المؤلفون: E. FERNANDEZ MELLID, P. MELERO VALENTIN, P. CADAHIA FERNANDEZ, A. DE ANDRES Y JACOB, L. BAO PEREZ, A. ABUIN BLANCO, R. FERREIRO FERRO, A. PELETEIRO RAINDO, M. RODRIGUEZ RUIZ

المصدر: HemaSphere, Vol 6, Pp 1541-1542 (2022)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000849496.85094.32; https://doaj.org/toc/2572-9241

URL الوصول: https://doaj.org/article/6d077f9dc84d4523b01c0a2035e19437

المؤلفون: A. Peleteiro Raindo, M. F. Fraga Rodríguez, J. L. Bello López, L. Bao Perez, M. Cid López, C. Aliste Santos, Carlo Visco, B. Antelo Rodríguez, M. M. Pérez Encinas, Ken H. Young, J. Án. Díaz Arias, A. Mosquera Orgueira, M. S. Gonzalez Perez, R. Ferreiro Ferro, Zijun Y. Xu-Monette

المصدر: Hematological Oncology. 39

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, business.industry, Internal medicine, medicine, Hematology, General Medicine, business, medicine.disease, Diffuse large B-cell lymphoma, Prognostic models

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2412f4d189aac335dfa1e9fd97848d76
https://doi.org/10.1002/hon.79_2880

المؤلفون: D. Martínez Señarís, A. Lorenzo Vizcaya, F. Taboada Alameda, M. E. González García, J. Vázquez Álvarez, E. Lavilla Rubira, A. M. Dios Loureiro, J. Á. Méndez Sánchez, R. Ferreiro Ferro, F. Escalante Barrigón, Á. Ramírez Player, J. Labrador Gómez, M. A. Bermúdez Rodríguez

المصدر: HemaSphere. 3:960

مصطلحات موضوعية: Clinical Practice, Oncology, medicine.medical_specialty, business.industry, Internal medicine, Medicine, Daratumumab, Retrospective cohort study, Refractory Multiple Myeloma, Hematology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::087df77e0a5793a63aba07a83012a712
https://doi.org/10.1097/01.hs9.0000567012.00570.06

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المؤلفون: Mosquera Orgueira A, Peleteiro Raíndo A, Cid López M, Antelo Rodríguez B, Díaz Arias JÁ, Ferreiro Ferro R, Alonso Vence N, Bendaña López Á, Abuín Blanco A, Bao Pérez L, Melero Valentín P, Sonia González Pérez M, Cerchione C, Martinelli G, Montesinos Fernández P, Mateo Pérez Encinas M, Luis Bello López J

المصدر: PloS one [PLoS One] 2022 Sep 15; Vol. 17 (9), pp. e0274984. Date of Electronic Publication: 2022 Sep 15 (Print Publication: 2022).

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Mosquera Orgueira A; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain.; University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain., Ferreiro Ferro R; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain., Díaz Arias JÁ; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain., Aliste Santos C; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain.; Department of Pathology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain., Antelo Rodríguez B; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain.; Department of Pathology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain., Bao Pérez L; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain., Alonso Vence N; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain., Bendaña López Á; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain.; University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain., Abuin Blanco A; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain., Melero Valentín P; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain., Peleteiro Raindo AR; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain.; University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain., Cid López M; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain.; University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain., Pérez Encinas MM; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain.; University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain., González Pérez MS; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain., Fraga Rodríguez MF; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain.; University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain.; Department of Pathology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain., Bello López JL; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Galicia, Spain.; University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain.

المصدر: PloS one [PLoS One] 2021 May 04; Vol. 16 (5), pp. e0248886. Date of Electronic Publication: 2021 May 04 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Genome, Human* , Mutation*, Leukemia, B-Cell/*genetics , Lymphoma, B-Cell/*genetics, CREB-Binding Protein/genetics ; DNA-Binding Proteins/genetics ; GTP-Binding Protein alpha Subunits, G12-G13/genetics ; Gene Regulatory Networks ; Humans ; Neoplasm Proteins/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; Receptors, Tumor Necrosis Factor, Member 14/genetics ; STAT6 Transcription Factor/genetics ; Tumor Suppressor Protein p53/genetics

المؤلفون: Mosquera Orgueira A; Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Hematology, SERGAS, 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Pathology, SERGAS, 15706 Santiago de Compostela, Spain., Cid López M; Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Hematology, SERGAS, 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Pathology, SERGAS, 15706 Santiago de Compostela, Spain., Peleteiro Raíndo A; Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Hematology, SERGAS, 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Pathology, SERGAS, 15706 Santiago de Compostela, Spain., Díaz Arias JÁ; Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Hematology, SERGAS, 15706 Santiago de Compostela, Spain., Antelo Rodríguez B; Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Pathology, SERGAS, 15706 Santiago de Compostela, Spain., Bao Pérez L; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Hematology, SERGAS, 15706 Santiago de Compostela, Spain., Alonso Vence N; Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Hematology, SERGAS, 15706 Santiago de Compostela, Spain., Bendaña López Á; Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Hematology, SERGAS, 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Pathology, SERGAS, 15706 Santiago de Compostela, Spain., Abuin Blanco A; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Hematology, SERGAS, 15706 Santiago de Compostela, Spain., Melero Valentín P; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Hematology, SERGAS, 15706 Santiago de Compostela, Spain., Ferreiro Ferro R; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Hematology, SERGAS, 15706 Santiago de Compostela, Spain., Aliste Santos C; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Pathology, SERGAS, 15706 Santiago de Compostela, Spain., Fraga Rodríguez MF; Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Pathology, SERGAS, 15706 Santiago de Compostela, Spain.; Department of Medicine, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain., González Pérez MS; Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Hematology, SERGAS, 15706 Santiago de Compostela, Spain., Pérez Encinas MM; Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Hematology, SERGAS, 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Pathology, SERGAS, 15706 Santiago de Compostela, Spain., Bello López JL; Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Department of Hematology, SERGAS, 15706 Santiago de Compostela, Spain.; Department of Medicine, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain.

