المؤلفون: Sharon D. Bryant, Thierry Langer, Brigitte Lesur, Rémy Hoffmann

المصدر: Current Opinion in Pharmacology. 9:589-593

مصطلحات موضوعية: Models, Molecular, Pharmacology, Prioritization, Computer science, Drug discovery, media_common.quotation_subject, Ligands, Bioinformatics, High-Throughput Screening Assays, Small Molecule Libraries, Structure-Activity Relationship, Databases as Topic, Risk analysis (engineering), Cheminformatics, Drug Design, Drug Discovery, Animals, Computer-Aided Design, Humans, Computer Simulation, Quality (business), Selection (genetic algorithm), media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90d6d89c30015692904cd70b4a4dda0
https://doi.org/10.1016/j.coph.2009.06.001

المؤلفون: Konstantin Poptodorov, Tien Luu, Rémy Hoffmann

المصدر: Pharmacophores and Pharmacophore Searches

مصطلحات موضوعية: Software, Computer science, business.industry, Pharmacophore, Software engineering, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a7f0d095cc006b5deea26c2df52ab83f
https://doi.org/10.1002/3527609164.ch2

المؤلفون: S Begle, Thierry Langer, F Bachmair, Rémy Hoffmann

المصدر: Journal of Molecular Structure: THEOCHEM. 503:59-72

مصطلحات موضوعية: Aldose reductase, Virtual screening, Database, Chemistry, Condensed Matter Physics, computer.software_genre, Biochemistry, Combinatorial chemistry, Set (abstract data type), Biological target, Physical and Theoretical Chemistry, Pharmacophore, computer, Chemical function

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::182c5cedf91275e958df12e5a6581d4a
https://doi.org/10.1016/s0166-1280(99)00363-2

المؤلفون: Rémy Hoffmann, Thierry Langer

المصدر: Expert opinion on drug discovery. 1(3)

مصطلحات موضوعية: Library design, Lead finding, Virtual screening, Application areas, Drug discovery, Computer science, Activity profiling, Drug Discovery, Profiling (information science), Computational biology, Pharmacophore, Bioinformatics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ae9076746e61142050c954f0ec48cf
https://pubmed.ncbi.nlm.nih.gov/23495846

المؤلفون: Robert Boigegrain, Roger Brodin, Philippe Soubrié, Camille G. Wermuth, Jean-Paul Kan, Jean-Jacques Bourguignon, Rémy Hoffmann

المصدر: Bioorganic & Medicinal Chemistry Letters. 2:833-838

مصطلحات موضوعية: Chemistry, organic chemicals, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Muscarinic agonist, CHOLINERGIC SYNDROME, Aminopyridazine, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Muscarinic acetylcholine receptor M4, Lead structure, Molecular Medicine, heterocyclic compounds, Molecular Biology, Minaprine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9661b5e682e1cf56494ef26bfe1630c5
https://doi.org/10.1016/s0960-894x(00)80540-5

المؤلفون: Didier Rognan, Rémy Hoffmann, François Durant, Daniel P. Vercauteren, Thierry Boulanger, Jean-Marie André, Camille G. Wermuth

المصدر: Journal of Medicinal Chemistry. 35:1969-1977

مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Molecular Conformation, Ab initio, Tubocurarine, Bicuculline, Heterocyclic Compounds, 4 or More Rings, GABAA-rho receptor, Lactones, Structure-Activity Relationship, Alkaloids, Piperidines, X-Ray Diffraction, Dibenzazepines, Drug Discovery, medicine, Structure–activity relationship, GABA-A Receptor Antagonists, Binding site, gamma-Aminobutyric Acid, Molecular Structure, GABAA receptor, Chemistry, Azepines, Isoxazoles, Receptors, GABA-A, Heterocyclic Compounds, Bridged-Ring, Pyridazines, Azasteroids, Gabazine, Molecular Medicine, Pharmacophore, Crystallization, Androstanes, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33b03e02a938a6bb7ce910e2440ab55
https://doi.org/10.1021/jm00089a005

