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المؤلفون: Ramón Pérez-Núñez, Alejandro Chamorro, María Fernanda González, Pamela Contreras, Rocío Artigas, Alejandro H. Corvalán, Brigitte van Zundert, Christopher Reyes, Pablo R. Moya, Ana María Avalos, Pascal Schneider, Andrew F. G. Quest, Lisette Leyton
المصدر: Journal of neuroinflammation, vol. 20, no. 1, pp. 5
مصطلحات موضوعية: Cellular and Molecular Neuroscience, Neurology, Animals, Mice, Rats, Adenosine Triphosphate/pharmacology, Adenosine Triphosphate/metabolism, Astrocytes/metabolism, Brain Injuries/metabolism, Connexin 43/metabolism, Gliosis/metabolism, Inflammation/metabolism, Integrin beta3/genetics, Integrin beta3/metabolism, Integrin beta3/pharmacology, Phosphatidylinositol 3-Kinases/metabolism, Phosphorylation, Proto-Oncogene Proteins c-akt/metabolism, Up-Regulation, Thy-1 Antigens/metabolism, Integrin alpha5/metabolism, ALS model, Astrogliosis, Bioinformatics analysis, Brain damage, Connexin43, Inflammation, PI3K/AKT signaling pathway, General Neuroscience, Immunology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb301e5d6b950fe73cff422018afa9d9
https://serval.unil.ch/notice/serval:BIB_9764A8B87F3E -
2دورية أكاديمية
المؤلفون: Mitroshina, Еlena V, Mishchenko, Tatiana A, Shirokova, Olesya M, Astrakhanova, Tatiana A, Loginova, Maria M, Epifanova, Ekaterina, Babaev, Alexey A, Tarabykin, Victor S, Vedunova, Maria V
المصدر: Oxidative Medicine and Cellular Longevity, 2019, 1036907 (2019)
مصطلحات موضوعية: Glial Cell Line-Derived Neurotrophic Factor, Hypoxia-Inducible Factor 1, alpha Subunit, Neuroprotective Agents, Protein Kinase Inhibitors, EC 2.7.10.1 (Proto-Oncogene Proteins c-ret), EC 2.7.11.1 (Proto-Oncogene Proteins c-akt), SY7Q814VUP (Calcium), Animals, Calcium/metabolism, Cell Hypoxia, Cell Survival/drug effects, Cells, Cultured, Glial Cell Line-Derived Neurotrophic Factor/pharmacology, Hippocampus/cytology/drug effects/metabolism/ultrastructure, Hypoxia-Inducible Factor 1, alpha Subunit/genetics/metabolism, Mice, Mitochondria/drug effects/metabolism, Neuroprotective Agents/pharmacology, Phosphatidylinositol 3-Kinases/metabolism, Protein Kinase Inhibitors/pharmacology, Proto-Oncogene Proteins c-akt/metabolism, Proto-Oncogene Proteins c-ret/antagonists & inhibitors/metabolism, Signal Transduction/drug effects, Life sciences, Anatomy (cytology, histology, embryology...) & physiology, Sciences du vivant, Anatomie (cytologie, histologie, embryologie...) & physiologie
Relation: urn:issn:1942-0900; urn:issn:1942-0994
URL الوصول: https://orbi.uliege.be/handle/2268/303076
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المؤلفون: Hengjing Cui, Susanna Norrbacka, Freke Mertens, Timo T. Myöhänen
المساهمون: Faculty of Pharmacy, Divisions of Faculty of Pharmacy, Division of Pharmacology and Pharmacotherapy, Drug Research Program, Regenerative pharmacology group, PREP in neurodegenerative disorders
المصدر: Myöhänen, T T, Mertens, F, Norrbacka, S & Cui, H 2021, ' Deletion or inhibition of prolyl oligopeptidase blocks lithium-induced phosphorylation of GSK3b and Akt by activation of protein phosphatase 2A ', Basic and Clinical Pharmacology and Toxicology, vol. 129, no. 4, pp. 287-296 . https://doi.org/10.1111/bcpt.13632
مصطلحات موضوعية: Proline, Lithium (medication), education, Oligopeptidase, Lithium, Glycogen Synthase Kinase 3 beta/metabolism, Toxicology, Lithium/pharmacology, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Okadaic Acid/pharmacology, 0302 clinical medicine, Cell Line, Tumor, Okadaic Acid, Proto-Oncogene Proteins c-akt/metabolism, medicine, Humans, Protein Phosphatase 2/antagonists & inhibitors, Inositol, Protein Phosphatase 2, Phosphorylation, Protein kinase B, GSK3B, Proline/analogs & derivatives, 030304 developmental biology, Pharmacology, 0303 health sciences, Tumor, Glycogen Synthase Kinase 3 beta, Chemistry, Phosphorylation/drug effects, Prolyl Oligopeptidases/antagonists & inhibitors, General Medicine, Protein phosphatase 2, Okadaic acid, Molecular biology, HEK293 Cells, 317 Pharmacy, Prolyl Oligopeptidases, Proto-Oncogene Proteins c-akt, 030217 neurology & neurosurgery, medicine.drug
