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1
المؤلفون: Chek Shik Lim, Advait Nagle, Chun Li, Clemens H. M. Kocken, Pranab Mishra, Tove Tuntland, Wei Lin Sandra Sim, Rachel Borboa, Case W. McNamara, Seh Yong Leong, Nobutaka Kato, Christophe Bodenreider, Anne-Marie Zeeman, Prasuna Guntapalli, Kelli Kuhen, Thomas Hollenbeck, Thierry T. Diagana, Arnab K. Chatterjee, Elizabeth A. Winzeler, Liying Jocelyn Tan, Jonathan Chang, Siti Nurdiana Abas, Paul W. Smith, Bryan K. S. Yeung, Yong Cheng Tan, David C. Tully, Jason Roland, Suresh B. Lakshminarayana, Bin Zou, Kerstin Gagaring
المصدر: ACS Medicinal Chemistry Letters. 5:947-950
مصطلحات موضوعية: 0303 health sciences, Imidazopyridine, 030306 microbiology, Phenotypic screening, Organic Chemistry, Cell, Biology, Simian, Bioinformatics, biology.organism_classification, Biochemistry, Virology, Plasmodium, 3. Good health, 03 medical and health sciences, medicine.anatomical_structure, In vivo, parasitic diseases, Drug Discovery, medicine, Structure–activity relationship, Parasite hosting, 030304 developmental biology
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المؤلفون: Xuena Lin, Kelli Kuhen, Tao Wu, Elizabeth A. Winzeler, Christoph Fischli, Chun Li, Kerstin Gagaring, Jared Ek, Tiffany Chuan, Suresh B. Lakshminarayana, Rachel Borboa, Thomas Hollenbeck, Arnab K. Chatterjee, Fenghua Liu, Thierry T. Diagana, Richard Glynne, Caroline Francek, Reto Brun, Advait Nagle, John Isbell, Bo Liu, Christopher Caldwell, David C. Tully, David Plouffe, Tove Tuntland, Philip B. Alper, Suzanne Skolnik, Jonathan Chang, Jianling Wang, Matthias Rottmann, Zhong Chen
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Plasmodium falciparum, Biological Availability, Pharmacology, Article, Piperazines, Antimalarials, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Antimalarial Agent, Malaria, Falciparum, Rats, Wistar, Mice, Inbred BALB C, biology, Imidazoles, biology.organism_classification, In vitro, Rats, Piperazine, chemistry, Molecular Medicine, Caco-2 Cells
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3
المؤلفون: Els J. Klooster, Robert W. Sauerwein, David Plouffe, Kelli L. Kuhen, Anne-Marie Zeeman, Geert-Jan van Gemert, Alan W. Thomas, Rachel Borboa, Clemens H. M. Kocken, Elizabeth A. Winzeler, Brice Campo, Kerstin Gagaring, Richard Glynne, Edmond J. Remarque, Sandra M. van Amsterdam, Adrian J. F. Luty, Annemarie Voorberg-van der Wel, Advait Nagle, Bryan K. S. Yeung, Zhong Chen, Jason Roland, Case W. McNamara, Thierry T. Diagana, Alexander van den Berg, Arnab K. Chatterjee, Didier Leroy
المصدر: Antimicrobial Agents and Chemotherapy, 58, 1586-95
Antimicrobial Agents and Chemotherapy; Vol 58
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 58, 3, pp. 1586-95
Antimicrobial agents and chemotherapy, vol 58, iss 3مصطلحات موضوعية: Primaquine, Plasmodium vivax, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Drug Evaluation, Preclinical, Parasitemia, chemistry.chemical_compound, Mice, 0302 clinical medicine, Pharmacology (medical), GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), 0303 health sciences, Mice, Inbred ICR, biology, Imidazoles, Pharmacology and Pharmaceutical Sciences, Inbred ICR, Preclinical, 3. Good health, Infectious Diseases, Liver, Medical Microbiology, Sporozoites, Pyrazines, Female, Antibody, medicine.drug, Plasmodium cynomolgi, 8-Aminoquinoline, 030231 tropical medicine, In Vitro Techniques, Microbiology, 03 medical and health sciences, Antimalarials, parasitic diseases, medicine, Animals, Experimental Therapeutics, IC50, 030304 developmental biology, Pharmacology, medicine.disease, biology.organism_classification, Virology, Macaca mulatta, In vitro, Malaria, chemistry, biology.protein, Hepatocytes, Drug Evaluation
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e4c0443476d14226de728c1d2b8ab4
http://hdl.handle.net/2066/138513 -
