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المؤلفون: Ed Kerns, Cornelis E. C. A. Hop, A. Q. Wang, Pranav Shah, J. McKew, Alexey V. Zakharov, Xin Xu, Anton Simeonov, D.-T. Nguyen, R. S. Obach
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Accuracy and precision, Chromatography, Chemistry, Analytical chemistry, Pharmaceutical Science, Articles, Metabolic stability, Mass spectrometry, High-performance liquid chromatography, Mass Spectrometry, Automated data, 03 medical and health sciences, Automation, 030104 developmental biology, Linear range, Cytochrome P-450 Enzyme System, Analysis software, Humans, Throughput (business), Software, Chromatography, Liquid, Half-Life
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea4ea821897fd03ac690c5f265fb0bf
https://europepmc.org/articles/PMC5034701/ -
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المؤلفون: Patrick Robert Verhoest, Vinod D. Parikh, Carrie Funk, Marielle Delnomdedieu, Wonkyung Byon, Aarti Sawant Basak, Linda S. Wood, Loretta M. Cox, Hongying Gao, Emily Miller, Chang Lin, Elaine Tseng-Lovering, R S Obach
المصدر: Xenobiotica. 44:438-454
مصطلحات موضوعية: Male, CYP2D6, Erythrocytes, Monoamine oxidase, Health, Toxicology and Mutagenesis, Pharmacology, Biology, Toxicology, Biochemistry, Rats, Sprague-Dawley, Dogs, Pharmacokinetics, Animals, Cytochrome P-450 CYP3A, Humans, Monoamine Oxidase, ADME, Sulfonamides, CYP3A4, Biphenyl Compounds, Cytochrome P450, General Medicine, Rats, Macaca fascicularis, Cytochrome P-450 CYP2D6, Inactivation, Metabolic, Hepatocytes, Microsomes, Liver, Microsome, biology.protein, Monoamine oxidase A
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المؤلفون: Ping Zhao, Richard E. Higgs, Shiew-Mei Huang, Brian J. Kirby, Isabelle Ragueneau-Majlessi, Lei Zhang, David R. Plowchalk, R S Obach, Heidi J. Einolf, E. Seibert, Eva Gil Berglund, Kellie S. Reynolds, Adrian J. Fretland, Stephen D. Hall, Karthik Venkatakrishnan, Jenny Y. Chien, V. Fischer, Ken Grime, T. H. Waterhouse, L T Vieira, Jan Snoeys, Odette A. Fahmi, K. Skordos, Aleksandra Galetin, R. Riley
المصدر: Clinical Pharmacology & Therapeutics. 95:189-198
مصطلحات موضوعية: Pharmacology, Investigational drug, CYP3A, Chemistry, Area under the curve, Organ specific, medicine, Midazolam, Cutoff, Pharmacology (medical), In vitro in vivo, Risk assessment, medicine.drug
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المؤلفون: Jaclyn Louise Henderson, Ji-Young Kim, Edelweiss Evrard, Laura A. McAllister, Somraj Ghosh, Patrick Robert Verhoest, R S Obach, Rong Suobao, Michelle A. Salafia, Cheng Chang, Jayvardhan Pandit, Kari R. Fonseca, Xinjun Hou, Aarti Sawant-Basak, Laura E. Zawadzke, Vinod D. Parikh, Jamison B. Tuttle, Alan J. Clark, Amy B. Dounay, Bruce M. Bechle, Brian Rago
المصدر: MedChemComm. 4:125-129
مصطلحات موضوعية: Pharmacology, biology, Stereochemistry, Organic Chemistry, Irreversible binding, Pharmaceutical Science, Kynurenine aminotransferase II, Biochemistry, Bioavailability, chemistry.chemical_compound, chemistry, Pharmacokinetics, Drug Discovery, Molecular Medicine, Bioisostere, biology.gene
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::38310baeca680e1af94407407cfea095
https://doi.org/10.1039/c2md20166f -
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المؤلفون: Deepak Dalvie, R S Obach, Michael Zientek, James Matthew Hutzler
المصدر: Expert Opinion on Drug Metabolism & Toxicology. 9:153-168