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المؤلفون: Vera J. M. Nies, Dicky Struik, Sihao Liu, Weilin Liu, Janine K. Kruit, Michael Downes, Tim van Zutphen, Henkjan J. Verkade, Ronald M. Evans, Johan W. Jonker
المساهمون: Center for Liver, Digestive and Metabolic Diseases (CLDM), Health & Food
المصدر: Proceedings of the National Academy of Sciences of the United States of America, 119(40):e2122382119. NATL ACAD SCIENCES
مصطلحات موضوعية: Adipose Tissue, White/metabolism, Insulin/metabolism, Adipose Tissue, White, Fibroblast Growth Factor/metabolism, Mice, Glucose Transporter Type 4/genetics, 3T3-L1 Cells, Receptors, Proto-Oncogene Proteins c-akt/metabolism, Adipocytes, Glucose/metabolism, Animals, Insulin, Glucose Transporter Type 1/genetics, Glucose Transporter Type 1, Glucose Transporter Type 4, Multidisciplinary, Receptors, Fibroblast Growth Factor/metabolism, Receptors, Fibroblast Growth Factor, White/metabolism, Glucose, Adipose Tissue, Adipocytes/metabolism, Fibroblast Growth Factor 1, Proto-Oncogene Proteins c-akt, Fibroblast Growth Factor 1/genetics
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e743138547b0be6aab799b2becc0b11c
https://doi.org/10.1073/pnas.2122382119 -
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المؤلفون: Hai-Ying Mo, Qi-Yao Wei, Qiu-Hua Zhong, Xiao-Yun Zhao, Dan Guo, Jin Han, Wachiraporn Noracharttiyapot, Lydia Visser, Anke van den Berg, Yan-Ming Xu, Andy T. Y. Lau
المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL), Translational Immunology Groningen (TRIGR)
المصدر: International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7853
International Journal of Molecular Sciences, 23(14):7853. MDPI AGمصطلحات موضوعية: Lung Neoplasms, Cytochrome P-450 Enzyme System/genetics, Antineoplastic Agents, Apoptosis, IGF Type 1/genetics, Catalysis, Receptor, IGF Type 1, Cell Line, Inorganic Chemistry, Cytochrome P-450 Enzyme System, Cell Line, Tumor, Proto-Oncogene Proteins c-akt/metabolism, Humans, Physical and Theoretical Chemistry, Lung Neoplasms/drug therapy, Molecular Biology, Spectroscopy, Cell Proliferation, Tumor, Receptor, IGF Type 1/genetics, Organic Chemistry, General Medicine, CYP27C1, lung cancer, tumorigenesis, drug sensitivity, IGF-1R/Akt/p53 signaling, Computer Science Applications, Tumor Suppressor Protein p53/genetics, Tumor Suppressor Protein p53, Proto-Oncogene Proteins c-akt, Antineoplastic Agents/pharmacology, Receptor, Signal Transduction
وصف الملف: application/pdf
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المؤلفون: Marta Gil-Ortega, Beatriz Somoza, María S. Fernández-Alfonso, Marta Viana, M. Paz Lorenzo, Martín Alcalá, Thomas Unger, Raquel González-Blázquez, William A. Boisvert, Ulrike Muscha Steckelings
المساهمون: Bedrijfsbureau CD, RS: CARIM other
المصدر: González-Blázquez, R, Alcalá, M, Fernández-Alfonso, M S, Steckelings, U M, Lorenzo, M P, Viana, M, Boisvert, W, Unger, T, Ortega, M G & Somoza, B 2021, ' C21 preserves endothelial function in the thoracic aorta from DIO mice : role for AT2, Mas and B2 receptors ', Clinical Science, vol. 135, no. 9, pp. 1145-1163 . https://doi.org/10.1042/CS20210049
