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المؤلفون: Jin Gyu Jung, Sunghyun Kim, Bum Soo Kim, Anca Streinu-Cercel, Oana Săndulescu, Da Bee Jeon, Adrian Streinu-Cercel, Seul Gi Lee, Sang Joon Lee, Yeon Sook Kim, Yeo Jin Lee, Jin Yong Kim, Yeon Mi Lee, Min Kyung Kim, Jae-Hyeong Park, Jang Hee Hong, Jeong Eun Park, Young Rock Jang, Na Hyun Jung
المصدر: Clinical Therapeutics
مصطلحات موضوعية: CTCAE, Common Toxicity Criteria for Adverse Events, BMI, body mass index, Cmax/dose, dose-normalized maximum serum concentration, Gastroenterology, CPK, creatine phosphokinase, regdanvimab, Pharmacology (medical), Original Research, COVID-19, coronavirus disease 2019, AUC0–inf, area under the serum concentration–time curve from time zero to infinity, biology, ADE, antibody-dependent enhancement, Antibodies, Monoclonal, EudraCT, European Union Drug Regulating Authorities Clinical Trials Database, RBD, receptor-binding domain, Common Terminology Criteria for Adverse Events, CL, total body clearance, IRR, infusion-related reaction, Vz, volume of distribution during the terminal phase, Tolerability, t½, terminal elimination half-life, Cohort, CRP, C-reactive protein, Antibody, ADA, anti-drug antibody, AE, adverse event, Adult, CT-P59, medicine.medical_specialty, Antibodies, Monoclonal, Humanized, ACE2, angiotensin-converting enzyme 2, Placebo, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, DEC, Dose Escalation Committee, S, spike [protein], Double-Blind Method, MedDRA, Medical Dictionary for Regulatory Activities, Pharmacokinetics, ALT, alanine aminotransferase, Internal medicine, medicine, Humans, Adverse effect, RT-PCR, reverse transcription–polymerase chain reaction, IQR, interquartile range, Pharmacology, SAE, serious adverse event, SE, standard error, SARS-CoV-2, business.industry, COVID-19, RT-qPCR, quantitative reverse transcription–polymerase chain reaction, Antibodies, Neutralizing, Discontinuation, CI, confidence interval, AUC0–inf/dose, dose-normalized area under the serum concentration–time curve from time zero to infinity, Neutralizing monoclonal antibody, cp, copies, Immunoglobulin G, Ct, cycle threshold, biology.protein, Cmax, maximum serum concentration, Tmax, time to maximum serum concentration, Carrier Proteins, SD, standard deviation, business
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المؤلفون: Jhon Paul Iakov Mezarina Mendoza, Briggitte Patricia Trelles Ubillús, Gabriela Tazziana Salcedo Bolívar, Rosa Del Pilar Castañeda Palacios, Paulo Sergio Gilmar Herrera Lopez, David Alex Padilla Rodríguez, Karin Harumi Uchima Koecklin
المصدر: The Saudi Dental Journal
مصطلحات موضوعية: CCID50, 50% of cell culture infectious dose, Mouthwashes, PBS, phosphate-buffered saline, COVID-19, non-RCT, non-randomized controlled trials, Review Article, OCT, octenidine dihydrochloride, CHX, chlorhexidine digluconate, APD, anionic phthalocyanine derivate, RT-qPCR, quantitative reverse transcription polymerase chain reaction, pfu/mL, plaque forming units per milliliter, Coronavirus, TCID50/mL, 50% of tissue culture infective dose, RCT, randomized controlled trials, Oral hygiene, H2O2, hydrogen peroxide, CPC, cetylpyridinium chloride, Viral load, CDCM, β-cyclodextrin-citrox, General Dentistry, PVP-I, povidone-iodine
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المؤلفون: Christopher R. Paradise, Joanna S. Price, Gabriel L. Galea, Andre J. van Wijnen, Emily T. Camilleri, Gary S. Stein, Lance E. Lanyon, Amel Dudakovic, Lee B Meakin, Hanna Taipaleenmäki
