المؤلفون: Thavy Long, R Jeffrey Neitz, Rachel Beasley, Chakrapani Kalyanaraman, Brian M Suzuki, Matthew P Jacobson, Colette Dissous, James H McKerrow, David H Drewry, William J Zuercher, Rahul Singh, Conor R Caffrey

المصدر: PLoS Neglected Tropical Diseases, Vol 10, Iss 1, p e0004356 (2016)

مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC4709140?pdf=render; https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

URL الوصول: https://doaj.org/article/1f31106f26284b5db634a718d8bb99bb

المؤلفون: Shilpi Khare, Steven L Roach, S Whitney Barnes, Dominic Hoepfner, John R Walker, Arnab K Chatterjee, R Jeffrey Neitz, Michelle R Arkin, Case W McNamara, Jaime Ballard, Yin Lai, Yue Fu, Valentina Molteni, Vince Yeh, James H McKerrow, Richard J Glynne, Frantisek Supek

المصدر: PLoS Pathogens, Vol 11, Iss 7, p e1005058 (2015)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC4506092?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

URL الوصول: https://doaj.org/article/74c1eaf7a3e241ef97a84b81f3a2894a

المؤلفون: Dyana N. Kenanova, Emira J. Visser, Johanna M. Virta, Eline Sijbesma, Federica Centorrino, Holly R. Vickery, Mengqi Zhong, R. Jeffrey Neitz, Luc Brunsveld, Christian Ottmann, Michelle R. Arkin

المساهمون: Chemical Biology, ICMS Core

المصدر: ACS Central Science, 9(5), 937-946. American Chemical Society
ACS central science, vol 9, iss 5

مصطلحات موضوعية: General Chemical Engineering, Chemical Sciences, General Chemistry, Generic health relevance

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d5dfbb9f85f0ba6a6dbf92e3bacf2b
https://research.tue.nl/nl/publications/076d1025-cb55-4575-b0a2-584f109c7743

المؤلفون: Stefan Gahbauer, Galen J. Correy, Marion Schuller, Matteo P. Ferla, Yagmur Umay Doruk, Moira Rachman, Taiasean Wu, Morgan Diolaiti, Siyi Wang, R. Jeffrey Neitz, Daren Fearon, Dmytro Radchenko, Yurii Moroz, John J. Irwin, Adam R. Renslo, Jenny C. Taylor, Jason E. Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K. Shoichet, James S. Fraser

المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 2

مصطلحات موضوعية: Multidisciplinary, Crystallography, SARS-CoV-2, Prevention, coronavirus, COVID-19, macrodomain, Ligands, virtual screening, Antiviral Agents, Molecular Docking Simulation, Vaccine Related, Infectious Diseases, Emerging Infectious Diseases, 5.1 Pharmaceuticals, Biodefense, Pneumonia & Influenza, Humans, Protease Inhibitors, Generic health relevance, Development of treatments and therapeutic interventions, fragment-based drug discovery, Pandemics, Lung

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991faf3ec537a19849a09bb30d7edb38
https://pubmed.ncbi.nlm.nih.gov/36598939

المؤلفون: Stefan, Gahbauer, Galen J, Correy, Marion, Schuller, Matteo P, Ferla, Yagmur Umay, Doruk, Moira, Rachman, Taiasean, Wu, Morgan, Diolaiti, Siyi, Wang, R Jeffrey, Neitz, Daren, Fearon, Dmytro, Radchenko, Yurii, Moroz, John J, Irwin, Adam R, Renslo, Jenny C, Taylor, Jason E, Gestwicki, Frank, von Delft, Alan, Ashworth, Ivan, Ahel, Brian K, Shoichet, James S, Fraser

المصدر: bioRxiv : the preprint server for biology.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::d0d1f125f48c87de315a09265cca538b
https://pubmed.ncbi.nlm.nih.gov/35794891

المؤلفون: Mark A. Burlingame, David Lee Nelson, R. Jeffrey Neitz, Alan R. Wolfe, Brian M. Suzuki, K. C. Lim, Leslie Z. Benet, Mark A. Scheideler, Conor R. Caffrey

المصدر: International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 571-586 (2018)
International journal for parasitology. Drugs and drug resistance, vol 8, iss 3
International Journal for Parasitology: Drugs and Drug Resistance

مصطلحات موضوعية: 0301 basic medicine, Male, Metabolite, Administration, Oral, Pharmacology, Praziquantel, chemistry.chemical_compound, Mice, 0302 clinical medicine, Drug Discovery, Anthelmintic, Schistosomiasis, Pharmacology (medical), Prodrugs, Arylsulfonates, biology, Chemistry, Schistosoma mansoni, Prodrug, 3. Good health, Infectious Diseases, Liver, 5.1 Pharmaceuticals, Medical Microbiology, Administration, Schistosoma haematobium, Schistosoma, Female, medicine.symptom, Development of treatments and therapeutic interventions, Alkylaminoalkanethiosulfuric acid, medicine.drug, Oral, 030231 tropical medicine, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Schistosomicides, Rare Diseases, In vivo, parasitic diseases, medicine, Animals, Metabolomics, lcsh:RC109-216, Drug metabolism, Animal, Articles from the scientific meeting: "Anthelmintics: From Discovery to Resistance III", pp. 494 - 628, biology.organism_classification, Schistosomiasis mansoni, Vector-Borne Diseases, Disease Models, Animal, 030104 developmental biology, Orphan Drug, Good Health and Well Being, Mechanism of action, Disease Models, Parasitology, Drug disposition, Digestive Diseases

