المؤلفون: Kanakkanthara A; Department of Oncology, Mayo Clinic, Rochester, Minnesota.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Kurmi K; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Ekstrom TL; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Hou X; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Purfeerst ER; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Heinzen EP; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Correia C; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Huntoon CJ; Department of Oncology, Mayo Clinic, Rochester, Minnesota., O'Brien D; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Wahner Hendrickson AE; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Dowdy SC; Division of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota., Li H; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Oberg AL; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Hitosugi T; Department of Oncology, Mayo Clinic, Rochester, Minnesota.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Kaufmann SH; Department of Oncology, Mayo Clinic, Rochester, Minnesota.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Weroha SJ; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Karnitz LM; Department of Oncology, Mayo Clinic, Rochester, Minnesota. karnitz.larry@mayo.edu.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota.

المصدر: Cancer research [Cancer Res] 2019 Dec 01; Vol. 79 (23), pp. 5920-5929. Date of Electronic Publication: 2019 Oct 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*pharmacology , BRCA1 Protein/*genetics , Carcinoma, Ovarian Epithelial/*drug therapy , Nicotinamide N-Methyltransferase/*metabolism , Ovarian Neoplasms/*drug therapy, Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; BRCA1 Protein/deficiency ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/pathology ; Cell Line, Tumor ; Cyclin-Dependent Kinases/genetics ; DNA Methylation ; Energy Metabolism/drug effects ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Hydrazones/pharmacology ; Hydrazones/therapeutic use ; Hydroxybenzoates/pharmacology ; Hydroxybenzoates/therapeutic use ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mutation ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Ovary/pathology ; Oxidative Phosphorylation/drug effects ; Promoter Regions, Genetic/genetics ; Tigecycline/pharmacology ; Tigecycline/therapeutic use ; Triazoles/pharmacology ; Triazoles/therapeutic use ; Up-Regulation ; Xenograft Model Antitumor Assays