المؤلفون: Akashita G; Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Teikyo University, Tokyo, Japan., Nakatani E; Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Teikyo University, Tokyo, Japan., Tanaka S; Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Teikyo University, Tokyo, Japan., Okura T; Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Teikyo University, Tokyo, Japan. Electronic address: okura@pharm.teikyo-u.ac.jp.

المصدر: Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2024 May-Jun; Vol. 127, pp. 107518. Date of Electronic Publication: 2024 May 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 9206091 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-488X (Electronic) Linking ISSN: 10568719 NLM ISO Abbreviation: J Pharmacol Toxicol Methods Subsets: MEDLINE

مواضيع طبية MeSH: Tandem Mass Spectrometry*/methods , Antipsychotic Agents*/administration & dosage , Receptors, Dopamine D2*/metabolism , Rats, Sprague-Dawley* , Receptors, Muscarinic*/metabolism , Receptors, Muscarinic*/drug effects , Receptors, Histamine H1*/metabolism , Olanzapine*/pharmacokinetics , Olanzapine*/administration & dosage, Animals ; Rats ; Male ; Chromatography, Liquid/methods ; Brain/metabolism ; Brain/drug effects ; Benzodiazepines/analysis ; Benzodiazepines/metabolism ; Benzodiazepines/pharmacokinetics ; Raclopride/metabolism ; Doxepin/pharmacokinetics ; Quinuclidinyl Benzilate/metabolism ; Dose-Response Relationship, Drug

المؤلفون: Dlabkova A; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences in Hradec Kralove, University of Defence, Brno, Czech Republic., Herman D; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences in Hradec Kralove, University of Defence, Brno, Czech Republic., Cechova L; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences in Hradec Kralove, University of Defence, Brno, Czech Republic.; Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy, Charles University, Prague, Czech Republic., Hroch M; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Prague, Czech Republic., Vanova N; Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy, Charles University, Prague, Czech Republic., Zdarova Karasova J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences in Hradec Kralove, University of Defence, Brno, Czech Republic.

المصدر: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2021 Sep; Vol. 129 (3), pp. 246-255. Date of Electronic Publication: 2021 Jun 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Blackwell Country of Publication: England NLM ID: 101208422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-7843 (Electronic) Linking ISSN: 17427835 NLM ISO Abbreviation: Basic Clin Pharmacol Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Muscarinic Antagonists/*metabolism , Muscarinic Antagonists/*toxicity , Quinuclidinyl Benzilate/*metabolism , Quinuclidinyl Benzilate/*toxicity, Animals ; Bile/metabolism ; Brain/metabolism ; Male ; Metabolome ; Muscarinic Antagonists/blood ; Muscarinic Antagonists/urine ; Quinuclidinyl Benzilate/blood ; Quinuclidinyl Benzilate/urine ; Rats ; Rats, Wistar ; Toxicokinetics ; Urine

المؤلفون: Herman D; Department of Toxicology and Military Pharmacy, University of Defense Faculty of Military Health Sciences, Czech Republic., Dlabkova A; Department of Toxicology and Military Pharmacy, University of Defense Faculty of Military Health Sciences, Czech Republic., Cechova L; Department of Toxicology and Military Pharmacy, University of Defense Faculty of Military Health Sciences, Czech Republic., Vanova N; Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Charles University Faculty of Pharmacy in Hradec Kralove, Czech Republic., Misik J; Department of Toxicology and Military Pharmacy, University of Defense Faculty of Military Health Sciences, Czech Republic., Jun D; Department of Toxicology and Military Pharmacy, University of Defense Faculty of Military Health Sciences, Czech Republic., Zdarova Karasova J; Department of Toxicology and Military Pharmacy, University of Defense Faculty of Military Health Sciences, Czech Republic.

المصدر: Drug testing and analysis [Drug Test Anal] 2020 Apr; Vol. 12 (4), pp. 431-438. Date of Electronic Publication: 2020 Jan 10.

