المؤلفون: Worley, Matthew J, Heinzerling, Keith G, Roche, Daniel J O, Shoptaw, Steve

المصدر: Drug and alcohol dependence. 162

مصطلحات موضوعية: Adult, Amphetamine-Related Disorders: drug therapy, psychology, Cross-Over Studies, Double-Blind Method, Female, Humans, Inpatients, Male, Methamphetamine: antagonists & inhibitors, Middle Aged, Pyridines: pharmacology, Reward, Self Administration, Vasodilator Agents: pharmacology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7jb7d9rq

المؤلفون: Dunning, D D, Hoover, C L, Soltesz, I, Smith, M A, O'Dowd, Diane K

المصدر: Journal of neurophysiology. 82(6)

مصطلحات موضوعية: Animals, Animals, Newborn, Biophysical Phenomena, Biophysics, Cerebral Cortex: cytology, growth & development, Electric Stimulation, Electrophysiology, Excitatory Postsynaptic Potentials: physiology, Hypnotics and Sedatives: pharmacology, Immunohistochemistry, Kinetics, Membrane Potentials: physiology, Mice, Mice, Inbred ICR, Patch-Clamp Techniques, Pyridines: pharmacology, Receptors, GABA-A: biosynthesis, genetics, physiology, Reverse Transcriptase Polymerase Chain Reaction, Synaptic Transmission: physiology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/15f257tg

المؤلفون: Konrad, David, Haney, Michael, Johansson, Göran, Wanecek, Michael, Weitzberg, Eddie, Oldner, Ander

المصدر: Am J Physiol Heart Circ Physiol. 293(2):H988-96

مصطلحات موضوعية: Animals, Blood Pressure/drug effects, Cardiovascular Agents/*pharmacology/therapeutic use, Coronary Circulation/drug effects, Disease Models, Animal, Endothelin-1/blood, Endotoxemia/chemically induced/*drug therapy/metabolism/physiopathology, Endotoxins, Female, Heart Rate/drug effects, Myocardial Contraction/drug effects, Oxygen Consumption/drug effects, Pyridines/*pharmacology/therapeutic use, Receptor, Endothelin A/*antagonists & inhibitors/metabolism, Endothelin B/*antagonists & inhibitors/metabolism, Sus scrofa, Tetrazoles/*pharmacology/therapeutic use, Time Factors, Ventricular Function, Left/*drug effects, Ventricular Pressure/drug effects

وصف الملف: electronic

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-7146
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17400719&dopt=Citation
https://umu.diva-portal.org/smash/get/diva2:146817/FULLTEXT01.pdf

المؤلفون: Piltti, Juha

المساهمون: Umeå universitet. Institutionen för integrativ medicinsk biologi

مصطلحات موضوعية: Rho-kinase inhibition, Y-27632, Hypoxia, Cyclic stretching, Human chondrosarcoma 2/8 cells, Chondrocyte phenotype, Fibroblasts, Proteomics, Protein pathway analytics, Amides -- pharmacology, Fibroblasts -- cytology, Protein kinase inhibitors -- pharmacology, Pyridines -- pharmacology, rho-associated kinases -- antagonists & inhibitors, Chondrocytes -- metabolism, Chondrosarcoma -- metabolism, Chondrosarcoma -- pathology, Mitogen-activated protein kinases -- metabolism, Peptide elongation factor 2 -- metabolism, Phosphoproteins -- metabolism, Proteomics

URL الوصول: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133851

Degree: Diss. (sammanfattning) Umeå : Umeå universitet, 2017

المؤلفون: Pancholi, Sunil, Ribas, Ricardo, Simigdala, Nikiana, Schuster, Eugene, Nikitorowicz-Buniak, Joanna, Ressa, Anna, Gao, Qiong, Leal, Mariana Ferreira, Bhamra, Amandeep, Thornhill, Allan, Morisset, Ludivine, Montaudon, Elodie, Sourd, Laura, Fitzpatrick, Martin, Altelaar, Maarten, Johnston, Stephen R, Marangoni, Elisabetta, Dowsett, Mitch, Martin, Lesley-Ann, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics

المساهمون: Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics

المصدر: Oncogene, 39(25), 4781. Nature Publishing Group
Oncogene

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cancer Research, Fulvestrant/administration & dosage, Pyridines, Nude, Drug Resistance, Cyclin-Dependent Kinase 4/genetics, Drug Resistance, Neoplasm/drug effects, Retinoblastoma Protein, Piperazines, Tamoxifen/administration & dosage, Mice, Breast cancer, 0302 clinical medicine, Neoplasm/drug effects, Antineoplastic Combined Chemotherapy Protocols, Receptors, Kinome, Piperazines/pharmacology, Fulvestrant, Inbred BALB C, Pyridines/pharmacology, Mice, Inbred BALB C, Tumor, Cyclin-Dependent Kinase 6/genetics, biology, Receptors, Estrogen/genetics, Cell cycle, Wee1, Receptors, Estrogen, 030220 oncology & carcinogenesis, MCF-7 Cells, Female, RNA Interference, medicine.drug, Mice, Nude, Breast Neoplasms, Breast Neoplasms/genetics, Palbociclib, Antineoplastic Combined Chemotherapy Protocols/pharmacology, Article, Cell Line, 03 medical and health sciences, Cell Line, Tumor, Genetics, medicine, Animals, Humans, Cancer models, Protein Kinase Inhibitors, Molecular Biology, Retinoblastoma Protein/genetics, Cyclin-Dependent Kinase 4, Estrogen/genetics, Cyclin-Dependent Kinase 6, Xenograft Model Antitumor Assays, Tamoxifen, 030104 developmental biology, Xenograft Model Antitumor Assays/methods, Drug Resistance, Neoplasm, Protein Kinase Inhibitors/pharmacology, biology.protein, Cancer research, TSC2

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83726164166fa3f899deca8969edd34c
https://doi.org/10.1038/s41388-020-1284-6

المؤلفون: Chanyi Lu, Xiaoli Lin, Jumpei Yamashita, Ranhui Xi, Minliang Zhou, Yali V. Zhang, Hong Wang, Robert F. Margolskee, Bon-Kyoung Koo, Hans Clevers, Ichiro Matsumoto, Peihua Jiang

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research

المصدر: Stem Cell Reports, 17(2), 369-383. Cell Press

مصطلحات موضوعية: Glossopharyngeal Nerve/surgery, Pyridines, Knockout, Ubiquitin-Protein Ligases, Benzeneacetamides, Inbred C57BL, Taste Buds/metabolism, Biochemistry, Epithelium, Mice, Tongue, Wnt Signaling Pathway/drug effects, Genetics, Stem Cells/cytology, Animals, Wnt Signaling Pathway, Ubiquitin-Protein Ligases/deficiency, Glossopharyngeal Nerve, Tongue/cytology, Pyridines/pharmacology, Mice, Knockout, Taste/physiology, Stem Cells, Cell Biology, Benzeneacetamides/pharmacology, Taste Buds, Epithelium/metabolism, Mice, Inbred C57BL, Taste, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fbbb32fc7ce9e25325c3bf90b0952a
https://pubmed.ncbi.nlm.nih.gov/34995498

المؤلفون: Sabina S Cosulich, Abigail Shea, Maurizio Callari, A. Dariush, Elena Provenzano, Martin O'Reilly, Carlos Caldas, Dimitra Georgopoulou, Agnese Giovannetti, Oscar M. Rueda, Gregory J. Hannon, Suet-Feung Chin, Giulia Lerda, Elham Esmaeilishirazifard, Alistair Martin, Violeta Serra, Fatime Qosaj, Wendy Greenwood, Dario Bressan, Larissa S. Carnevalli, Alejandra Bruna, H. Raza Ali, Gordon B. Mills

المساهمون: Rueda, Oscar M [0000-0003-0008-4884], Giovannetti, Agnese [0000-0001-5207-7243], Chin, Suet-Feung [0000-0001-5697-1082], Carnevalli, Larissa S [0000-0001-7432-0195], Provenzano, Elena [0000-0003-3345-3965], Serra, Violeta [0000-0001-6620-1065], Bressan, Dario [0000-0003-3592-699X], Mills, Gordon B [0000-0002-0144-9614], Ali, H Raza [0000-0001-7587-0906], Caldas, Carlos [0000-0003-3547-1489], Apollo - University of Cambridge Repository, IMAXT Consortium, Ali, H.R., Al Sa'd, M., Alon, S., Aparicio, S., Battistoni, G., Balasubramanian, S., Becker, R., Bodenmiller, B., Boyden, E.S., Bressan, D., Bruna, A., Burger, M., Caldas, C., Callari, M., Cannell, I.G., Casbolt, H., Chornay, N., Cui, Y., Dariush, A., Dinh, K., Emenari, A., Eyal-Lubling, Y., Fan, J., Fatemi, A., Fisher, E., González-Solares, E.A., González-Fernández, C., Goodwin, D., Greenwood, W., Grimaldi, F., Hannon, G.J., Harris, O., Harris, S., Jauset, C., Joyce, J.A., Karagiannis, E.D., Kovačević, T., Kuett, L., Kunes, R., Küpcü, Y.A., Lai, D., Laks, E., Lee, H., Lee, M., Lerda, G., Li, Y., McPherson, A., Millar, N., Mulvey, C.M., Nugent, F., O'Flanagan, C.H., Paez-Ribes, M., Pearsall, I., Qosaj, F., Roth, A.J., Rueda, O.M., Ruiz, T., Sawicka, K., Sepúlveda, L.A., Shah, S.P., Shea, A., Sinha, A., Smith, A., Tavaré, S., Tietscher, S., Vázquez-García, I., Vogl, S.L., Walton, N.A., Wassie, A.T., Watson, S.S., Weselak, J., Wild, S.A., Williams, E., Windhager, J., Whitmarsh, T., Xia, C., Zheng, P., Zhuang, X.