Clinical Science, 135(9), 1145-1163. Portland Press Ltd.مصطلحات موضوعية: Male, Receptor, Bradykinin B2, Drug Evaluation, Preclinical, Aorta, Thoracic, Vasodilation, Inbred C57BL, Proto-Oncogene Mas, Receptors, G-Protein-Coupled, Renin-Angiotensin System, Mice, Angiotensin, chemistry.chemical_compound, Bradykinin B2/metabolism, Signal Transduction/drug effects, Receptors, Proto-Oncogene Proteins c-akt/metabolism, Thoracic aorta, Thoracic/drug effects, Endothelial dysfunction, Receptor, Aorta, Vascular/drug effects, Imidazoles/pharmacology, Sulfonamides, Imidazoles, General Medicine, Receptor, Angiotensin, Type 2/agonists, Preclinical, Aorta, Thoracic/drug effects, Signal transduction, Signal Transduction, Type 2/agonists, Agonist, Endothelium, Vascular/drug effects, medicine.medical_specialty, Nitric Oxide Synthase Type III, Sulfonamides/pharmacology, medicine.drug_class, Bradykinin, Thiophenes/pharmacology, Thiophenes, Diet, High-Fat, Nitric Oxide, Cyclic AMP-Dependent Protein Kinases/metabolism, Receptor, Angiotensin, Type 2, Proto-Oncogene Proteins, medicine.artery, Internal medicine, Human Umbilical Vein Endothelial Cells, medicine, Animals, Humans, Endothelium, Obesity, Vascular Diseases, Receptor, Bradykinin B2/metabolism, Protein kinase B, G-Protein-Coupled/metabolism, Vascular Diseases/etiology, Nitric Oxide Synthase Type III/metabolism, Receptor Cross-Talk, Receptors, G-Protein-Coupled/metabolism, Proto-Oncogene Proteins/metabolism, medicine.disease, Cyclic AMP-Dependent Protein Kinases, Diet, Mice, Inbred C57BL, High-Fat, Endocrinology, chemistry, Renin-Angiotensin System/drug effects, Nitric Oxide/metabolism, Drug Evaluation, Endothelium, Vascular, Obesity/complications, Proto-Oncogene Proteins c-akt
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877a98634f9c9ee846c5eeeae1f14062
https://portal.findresearcher.sdu.dk/da/publications/d3fcf2be-7770-4967-9d40-5384bb58c9fe -
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المصدر: Biochemical and biophysical research communications, vol. 513, no. 3, pp. 546-552
مصطلحات موضوعية: 0301 basic medicine, Drug, media_common.quotation_subject, Biophysics, Antineoplastic Agents, Biochemistry, Receptor, IGF Type 1, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Neoplasms, medicine, Humans, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, media_common, Kinase, business.industry, TOR Serine-Threonine Kinases, Cancer, Cell Biology, medicine.disease, Discontinuation, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Phosphorylation, Antineoplastic Agents/pharmacology, HT29 Cells, Heterocyclic Compounds, 3-Ring/pharmacology, Neoplasms/enzymology, Neoplasms/pathology, Phosphoinositide-3 Kinase Inhibitors/pharmacology, Protein Kinase Inhibitors/pharmacology, Proto-Oncogene Proteins c-akt/antagonists & inhibitors, Proto-Oncogene Proteins c-akt/metabolism, Receptor, IGF Type 1/antagonists & inhibitors, TOR Serine-Threonine Kinases/antagonists & inhibitors, PI3K, Targeted therapies, Washout, mTOR, business, Heterocyclic Compounds, 3-Ring, Proto-Oncogene Proteins c-akt
وصف الملف: application/pdf
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المؤلفون: Eirini Sevdali, Violeta Block, Marie Lataretu, Huiying Li, Cristian R. Smulski, Jana-Susann Briem, Yannic Heitz, Beate Fischer, Neftali-Jose Ramirez, Bodo Grimbacher, Hans-Martin Jäck, Reinhard E. Voll, Martin Hölzer, Pascal Schneider, Hermann Eibel
المصدر: Cell reports, vol. 39, no. 13, pp. 111019
مصطلحات موضوعية: History, Phosphatidylinositol 3-Kinases, Polymers and Plastics, Memory B Cells, B-Cell Activating Factor, Humans, Receptors, Antigen, B-Cell, Business and International Management, Proto-Oncogene Proteins c-akt, Immunology, PI3K signaling, human memory B cells [B-Cell Activating Factor/immunology, B-Cell Activating Factor/metabolism, B-Cell Activation Factor Receptor/immunology, B-Cell Activation Factor Receptor/metabolism, Memory B Cells/immunology, Memory B Cells/metabolism, Phosphatidylinositol 3-Kinases/immunology, Phosphatidylinositol 3-Kinases/metabolism, Proto-Oncogene Proteins c-akt/immunology, Proto-Oncogene Proteins c-akt/metabolism, Receptors, Antigen, B-Cell/immunology, Receptors, Antigen, B-Cell/metabolism, BAFF, BAFFR, BCR, CP], Industrial and Manufacturing Engineering, General Biochemistry, Genetics and Molecular Biology, B-Cell Activation Factor Receptor