المؤلفون: Michael Dooley, Teresa Lyons, Rémy Hoffmann, Hugues-Olivier Bertrand, Anne Goupil-Lamy, Marguerita Lim-Wilby, Sunil Patel, Christoph Schneider, Osman G√ºner

المصدر: Virtual Screening in Drug Discovery ISBN: 9780824754792
Virtual Screening in Drug Discovery

مصطلحات موضوعية: Chemistry, Stereochemistry, Ligand (biochemistry), Receptor binding site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2dce8b0b2a334f084aa0165c0aec1a63
https://doi.org/10.1201/9781420028775.ch11

المؤلفون: Serge Christmann-Franck, Serge Fermandjian, P. Arsène Der Garabedian, Rémy Hoffmann, Anne Goupil-Lamy, Olivier Mauffret, Hugues-Olivier Bertrand

المساهمون: Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Accelrys, Biochimie des signaux régulateurs cellulaires et moléculaires (BSRCM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2004, 47 (27), pp.6840-53. ⟨10.1021/jm049745w⟩
Journal of Medicinal Chemistry, American Chemical Society, 2004, 47 (27), pp.6840-53. ⟨10.1021/jm049745w⟩

مصطلحات موضوعية: Models, Molecular, Molecular model, MESH: Antigens, Neoplasm, MESH: Amino Acid Sequence, 0302 clinical medicine, Protein structure, Drug Discovery, Topoisomerase II Inhibitors, Enzyme Inhibitors, 0303 health sciences, biology, Molecular Structure, Chemistry, 3. Good health, DNA-Binding Proteins, Biochemistry, Enzyme inhibitor, MESH: Enzyme Inhibitors, 030220 oncology & carcinogenesis, Molecular Medicine, medicine.symptom, Pharmacophore, Dimerization, MESH: Models, Molecular, Molecular Sequence Data, MESH: Molecular Structure, MESH: Sequence Alignment, 03 medical and health sciences, Antigens, Neoplasm, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Amino Acid Sequence, MESH: Templates, Genetic, 030304 developmental biology, MESH: DNA Topoisomerases, Type II, Eukaryotic, Virtual screening, Binding Sites, MESH: Humans, MESH: Molecular Sequence Data, Topoisomerase, Templates, Genetic, DNA Topoisomerases, Type II, Mechanism of action, Structural biology, MESH: Binding Sites, MESH: Dimerization, biology.protein, Sequence Alignment, MESH: DNA-Binding Proteins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49caaaacf4f3f9c5e257ea1e9b183fc
https://hal.science/hal-00284749

المؤلفون: Jean-Jacques Bourguignon, Bruno Didier, Rémy Hoffmann, Camilles Wermuth

المصدر: Proceedings of The 2nd International Electronic Conference on Synthetic Organic Chemistry.

مصطلحات موضوعية: High affinity binding, Peptidomimetic, Stereochemistry, Chemistry, Fibrinogen binding, Platelet, Sequence (biology), Tripeptide, Platelet activation, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c6fcc57eb9f5e687165733a51bd2bed3
https://doi.org/10.3390/ecsoc-2-01696

المؤلفون: Rémy Hoffmann, Yveline Rival, Bruno Didier, Camille G. Wermuth, Jean Bourguignon, Volodymyr Rybaltchenko

المصدر: Journal of medicinal chemistry. 41(3)

مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Protein Conformation, Ether, In Vitro Techniques, Muscarinic Agonists, Hippocampus, Amidine, chemistry.chemical_compound, Drug Discovery, Muscarinic acetylcholine receptor, Animals, Muscarine, Bicyclic molecule, Myocardium, Receptors, Muscarinic, Rats, Pyridazines, chemistry, Dioxolane, Receptors, Serotonin, Molecular Medicine, Serotonin Antagonists, Pharmacophore, Receptors, Serotonin, 5-HT3, Brain Stem

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d02a218479b64c7dc6514c1e871b347
https://pubmed.ncbi.nlm.nih.gov/9464362