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1
المؤلفون: Stephan G. Zech, Feng Li, Rachel M. Squillace, R. Mathew Thomas, David C. Dalgarno, David Miller, Yihan Wang, Matthew T. Greenfield, Xiaotian Zhu, William C. Shakespeare, Yongjin Xu, Jiwei Qi, Lois Parillon, Tianjun Zhou, Anna Kohlmann, Juan J. Miret
المصدر: Journal of medicinal chemistry. 59(2)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Choline kinase, Phosphorylcholine, Fragment-based lead discovery, Antineoplastic Agents, Apoptosis, medicine.disease_cause, Crystallography, X-Ray, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, medicine, Choline Kinase, Humans, Enzyme Inhibitors, Phosphocholine, Cell Proliferation, chemistry.chemical_classification, Oncogene, Dose-Response Relationship, Drug, Cell growth, Small molecule, High-Throughput Screening Assays, 030104 developmental biology, Enzyme, chemistry, Biochemistry, 030220 oncology & carcinogenesis, Molecular Medicine, Carcinogenesis, Protein Binding
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2
المؤلفون: Yaoyu Ning, Chester A. Metcalf, Lois Commodore, Jan Romero, Scott Wardwell, Tomi K. Sawyer, Yihan Wang, Qurish K. Mohemmad, Scott Paul Lentini, Ingrid Chen, Victor M. Rivera, Karin Russian, Geetha Banda, Sasmita Das, Narayana I. Narasimhan, Xiaotian Zhu, Raji Sundaramoorthi, Lisi Cai, Tianjun Zhou, Jeff Keats, Frank Wang, Tim Clackson, Qihong Xu, Jiwei Qi, David Wen, Joseph Snodgrass, Shuangying Liu, William C. Shakespeare, R. Mathew Thomas, Marc I Broudy, John Iuliucci, Wei-Sheng Huang, David C. Dalgarno, Dong Zou
المصدر: Journal of Medicinal Chemistry. 53:4701-4719
مصطلحات موضوعية: Models, Molecular, Mutant, Fusion Proteins, bcr-abl, Administration, Oral, Antineoplastic Agents, Mice, SCID, Pharmacology, Crystallography, X-Ray, Mice, chemistry.chemical_compound, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Kinase activity, Benzamide, Protein Kinase Inhibitors, ADME, Kinase, Chemistry, Imidazoles, breakpoint cluster region, Myeloid leukemia, medicine.disease, Rats, Pyridazines, Leukemia, Blood-Brain Barrier, Mutation, Molecular Medicine, Drug Screening Assays, Antitumor
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3
المؤلفون: Jeff Keats, Marc I Broudy, John Iuliucci, Scott Wardwell, Karin Russian, Sasmita Das, Yaoyu Ning, Scott Paul Lentini, Yihan Wang, David Wen, William C. Shakespeare, Joseph Snodgrass, Tomi K. Sawyer, David C. Dalgarno, R. Mathew Thomas, Xiaotian Zhu, Mohammad Azam, Shuangying Liu, George Q. Daley, Wei-Sheng Huang, Raji Sundaramoorthi, Tim Clackson, Geetha Banda, Qihong Xu, Frank Wang
المصدر: Journal of Medicinal Chemistry. 52:4743-4756
مصطلحات موضوعية: Protein Conformation, Pharmacology, Mice, Structure-Activity Relationship, In vivo, hemic and lymphatic diseases, Drug Discovery, Animals, Humans, Proto-Oncogene Proteins c-abl, Protein Kinase Inhibitors, ABL, biology, Kinase, Chemistry, Wild type, Myeloid leukemia, Rats, src-Family Kinases, Purines, Enzyme inhibitor, Drug Design, NIH 3T3 Cells, biology.protein, Molecular Medicine, Female, K562 Cells, Proto-oncogene tyrosine-protein kinase Src, K562 cells
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4
المؤلفون: Tomi K. Sawyer, Sasmita Das, Yihan Wang, R. Mathew Thomas, David Wen, Scott Paul Lentini, William C. Shakespeare, Wei-Sheng Huang, Raji Sundaramoorthi, Shuangying Liu, Geetha Banda
المصدر: Tetrahedron Letters. 48:7388-7391
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Heck reaction, Aryl, Organic Chemistry, Drug Discovery, Organic chemistry, Halide, Purine metabolism, Biochemistry
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5
المؤلفون: R. Mathew Thomas, D. S. Iyengar
المصدر: Synthetic Communications. 29:2507-2513
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Stereochemistry, Organic Chemistry, Organic chemistry, Glycosyl, Cyclotriveratrylene, Sugar
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6
المؤلفون: R. Mathew Thomas, D. S. Iyengar, G. Hari Mohan
المصدر: Tetrahedron Letters. 38:4721-4724
مصطلحات موضوعية: Chemistry, Reductive cleavage, Organic Chemistry, Drug Discovery, Organic chemistry, Biochemistry
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7
المؤلفون: Sen Zhang, Yihan Wang, Feng Li, Rory Dodd, Lois Commodore, Anna Kohlmann, David C. Dalgarno, Victor M. Rivera, Matthew T. Greenfield, Tim Clackson, Jiwei Qi, William C. Shakespeare, Stephan G. Zech, Shuangying Liu, Juan J. Miret, Rachel M. Squillace, David Miller, Xiaohui Lu, R. Mathew Thomas, Wei-Sheng Huang, Xiaotian Zhu, Yongjin Xu, Tianjun Zhou, Rongsong Xu
المصدر: Journal of medicinal chemistry. 56(3)
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Protein Conformation, Lactate dehydrogenase A, Oxidative phosphorylation, Crystallography, X-Ray, Oxidative Phosphorylation, chemistry.chemical_compound, Lactate dehydrogenase, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Humans, Glycolysis, Enzyme Inhibitors, education, education.field_of_study, L-Lactate Dehydrogenase, Chemistry, Drug discovery, Ligand (biochemistry), Small molecule, Warburg effect, Biochemistry, Molecular Medicine
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8
المؤلفون: D. S. Iyengar, R. Mathew Thomas
المصدر: ChemInform. 30
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Stereochemistry, Cyclotriveratrylene, Glycosyl, General Medicine, Sugar
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9
المؤلفون: G. Sudhakar Reddy, D. S. Iyengar, R. Mathew Thomas
المصدر: ChemInform. 30
مصطلحات موضوعية: Chemistry, General Medicine, Combinatorial chemistry
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10
المؤلفون: D. S. Iyengar, R. Mathew Thomas, K. Purushothama Chary
المصدر: ChemInform. 31
مصطلحات موضوعية: Reduction (complexity), Chemistry, Organic chemistry, General Medicine