المصدر: Nature Communications
Nature communications, vol. 12, no. 1, pp. 1998
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

مصطلحات موضوعية: 0301 basic medicine, Pyridines, Science, Tumour heterogeneity, Morpholines, Cell, General Physics and Astronomy, Breast Neoplasms, Drug resistance, Mice, SCID, Biology, Animals, Benzamides/pharmacology, Breast Neoplasms/drug therapy, Breast Neoplasms/genetics, Breast Neoplasms/metabolism, Cell Line, Tumor, Drug Resistance, Neoplasm/drug effects, Drug Resistance, Neoplasm/genetics, Female, Heterografts/drug effects, Heterografts/metabolism, Humans, MCF-7 Cells, Mice, Inbred NOD, Mice, Knockout, Morpholines/pharmacology, Piperazines/pharmacology, Protein Kinase Inhibitors/pharmacology, Pyridines/pharmacology, Pyrimidines/pharmacology, Treatment Outcome, Xenograft Model Antitumor Assays/methods, General Biochemistry, Genetics and Molecular Biology, Article, Piperazines, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, medicine, Mass cytometry, Protein Kinase Inhibitors, Multidisciplinary, Genetic heterogeneity, Cancer, General Chemistry, medicine.disease, Biobank, Phenotype, Xenograft Model Antitumor Assays, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Pyrimidines, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Benzamides, Cancer research, Heterografts

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0712127e8562959156b1ae7983d647f

المؤلفون: Li, Qiao

مصطلحات موضوعية: Cell Death -- drug effects, Forkhead Transcription Factors -- genetics, Forkhead Transcription Factors -- metabolism, Telomerase -- genetics, Telomerase -- metabolism, Carrier Proteins -- genetics, Carrier Proteins -- metabolism, DNA Helicases -- genetics, DNA Helicases -- metabolism, Benzenesulfonates -- pharmacology, Benzenesulfonates -- therapeutic use, Pyridines -- pharmacology, Pyridines -- therapeutic use, Antineoplastic Agents -- pharmacology, Antineoplastic Agents -- therapeutic use, Cell Transformation, Neoplastic, Stomach Neoplasms -- genetics, Stomach Neoplasms -- therapy, Prostatic Neoplasms -- genetics, Prostatic Neoplasms -- therapy

Degree: Diss. (sammanfattning) Stockholm : Karolinska institutet, 2013

المؤلفون: Aakash Patel, Hala Guedouari, Elzbieta Janda, Karine Reybier, Istvan Gacsalyi, Vishalgiri Goswami, Jean A. Boutin, Adeline Giganti, Mathias Antoine, Monivan Chhour, Marie-Claude Viaud-Massuard, Hervé Da Costa, Marc Bertrand, Pierre Ducrot, Jérôme Paysant, Patrick P. Michel, Gilles Ferry, Thierry Le Diguarher, Daniel A. Kane, Françoise Nepveu, Frédéric Bouillaud, Karen Brebner, Gérald Guillaumet, Etienne C. Hirsch, Philippe Dupuis, Johann Stojko

المساهمون: Institut de Recherches SERVIER (IRS), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Università degli Studi 'Magna Graecia' di Catanzaro [Catanzaro, Italie] (UMG), Egis Pharmaceuticals, Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), St. Francis Xavier University (StFX), Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut de Recherche pour le Développement (IRD), Eurofins-Cerep, Technologie Servier, GICC UMR 7292 CNRS, IMT (Innovation moléculaire et thérapeutique) (IMT), Génétique, immunothérapie, chimie et cancer (GICC), UMR 7292 CNRS [2012-2017] (GICC UMR 7292 CNRS), Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Oxygen Healthcare Pvt Ltd, Institut de Recherches Internationales Servier [Suresnes] (IRIS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), GICC EA 7501, IMT (Innovation moléculaire et thérapeutique) (IMT), Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...] (GICC EA 7501), Université de Tours (UT)-Université de Tours (UT), Hirsch, Etienne, Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2019, 95 (3), pp.269-285. ⟨10.1124/mol.118.114231⟩
Molecular Pharmacology, 2019, 95 (3), pp.269-285. ⟨10.1124/mol.118.114231⟩