المصدر: Gene: X
Galea, G L, Paradise, C R, Meakin, L B, Camilleri, E T, Taipaleenmaki, H, Stein, G S, Lanyon, L E, Price, J S, van Wijnen, A J & Dudakovic, A 2020, ' Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2 ', Gene, vol. 763S, 100027, pp. 100027 . https://doi.org/10.1016/j.gene.2020.100027
Gene: X, Vol 5, Iss, Pp 100027-(2020)مصطلحات موضوعية: 0301 basic medicine, β2MG, Beta-2-Microglobulin, ActD, Actinomycin D, ALP, Alkaline phosphatase, Osteoclasts, Core Binding Factor Alpha 1 Subunit, CO2, Carbon Dioxide, PGE2, Prostaglandin E2, Binding Sites/genetics, Bone remodeling, Epigenesis, Genetic, Ki-67, Antigen KI-67, chemistry.chemical_compound, 0302 clinical medicine, PCR, polymerase chain reaction, ChIP, Chromatin immunoprecipitation, Osteogenesis, OPG, Osteoprotegerin/tumour necrosis factor receptor superfamily member 11B, Osteoblasts/metabolism, Gene knockdown, biology, IgG, Immunoglobulin G, Gene Expression Regulation, Developmental, Cell Differentiation, Epigenesis, Genetic/genetics, General Medicine, FACS, Fluorescence-activated cell sorting, Cell biology, RUNX2, IU, International unit, eGFP, enhanced green fluorescent protein, RANKL, RANKL/TNFSF11, receptor activator of nuclear factor-κB ligand, GAPDH, Glyceraldehyde 3-Phosphate Dehydrogenase, 030220 oncology & carcinogenesis, Osteogenesis/genetics, Osteoclasts/metabolism, BRD2, Epigenetics, Bone Remodeling, sh, Short hairpin, musculoskeletal diseases, Mechanical strain, lcsh:QH426-470, Sclerostin, Bone Remodeling/genetics, Bone Resorption/genetics, Cell Differentiation/genetics, Transcription Factors/genetics, BRD2, Bromodomain-containing protein 2, RANK Ligand/genetics, DMEM, Dulbecco's Modified Eagle Medium, Osteocytes, Article, Cell Line, Core Binding Factor Alpha 1 Subunit/genetics, 03 medical and health sciences, PBS, Phosphate-Buffered Saline, Genetics, Humans, Bone Resorption, Transcription factor, FCS, Fetal calf serum, Binding Sites, Osteoblasts, Activator (genetics), Sprains and Strains/genetics, HDAC, Histone deacetylase, RANK Ligand, RNA, Ribonucleic Acid, HPRT, Hypoxanthine Phosphoribosyltransferase 1, RT-qPCR, Quantitative reverse transcription polymerase chain reaction, lcsh:Genetics, Receptor activator of nuclear factor-κB ligand, 030104 developmental biology, chemistry, biology.protein, Sprains and Strains, SOST, Sclerostin, AzadC, 5-Aza-2′-deoxycytidine, Stress, Mechanical, RUNX2, Runt-related transcription factor 2, Chromatin immunoprecipitation, Osteocytes/metabolism, Transcription Factors, DNA, Deoxyribonucleic Acid, DAPI, 4′,6-diamidino-2-phenylindole
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25bf36d9a55ee08ac308c9e986aaf2e
http://europepmc.org/articles/PMC7285908 -
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المؤلفون: Gerhard Rogler, Pedro A. Ruiz, Cheryl de Valliere, Jonas Zeitz, Jyrki J. Eloranta, Hassan Melhem, Irina Tcymbarevich, Kirstin Atrott, Benjamin Misselwitz, Gerd A. Kullak-Ublick, Michael Fried, Klaus Seuwen, Carsten A. Wagner, Mehdi Madanchi, Jesus Cosin-Roger, Simona Simmen, Stephan R. Vavricka
