يعرض 1 - 10 نتائج من 70 نتيجة بحث عن '"Quinolines chemistry"', وقت الاستعلام: 2.08s تنقيح النتائج
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    المصدر: Alonso, C, Fuertes, M, Martín-Encinas, E, Selas, A, Rubiales, G, Tesauro, C, Knudssen, B K & Palacios, F 2018, ' Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity ', European Journal of Medicinal Chemistry, vol. 149, pp. 225-237 . https://doi.org/10.1016/j.ejmech.2018.02.058

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    المساهمون: Istituto Ortopedico Rizzoli [Bologna, Italy], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Centre National de la Recherche Scientifique (CNRS), Department of Medicinal Chemistry and Technologies, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], This work was funded by AIRC (IG 18451 to K. Scotlandi, IG 19162 to A. Mai), the Italian Ministry of Health (TRANSCAN_ project TORPEDO_ER-2015-23604059 to K. Scotlandi), Progetto Ateneo Sapienza (to A. Mai), PRIN 2016 (prot 20152TE5PK to A. Mai), and the NIH (R01GM114306 to A. Mai)., The authors thank Cristina Ghinelli for editing the manuscript., Manara, Maria Cristina, Valente, Sergio, Cristalli, Camilla, Nicoletti, Giordano, Landuzzi, Lorena, Zwergel, Clemen, Mazzone, Roberta, Stazi, Giulia, Arimondo, Paola B, Pasello, Michela, Guerzoni, Clara, Picci, Piero, Nanni, Patrizia, Lollini, Pier-Luigi, Mai, Antonello, Scotlandi, Katia

    المصدر: Molecular Cancer Therapeutics
    Molecular Cancer Therapeutics, American Association for Cancer Research, 2018, 17 (9), pp.1881-1892. ⟨10.1158/1535-7163.MCT-17-0818⟩

    مصطلحات موضوعية: 0301 basic medicine, Male, patient-derived xenograft (PDX), MESH: Osteosarcoma/genetics, MESH: Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Cellular differentiation, DNA Methyltransferase Inhibitor, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, chemotherapy, MESH: Mice, Knockout, 0302 clinical medicine, MESH: Osteosarcoma/drug therapy, Antineoplastic Combined Chemotherapy Protocols, MESH: Aminoquinolines/administration & dosage, MESH: Animals, MESH: Quinolines/chemistry, Enzyme Inhibitors, MESH: DNA (Cytosine-5-)-Methyltransferase 1/metabolism, Mice, Knockout, DNA methylation, Chemistry, 3. Good health, Tumor Burden, MESH: Benzamides/pharmacology, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Benzamides, oncology, Aminoquinolines, Quinolines, MESH: Cisplatin/administration & dosage, MESH: Bone Neoplasms/metabolism, Osteosarcoma, MESH: Doxorubicin/administration & dosage, epigenetic, MESH: Bone Neoplasms/genetics, medicine.drug, DNA (Cytosine-5-)-Methyltransferase 1, musculoskeletal diseases, MESH: Aminoquinolines/pharmacology, MESH: Cell Line, Tumor, DNA damage, MESH: Gene Expression Regulation, Neoplastic/drug effects, MESH: Tumor Burden/genetics, MESH: Xenograft Model Antitumor Assays, Bone Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, Cell Line, Tumor, osteosarcoma, medicine, Animals, Humans, Doxorubicin, MESH: DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors, MESH: Enzyme Inhibitors/chemistry, Cisplatin, MESH: Humans, Nucleoside inhibitor, medicine.disease, MESH: Enzyme Inhibitors/pharmacology, Xenograft Model Antitumor Assays, MESH: Male, MESH: Enzyme Inhibitors/administration & dosage, MESH: Bone Neoplasms/drug therapy, 030104 developmental biology, MESH: Osteosarcoma/metabolism, Cancer research, cancer research, MESH: DNA (Cytosine-5-)-Methyltransferase 1/genetics, MESH: Benzamides/administration & dosage, MESH: Tumor Burden/drug effects

