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المؤلفون: Susanne Hougaard Bennekou, Rabea Graepel, Marcel Leist, Annette Bitsch, Gladys Ouedraogo, Jan G. Hengstler, Sylvia Escher, Hennicke Kamp, Derek Knight, Manuel Pastor, Ulf Norinder, Sharon B. Stuard, Matthias Herzler, Andrew White, Ciarán Fisher, Bob van de Water, Dinant Kroese, Barbara Zdrazil
المصدر: Archives of Toxicology, 93(12), 3643-3667
Archives of Toxicologyمصطلحات موضوعية: 0301 basic medicine, Hazard (logic), Physiologically based pharmacokinetic modelling, Toxicodynamics, Computer science, Health, Toxicology and Mutagenesis, In silico, Computational biology, 010501 environmental sciences, Hazard analysis, Toxicology, Risk Assessment, 01 natural sciences, Hazardous Substances, Workflow, 03 medical and health sciences, Terminology as Topic, ddc:570, Toxicity Tests, Similarity (psychology), Animals, Humans, Computer Simulation, 0105 earth and related environmental sciences, Adverse Outcome Pathways, General Medicine, Models, Theoretical, Toxicokinetics, Chemical hazard, 030104 developmental biology
وصف الملف: application/pdf
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المؤلفون: Alejandro Aguayo-Orozco, Liliana Capinha, Nazanin Golbamaki, Enrico Mombelli, Matthias Wehr, Bart van der Burg, Daria Goldmann, Nanette G Vrijenhoek, Thomas Exner, Richard Maclennan, Katharina Brotzmann, Ulf Norinder, Oliver Hatley, Alice Limonciel, Thomas Braunbeck, Sylvia Escher, Barbara Zdrazil, Frédéric Y. Bois, Paul Jennings, Emilio Benfenati, Domenico Gadaleta, Jose Castel, Ciarán Fisher, Sankalp Jain, Anthony Long, Rabea Graepel, Laia Tolosa, Andrew White, Bob van de Water, Barbara M.A. van Vugt-Lussenburg, Paul Walker, Annette Bitsch, Olivier Taboureau, Iain Gardner
المساهمون: AIMMS, Molecular and Computational Toxicology, Publica
المصدر: Toxicology in Vitro, 79:105269, 1-16. Elsevier Limited
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269, pp. 1-16 . https://doi.org/10.1016/j.tiv.2021.105269
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269 . https://doi.org/10.1016/j.tiv.2021.105269
Toxicology in Vitro
Toxicology In Vitro, 79مصطلحات موضوعية: Test strategy, Mechanistic hazard assessment, Adverse Outcome Pathways, Computer science, In silico, Gene Expression Profiling, Liver steatosis, Carboxylic Acids, General Medicine, Computational biology, Toxicology, AOP-network, Fatty Liver, Differentially expressed genes, Workflow, Action (philosophy), NAM, Read-across, Adverse Outcome Pathway, Animals, Humans, Computer Simulation, Zebrafish
وصف الملف: application/pdf
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المؤلفون: Andrew Worth, Maurice Whelan, David Asturiol, Elisabet Berggren, Lara Lamon, Rabea Graepel, Alicia Paini, Elisabeth Joossens, Pilar Prieto
المصدر: Toxicology in Vitro
مصطلحات موضوعية: Chemical fate,In vitro,Nanomaterial,Toxicity,VCBA,Virtual cell, 0301 basic medicine, High-throughput screening, Cell, 010501 environmental sciences, Biology, Pharmacology, Toxicology, Models, Biological, Risk Assessment, 01 natural sciences, Article, 3T3 cells, VCBA, Cell Line, 03 medical and health sciences, In vitro, In vivo, High-Throughput Screening Assays, medicine, Animals, Humans, Settore CHIM/12 - Chimica dell'Ambiente e dei Beni Culturali, 0105 earth and related environmental sciences, Toxicity, Chemical fate, Virtual cell, General Medicine, Nanomaterial, 030104 developmental biology, medicine.anatomical_structure, Cell culture
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المؤلفون: Alberto Mantovani, Tanja Waldmann, Bob van de Water, Cristina Cadenas, Hennicke Kamp, Thomas Braunbeck, Annemarie H. Meijer, Mathieu Vinken, Sylvia Escher, Domenico Gadaleta, Patricio Godoy, Anna Forsby, Stefan Schildknecht, Chris T. Evelo, Stefan Höhme, Rosemarie Marchan, Gerhard F. Ecker, Harry Vrieling, Susanne Hougaard Bennekou, Ciarán Fisher, Alice Limonciel, Enrico Mombelli, Rabea Graepel, Marcel Leist, Ahmed Ghallab, Michael Schwarz, Joost B. Beltman, Jens M. Kelm, Albert Braeuning, Olivier Taboureau, Bart van der Burg, Andrea Terron, Ferran Sanz, Frédéric Y. Bois, Steven Dooley, Dinant Kroese, Jan G. Hengstler, Paul Jennings, Egon Willighagen, Barbara Zdrazil, Barry Hardy, Erik H.J. Danen, Bjørn E. V. Koch, David A. Fluri, Christoph van Thriel, Dirk Drasdo, Ben van Ravenzwaay, Iain Gardner, Franz Oesch, Reham Hassan, Raymond Reif, Marvin Martens, Thomas Hartung