مصطلحات موضوعية: 0301 basic medicine, Male, Rats Wistar, Pyridines, [SDV]Life Sciences [q-bio], Quinone Reductases / antagonists & inhibitors, Reductase, Cell Membrane / drug effects, 03 medical and health sciences, Mice, 0302 clinical medicine, Pyrrolizidine Alkaloids / pharmacology, In vivo, Cell Line, Tumor, NAD(P)H Dehydrogenase (Quinone), [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, medicine, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Quinone Reductases, Rats, Wistar, NAD(P)H Dehydrogenase (Quinone) / metabolism, Pyrrolizidine Alkaloids, Pharmacology, chemistry.chemical_classification, Reactive oxygen species, Chemistry, Cell Membrane, Autophagy, Neurodegeneration, Reactive Oxygen Species / metabolism, Hep G2 Cells, Cell Membrane / metabolism, medicine.disease, Quinone, Cell Line / Tumor, Rats, [SDV] Life Sciences [q-bio], 030104 developmental biology, Enzyme, Biochemistry, Molecular Medicine, NAD+ kinase, Reactive Oxygen Species, 030217 neurology & neurosurgery, Pyridines / pharmacology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c332ae7dd4579c5014783569d4574301
https://www.hal.inserm.fr/inserm-02334766

المؤلفون: Dangxiao Cheng, Zhuo Chen, Henry Thai, Trevor Morey, Laurie Ailles, Osvaldo Espin-Garcia, Joerg Schwock, Lucy Liu, Helen Mackay, Hala Girgis, Jennifer Teichman, Geoffrey Liu, Andrew Fleet, Gail Darling, Wei Xu, Madison McGregor, Yuyao Song, Robert G. Bristow, Yonathan Brhane, Lorin Dodbiba

المصدر: PLoS ONE
Teichman, J, Dodbiba, L, Thai, H, Fleet, A, Morey, T, Liu, L, McGregor, M, Cheng, D, Chen, Z, Darling, G, Brhane, Y, Song, Y, Espin-Garcia, O, Xu, W, Girgis, H, Schwock, J, MacKay, H, Bristow, R, Ailles, L & Liu, G 2018, ' Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma ', PLoS ONE, vol. 13, no. 5, pp. e0194809 . https://doi.org/10.1371/journal.pone.0194809
PLoS ONE, Vol 13, Iss 5, p e0194809 (2018)

مصطلحات موضوعية: 0301 basic medicine, Cancer Treatment, lcsh:Medicine, Gene Expression, Mice, SCID, Epithelium, Cell Proliferation/drug effects, Mice, 0302 clinical medicine, Radiation sensitivity, Cell Signaling, Mice, Inbred NOD, Tumor Cells, Cultured, Medicine and Health Sciences, lcsh:Science, Pyridines/pharmacology, Multidisciplinary, Manchester Cancer Research Centre, Chemistry, Pharmaceutics, Chemoradiotherapy, Animal Models, Esophageal cancer, Hedgehog signaling pathway, medicine.anatomical_structure, Oncology, Experimental Organism Systems, 030220 oncology & carcinogenesis, Monoclonal, Signal transduction, Esophageal Neoplasms/drug therapy, Anatomy, Research Article, Signal Transduction, Hedgehog Proteins/antagonists & inhibitors, Clinical Oncology, endocrine system, Radiation Therapy, Mouse Models, Radiation Tolerance/drug effects, Research and Analysis Methods, 03 medical and health sciences, Cancer Chemotherapy, Model Organisms, Esophagus, Drug Therapy, Adenocarcinoma/drug therapy, Radioresistance, medicine, Genetics, Animals, Humans, Chemotherapy, Hedgehog, ResearchInstitutes_Networks_Beacons/mcrc, lcsh:R, Apoptosis/drug effects, Biology and Life Sciences, Cell Biology, medicine.disease, Xenograft Model Antitumor Assays, Gastrointestinal Tract, 030104 developmental biology, Biological Tissue, Gene Expression Regulation, Neoplastic/drug effects, Cancer research, Hedgehog Signaling, lcsh:Q, Biphenyl Compounds/pharmacology, Clinical Medicine, Combination Chemotherapy, Digestive System

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba143b2fd9699ec9f7d0ce18b82f7ba
http://europepmc.org/articles/PMC5929523