المؤلفون: Fei Luo, Eriks Smagris, Sarah A. Martin, Goncalo Vale, Jeffrey G. McDonald, Justin A. Fletcher, Shawn C. Burgess, Helen H. Hobbs, Jonathan C. Cohen

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 879-899 (2022)

مصطلحات موضوعية: SDS, sodium dodecyl sulfate, PBS, phosphate-buffered saline, RC799-869, PE, phosphatidylethanolamine, ER, endoplasmic reticulum, PC, phosphatidylcholine, Mice, FLD, fatty liver disease, PCR, polymerase chain reaction, VLDL, very low density lipoprotein, Non-alcoholic Fatty Liver Disease, Animals, mAb, monoclonal antibody, RIPA, radioimmunoprecipitation assay buffer, SER, smooth endoplasmic reticulum, Triglycerides, Original Research, Liver Perfusion, KO, knockout, Hepatology, CE, cholesteryl ester, TG, triglyceride, S2, second supernatant, ACSL5, acyl-CoA synthetase long chain family member 5, Gastroenterology, Membrane Proteins, IP, immunoprecipitation, Diseases of the digestive system. Gastroenterology, LC-MS/MS, liquid chromatography–mass spectrometry, CRISPR/Cas9, clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9, WT, wild-type, Rats, Fatty Liver, ERGIC, endoplasmic reticulum–Golgi intermediate compartment, RER, rough endoplasmic reticulum, TM6SF2, transmembrane 6 superfamily 2, Apo, apolipoprotein, PI, protease inhibitor cocktail, UTSW, University of Texas Southwestern Medical Center, PFA, paraformaldehyde, VLDL

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c501eab0983bab28ced1482110d3291c
http://europepmc.org/articles/PMC8804273

المؤلفون: Rui Wang, Dandan Zhong, Yiqing Qiu, Jingni Wu, Yongliang Zhu, Zhenya Song, Jingwen Liu, Hongping Wang

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1433-1455 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: Models, Molecular, ANKRD22, ankyrin repeat domain-containing protein 22, RC799-869, BrdU+, bromodeoxyuridine-incorporating, Receptors, G-Protein-Coupled, Mice, FACS, fluorescence-activated cell sorting, Macrophage, IFN-γ, interferon-γ, Receptor, Wnt Signaling Pathway, TNF-α, tumor necrosis factor α, Original Research, Mice, Knockout, medicine.diagnostic_test, Chemistry, Wnt, Wingless/Int1, Gastroenterology, LGR5, ELISA, enzyme-linked immunosorbent assay, Diseases of the digestive system. Gastroenterology, FCM, flow cytometry, Immunohistochemistry, mRNA, messenger RNA, Ssea, stage-specific embryonic antigen, Mitochondria, Sox, SRY-box transcription factor, NFAT, nuclear factor of activated T cells, Rhod-2, Dihydrorhod-2, c-Myc, Myc proto-oncogene protein, AXIN2, axis inhibition protein 2, LPS, lipopolysaccharide, Tumor necrosis factor alpha, FITC, fluorescein isothiocyanate, RIPA, radioimmunoprecipitation assay, medicine.symptom, IL1α, interleukin-1α, IHC, immunohistochemistry, Targeted Gene Repair, Gastric Mucosal Injury, PBS, phosphate-buffered saline, Stomach Diseases, Inhibitory Compound, Inflammation, THP-1, Human myeloid leukemia mononuclear cell, Immunophenotyping, Flow cytometry, Structure-Activity Relationship, FBS, fetal bovine serum, Drug Development, In vivo, Cell Line, Tumor, medicine, Animals, Progenitor cell, Cell Proliferation, Cd, cluster of differentiation, Hepatology, Macrophages, Lgr5+, leucine-rich repeat-containing G-protein–coupled receptor 5–positive, Membrane Proteins, PE, Phycoerythrin, Macrophage Activation, WT, wild-type, qRT-PCR, quantitative reverse-transcription polymerase chain reaction, ANKRD22, TBS, Tris-buffered saline, Disease Models, Animal, Gene Expression Regulation, Mist, Muscle, intestine and stomach expression, Gastric Mucosa, CaMKII, calmodulin-dependent protein kinase II, Cancer research, EPC, epithelial progenitor cell, DMEM, Dulbecco’s modified Eagle medium, Epithelial Progenitor Cells, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f416abd6bb2732c90ffabe02f872fe52
https://doi.org/10.1016/j.jcmgh.2021.06.020

المؤلفون: Farah Khashab, May Al-Maghrebi, Nora Al-Kandari, Farah Al-Saleh, Fatemah Fadel