وصف الملف: application/pdf
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المؤلفون: Shao-Pei Hung, Wen-Chin Lee, Hsiang-Hao Hsu, Jin-Bor Chen, You-Ying Chau, Terry Ting-Yu Chiou
المصدر: Biomedicine & Pharmacotherapy, Vol 144, Iss, Pp 112349-(2021)
Chioua, T T-Y, Chau, Y-Y, Chen, J-B, Hsu, H-H, Huang, S-P & Lee, W-C 2021, ' Rapamycin attenuates PLA2R activation-mediated podocyte apoptosis via the PI3K/AKT/mTOR pathway ', Biomedicine and Pharmacotherapy, vol. 144 . https://doi.org/10.1016/j.biopha.2021.112349مصطلحات موضوعية: Membranous nephropathy, Apoptosis Regulatory Proteins/metabolism, Phospholipase A2 receptor, Podocyte, Apoptosis, RM1-950, Glomerulonephritis, Membranous, Cell Line, chemistry.chemical_compound, Downregulation and upregulation, Proto-Oncogene Proteins c-akt/metabolism, medicine, Humans, LY294002, Protein kinase B, PI3K/AKT/mTOR pathway, Sirolimus, MTOR Inhibitors/pharmacology, Pharmacology, TOR Serine-Threonine Kinases/antagonists & inhibitors, Mammalian target of rapamycin, biology, Podocytes, Chemistry, Receptors, Phospholipase A2, TOR Serine-Threonine Kinases, Cytochrome c, Apoptosis/drug effects, Sirolimus/pharmacology, MTOR Inhibitors, General Medicine, Enzyme Activation, Crosstalk (biology), Receptors, Phospholipase A2/metabolism, medicine.anatomical_structure, Cancer research, biology.protein, Therapeutics. Pharmacology, Phosphatidylinositol 3-Kinase, Podocytes/drug effects, Apoptosis Regulatory Proteins, Proto-Oncogene Proteins c-akt, Phosphatidylinositol 3-Kinase/metabolism, Glomerulonephritis, Membranous/drug therapy, Signal Transduction
وصف الملف: application/pdf
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المؤلفون: Raphael Gottardo, Khalid Ohmiti, Line Esteves-Leuenberger, Victor S. Joo, Alex Farina, Thibaut Decaillon, Céline Pellaton, Madeleine Suffiotti, Navina Rajah, Alessandra Noto, Juan-Luis Loredo-Varela, Winfried Weissenhorn, Craig Fenwick, Giuseppe Pantaleo
المساهمون: Service of Immunology and Allergy, Department of Medicine, Lausanne University Hospital, Institut de biologie structurale (IBS - UMR 5075 ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Division of Public Health Sciences, Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Journal of Experimental Medicine
Journal of Experimental Medicine, 2019, 216 (7), pp.jem.20182359. ⟨10.1084/jem.20182359⟩
The Journal of experimental medicine, vol. 216, no. 7, pp. 1525-1541
Journal of Experimental Medicine, Rockefeller University Press, 2019, 216 (7), pp.jem.20182359. ⟨10.1084/jem.20182359⟩
The Journal of Experimental Medicine
'Journal of Experimental Medicine ', vol: 216, pages: 1525-1541 (2019)مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Immunology, Programmed Cell Death 1 Receptor, CD8-Positive T-Lymphocytes, Jurkat cells, Epitope, Article, 03 medical and health sciences, Epitopes, Jurkat Cells, Mice, 0302 clinical medicine, Immune system, Antineoplastic Agents, Immunological, CD28 Antigens, medicine, Immunology and Allergy, Cytotoxic T cell, Animals, Humans, Research Articles, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Chemistry, NF-kappa B, CD28, Immunotherapy, Neoplasms, Experimental, 3. Good health, 030104 developmental biology, 030220 oncology & carcinogenesis, Antineoplastic Agents, Immunological/immunology, Antineoplastic Agents, Immunological/therapeutic use, CD28 Antigens/metabolism, CD8-Positive T-Lymphocytes/immunology, Epitopes/immunology, NF-kappa B/metabolism, Neoplasms, Experimental/immunology, Neoplasms, Experimental/therapy, Programmed Cell Death 1 Receptor/immunology, Proto-Oncogene Proteins c-akt/metabolism, Signal Transduction, Cancer research, Nivolumab, Signal transduction, Proto-Oncogene Proteins c-akt
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bdbad1211b199e4d0110777d2275bf9
https://hal.science/hal-02139677
Full Text via ClinicalKey