المساهمون: University of Konstanz, Department of Forensic Medicine and Veterinary Toxicology [Qena], Faculty of Veterinary Medicine [Qena], South Valley University [Qena]-South Valley University [Qena], Universiteit Leiden, Leibniz Research Centre for Working Environment and Human Factors [Dortmund] (IFADO), Technische Universität Dortmund [Dortmund] (TU), The Danish Epidemiology Science Centre, Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Vrije Universiteit Brussel (VUB), BASF [Ludwigshafen], SimCYP Ltd, Institut National de l'Environnement Industriel et des Risques (INERIS), Bundesinstitut für Risikobewertung - Federal Institute for Risk Assessment (BfR), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Modelling and Analysis for Medical and Biological Applications (MAMBA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jacques-Louis Lions (LJLL (UMR_7598)), Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universität Leipzig, Medical University Graz, Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), University of Heidelberg, Medical Faculty, Universitat Pompeu Fabra [Barcelona] (UPF), Karolinska Institutet [Stockholm], Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), InSphero [Schlieren], University of Vienna [Vienna], Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), BioDetection Systems, Universität Mannheim, Maastricht University [Maastricht], Institut National de la Santé et de la Recherche Médicale (INSERM), IT University of Copenhagen (ITU), Istituto Superiore di Sanità (ISS), Douglas Connect GmbH, Fraunhofer Institute for Toxicology and Experimental Medicine (Fraunhofer ITEM), Fraunhofer (Fraunhofer-Gesellschaft), Carl Zeiss SMT AG, Carl Zeiss, Oberkochen, Faculty of Biology, Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University [Austria] (IMU), BASF, DRC/VIVA/METO, Institut National de l'Environnement Industriel et des Risques, Department of Experimental and Clinical Pharmacology andToxicology [Tübingen], Eberhard Karls Universität Tübingen, Interdisciplinary Centre for Bioinformatics [Leipzig] (IZBI), Universität Leipzig [Leipzig], Institute for Health and Consumer Protection, European Commission - Joint Research Centre, Université Grenoble Alpes - UFR Médecine [ ?-2019] (UGA UFRM [ ?-2019]), Molecular Hepatology - Alcohol Associated Diseases, Department of Medicine II, University of Heidelberg, Medical Faculty of Mannheim-University of Heidelberg, Medical Faculty of Mannheim, BigCat - Bioinformatics and Systems Biology Research Group, UMR-S973, MTi, Université Paris Diderot - Paris 7 (UPD7), Department of Immunology and Cell Biology, Mario Negri Institute, Leiden University, Vrije Universiteit [Brussels] (VUB), Universiteit Leiden [Leiden], BASF SE, 67056 Ludwigshafen, Johannes Gutenberg - University of Mainz (JGU), Centre for Alternatives to Animal Testing (CAAT EU), Universitat Pompeu Fabra [Barcelona], European Food Safety Authority = Autorité européenne de sécurité des aliments, Université Grenoble Alpes (UGA), Universität Mannheim [Mannheim], Istituto Superiore di Sanita [Rome], Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Johannes Gutenberg - Universität Mainz (JGU), IT University of Copenhagen, Molecular and Computational Toxicology, AIMMS, Bioinformatica, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM - R4 - Gene-environment interaction, Promovendi NTM, RS: FHML MaCSBio, Publica, Pharmaceutical and Pharmacological Sciences, Connexin Signalling Research Group, Liver Connexin and Pannexin Research Group, Experimental in vitro toxicology and dermato-cosmetology
