المؤلفون: Luc Pilotte, Benoit J Van den Eynde, Jingjing Zhu, Christine Sers, Marie Solvay, Pauline Holfelder, Simon Klaessens, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphaël Frédérick, Etienne De Plaen, Christiane A Opitz

المصدر: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://jitc.bmj.com/content/11/6/e006728.full; https://doaj.org/toc/2051-1426

URL الوصول: https://doaj.org/article/8b5d6705c624408ca6c9425808c1b3f5

المؤلفون: Quentin Spillier, Séverine Ravez, Simon Dochain, Didier Vertommen, Léopold Thabault, Olivier Feron, Raphaël Frédérick

المصدر: Molecules, Vol 26, Iss 2, p 477 (2021)

مصطلحات موضوعية: PHGDH, diazirine, photoaffinity labeling, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/2/477; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/397fdc8286c44ecab44d04acdbe41aea

المؤلفون: Quentin Spillier, Séverine Ravez, Judith Unterlass, Cyril Corbet, Charline Degavre, Olivier Feron, Raphaël Frédérick

المصدر: Pharmaceuticals, Vol 13, Iss 2, p 20 (2020)

مصطلحات موضوعية: phgdh, α-ketothioamides, serine synthesis pathway inhibitors, Medicine, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1424-8247/13/2/20; https://doaj.org/toc/1424-8247

URL الوصول: https://doaj.org/article/9c98f002cc4a4f8fae8c764f82e6ce92

المؤلفون: Marie Solvay, Pauline Pfänder, Simon Klaessens, Luc Pilotte, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphaël Frédérick, Etienne De Plaen, Christine Sers, Christiane A. Opitz, Benoit J. Van den Eynde, Jing-Jing Zhu

المساهمون: UCL - SSS/DDUV/GECE - Génétique cellulaire, UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Journal for ImmunoTherapy of Cancer, Vol. 11, no. 6, p. e006728 (2023)

مصطلحات موضوعية: Pharmacology, Cancer Research, Oncology, Immunology, Molecular Medicine, Immunology and Allergy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb910b1a5937411c7ca8b70616f19263
https://hdl.handle.net/2078.1/275939

المؤلفون: Quentin Spillier, Raphaël Frédérick

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Expert Opinion on Therapeutic Patents, Vol. 31, no. 7, p. 597-608 (2021)

مصطلحات موضوعية: Antineoplastic Agents, Dehydrogenase, Biology, 01 natural sciences, Serine synthetic pathway, cancer metabolism, phosphoglycerate dehydrogenase, targeted therapies, Patents as Topic, Serine, 03 medical and health sciences, 0302 clinical medicine, Drug Development, In vivo, Neoplasms, Drug Discovery, medicine, Animals, Humans, Gene silencing, Phosphoglycerate dehydrogenase, Enzyme Inhibitors, Phosphoglycerate Dehydrogenase, Pharmacology, chemistry.chemical_classification, Cancer, General Medicine, medicine.disease, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, 030220 oncology & carcinogenesis, Cancer research

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efd694f05e496106da62c2b45a55be1
https://doi.org/10.1080/13543776.2021.1890028

المؤلفون: Robert S. Banh, Esther S. Kim, Quentin Spillier, Douglas E. Biancur, Keisuke Yamamoto, Albert S. W. Sohn, Guangbin Shi, Drew R. Jones, Alec C. Kimmelman, Michael E. Pacold

المصدر: Nature, Nature. 597(7876):420-425

الإتاحة: https://ideas.repec.org/a/nat/nature/v597y2021i7876d10.1038_s41586-021-03865-w.html

المؤلفون: Didier Vertommen, Romain Marteau, Quentin Thémans, Séverine Ravez, Quentin Spillier, Raphaël Frédérick, Cyril Corbet, Olivier Feron, Johan Wouters

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UNamur - SCHI_GCPTS (groupe de chimie physique, théorique et structurale), UCL - SSS/DDUV/PHOS - Protein phosphorylation, UCL - SSS/IREC - Institut de recherche expérimentale et clinique

المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Spillier, Q, Vertommen, D, Ravez, S, Marteau, R, Thémans, Q, Corbet, C, Feron, O, Wouters, J & Frédérick, R 2019, ' Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation ', Scientific Reports, vol. 9, no. 1, 4737 . https://doi.org/10.1038/s41598-019-41187-0
Scientific Reports, Vol. 9, no. 1, p. 4737 (2019)

مصطلحات موضوعية: 0301 basic medicine, lcsh:Medicine, Antineoplastic Agents, Article, Serine, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Disulfiram, medicine, Humans, Cysteine, Phosphoglycerate dehydrogenase, lcsh:Science, Phosphoglycerate Dehydrogenase, chemistry.chemical_classification, Multidisciplinary, Mutagenesis, lcsh:R, Drug Repositioning, Drug repositioning, 030104 developmental biology, Enzyme, Mechanism of action, chemistry, Biochemistry, lcsh:Q, Protein Multimerization, medicine.symptom, Oxidation-Reduction, 030217 neurology & neurosurgery, Alcohol Deterrents, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da487061661e0a8a67a1ee8e9accf1e5
http://link.springer.com/article/10.1038/s41598-019-41187-0

المؤلفون: Albert S. W. Sohn, Keisuke Yamamoto, Quentin Spillier, Michael E. Pacold, Guangbin Shi, Robert S. Banh, Esther S. Kim, Alec C. Kimmelman, Drew R. Jones, Douglas E. Biancur

المصدر: Nature

مصطلحات موضوعية: Coenzyme Q10, chemistry.chemical_classification, Multidisciplinary, Ubiquinone, Biomolecule, Mice, Nude, 4-Hydroxyphenylpyruvate Dioxygenase, Article, Cell Line, chemistry.chemical_compound, Metabolic pathway, Mice, Metabolomics, chemistry, Biosynthesis, Biochemistry, Cell culture, Metabolome, Animals, Humans, Mandelic Acids, Tyrosine, Female, Function (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016c0d50b705c5e084c73dc631830716
https://pubmed.ncbi.nlm.nih.gov/34471290

المؤلفون: Raphaël Frédérick, Olivier Feron, Romain Marteau, Séverine Ravez, Quentin Spillier

المصدر: Journal of Medicinal Chemistry. 60:1227-1237

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Drug discovery, Cancer, Biology, medicine.disease, Serine, 03 medical and health sciences, 030104 developmental biology, Enzyme, chemistry, Biochemistry, RNA interference, Drug Discovery, Cancer cell, medicine, Molecular Medicine, Phosphoserine Aminotransferase, Phosphoglycerate dehydrogenase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d20a244de1ff5375f90ab1164836df23
https://doi.org/10.1021/acs.jmedchem.6b01167

المؤلفون: Raphaël Frédérick, Quentin Spillier, Simon Dochain, Séverine Ravez, Léopold Thabault, Olivier Feron, Didier Vertommen

المصدر: Molecules
Molecules, Vol 26, Iss 477, p 477 (2021)
Volume 26
Issue 2

مصطلحات موضوعية: diazirine, Allosteric regulation, Pharmaceutical Science, Mass Spectrometry, Article, Analytical Chemistry, lcsh:QD241-441, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, lcsh:Organic chemistry, Protein Domains, Drug Discovery, Humans, Aspartate Kinase, Phosphoglycerate dehydrogenase, Enzyme Inhibitors, Physical and Theoretical Chemistry, Binding site, PHGDH, Phosphoglycerate Dehydrogenase, 030304 developmental biology, 0303 health sciences, Binding Sites, Molecular Structure, Photoaffinity labeling, Chemistry, Organic Chemistry, Rational design, Diazomethane, Drug development, Biochemistry, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Diazirine, Molecular Medicine, Allosteric Site, photoaffinity labeling, Chorismate Mutase, Binding domain

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2b9452e418c2a64a65f8f3c405e9d4
https://doi.org/10.3390/molecules26020477