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المؤلفون: Ric N. Price, Jutta Marfurt, Matthias Rottmann, Zhong Chen, Grennady Wirjanata, Kailash P. Patra, Arnab K. Chatterjee, Jetsumon Sattabongkot, Carolyn Francek, Marcus C. S. Lee, Anchalee Tungtaeng, Jennifer Buenviaje, Advait Nagle, Laurent Rénia, Robert W. Sauerwein, Marga van de Vegte-Bolmer, John R. Walker, Elizabeth A. Winzeler, Thierry T. Diagana, Erika L. Flannery, David Plouffe, François Nosten, Rachel Borboa, Montip Gettayacamin, Boni F. Sebayang, Kerstin Gagaring, Rossarin Suwanarusk, Tao Wu, Joseph M. Vinetz, Geert Jan A. Van Gemert, S. Whitney Barnes, Wouter Graumans, Jennifer Taylor, David A. Fidock, Bruce Russell, David C. Tully, Richard Glynne, Kelli Kuhen
المصدر: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 58, 9, pp. 5060-7
Antimicrobial agents and chemotherapy, vol 58, iss 9
Antimicrobial Agents and Chemotherapy, 58, 5060-7مصطلحات موضوعية: lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Pharmacology, Piperazines, chemistry.chemical_compound, Mice, 0302 clinical medicine, Chloroquine, Pharmacology (medical), Antimalarial Agent, Malaria, Falciparum, 0303 health sciences, Mice, Inbred ICR, Mefloquine, Anopheles, Imidazoles, Pharmacology and Pharmaceutical Sciences, Inbred ICR, 3. Good health, Infectious Diseases, 5.1 Pharmaceuticals, Medical Microbiology, Sporozoites, HIV/AIDS, Development of treatments and therapeutic interventions, Infection, medicine.drug, Falciparum, 030231 tropical medicine, Plasmodium falciparum, Biology, Microbiology, 03 medical and health sciences, Antimalarials, Inhibitory Concentration 50, Rare Diseases, medicine, Animals, Experimental Therapeutics, 030304 developmental biology, Prevention, Genetic strain, medicine.disease, biology.organism_classification, Malaria, Vector-Borne Diseases, Orphan Drug, Good Health and Well Being, chemistry, Artesunate, Immunology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277a20585d6cba3b9f40adbe1b1eeae1
https://doi.org/10.1128/AAC.02727-13 -
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المؤلفون: Wendy Richmond, Matthias Rottmann, Bin Zhou, Thierry T. Diagana, Patrick Froissard, Elizabeth A. Winzeler, Tao Wu, Marcus C. S. Lee, Selina Bopp, Kerstin Gagaring, Kelli Kuhen, Advait Nagle, Todd Groessl, Richard Glynne, John R. Walker, Perry Gordon, Dominique Mazier, Case W. McNamara, S. Whitney Barnes, Rachel Borboa, David A. Fidock, Jetsumon Sattabongkot, Jason Roland, Tae-gyu Nam, Peter G. Schultz, Jianwei Che, Arnab K. Chatterjee, Steve Cohen, Ghislain M. C. Bonamy, Yingyao Zhou, Stephan Meister, A. Taylor Bright, Neekesh V. Dharia, Montip Gettayacamin, Nobutaka Kato, David Plouffe, Tove Tuntland
المصدر: Science (New York, N.Y.). 334(6061)
مصطلحات موضوعية: Plasmodium, Erythrocytes, Plasmodium berghei, Plasmodium falciparum, Drug Evaluation, Preclinical, Drug Resistance, Protozoan Proteins, Drug resistance, Pharmacology, Polymorphism, Single Nucleotide, Article, Piperazines, Small Molecule Libraries, Antimalarials, Mice, Random Allocation, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Mice, Inbred BALB C, Multidisciplinary, biology, Molecular Structure, Drug discovery, Imidazoles, Plasmodium yoelii, biology.organism_classification, medicine.disease, Malaria, Drug development, Liver, Sporozoites
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc5a5cbf5c6d7c5bda12e264a4534af
https://pubmed.ncbi.nlm.nih.gov/22212678 -
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المؤلفون: Chun Li, Véronique Dartois, Jeanette Wu, Suzanne Skolnik, Thierry T. Diagana, Thomas H. Keller, Advait Nagle, David Plouffe, Maria Tan, Matthias Rottmann, Xuena Lin, Arnab K. Chatterjee, Jonathan Chang, Elizabeth A. Winzeler, Suresh B. Lakshminarayana, Fenghua Liu, Kerstin Gagaring, John Isbell, Tao Wu, William Tan, Christopher Caldwell, Richard Glynne, Zhong Chen, Christoph Fischli, David C. Tully, Anne Goh, Tove Tuntland, Min Low Kang, Nicole Y. Ye, Jared Ek, Reto Brun, Hui Qing Ang, Rachel Borboa, Thomas Hollenbeck, Jianling Wang, Peiting Zeng, Kelli L. Kuhen, Caroline Francek
المصدر: Journal of medicinal chemistry. 54(14)