المصدر: Saudi Journal of Biological Sciences, Vol 27, Iss 8, Pp 2174-2184 (2020)
Saudi Journal of Biological Sciences

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, O2, molecular oxygen, PERK, pancreatic ER kinase, NADP, nicotinamide adenine dinucleotide phosphate, PCC, protein carbonyl content, DMSO, dimethyl sulfoxide, ST, seminiferous tubule, medicine.disease_cause, 01 natural sciences, ATF, activating transcription factor, eIF2α1, eukaryotic initiation factor 2α1, PVDF, polyvinylidene difluoride, chemistry.chemical_compound, DNA, deoxyribonucleic acid, PCR, polymerase chain reaction, UPR, unfolded protein response, ECL, electrochemiluminescence, TOS, testicular oxidative stress, ASK1, PARP, poly ADP-ribose polymerase, lcsh:QH301-705.5, ANOVA, analysis of variance, ATM, ataxia telangiectasia mutated, NADPH oxidase, RT, reverse transcription, biology, Chemistry, ELISA, enzyme-linked immunosorbent assay, BTB, blood-testis barrier, i.p., intraperitoneal, NOX, NADPH oxidase, JNK, c-Jun N-terminal Kinase, OS, oxidative stress, H2O2, hydrogen peroxide, IAP, inhibitors of apoptosis, p-, phosphorylated, RIPA, radioimmunoprecipitation assay, Germ cell apoptosis, General Agricultural and Biological Sciences, ER stress, kDa, kilodalton, phox, phagocyte oxidase, DNA damage, mRNA, messenger ribonucleic acid, H2AX, histone variant, IRE1, inositol requiring kinase 1, DAPI, diamidino phenylindole, CHOP, CCAAT-enhancer-binding protein homologous protein, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, Article, DDR, DNA damage response, Testicular ischemia Reperfusion Injury, ER, endoplasmic reticulum, Superoxide dismutase, Andrology, cDNA, complementary DNA, 03 medical and health sciences, ROS, reactive oxygen species, SOD, superoxide dismutase, GCA, germ cell apoptosis, medicine, IF, immunofluorescence, MDA, malondialdehyde, GRP78, glucose-related protein 78, medicine.disease, O2−, superoxide anion, Chk, checkpoint kinase, 8-OHdG, 8-hydroxy-2′-deoxyguanosine, 030104 developmental biology, lcsh:Biology (General), Oxidative stress, TRAF-2, tumor-necrosis-factor receptor-associated factor 2, SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis, Apocynin, H&E, hematoxylin and eosin, RNA, ribonucleic acid, γ-H2AX, 139 serine-phosphorylated histone variant, Unfolded protein response, biology.protein, ASK1, apoptosis signaling kinase 1, BSA, bovine serum albumin, gDNA, genomic DNA, SD, standard deviation, Reperfusion injury, 010606 plant biology & botany

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b9b9c3762cf95184a4b635e3a70e69
http://www.sciencedirect.com/science/article/pii/S1319562X20301364

المؤلفون: Ping Zhang, Dingyuan Ma, Li-Ying Peng, Ning-Yuan Sun, Jun Chen, Xiao-Wei Zhang, Weiwei Tang, Lin An

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1397-1413 (2020)

مصطلحات موضوعية: LDH, lactic dehydrogenase, MMP, mitochondrial membrane potential, Hepatocellular carcinoma, 7-AAD, 7-aminoactinomycin D, NS, no significance, TBST, Tris-buffered saline with Tween solution, DMSO, dimethyl sulfoxide, ECL, enhanced chemiluminescence, NC, negative control, 0302 clinical medicine, GSDME, gasdermin E, General Pharmacology, Toxicology and Pharmaceutics, N-GSDME, N-terminal GSDME, PARP, poly ADP-ribose polymerase, Caspase, ANOVA, analysis of variance, p-MEK, phosphorylated-MEK, DCFH-DA, dye 2,7-dichlorofluoresce diacetate, MEK, mitogen-activated and extracellular signal-regulated kinase, 0303 health sciences, DMEM, Dulbecco's modified Eagle's medium, biology, Kinase, Chemistry, Pyroptosis, HRP, horseradish peroxidase, PI3K, phosphatidylinositol 3-kinase, gRNA, guide RNA, i.p., intraperitoneal, VEGF, vascular endothelial growth factor, PBS, phosphate-based buffer, SDS-PAGE, sodium dodecyl sulphate-polyacrylamide gel electrophoresis, CRISPR, clustered regularly interspaced short palindromic repeats, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, 030220 oncology & carcinogenesis, Original Article, FITC, fluorescein isothiocyanate, RIPA, radioimmunoprecipitation assay, p-AKT, phosphorylated-AKT, IgG (H + L), immunoglobulin G (heavy chain + light chain), Intracellular, Cell death, Programmed cell death, HepG2, Miltirone, TCGA, the Cancer Genome Atlas, p-ERK1/2, phosphorylated-ERK1/2, Caspase 3, IC50, the half maximal inhibitory concentration, mTOR, mammalian target of rapamycin, MEM, minimum essential medium, PI, propidium iodide, 03 medical and health sciences, CCK-8, cell counting kit-8, ROS, reactive oxygen species, FBS, fetal bovine serum, i.v., intravenous, Viability assay, GSDMD, gasdermin D, AKT, AKT serine/threonine kinase, also known as protein kinase B, NMR, nuclear magnetic resonance, Cas9, caspase 9, 030304 developmental biology, Hepa1-6, KO, knockout, lcsh:RM1-950, lcsh:Therapeutics. Pharmacology, BAX, BCL2-associated X, Apoptosis, NAC, N-acetyl cysteine, ERK1/2, extracellular regulated protein kinases 1/2, Cancer research, biology.protein, H&E, hematoxylin and eosin, GSDME, HCC, hepatocellular carcinoma, SD, standard deviation, MS, mass spectrum