مصطلحات موضوعية: Pharmacology, Drug, Drug discovery, media_common.quotation_subject, General Medicine, Metabolism, Biology, Toxicology, Aldehyde Oxidase, Metabolic pathway, chemistry.chemical_compound, Pharmaceutical Preparations, Biochemistry, chemistry, In vivo, Animals, Humans, Xenobiotic, Aldehyde oxidase, Metabolic Networks and Pathways, Drug metabolism, media_common
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المؤلفون: Michael Aaron Brodney, R S Obach, Michelle Vanase-Frawley, Gregory W. Kauffman, Erik Alphie Lachapelle, Aarti Sawant-Basak
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Serotonin, Oxazolidine, Stereochemistry, Health, Toxicology and Mutagenesis, Metabolite, Azetidine, Biological activity, General Medicine, Toxicology, Biochemistry, Partial agonist, Pyrrolidine, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Piperidines, chemistry, 030220 oncology & carcinogenesis, Azetidines, Humans, Piperidine, Isoxazole
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e0427ce3ce8afa0edb8491f587a6b4
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7Understanding the clinical pharmacokinetics of a GABAApartial agonist by application ofin vitrotools
المؤلفون: S M Winter, Alfin D. N. Vaz, Emily Miller, R S Obach, Aarti Sawant, J Brodfuehrer, D B Duignan, F R Nelson, A Kamel
المصدر: Xenobiotica. 40:476-484
مصطلحات موضوعية: Indoles, Monoamine oxidase, Health, Toxicology and Mutagenesis, In Vitro Techniques, Pharmacology, Toxicology, Biochemistry, Partial agonist, Dogs, Cytochrome P-450 Enzyme System, Pharmacokinetics, Cell Line, Tumor, medicine, Animals, Humans, Anilides, GABA-A Receptor Agonists, Monoamine Oxidase, Cells, Cultured, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, GABAA receptor, Cytochrome P450, General Medicine, In vitro, medicine.anatomical_structure, Anti-Anxiety Agents, Liver, Hepatocyte, biology.protein, Monoamine oxidase A
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المؤلفون: R S Obach, Amin Kamel, Elaine E. Tseng, Aarti Sawant
المصدر: Xenobiotica. 40:400-414
مصطلحات موضوعية: Male, medicine.medical_specialty, Indoles, Health, Toxicology and Mutagenesis, Metabolite, Drug Evaluation, Preclinical, Administration, Oral, Pharmacology, Toxicology, Biochemistry, Partial agonist, Rats, Sprague-Dawley, Excretion, Feces, chemistry.chemical_compound, Pharmacokinetics, Tandem Mass Spectrometry, Oral administration, Internal medicine, medicine, Animals, Anilides, Carbon Radioisotopes, GABA-A Receptor Agonists, Volume of distribution, Molecular Structure, Oxidative deamination, General Medicine, Rats, Bioavailability, Endocrinology, chemistry, Injections, Intravenous, Female, Chromatography, Liquid
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المؤلفون: R S Obach
المصدر: Clinical Pharmacology & Therapeutics. 91:385-387
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Clinical pharmacology, Cytochrome, biology, Chemistry, Ligand (biochemistry), In vitro, law.invention, Drug metabolizing enzymes, Enzyme, In vivo, law, biology.protein, Pharmacology (medical)
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المؤلفون: Stafford McLean, J B Lucot, J. W. Watson, R S Obach
المصدر: British Journal of Pharmacology. 120:116-120
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, medicine.drug_class, business.industry, Antagonist, Substance P, chemistry.chemical_compound, Endocrinology, Mechanism of action, chemistry, Internal medicine, medicine, Reflex, Vomiting, Antiemetic, NK1 receptor antagonist, Retching, medicine.symptom, business