    وصف الملف: STAMPA

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    المساهمون: Ministerio de Economía y Competitividad (España), Consejo Superior de Investigaciones Científicas (España), European Commission, Spanish National Research Council [Madrid] (CSIC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Instituto de Quimica Médica (CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)

    المصدر: Chemical Communications
    Chemical Communications, Royal Society of Chemistry, 2016, 52 (62), pp.9652-9655. ⟨10.1039/c6cc04566a⟩
    Digital.CSIC. Repositorio Institucional del CSIC
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    المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

    المصدر: Antimicrobial Agents and Chemotherapy, Vol. 55, no. 2, p. 649-658 (2011)

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    المساهمون: Laboratoire de Parasitologie, Centre National de Référence du Paludisme - Région Antilles-Guyane, Institut Pasteur de la Guyane - Réseau International des Instituts Pasteur - WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Broad Institute of MIT and Harvard, Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, Harvard School of Public Health, This work was supported by European Commission Grant REGPOT-CT-2011-285837-430 STRonGer (to S.P.), AgenceNationale de la Recherche Investissements d’Avenir Grant ANR-10-LABX-25-01(to S.P. and L.M.), NIH Grants R01AI50234 (to D.A.F.) and R01AI109023 (to D.A.F.),and the Institut de Veille Sanitaire. Sequencing was supported, in part, byNational Institute of Allergy and Infectious Diseases, NIH, Department ofHealth and Human Services Contract HHSN272200900018C., ANR-10-LABX-25-01/10-LABX-0025, CEBA, CEnter of the study of Biodiversity in Amazonia(2010), European Project : 285837, EC:FP7:REGPOT, FP7-REGPOT-2011-1, STRONGER(2011), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Columbia University College of Physicians and Surgeons, ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), European Project: 285837,EC:FP7:REGPOT,FP7-REGPOT-2011-1,STRONGER(2011), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Centre National de Référence du Paludisme - Laboratoire de parasitologie [Cayenne, Guyane française] (CNR)

    المصدر: Proceedings of the National Academy of Sciences of the United States of America
    Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (37), pp.11672-7
    Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (37), pp.11672-11677. ⟨10.1073/pnas.1507142112⟩
    Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (37), pp.11672-11677. ⟨10.1073/pnas.1507142112⟩

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    المساهمون: Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physiologie cérébrale (LPC - UMR 8118), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Chimie et Photonique Moléculaires (CPM), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Gallavardin, Thibault, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)

    المصدر: Organic Letters
    Organic Letters, 2012, 14 (24), pp.6366-6369. ⟨10.1021/ol3031704⟩
    Organic Letters, American Chemical Society, 2012, 14 (24), pp.6366-6369. ⟨10.1021/ol3031704⟩

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    المساهمون: Department of Bio-engineering Sciences, Structural Biology Brussels

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    المساهمون: Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, Schistosomiase, paludisme et inflammation, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Université Lille 2 - Faculté de Médecine, Université de Lille, Institut de Médecine Tropicale du Service de Santé des Armées (IMTSSA), Service de Santé des Armées, SANOFI Recherche, Pharmacochimie (EA2962), Université Bordeaux Segalen - Bordeaux 2, This work was supported by Sanofi Aventis (fellowship attributed to W.D.), by the 'Fondation des Treilles' (fellowship attributed to W.D.) by the CNRS, by the Universités de Lille I and Lille II, and by the Inserm. A BDI fellowship from CNRS and Region Nord-Pas-de-Calais to N.C. is also gratefully acknowledged., C.B. thanks Timothy J. Egan for stimulating discussions and careful reading of the manuscript. L. Maciejewski is acknowledged for helpful discussions. I. Ricard, L. Cattiaux, H. Kalamou, and D. Lamberton are acknowledged for their expert technical intervention., Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Faculté de Médecine Henri Warembourg - Université de Lille

    المصدر: Journal of Medicinal Chemistry
    Journal of Medicinal Chemistry, American Chemical Society, 2006, 49, pp.4707-4714. ⟨10.1021/jm060259d⟩
    Journal of Medicinal Chemistry, 2006, 49, pp.4707-4714. ⟨10.1021/jm060259d⟩

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