang F; Department of Oncology, The First People's Hospital Affiliated to Yangtze University, Jingzhou City, Hubei Province 434000, China., Zhu Y; Department of Oncology, The First People's Hospital Affiliated to Yangtze University, Jingzhou City, Hubei Province 434000, China., Zeng H; Department of Oncology, The First People's Hospital Affiliated to Yangtze University, Jingzhou City, Hubei Province 434000, China., Li S; Department of Oncology, The First People's Hospital Affiliated to Yangtze University, Jingzhou City, Hubei Province 434000, China. Electronic address: ShuangllIII@163.com.

المصدر: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2024 Sep; Vol. 174, pp. 106621.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9508482 Publication Model: Print Cited Medium: Internet ISSN: 1878-5875 (Electronic) Linking ISSN: 13572725 NLM ISO Abbreviation: Int J Biochem Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: Down-Regulation* , Mice, Nude* , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/immunology , Stomach Neoplasms*/immunology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/pathology , Tumor Escape*/genetics, Animals ; Female ; Humans ; Male ; Mice ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Mice, Inbred BALB C

المؤلفون: Dong H; West Campus of Zibo Central Hospital, Zibo, Shandong, China., Liu X; Zibo Central Hospital, Zibo, Shandong, China., Duan J; West Campus of Zibo Central Hospital, Zibo, Shandong, China., Zhang J; Zibo Central Hospital, Zibo, Shandong, China., Liu H; Zibo Central Hospital, Zibo, Shandong, China., Shen T; West Campus of Zibo Central Hospital, Zibo, Shandong, China.

المصدر: Aging [Aging (Albany NY)] 2024 Aug 27; Vol. 16 (17), pp. 12263-12276. Date of Electronic Publication: 2024 Aug 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE

مواضيع طبية MeSH: RANK Ligand*/metabolism , Osteoclasts*/metabolism , Osteoclasts*/drug effects , Cell Differentiation*/drug effects , Signal Transduction*/drug effects , NF-kappa B*/metabolism , Syk Kinase*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/genetics , Glucocorticoids*/pharmacology , Osteoporosis*/metabolism , Osteoporosis*/pathology , Macrophages*/metabolism , Macrophages*/drug effects, Animals ; Mice ; Female ; Mice, Inbred C57BL

المؤلفون: Ma C; Medicinal Chemistry, Jacobio Pharmaceuticals, Beijing 101111, China., Kang D; Pharmacology, Jacobio Pharmaceuticals, Beijing 101111, China., Gao P; Medicinal Chemistry, Jacobio Pharmaceuticals, Beijing 101111, China., Zhang W; Hits Discovery, Jacobio Pharmaceuticals, Beijing 101111, China., Wu X; Medicinal Chemistry, Jacobio Pharmaceuticals, Beijing 101111, China., Xu Z; Medicinal Chemistry, Jacobio Pharmaceuticals, Beijing 101111, China., Han H; Pharmacology, Jacobio Pharmaceuticals, Beijing 101111, China., Zhang L; Pharmacology, Jacobio Pharmaceuticals, Beijing 101111, China., Cai Y; Pharmacology, Jacobio Pharmaceuticals, Beijing 101111, China., Wang Y; Pharmacology, Jacobio Pharmaceuticals, Beijing 101111, China., Wang Y; Pharmacology, Jacobio Pharmaceuticals, Beijing 101111, China., Long W; Medicinal Chemistry, Jacobio Pharmaceuticals, Beijing 101111, China.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 13534-13549. Date of Electronic Publication: 2024 Aug 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Protein Tyrosine Phosphatase, Non-Receptor Type 11*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/chemical synthesis, Humans ; Animals ; Mice ; Allosteric Regulation/drug effects ; Cell Line, Tumor ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays ; Cell Proliferation/drug effects ; Drug Discovery ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/therapeutic use ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/pharmacokinetics ; Mice, Nude ; Female ; Neoplasms/drug therapy

المؤلفون: Chen YQ; Cancer Progression Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Lee HC; Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan., Lee HH; Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: hhl@nycu.edu.tw.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Aug 20; Vol. 721, pp. 150144. Date of Electronic Publication: 2024 May 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/genetics , Elasticity* , Cell Nucleus*/metabolism , Focal Adhesions*/metabolism, Viscosity ; Animals ; Mice ; Fibronectins/metabolism ; Humans ; Cell Adhesion ; Actin Cytoskeleton/metabolism ; Actomyosin/metabolism ; Mechanotransduction, Cellular/physiology ; rho-Associated Kinases/metabolism

المؤلفون: Rajala A; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; Dean McGee Eye Institute, Oklahoma City, OK, 73104, USA., Rajala R; Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA., Bhat MA; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; Dean McGee Eye Institute, Oklahoma City, OK, 73104, USA., Eminhizer M; Departments of Ophthalmology and Visual Sciences and Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV, 26505, USA., Hao J; Departments of Ophthalmology and Visual Sciences and Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV, 26505, USA., Du J; Departments of Ophthalmology and Visual Sciences and Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV, 26505, USA., Rajala RVS; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. raju-rajala@ouhsc.edu.; Dean McGee Eye Institute, Oklahoma City, OK, 73104, USA. raju-rajala@ouhsc.edu.; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. raju-rajala@ouhsc.edu.; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. raju-rajala@ouhsc.edu.

المصدر: Cell death & disease [Cell Death Dis] 2024 Aug 08; Vol. 15 (8), pp. 577. Date of Electronic Publication: 2024 Aug 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

مواضيع طبية MeSH: Retinal Degeneration*/pathology , Retinal Degeneration*/metabolism , Retinal Degeneration*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/genetics, Animals ; Mice ; Retinal Rod Photoreceptor Cells/metabolism ; Retinal Rod Photoreceptor Cells/pathology ; Retinal Pigment Epithelium/metabolism ; Retinal Pigment Epithelium/pathology ; Mice, Knockout ; Aging/metabolism ; Aging/genetics ; Occludin/metabolism ; Occludin/genetics ; Mice, Inbred C57BL ; Gene Deletion ; Retina/metabolism ; Retina/pathology