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8571431547e2babe3cffa7de089f3348
http://www.sciencedirect.com/science/article/pii/S221132071830109X

المؤلفون: R. Jeffrey Neitz, Zhizhou Yue, Neal Jeffrey Green, Shan Li, Stacie L. Bulfer, Tsui-Fen Chou, Raffaele Colombo, James C. Burnett, Matthew G. LaPorte, Peter Wipf, Donna M. Huryn, Michelle R. Arkin, Celeste Alverez, William J. Moore

المصدر: ACS medicinal chemistry letters, vol 9, iss 11
ACS Medicinal Chemistry Letters

مصطلحات موضوعية: p97, 0301 basic medicine, Molecular model, protein homeostasis modulator, Stereochemistry, ATPase, Allosteric regulation, anticancer, Biochemistry, Medicinal and Biomolecular Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Rare Diseases, Drug Discovery, Potency, Indole test, allosteric inhibitor, phenyl indole, biology, Prevention, Organic Chemistry, Assay, Pharmacology and Pharmaceutical Sciences, AAA plus ATPase, Featured Letter, AAA proteins, Piperazine, 030104 developmental biology, chemistry, biology.protein, AAA+ ATPase, Biotechnology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a97309d2f36bd3f55226152fc25aff
https://doi.org/10.1021/acsmedchemlett.8b00372

المؤلفون: Jonathan A. Ellman, Estefania Hugo Caselli, Hai-Chao Xu, Somenath Chowdhury, Clifford Bryant, Steven Chen, Servando Ponce, Michelle R. Arkin, R. Jeffrey Neitz, Jiri Gut, Adam R. Renslo

المصدر: Bioorganic & medicinal chemistry letters, vol 25, iss 21

مصطلحات موضوعية: Hydrocarbons, Fluorinated, Clinical Biochemistry, Protozoan Proteins, Pharmaceutical Science, Pharmacology, Biochemistry, Fluorinated, Drug Discovery, Enzyme Inhibitors, Molecular Structure, biology, Chemistry, Pharmacology and Pharmaceutical Sciences, Ketones, Cruzain, Trypanocidal Agents, Cysteine protease, Cysteine Endopeptidases, Infectious Diseases, 5.1 Pharmaceuticals, Lipophilicity, Molecular Medicine, Drug, Development of treatments and therapeutic interventions, Chagas’ disease, Chagas disease, Medicinal & Biomolecular Chemistry, Trypanosoma cruzi, Biological Availability, Article, Dose-Response Relationship, Medicinal and Biomolecular Chemistry, Structure-Activity Relationship, Rare Diseases, Pharmacokinetics, In vivo, medicine, Humans, Potency, Chagas Disease, Molecular Biology, Lead optimization, Dose-Response Relationship, Drug, Organic Chemistry, Protease inhibitors, biology.organism_classification, medicine.disease, Hydrocarbons, Bioavailability, Vector-Borne Diseases, Chagas' disease, Orphan Drug, Good Health and Well Being

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e40868b31dc6a459de196e31f2fb4b
https://doi.org/10.1016/j.bmcl.2015.06.066

المؤلفون: James H. McKerrow, R. Jeffrey Neitz, Jiri Gut, Adam R. Renslo, Michelle R. Arkin, Danielle Kellar, Frantisek Supek, Valentina Molteni, Stephanie A. Robertson, Alejandra Gallardo-Godoy, Steven Chen, Jair L. Siqueira-Neto, Vince Yeh, Richard Glynne, Steven L. Roach, Clifford Bryant, Arnab K. Chatterjee

المصدر: SLAS Discovery. 20:101-111

مصطلحات موضوعية: Chagas disease, medicine.medical_specialty, Latin Americans, Trypanosoma cruzi, Drug Evaluation, Preclinical, Pharmacology, Xanthine, Biochemistry, Cell Line, Analytical Chemistry, Small Molecule Libraries, Mice, Drug Discovery, Animals, Humans, Medicine, Chagas Disease, Intensive care medicine, Selection (genetic algorithm), Cause of death, business.industry, Neglected Diseases, medicine.disease, Cell based assays, Trypanocidal Agents, High-Throughput Screening Assays, Disease Models, Animal, Heart failure, Molecular Medicine, Colorimetry, Identification (biology), business, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe87b7f6b3b7366cba4100e54ca8f43
https://doi.org/10.1177/1087057114553103

المؤلفون: David F. Nakamura, Hing L. Sham, John-Michael Sauer, Dean R. Artis, Lany Ruslim, Ted Yednock, Michael A. Pleiss, Gary Probst, Marc Adler, Minghua Sun, Louis Brogley, Michael S. Dappen, Roy K. Hom, Michel Maillard, Nanhua Yao, Simeon Bowers, Andrei W. Konradi, Jay S. Tung, Raymond A. Ng, Andrea Gailunas, Wes Zmolek, Kevin P. Quinn, Fang Lawrence Y, Varghese John, R. Jeffrey Neitz, Michael P. Bova

المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4674-4679

مصطلحات موضوعية: Models, Molecular, Binding Sites, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Design, Drug Discovery, Ethylamines, Aspartic Acid Endopeptidases, Molecular Medicine, Structure–activity relationship, Chromane, Amyloid Precursor Protein Secretases, Chromans, Enzyme Inhibitors, Selectivity, Molecular Biology, Cells, Cultured

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7bd8b1a206227969363800a4024a00c
https://doi.org/10.1016/j.bmcl.2013.06.006