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750fb5bad337ad6389f2c3000e4927a2
http://europepmc.org/articles/PMC7488361

المؤلفون: Hongwei Fang, Peng Shang, Min Li, Atik Badshah Shaikh, Shiyi Chen, Xiliang Shang

المصدر: Journal of Orthopaedic Translation, Vol 22, Iss, Pp 116-123 (2020)
Journal of Orthopaedic Translation

مصطلحات موضوعية: medicine.medical_specialty, ATP, adenosine triphosphate, lcsh:Diseases of the musculoskeletal system, SDS–PAGE gel, sodium dodecyl sulphate–polyacrylamide gel electrophoresis, SD, Sprague Dawley, Intracellular pH, PBS, phosphate-buffered saline, Stimulation, Ct, threshold cycle, PBST, PBS with Tween 20, PVDF, polyvinylidene difluoride, chemistry.chemical_compound, ROS, reactive oxygen species, Downregulation and upregulation, Internal medicine, medicine, Orthopedics and Sports Medicine, CAs, carbonic anhydrases, Muscle fatigue, MDA, malondialdehyde, Soleus muscle, Gene knockdown, Chemistry, CAIII, carbonic anhydrase III, NS, saline injection group, Carbonic anhydrase III, Endocrinology, Original Article, RIPA, radioimmunoprecipitation assay, lcsh:RC925-935, Adenosine triphosphate, Intracellular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675c600ccef46d6cbd3d31f526038b73
http://www.sciencedirect.com/science/article/pii/S2214031X19302049

المؤلفون: Yubao Cui, Xiaotao Chen, Yanming Ma

المصدر: Journal of Bone Oncology, Vol 25, Iss, Pp 100314-(2020)
Journal of Bone Oncology

مصطلحات موضوعية: 0301 basic medicine, PVDF, polyvinylidene fluoride, lcsh:Diseases of the musculoskeletal system, lcsh:RC254-282, DMEM, Dulbecco’s modified Eagle’s medium, RT-qPCR, RNA extraction and quantitative real-time polymerase chain reaction, 03 medical and health sciences, SOX12, 0302 clinical medicine, FBS, fetal bovine serum, Western blot, medicine, miRNAs, microRNAs, BLACAT1, OS, osteosarcoma, FISH, Fluorescence in situ hybridization, ANOVA, analysis of variance, miR-608, Messenger RNA, Osteosarcoma, TUNEL assay, medicine.diagnostic_test, business.industry, Cell growth, ATCC, American type culture collection, lncRNAs, long non-coding RNAs, Mut, mutant, HRP, horseradish peroxidase, Cancer, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, WT, wild-type, mRNA, messenger RNA, Long non-coding RNA, SDS-PAGE, sulphate-polyacrylamide gel electrophoresis, 030104 developmental biology, Oncology, ceRNAs, competing endogenous RNAs, Apoptosis, 030220 oncology & carcinogenesis, SOX, sex-determining region Y (SRY)-box, SOX12, sex determining region Y-box protein 12, Cancer research, RIPA, radioimmunoprecipitation assay, lcsh:RC925-935, SD, standard deviation, business, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e419725433635817b7c2d2f13415912
http://www.sciencedirect.com/science/article/pii/S2212137420300695