نوع المنشور: Journal Article; Validation Study

بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 101483449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-7611 (Electronic) Linking ISSN: 19427603 NLM ISO Abbreviation: Drug Test Anal Subsets: MEDLINE

مواضيع طبية MeSH: Cholinergic Antagonists/*blood , Quinuclidinyl Benzilate/*blood, Animals ; Cholinergic Antagonists/analysis ; Chromatography, High Pressure Liquid ; Limit of Detection ; Male ; Quinuclidinyl Benzilate/analysis ; Rats ; Rats, Wistar ; Spectrometry, Mass, Electrospray Ionization ; Tandem Mass Spectrometry

المؤلفون: Nessim CK; Ahram Canadian University in Egypt, Faculty of Pharmacy, Analytical Chemistry Department, 4th Industrial Zone, Banks Complex, 6th of October City 12566, Egypt., Michael AM; Ahram Canadian University in Egypt, Faculty of Pharmacy, Analytical Chemistry Department, 4th Industrial Zone, Banks Complex, 6th of October City 12566, Egypt., Fayez YM; Cairo University, Faculty of Pharmacy, Analytical Chemistry Department, Kasr El-Aini St, Cairo 11562, Egypt., Lotfy HM; Future University in Egypt, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Pharmaceutical Chemistry Department, New Cairo, Cairo 12311, Egypt.

المصدر: Journal of AOAC International [J AOAC Int] 2018 May 01; Vol. 101 (3), pp. 714-722. Date of Electronic Publication: 2017 Sep 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9215446 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-7922 (Electronic) Linking ISSN: 10603271 NLM ISO Abbreviation: J AOAC Int Subsets: MEDLINE

مواضيع طبية MeSH: Chlordiazepoxide/*analysis , Quinuclidinyl Benzilate/*analogs & derivatives , Spectrophotometry, Ultraviolet/*methods, Benzilates/chemistry ; Calibration ; Drug Stability ; Hydrolysis ; Least-Squares Analysis ; Principal Component Analysis ; Quinuclidinyl Benzilate/analysis ; Quinuclidinyl Benzilate/chemistry ; Reproducibility of Results ; Sodium Hydroxide/chemistry

المؤلفون: Miao Y; Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093; yimiao@ucsd.edu jmccammon@ucsd.edu., McCammon JA; Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 yimiao@ucsd.edu jmccammon@ucsd.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Oct 25; Vol. 113 (43), pp. 12162-12167. Date of Electronic Publication: 2016 Oct 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Arecoline/*chemistry , Isoxazoles/*chemistry , Quaternary Ammonium Compounds/*chemistry , Quinuclidinyl Benzilate/*chemistry , Receptor, Muscarinic M2/*agonists , Single-Domain Antibodies/*chemistry, Arecoline/metabolism ; Binding Sites ; Crystallography, X-Ray ; Humans ; Isoxazoles/metabolism ; Ligands ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Interaction Domains and Motifs ; Quaternary Ammonium Compounds/metabolism ; Quinuclidinyl Benzilate/metabolism ; Receptor, Muscarinic M2/chemistry ; Receptor, Muscarinic M2/metabolism ; Single-Domain Antibodies/metabolism ; Thermodynamics

المؤلفون: Misik J; University of Defence, Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic. Electronic address: misik@pmfhk.cz., Korabecny J; University of Defence, Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Nepovimova E; University of Defence, Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Kracmarova A; University of Defence, Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Kassa J; University of Defence, Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.

المصدر: Neuroscience letters [Neurosci Lett] 2016 Jan 26; Vol. 612, pp. 261-268. Date of Electronic Publication: 2015 Dec 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE

مواضيع طبية MeSH: Muscarinic Antagonists* , Quinuclidinyl Benzilate*, Alzheimer Disease/*drug therapy , Cholinesterase Inhibitors/*pharmacology , Cognition Disorders/*drug therapy , Tacrine/*analogs & derivatives , Tacrine/*pharmacology, Animals ; Avoidance Learning/drug effects ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/therapeutic use ; Cognition Disorders/chemically induced ; Cognition Disorders/psychology ; Donepezil ; Indans/pharmacology ; Indans/therapeutic use ; Male ; Maze Learning/drug effects ; Piperidines/pharmacology ; Piperidines/therapeutic use ; Rats, Wistar ; Tacrine/chemical synthesis