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 6, Pp 796-810 (2016)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: WT, wild type, 0301 basic medicine, MM6, MonoMac 6, HV, healthy volunteer, SPARC, secreted protein acidic and rich in cysteine, NF-κB, nuclear factor-κB, Inflammation, Biology, IEC, intestinal epithelial cell, 03 medical and health sciences, Intestinal mucosa, TDAG8, Ovarian Cancer G-Protein–Coupled Receptor, medicine, OGR1, ovarian cancer G-protein–coupled receptor 1 (GPR68), IFN, interferon, lcsh:RC799-869, Receptor, Original Research, Th, T-helper, TNF, tumor necrosis factor, IBD, inflammatory bowel disease, Hepatology, RT-qPCR, quantitative reverse-transcription polymerase chain reaction, AICAR, 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside, TDAG8, T-cell death-associated gene 8 (GPR65), Inflammatory Bowel Disease, GRP65, Gastroenterology, Hypoxia (medical), Molecular biology, GPR, G-protein–coupled receptor, mRNA, messenger RNA, IL, interleukin, ChIP, chromatin immunoprecipitation, HIF, hypoxia-inducible factor, UC, ulcerative colitis, 030104 developmental biology, Hypoxia-inducible factors, Cancer research, CD, Crohn's disease, lcsh:Diseases of the digestive system. Gastroenterology, Tumor necrosis factor alpha, FCS, fetal calf serum, medicine.symptom, Chromatin immunoprecipitation, Homeostasis
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المؤلفون: Christopher Benner, Elvira Mennillo, Miles Paszek, Xiaojing Yang, Johan Auwerx, Shujuan Chen
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 133-147 (2020)
Cellular and molecular gastroenterology and hepatology, vol 10, iss 1مصطلحات موضوعية: 0301 basic medicine, Male, HFD, high-fat diet, Ulcerative, Apoptosis, NCoR1, HDAC, histone deacetylase, H3K, histone H3, Transgenic, Epigenesis, Genetic, IEC, intestinal epithelial cell, Histones, BrdU, bromodeoxyuridine, Mice, 0302 clinical medicine, 2.1 Biological and endogenous factors, AMP, antimicrobial peptide, DSS, dextran sodium sulfate, FITC-d, fluorescein isothiocyanate–dextran, Aetiology, Intestinal Mucosa, Cancer, Original Research, Chemistry, RT-qPCR, quantitative reverse-transcription polymerase chain reaction, BW, body weight, Dextran Sulfate, UCSD, University of California, San Diego, Gastroenterology, Acetylation, WRN, Wnt-3A, R-Spondin 3, and Noggin, Colitis, Cell biology, Organoids, TNFα, tumor necrosis factor α, Adult Stem Cells, Butyrates, Stem Cell Research - Nonembryonic - Non-Human, 030211 gastroenterology & hepatology, Female, Stem cell, Colon, Cldns, claudins, Crypt, Primary Cell Culture, Mice, Transgenic, Butyrate, Autoimmune Disease, 03 medical and health sciences, Genetic, Genetics, medicine, Animals, Humans, Nuclear Receptor Co-Repressor 1, Ulcerative Colitis, IBD, inflammatory bowel disease, lcsh:RC799-869, Cell Proliferation, Hepatology, Animal, Cell growth, Inflammatory Bowel Disease, DCS, deep crypt secretory, Epithelial Cells, Stem Cell Research, medicine.disease, IL, interleukin, Disease Models, Animal, UC, ulcerative colitis, 030104 developmental biology, Disease Models, NCoR1, nuclear receptor co-repressor 1, lcsh:Diseases of the digestive system. Gastroenterology, Colitis, Ulcerative, Colonic Crypt Cell, Digestive Diseases, Immunostaining, Epigenesis
وصف الملف: application/pdf
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المؤلفون: Łukasz Sędek, Roman Jaksik, Bronisława Szarzyńska-Zawadzka, Monika Drobna, Jerzy Kowalczyk, Tomasz Szczepański, Michał Witt, Małgorzata Dawidowska, Krzysztof Kałwak, Monika Lejman, Anna Lalik, Maria Kosmalska, Marek Ussowicz, Ludomiła Machowska
المصدر: Neoplasia (New York, N.Y.)
