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المساهمون: Cardiology, ACS - Heart failure & arrhythmias
المصدر: Heart rhythm, 17(9), 1487-1492. Elsevier
Heart Rhythmمصطلحات موضوعية: DI-SCD, drug-induced sudden cardiac death, QTc, heart rate-corrected QT interval, medicine.medical_specialty, Long QT syndrome, Pneumonia, Viral, Population, Torsades de pointes, DI-TdP, drug-induced torsades de pointes, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, QT interval, Article, Sudden cardiac death, SIDS, sudden infant death syndrome, Betacoronavirus, and sudden cardiac death, DI-LQTS, drug-induced long QT syndrome, APD, action potential duration, Physiology (medical), VA, ventricular arrhythmia, Epidemiology, Genetics, medicine, Humans, Genetic Predisposition to Disease, education, Pandemics, LQT3, type 3 long QT syndrome, education.field_of_study, SARS-CoV-2, business.industry, Mortality rate, COVID-19, Hydroxychloroquine, medicine.disease, FDA, Food and Drug Administration, Black or African American, IL-6, interleukin 6, Death, Sudden, Cardiac, SCD, sudden cardiac death, Health disparities, Coronavirus Infections, Cardiology and Cardiovascular Medicine, business, COVID-19, coronavirus disease 19, Demography, medicine.drug
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المؤلفون: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez
المصدر: Toxicology and Applied Pharmacology
مصطلحات موضوعية: 0301 basic medicine, ICH, The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use, TN, True Negative, PPV, Positive Predictive Value, Pharmacology, TdP, Torsade de Pointes, Toxicology, Membrane Potentials, 0302 clinical medicine, HTS, High Throughput Screening, QTcVdW, Van de Water's Heart Rate QT-corrected Interval, In Silico modeling, Medicine, Translational PKPD modeling, NCEs, New Chemical Entities, CTD90, Ca2+-Transient Duration at 90% repolarization, education.field_of_study, Anesthetized Cardiovascular Guinea Pig, HR, Heart Rate, PNV, Predictive Negative Value, Safety pharmacology, ECG, Electrocardiogram, FIH, First in Human, IKr, rapidly-activating delayed rectifier potassium current, AP, Action Potential, QTc, Heart Rate corrected QT Interval, PX, PatchXpress®, 030220 oncology & carcinogenesis, Electrophysiologic Techniques, Cardiac, FP, False Positive, LVP, Left Ventricular Pressure, Anti-Arrhythmia Agents, In silico, Population, Guinea Pigs, QT interval, Models, Biological, Article, Ventricular action potential, Cell Line, CVGP, Cardiovascular Anesthetized Guinea Pig, GP, Guinea Pig, 03 medical and health sciences, hERG, Human Ether-a-go-go Related Gene, Pharmacokinetics, In vivo, Animals, Humans, Computer Simulation, education, QT corrected interval, BP, Blood Pressure, business.industry, M5P, M5 trees automated pruning model, tPKPD, thranslational pharmacokinetic/pharmacodynamic, FLIPR, Fluorescent Imaging Plate Reader, Arrhythmias, Cardiac, ORd, O'Hara Rudy model, Electrophysiological Phenomena, 030104 developmental biology, HEK293 Cells, Models, Chemical, Pharmacodynamics, Torsade de Pointes, EMw, Electromechanical window, FN, False Negative, TP, True Positive, Calcium, Calcium Channels, LOO, Leave-One-Out, business, APD90, Action Potential Duration at 90% repolarization