المؤلفون: Uher M; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Šimkova 870, 500 03, Hradec Králové, Czech Republic., Mžik M; Department of Clinical Biochemistry and Diagnostics, University Hospital and Faculty of Medicine Hradec Králové, Sokolská 581, 500 05, Hradec Králové, Czech Republic., Karasová JŽ; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 500 02, Hradec Králové, Czech Republic; Centre of Biomedical Research, University Hospital and Faculty of Medicine Hradec Kralove, Sokolská 581, 500 05, Hradec Králové, Czech Republic., Herman D; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 500 02, Hradec Králové, Czech Republic; Centre of Biomedical Research, University Hospital and Faculty of Medicine Hradec Kralove, Sokolská 581, 500 05, Hradec Králové, Czech Republic., Čechová L; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 500 02, Hradec Králové, Czech Republic., Dlabková A; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 500 02, Hradec Králové, Czech Republic., Mrkvicová A; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Šimkova 870, 500 03, Hradec Králové, Czech Republic., Hroch M; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Šimkova 870, 500 03, Hradec Králové, Czech Republic. Electronic address: hrochm@lfhk.cuni.cz.

المصدر: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2020 Oct 25; Vol. 190, pp. 113519. Date of Electronic Publication: 2020 Aug 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

مواضيع طبية MeSH: Brain*, Animals ; Biotransformation ; Mass Spectrometry ; Quinuclidinyl Benzilate ; Rats

المؤلفون: Filer CN; PerkinElmer Health Sciences Inc, Waltham, Massachusetts., Seguin RJ; PerkinElmer Health Sciences Inc, Waltham, Massachusetts.

المصدر: Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2019 Jul; Vol. 62 (9), pp. 604-607.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 7610510 Publication Model: Print Cited Medium: Internet ISSN: 1099-1344 (Electronic) Linking ISSN: 03624803 NLM ISO Abbreviation: J Labelled Comp Radiopharm Subsets: MEDLINE

مواضيع طبية MeSH: Chemistry Techniques, Synthetic/*methods , Cholinergic Antagonists/*chemical synthesis , Cholinergic Antagonists/*chemistry , Quinuclidinyl Benzilate/*chemical synthesis , Quinuclidinyl Benzilate/*chemistry , Tritium/*chemistry, Radiochemistry

المؤلفون: Misik J; Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic. Electronic address: misik@pmfhk.cz., Vanek J; Department of Public Health, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic., Musilek K; Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic., Kassa J; Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.

المصدر: Behavioural brain research [Behav Brain Res] 2014 Jun 01; Vol. 266, pp. 193-200. Date of Electronic Publication: 2014 Mar 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE

مواضيع طبية MeSH: Learning Disabilities/*chemically induced , Mental Recall/*drug effects , Muscarinic Antagonists/*toxicity , Quinuclidinyl Benzilate/*toxicity, Analysis of Variance ; Animals ; Avoidance Learning/drug effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Male ; Maze Learning/drug effects ; Motor Activity/drug effects ; Muscarinic Antagonists/chemistry ; Quinuclidinyl Benzilate/chemistry ; Rats ; Rats, Wistar ; Statistics, Nonparametric ; Time Factors

المؤلفون: Haga K; Department of Life Science, Faculty of Science, Gakushuin University, Mejiro 1-5-1, Tokyo 171-8588, Japan., Kruse AC, Asada H, Yurugi-Kobayashi T, Shiroishi M, Zhang C, Weis WI, Okada T, Kobilka BK, Haga T, Kobayashi T

المصدر: Nature [Nature] 2012 Jan 25; Vol. 482 (7386), pp. 547-51. Date of Electronic Publication: 2012 Jan 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cholinergic Antagonists/*chemistry , Cholinergic Antagonists/*pharmacology , Quinuclidinyl Benzilate/*analogs & derivatives , Quinuclidinyl Benzilate/*chemistry , Quinuclidinyl Benzilate/*pharmacology , Receptor, Muscarinic M2/*antagonists & inhibitors , Receptor, Muscarinic M2/*chemistry, Acetylcholine/analogs & derivatives ; Acetylcholine/chemistry ; Acetylcholine/metabolism ; Acetylcholinesterase/chemistry ; Acetylcholinesterase/metabolism ; Allosteric Regulation ; Binding Sites ; Carrier Proteins/chemistry ; Carrier Proteins/metabolism ; Cholinergic Antagonists/metabolism ; Crystallography, X-Ray ; Evolution, Molecular ; Humans ; Ligands ; Models, Molecular ; Protein Conformation ; Quinuclidinyl Benzilate/metabolism ; Receptor, Muscarinic M2/genetics ; Receptor, Muscarinic M2/metabolism ; Tyrosine/chemistry ; Tyrosine/metabolism