المؤلفون: Stephanie, Thibodeau, Weidong, Yang, Sunita, Sharma, Jonathan, Lytton

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: membrane transport, CaMKII, Ca2+-calmodulin-dependent kinase II, N4MAb, mouse monoclonal antibody against NCKX4 obtained from NeuroMab, plasma membrane, TMS, transmembrane segment, Antiporters, Sodium-Calcium Exchanger, SLC24, solute-linked carrier gene family 24, Calmodulin, S12, supernatant following centrifugation at 12,000g (crude cytosolic fraction), Two-Hybrid System Techniques, calcium transport, GST, glutathione-S-transferase, PKC, protein kinase C, sodium–(calcium + potassium) exchange, PSD, rabbit polyclonal serum D against NCKX4, Humans, Calcium Signaling, CaM, calmodulin, Cell Membrane, sodium–calcium exchange, HEK293 Cells, PMSF, phenylmethylsulfonyl fluoride, P12, pellet following centrifugation at 12,000g (crude cellular membrane fraction), Calcium, NCKX, Na+/(Ca2++K+)-exchanger, calmodulin (CaM), Protein Binding, Research Article, DAPI, 4′,6-diamidino-2-phenylindole, P150, pellet following centrifugation at 150,000g (synaptic marker-enriched membrane fraction), RIPA, radioimmunoprecipitation assay buffer (1% Triton X-100, 150 mM NaCl, 25 mM TrisCl, 1 mM EDTA, pH7.5)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::69064bc0853c49089740e82183038c4e
https://pubmed.ncbi.nlm.nih.gov/33199372

المؤلفون: Alice P. Sowton, Andrew J. Murray, Simon James Tunster, Erica D. Watson, Ben D. McNally, Nisha Padmanabhan, Julian L. Griffin, Antonio Murgia, Aisha Yusuf

المساهمون: Medical Research Council, Medical Research Council (MRC), Sowton, Alice [0000-0002-3718-7783], Tunster, Simon [0000-0002-2242-9452], Murray, Andrew [0000-0002-0929-9315], Watson, Erica [0000-0003-4496-2271], Apollo - University of Cambridge Repository, Watson, Erica D [0000-0003-4496-2271]

المصدر: Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, Vol 23, Iss, Pp-(2020)

مصطلحات موضوعية: CE, cholesteryl-ester, LC-MS, liquid chromatography-mass spectrometry, 5-methyl-THF, 5-methyltetrahydofolate, OXPHOS, oxidative phosphorylation, G6pc, glucose 6-phophastase gene, PG, phosphatidylglycerol, 0601 Biochemistry and Cell Biology, Gyg, glycogenin gene, PIP, phosphatidylinositol phosphate(s), Cebpa, CCAAT/enhancer binding protein (C/EBP), alpha gene, chemistry.chemical_compound, Isca1, iron‑sulfur cluster assembly 1 gene, PC, phosphatidylcholine, 0302 clinical medicine, Endocrinology, Nonalcoholic fatty liver disease, One‑carbon metabolism, PA, phosphatidic acid, lcsh:QH301-705.5, 0303 health sciences, lcsh:R5-920, biology, Glycogen, FCCP, p-trifluoromethoxyphenyl hydrazine, 030305 genetics & heredity, SAM, S-adenosylmethionine, Mthfr, methylenetetrahydrofolate reductase gene, Mtr, methionine synthase gene (also MS), PS, phosphatidylserine, 3. Good health, PL, phospholipid, Gsk3, glycogen synthase kinase gene, RIPA, Radioimmunoprecipitation assay, Agl, amylo-alpha-1,6-glucosidase,4-alpha-glucanotransferase gene, Ndufs, NADH:ubiquinone oxidoreductase core subunit (ETS complex I) gene, Liver metabolism, Bhmt, betaine-homocysteine S-methyltransferase gene, Hepatic fuel storage, lcsh:Medicine (General), Gbe1, glycogen branching enzyme 1 gene, Research Paper, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, TAG, triacylglycerol, NASH, non-alcoholic steatohepatitis, Cer, ceramide, PE, phosphatidylethanolamine, PI, phosphatidylinositol, 03 medical and health sciences, Internal medicine, FFA, free fatty acid, Genetics, medicine, JO2, oxygen flux, Glycogen synthase, GSK3A, Molecular Biology, Myc, myelocytomatosis oncogene, 0604 Genetics, Methionine, LPC, lysophosphatidylcholine, SM, sphingomyelin, Ddit3, DNA damage inducible transcript 3 gene, SAH, S-adenosylhomocysteine, Lipid metabolism, (Methionine synthase) reductase, Gys2, glycogen synthase 2 gene, Ugp2, UDP-glucose pyrophophorylase 2 gene, medicine.disease, MTRR, HOAD, 3-hydoxyacyl-CoA dehydrogenase, BCA, bicinchoninic acid, Mtrr, methionine synthase reductase gene (also MSR), chemistry, lcsh:Biology (General), gt, gene-trap, Lipidomics, biology.protein, Mitochondrial function, PAS, periodic acid Schiff, DAG, diacylglycerol, 030217 neurology & neurosurgery, ETS, electron transport system