Neoplasia
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 3, Pp 294-310 (2019)مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Small RNA, Original article, small RNA-seq, next-generation sequencing of small RNAs, Apoptosis, Computational biology, Biology, isomiR, isoform of miRNA, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, lcsh:RC254-282, KEGG, Kyoto Encyclopedia of Genes and Genomes, MiRBase, Immunophenotyping, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, RNA interference, Genes, Reporter, microRNA, GO, Gene Ontology, RNA, Messenger, GEO, Gene Expression Omnibus, KEGG, Regulation of gene expression, Gene Expression Regulation, Leukemic, MRE, miRNA response element, Gene Expression Profiling, Computational Biology, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, ALL, acute lymphoblastic leukemia, T-ALL, T-cell acute lymphoblastic leukemia, RT-qPCR, quantitative reverse transcription polymerase chain reaction, Gene expression profiling, MicroRNAs, 030104 developmental biology, EGIL, European Group for Immunological Classification of Leukemias, 030220 oncology & carcinogenesis, 3′UTR, 3′ untranslated region, RNA Interference, miRNome, transcriptome of miRNAs, OR, Odds ratio
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المؤلفون: Caterina Strambio-De-Castillia, Stuart W. Peltz, Christopher R. Trotta, Joseph M. Colacino, Elizabeth Goodwin, Liangxian Cao, Yetao Wang, Ellen L Suder, Elke Mühlberger, Sina Bavari, Jason D. Graci, Allan Jacobson, Mark Pykett, Kylie O'Keefe, Rachel A. Sattler, Ronald Kong, Ellen Welch, Jeremy Luban, Katherine Cintron-Lue, Marla Weetall, Slobodan Paessler, Veronica Soloveva, Nikolai Naryshkin
المصدر: Virus Research
bioRxivمصطلحات موضوعية: Cancer Research, BSL-3, biosafety level-three, viruses, medicine.medical_treatment, DHO, dihydroorotate, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, Dihydroorotate Dehydrogenase, coronavirus, RVFV, Rift Valley Fever virus, DMSO, dimethyl sulfoxide, Pharmacology, Virus Replication, medicine.disease_cause, Tissue culture, Chlorocebus aethiops, cytokine, TNF-α, tumor necrosis factor alpha, DHODH, dihydroorotate dehydrogenase, CDC, Centers for Disease Control and Prevention, MOI, multiplicity of infection, COVID-19, coronavirus disease 2019, Coronavirus, 0303 health sciences, TCR, T cell receptor, EC90, effective concentration required for 90% inhibition, WRCEVA, World Reference Center for Emerging Viruses and Arboviruses, Interleukin, ELISA, enzyme-linked immunosorbent assay, MCP-1, monocyte chemoattractant protein-1, VEGF, vascular endothelial growth factor, antiviral, Infectious Diseases, Cytokine, HCV, hepatitis C virus, BS-4, biosafety level-four, UTMB, University of Texas Medical Branch, cytokine storm, Cytokines, medicine.symptom, Cytokine Release Syndrome, DMEM, Dulbecco’s Modified Eagle Medium, Oxidoreductases Acting on CH-CH Group Donors, Carbazoles, Inflammation, CTP, cytidine triphosphate, Biology, Antiviral Agents, CC50, concentration required for 50% cytotoxicity, PK, pharmacokinetic, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Article, Virus, BioMAP, Biologically Multiplexed Activity Profiling, Proinflammatory cytokine, 03 medical and health sciences, FBS, fetal bovine serum, Virology, HUVEC, human umbilical vein endothelial cells, medicine, Animals, Humans, MMP-1, matrix metalloproteinase-1, Vero Cells, ARDS, acute respiratory distress syndrome, 030304 developmental biology, PBMCs, peripheral blood mononuclear cells, RT-qPCR, quantitative reverse transcription-polymerase chain reaction, Ebola virus, SARS-CoV-2, 030306 microbiology, PTC299, COVID-19, DHODH, medicine.disease, COVID-19 Drug Treatment, EC50, effective concentration required for 50% inhibition, IL, interleukin, IFN- γ, Interferon gamma, TGF-β1, transforming growth factor beta 1, Viral replication, SRB, sulforhodamine B, TCID50, 50% tissue culture infectious dose assay, Dihydroorotate dehydrogenase, Carbamates, DAPI, 4',6-diamidino-2-phenylindole, Cytokine storm, UTP, uridine triphosphate, HeLa Cells