المصدر: Archives of Toxicology
Archives of Toxicology, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, Springer Verlag, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, 91(11), 3477-3505. Springer Verlag
Archives of Toxicology, 91(11), 3477-3505
Archives of Toxicology, 91(11), 3477-3505. Springer
Archives of Toxicology, 11, 91, 3477-3505
Leist, M, Ghallab, A, Graepel, R, Marchan, R, Hassan, R, Bennekou, S H, Limonciel, A, Vinken, M, Schildknecht, S, Waldmann, T, Danen, E H J, van Ravenzwaay, B, Kamp, H, Gardner, I, Godoy, P, Bois, F Y, Braeuning, A, Reif, R, Oesch, F, Drasdo, D, Höhme, S, Schwarz, M, Hartung, T, Braunbeck, T, Beltman, J, Vrieling, H, Sanz, F, Forsby, A, Gadaleta, D, Fisher, C, Kelm, J, Fluri, D, Ecker, G F, Zdrazil, B, Terron, A, Jennings, P, van der Burg, B, Dooley, S, Meijer, A H, Willighagen, E, Martens, M, Evelo, C T, Mombelli, E, Taboureau, O, Mantovani, A, Hardy, B, Koch, B, Escher, S, van Thriel, C, Cadenas, C, Kroese, D, van de Water, B & Hengstler, J G 2017, ' Adverse outcome pathways : opportunities, limitations and open questions ', Archives of Toxicology, vol. 91, no. 11, pp. 3477-3505 . https://doi.org/10.1007/s00204-017-2045-3مصطلحات موضوعية: CCl4, 0301 basic medicine, Proof of non-toxicity, Health, Toxicology and Mutagenesis, CCl, RAPID - Risk Analysis for Products in Development, Biomedical Innovation, Signal transduction, Ecotoxicology, Toxicology, NATURAL-KILLER-CELLS, Prioritization of compounds, Life, Adverse Outcome Pathway, ACTIVATED STELLATE CELLS, ComputingMilieux_MISCELLANEOUS, Risk assessment, TUMOR-NECROSIS-FACTOR, Event (computing), EVIDENCE-BASED TOXICOLOGY, ENVIRONMENTAL CHEMICALS, General Medicine, Toxicokinetics, Multiple hit events Proof of non-toxicity, Evidence-based toxicology, Identification (information), Paracetamol, Risk analysis (engineering), Vinyl acetate, RISK-ASSESSMENT, Systems biology, Construct (philosophy), Healthy Living, Human, Quality Control, READ-ACROSS, Vinyl Compounds, Plasticity, Liver fibrosis, Nanotechnology, Harmonization, Multiple hit events, Biology, History, 21st Century, Risk Assessment, Binning of events, Adverse outcome, 03 medical and health sciences, Adverse outcome pathway, SDG 3 - Good Health and Well-being, ddc:570, Tumor promotion, Journal Article, Animals, Humans, Vinyl acetate Tumor promotion, Regulatory toxicology, Set (psychology), Epidemiological data, Adverse Outcome Pathways, Interspecies extrapolation, 030111 toxicology, SYSTEMS TOXICOLOGY, Nonhuman, Toxicity assay, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Mice, Inbred C57BL, Multi-scale integration, Metabolism, 030104 developmental biology, DEVELOPMENTAL NEUROTOXICITY, Computational toxicology, ELSS - Earth, Life and Social Sciences, Pathway unidirectionality
وصف الملف: application/pdf
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المؤلفون: Fernando Lopes, Keith A. Sharkey, José L. Reyes, Jason J. McDougall, Arthur Wang, Derek M. McKay, Rabea Graepel, Björn Petri
المصدر: Arthritis & Rheumatology. 68:542-552
مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.drug_class, Immunology, Arthritis, Inflammation, complex mixtures, Mast cell proliferation, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Monoarthritis, medicine, Immunology and Allergy, business.industry, medicine.disease, Mast cell, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Freund's adjuvant, Tumor necrosis factor alpha, medicine.symptom, business, 030217 neurology & neurosurgery
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المؤلفون: Rabea Graepel, Lara Lamon, Andrea-Nicole Richarz, Elisabeth Joossens, Andrew Worth, Karin Aschberger, David Asturiol
المصدر: Particle and Fibre Toxicology, Vol 15, Iss 1, Pp 1-17 (2018)