مصطلحات موضوعية: Plasmodium berghei, Plasmodium falciparum, Drug Resistance, Parasitemia, Pharmacology, Piperazines, Cell Line, chemistry.chemical_compound, Antimalarials, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, parasitic diseases, medicine, Benzene Derivatives, Potency, Animals, Humans, Amino Acids, Mice, Inbred BALB C, Aniline Compounds, biology, Chemistry, Imidazoles, Hit to lead, medicine.disease, biology.organism_classification, Malaria, Rats, Drug development, Molecular Medicine, Female, Lead compound
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المؤلفون: Neekesh V. Dharia, John R. Walker, Glenn C. Federe, Rachel Borboa, John W. Barnwell, Kelli Kuhen, Serge Batalov, Alejandro Llanos-Cuentas, Colleen M. McClean, Joseph M. Vinetz, S. Whitney Barnes, A. Taylor Bright, Elizabeth A. Winzeler, Scott J. Westenberger, Victor Neyra
مصطلحات موضوعية: Erythrocytes, Sequence analysis, Plasmodium vivax, Genes, Protozoan, Drug Resistance, Genomics, Genome, DNA sequencing, parasitic diseases, Malaria Vaccines, Peru, Leukocytes, Humans, Selection, Genetic, Oligonucleotide Array Sequence Analysis, Genetics, Whole genome sequencing, Multidisciplinary, Polymorphism, Genetic, biology, Plasmodium falciparum, Sequence Analysis, DNA, Biological Sciences, biology.organism_classification, Gene Expression Regulation, Multigene Family, Mutation, Sequence Alignment, Reference genome, Transcription Factors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753b1b0326ec85c1a945190051e2c1d9
https://europepmc.org/articles/PMC2993397/ -
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المؤلفون: Alberto J. Napuli, Michael H. Gelb, Lisa J. Castaneda, Pascal Fantauzzi, Zhong Chen, Achim Brinker, Philip P. Rodenbough, Carolyn Francek, Justin B. Stockmyer, Rachel Borboa, Kelli Kuhen, Janhavi Bhandari, Eleanor F. Dagostino, Jennifer Taylor, Richard Glynne, Ingo H. Engels, James Gilligan, Wesley C. Van Voorhis, David J. Leibly, Yu Wang, Arnab K. Chatterjee, Kerstin Gagaring, Gregory J. Crowther
مصطلحات موضوعية: Drug, Choline kinase, media_common.quotation_subject, Plasmodium falciparum, Farnesyl pyrophosphate, Druggability, Drug Evaluation, Preclinical, Protozoan Proteins, Biology, Pharmacology, Article, chemistry.chemical_compound, Antimalarials, Inhibitory Concentration 50, Enzyme Inhibitors, Molecular Biology, media_common, chemistry.chemical_classification, Adenylosuccinate synthase, biology.organism_classification, Enzymes, High-Throughput Screening Assays, Enzyme, Drug development, chemistry, Biochemistry, biology.protein, Parasitology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9823e905e2c93e725a854ee74f8ca50d
https://europepmc.org/articles/PMC3108854/ -
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المؤلفون: Jared Ek, Steven Howard, Kerstin Henson, Advait Nagle, Jonathan Chang, Tao Wu, Arnab K. Chatterjee, Zhong Chen, Susan Simerson, Elizabeth A. Winzeler, David Plouffe, Tove Tuntland, Francisco Adrian, Kelli Kuhen, Nathanael S. Gray, Tomoyo Sakata, Rachel Borboa, John Isbell, David C. Tully, Xianming Deng
المصدر: Bioorganic & Medicinal Chemistry Letters
مصطلحات موضوعية: Cellular assay, Kinase, medicine.drug_class, Clinical Biochemistry, Plasmodium falciparum, Pharmaceutical Science, Carboxamide, Resistant strains, 01 natural sciences, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, Antimalarials, Mice, In vivo, Drug Discovery, medicine, Animals, Humans, Pharmacokinetics, Kinase activity, Enzyme Inhibitors, Benzamide, Molecular Biology, 030304 developmental biology, ComputingMethodologies_COMPUTERGRAPHICS, 0303 health sciences, biology, 010405 organic chemistry, Cellular Assay, Organic Chemistry, Phosphotransferases, biology.organism_classification, In vitro, 3. Good health, 0104 chemical sciences, Malaria, Cyclic amines, chemistry, Benzamides, Molecular Medicine, Directed Molecular Evolution
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10دورية أكاديمية
المؤلفون: Tao Wu, Advait Nagle, Kelli Kuhen, Kerstin Gagaring, Rachel Borboa, Caroline Francek, Zhong Chen, David Plouffe, Anne Goh, Suresh B. Lakshminarayana, Jeanette Wu, Hui Qing Ang, Peiting Zeng, Min Low Kang, William Tan, Maria Tan, Nicole Ye, Xuena Lin, Christopher Caldwell, Jared Ek
المصدر: Journal of Medicinal Chemistry; Jul2011, Vol. 54 Issue 14, p5116-5130, 15p
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