المصدر: Cancers [Cancers (Basel)] 2021 Mar 16; Vol. 13 (6). Date of Electronic Publication: 2021 Mar 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Mosquera Orgueira A; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain.; University of Santiago de Compostela, Santiago, Spain., Peleteiro Raíndo A; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain.; University of Santiago de Compostela, Santiago, Spain., Cid López M; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain.; University of Santiago de Compostela, Santiago, Spain., Antelo Rodríguez B; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain.; University of Santiago de Compostela, Santiago, Spain., Díaz Arias JÁ; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain., Ferreiro Ferro R; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain., Alonso Vence N; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain., Bendaña López Á; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain., Abuín Blanco A; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain., Bao Pérez L; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain., Melero Valentín P; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain., González Pérez MS; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain., Cerchione C; University of Bologna, Bologna, Italy., Martinelli G; Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy., Montesinos Fernández P; University Hospital of La Fe in Valencia, Valencia, Spain., Pérez Encinas MM; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain.; University of Santiago de Compostela, Santiago, Spain., Bello López JL; Health Research Institute of Santiago de Compostela (IDIS), Santiago, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain.; University of Santiago de Compostela, Santiago, Spain.

المصدر: PloS one [PLoS One] 2021 Feb 16; Vol. 16 (2), pp. e0247093. Date of Electronic Publication: 2021 Feb 16 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia/*genetics , Leukemia, Myeloid, Acute/*genetics , Mutation/*genetics , fms-Like Tyrosine Kinase 3/*genetics, Biomarkers/metabolism ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA Methyltransferase 3A ; Gene Expression Profiling/methods ; Humans ; Nuclear Proteins/genetics ; Nucleophosmin ; Staurosporine/analogs & derivatives ; Staurosporine/pharmacology ; fms-Like Tyrosine Kinase 3/antagonists & inhibitors

المؤلفون: Mosquera Orgueira A; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain - adrian.mosquera@live.com.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS - SERGAS), Santiago de Compostela, Spain - adrian.mosquera@live.com.; University of Santiago de Compostela, Santiago de Compostela, Spain - adrian.mosquera@live.com., Bao Pérez L; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS - SERGAS), Santiago de Compostela, Spain., Mosquera Torre A; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS - SERGAS), Santiago de Compostela, Spain., Peleteiro Raíndo A; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS - SERGAS), Santiago de Compostela, Spain.; University of Santiago de Compostela, Santiago de Compostela, Spain., Cid López M; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS - SERGAS), Santiago de Compostela, Spain.; University of Santiago de Compostela, Santiago de Compostela, Spain., Díaz Arias JÁ; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS - SERGAS), Santiago de Compostela, Spain., Ferreiro Ferro R; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Antelo Rodríguez B; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS - SERGAS), Santiago de Compostela, Spain.; University of Santiago de Compostela, Santiago de Compostela, Spain., González Pérez MS; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS - SERGAS), Santiago de Compostela, Spain., Albors Ferreiro M; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS - SERGAS), Santiago de Compostela, Spain., Alonso Vence N; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS - SERGAS), Santiago de Compostela, Spain., Pérez Encinas MM; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS - SERGAS), Santiago de Compostela, Spain.; University of Santiago de Compostela, Santiago de Compostela, Spain., Bello López JL; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Division of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS - SERGAS), Santiago de Compostela, Spain.; University of Santiago de Compostela, Santiago de Compostela, Spain., Martinelli G; Unit of Hematology, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Forlì-Cesena, Italy., Cerchione C; Unit of Hematology, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Forlì-Cesena, Italy.

المصدر: Minerva medica [Minerva Med] 2020 Oct; Vol. 111 (5), pp. 427-442. Date of Electronic Publication: 2020 Sep 21.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Edizioni Minerva Medica Country of Publication: Italy NLM ID: 0400732 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1827-1669 (Electronic) Linking ISSN: 00264806 NLM ISO Abbreviation: Minerva Med Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Leukemia, Myeloid, Acute/*drug therapy , Protein Kinase Inhibitors/*pharmacology , Sorafenib/*pharmacology , fms-Like Tyrosine Kinase 3/*antagonists & inhibitors , fms-Like Tyrosine Kinase 3/*genetics, Aniline Compounds/pharmacology ; Benzimidazoles/pharmacology ; Benzothiazoles/pharmacology ; Carbazoles/pharmacology ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Forecasting ; Furans ; Hematopoietic Stem Cell Transplantation ; Humans ; Imidazoles/pharmacology ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Maintenance Chemotherapy/methods ; Mutation ; Phenylurea Compounds/pharmacology ; Piperidines/pharmacology ; Point Mutation ; Pyrazines/pharmacology ; Pyridazines/pharmacology ; Recurrence ; Staurosporine/analogs & derivatives ; Staurosporine/pharmacology