مصطلحات موضوعية: Hazard (logic), Databases, Factual, Endpoint Determination, Process (engineering), Computer science, Health, Toxicology and Mutagenesis, Pneumology/Respiratory System, lcsh:Industrial hygiene. Industrial welfare, 02 engineering and technology, 010501 environmental sciences, Toxicology, computer.software_genre, Risk Assessment, 01 natural sciences, Hazardous Substances, Nano-TiO2, Environmental Health,Nanotechnology,Pharmacology/Toxicology,Pneumology/Respiratory System,Public Health, Manufactured nanomaterials, Resource (project management), lcsh:RA1190-1270, Toxicity Tests, Grouping, Nanotechnology, Comet assay, Pharmacology/Toxicology, Settore CHIM/12 - Chimica dell'Ambiente e dei Beni Culturali, Nanomaterials, lcsh:Toxicology. Poisons, 0105 earth and related environmental sciences, Titanium, Principal Component Analysis, Data collection, RAAF, Chemical Safety, General Medicine, 021001 nanoscience & nanotechnology, Nanostructures, Identification (information), Workflow, Cheminformatics, Read-across, Public Health, Data mining, 0210 nano-technology, Environmental Health, computer, lcsh:HD7260-7780.8
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المؤلفون: Laura Gribaldo, Pilar Prieto, Magdalini Sachana, Kirsten Gerloff, Rabea Graepel, Francesca Pistollato, Anna Bal-Price, Lara Lamon, Andrew Worth
المصدر: ALTEX. 36(1)
مصطلحات موضوعية: 0301 basic medicine, Nervous system, Drug-Related Side Effects and Adverse Reactions, Cell Survival, target organ, Administration, Oral, 010501 environmental sciences, Bioinformatics, Animal Testing Alternatives, 01 natural sciences, 03 medical and health sciences, Animal data, Immune system, mechanism of toxicity, In vivo, Adverse Outcome Pathway, Toxicity Tests, Acute, Medicine, Animals, alternative method,cytotoxicity,integrated approach to testing and assessment (IATA),mechanism of toxicity,target organ, alternative method, Settore CHIM/12 - Chimica dell'Ambiente e dei Beni Culturali, 0105 earth and related environmental sciences, Pharmacology, Kidney, Lung, business.industry, General Medicine, Medical Laboratory Technology, 030104 developmental biology, medicine.anatomical_structure, Toxicity, cytotoxicity, business, integrated approach to testing and assessment (IATA)
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb2935a792872611f744de837a48946
https://pubmed.ncbi.nlm.nih.gov/30015985 -
8دورية أكاديمية
المؤلفون: Aisah A. Aubdool, Rabea Graepel, Xenia Kodji, Khadija M. Alawi, Jennifer V. Bodkin, Salil Srivastava, Clive Gentry, Richard Heads, Andrew D. Grant, Elizabeth S. Fernandes, Stuart Bevan, Sus
المصدر: Nature, Nature Communications. 5(1):1-13
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المؤلفون: Rabea Graepel, Sylvia Escher, B. van de Water, Steven Wink, Nanette G Vrijenhoek
المساهمون: Publica
المصدر: Toxicology Letters. 295:S194
مصطلحات موضوعية: Valproic Acid, Liver steatosis, Chemistry, medicine, General Medicine, Stress response pathway, Toxicology, Throughput (business), medicine.drug, Cell biology
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المؤلفون: Rabea Graepel, Pilar Prieto, Andrew Worth, David Asturiol
المصدر: Europe PubMed Central
Scopus-Elsevierمصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, No-observed-adverse-effect level, Context (language use), 010501 environmental sciences, Toxicology, Body weight, Animal Testing Alternatives, Animal Welfare, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, Oral route, Toxicity Tests, Acute, media_common.cataloged_instance, Animals, European Union, European union, Intensive care medicine, 0105 earth and related environmental sciences, media_common, Mammals, No-Observed-Adverse-Effect Level, Toxicity data, business.industry, General Medicine, Legislation, Drug, Medical Laboratory Technology, 030104 developmental biology, Systemic toxicity, Toxicity Tests, Subacute, Pharmaceutical Preparations, Toxicity, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd8386e8df99d9d13419a765e6c4f8a
https://pubmed.ncbi.nlm.nih.gov/27494626