المؤلفون: Marina V. Rodnina, K. Vester, Dmitry Burakovskiy, Markus C. Wahl, Pohl Milón, Eva Absmeier, Tahereh Ghane, Petra Imhof, Karine F. Santos

المصدر: The Journal of Biological Chemistry
Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, SF2, superfamily 2, intramolecular regulation, sn, small nuclear, T1, truncation 1, IG, immunoglobulin-like domain, Biochemistry, Substrate Specificity, HB, helical bundle domain, pre-mRNA, precursor messenger RNA, Protein structure, Tris, tris(hydroxymethyl)aminomethane, Adenosine Triphosphate, Adenine nucleotide, enzyme kinetics, Nucleotide, CC, C-terminal cassette, Amino Acids, chemistry.chemical_classification, biology, Chemistry, Adenine Nucleotides, Editors' Pick, NTR, N-terminal region, Ribonucleoproteins, Small Nuclear, RNA Helicase A, MD, molecular dynamics, Adenosine Diphosphate, superfamily 2 helicase, RNA splicing, HLH, helix–loop–helix domain, wt, wild type, 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften, RNA Helicases, Research Article, RNA helicase, NC, N-terminal cassette, Allosteric regulation, NTPase, nucleic-acid-dependent nucleotide triphosphatase, Molecular Dynamics Simulation, DSF, differential scanning fluorimetry, SEM, standard error of the mean, FRET, fluorescence resonance energy transfer, 03 medical and health sciences, h, human, Protein Domains, WH, winged-helix domain, protein conformation, Humans, Molecular Biology, RNP, ribonucleoprotein complex, Binding Sites, 030102 biochemistry & molecular biology, Helicase, Cell Biology, allosteric regulation, v/v, volume/volume, Kinetics, 030104 developmental biology, DTT, dithiothreitol, ss, single-stranded, Mutation, pre-mRNA splicing, biology.protein, Biophysics, BAC, bacterial artificial chromosome, mant, methylanthraniloyl, Structural communication, pre mRNA splicing

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebde8382e3bb7f7e295d497fb6fcc56

المؤلفون: Julie A. Pigza, Jared D. Hume, Jacques J. Kessl, Matthew Garrett Donahue, Jian Sun, Krunal Patel

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Integrase inhibitor, HIV Integrase, Virus Replication, Biochemistry, HIV-1, human immunodeficiency virus type 1, quinoline, HTRF, homogeneous time resolved fluorescence, human immunodeficiency virus, biology, Chemistry, CTD, C-terminal domain, DMSAO, dimethyl sulfoxide, Chromatin, Integrase, Cell biology, Quinolines, Intercellular Signaling Peptides and Proteins, CCD, catalytic core domain, I N, integrase, Research Article, Protein Binding, drug design, Virus Integration, Protein subunit, Allosteric regulation, ALLINI, allosteric IN inhibitors, Antiviral Agents, oligomerization, Protein–protein interaction, antiviral agent, 03 medical and health sciences, Allosteric Regulation, Humans, NTD, N-terminal domain, HIV Integrase Inhibitors, Binding site, Molecular Biology, RNP, ribonucleoprotein complex, 030102 biochemistry & molecular biology, Cell Biology, protein–protein interaction, HEK293 Cells, 030104 developmental biology, vDNA, viral cDNA, Viral replication, HIV-1, biology.protein, ALLINI, integrase, Protein Multimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812afed44ebca78da55c911ffeaba508
https://doi.org/10.1016/j.jbc.2021.100363

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