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المؤلفون: Paloma Maria Parvex
المصدر: EBioMedicine
EBioMedicine, Vol. 39 (2019) pp. 27-28مصطلحات موضوعية: Nephrotic Syndrome, Research paper, MCD, minimal change disease, GML, glomerular minor lesion, MEDLINE, Bioinformatics, Idiopathic Nephrotic Syndrome, General Biochemistry, Genetics and Molecular Biology, miRNA, microRNA, microRNA, Humans, Medicine, Urinary exosomes, NS, nephrotic syndrome, Child, ddc:618, MsPGN, mesangial proliferative glomerulonephritis, Illumina SBS technology, Illumina sequencing via synthesis technology, RT-qPCR, quantitative reverse-transcription polymerase chain reaction, business.industry, RT-qPCR, CKD, chronic kidney disease, FSGS, focal segmental glomerulonephritis, Nephrotic Syndrome/genetics, TEM, transmission electron microscope, Paediatric idiopathic nephrotic syndrome, ROC, receiver operating characteristic curves, Biomarker, General Medicine, Illumina sequencing via synthesis, NTA, nanoparticles tracking technology, OR, odds ratio, MicroRNAs, AUC, area under of the ROC curve, Potential biomarkers, Cq, quantification cycle, business, Biomarkers
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المؤلفون: Ondrej Cerny, Stéphanie Slupek, Fabian Amman, David Hot, Roy Gross, Ilona Bibova, Branislav Večerek, Kristina Keidel
المصدر: RNA Biology
مصطلحات موضوعية: wt, wild-type, Bordetella pertussis, Type V Secretion Systems, Mutant, Virulence, Host Factor 1 Protein, ABC protein, ATP-binding cassette protein, Regulon, Hfq, Type three secretion system, Microbiology, T3SS, Type III secretion system, Cell Line, Transcriptome, transcriptomics, Mice, Bacterial Proteins, Gene expression, Type III Secretion Systems, Animals, Virulence Factors, Bordetella, Molecular Biology, Bordetella Infections, 0604 Genetics, biology, Gene Expression Profiling, Macrophages, Cell Biology, SS medium, Steiner-Scholte medium, Gene Expression Regulation, Bacterial, biology.organism_classification, Research Papers, CFU, colony forming unit, RT-qPCR, quantitative reverse transcription polymerase chain reaction, infection, Bsp22, T3SS, virulence, RNA, Bacterial, Host-Pathogen Interactions, P, P-value, OMP, outer membrane protein, Developmental Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716cd279c9289556bb84992f69b31e1a
http://hdl.handle.net/10044/1/40293 -
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المؤلفون: Yanni Zhang, Nan Wang, Chen-Yu Zhang, Ming-De Xia, Anh Van Le, Ke Zen, Chunni Zhang, Junjun Wang, Xi Chen, Meng Ding, Wan-Jian Gu, Xiangdong Wang, Sidi Chen, Cheng Wang, Yi Shen, Rafael W. Soto-Gil
المصدر: EBioMedicine
EBioMedicine, Vol 2, Iss 10, Pp 1377-1385 (2015)مصطلحات موضوعية: Oncology, medicine.medical_specialty, Pathology, Lung Neoplasms, lcsh:Medicine, NSCLC, non-small-cell lung cancer, General Biochemistry, Genetics and Molecular Biology, Internal medicine, miRNA, microRNA, microRNA, Diagnosis, TNM, tumor–node–metastasis, Biomarkers, Tumor, medicine, TaqMan, Humans, Stage (cooking), Lung cancer, Early Detection of Cancer, Serum microRNAs, lcsh:R5-920, business.industry, lcsh:R, Case-control study, General Medicine, Biomarker, Ethnically diverse, TLDA, TaqMan Low-Density Array, medicine.disease, Multiethnic, RT-qPCR, quantitative reverse transcription polymerase chain reaction, MicroRNAs, Multicentric, AUC, the area under the ROC curve, Cohort, Cq, quantification cycle, Biomarker (medicine), lcsh:Medicine (General), business, Non-small-cell lung cancer, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aef8230416ca2b13297cb1e7e079ebf