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5de79e1f7ef67cef5ce425b58d812c6
http://hdl.handle.net/10044/1/82233

المؤلفون: Sabrina Schreiber, Elisabeth Petrasch-Parwez, Elke Porrmann-Kelterbaum, Eckart Förster, Jörg T. Epplen, Wanda M. Gerding

المصدر: IBRO Reports
IBRO Reports, Vol 5, Iss, Pp 43-53 (2018)

مصطلحات موضوعية: SEZ, subependymal zone, GL, glomerular layer, Ccdc66, EPL, external plexiform layer, PBS, phosphate-buffered saline, gPRA, generalized progressive retinal atrophy, SVZ, subventricular zone, ML, mitral cell layer, Article, lcsh:RC321-571, Mouse model, M, mitochondrion, SC, supporting cell, Olfactory bulb, OE, olfactory epithelium, Ccdc66 +/+, WT, wildtype, RMS, rostral migratory stream, Ccdc66 -/-, Ccdc66-deficient, Neurodegeneration, RP, retinitis pigmentosa, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, De, dendrite, CTX, cortex, P, postnatal day, ORN, olfactory receptor neuron(s), PG, periglomerular cells, IPL, internal plexiform layer, Retinitis pigmentosa, m, month/s, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, ioD, integrated optic density, ONF, olfactory nerve fibers, ONL, olfactory nerve layer, MOB, main olfactory bulb, AG, astroglia, RIPA, radioimmunoprecipitation assay

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::512d407e7c4dc88c74cb070df9346fc3
http://europepmc.org/articles/PMC6132079

المؤلفون: Adam S. Mastrocola, Weiyan Jia, Peter Tonzi, William M. Guns, Lu Liu, Robert J. Millikin, Randal S. Tibbetts, Sang Hwa Kim, Tony T. Huang, Mark Scalf, Lloyd M. Smith

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Genome instability, FTD, frontotemporal dementia, amyotrophic lateral sclerosis (ALS), DNA Repair, BrdU, 5-bromo-2′-deoxyuridine, CF, chromatin fraction, Biochemistry, DNA Replication Timing, DNA Breaks, Double-Stranded, LRD, late replication domain, HDR, homology-directed repair, LOF, loss-of-function, iPOND, isolation of proteins on nascent DNA, ORC, origin recognition complex, CLM, calicheamicin γ1, BRCA1 Protein, PAR, poly(ADP)-ribosyl, PARP, poly(ADP)-ribosyl polymerase, EdU, 5-ethynyl-2′-deoxyuridine, CHOP, CCAAT/enhancer-binding protein homologous protein, Sarcoma, IP, immunoprecipitation, LCD, low-complexity domain, ALS, amyotrophic lateral sclerosis, MRD, mid replication domain, RF, replication fork, Cell biology, CSK, cytoskeleton, NHEJ, nonhomologous end joining, ERD, early replication domain, RIPA, radioimmunoprecipitation assay, Tumor Suppressor p53-Binding Protein 1, Research Article, RGG, arginine–glycine–glycine repeat, DNA repair, pre-RC, prereplication complex, PCNA, proliferating cell nuclear antigen, replication timing, DNA replication, SSB, single-strand break, Biology, DDR, DNA damage response, PI, propidium iodide, cDNA, complementary DNA, GO, Gene Ontology, Humans, DSB, double-strand break, Molecular Biology, FET, FUS, EWSR1, TAF15, MMC, mitomycin C, Cell Proliferation, Transcriptionally active chromatin, Replication timing, RD, replication domain, CldU, 5-chloro-2′-deoxyuridine, Cell Biology, HEK293T, human embryonic kidney 293T, RNA binding protein, SCAI, suppressor of cancer cell invasion, Proliferating cell nuclear antigen, Kinetics, RT, replication timing, biology.protein, RNA-Binding Protein FUS, Origin recognition complex, BSA, bovine serum albumin, qPCR, quantitative PCR, fused in sarcoma (FUS), HU, hydroxyurea, DAPI, 4′,6-diamidino-2-phenylindole, FUS, fused in sarcoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a9a44d7275f5becac62657ed50f32a
https://doi.org/10.1016/j.jbc.2021.101049