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المؤلفون: Gordon C Jayson, Gary Acton, Jonathan A. Ledermann, Geoff Hall, Sarah Halford, Martin Highley, Nicola J. Curtin, Ruth Plummer, Julieann Sludden, R.M. Glasspool, David Jamieson, Alan V. Boddy, Zoe Backholer, Daniel Rea, Raffaella Mangano, Yvette Drew, James W. Murray
المساهمون: Drew, Yvette, Ledermann, Jonathan, Hall, Geoff, Rea, Daniel, Glasspool, Ros, Highley, Martin, Jayson, Gordon, Sludden, Julieann, Murray, James, Jamieson, David, Halford, Sarah, Acton, Gary, Backholer, Zoe, Mangano, Raffaella, Boddy, Alan, Curtin, Nicola, Plummer, Ruth
المصدر: British Journal of Cancer
Drew, Y, Ledermann, J, Hall, G, Rea, D, Glasspool, R, Highley, M, Jayson, G, Sludden, J, Murray, J, Jamieson, D, Halford, S, Acton, G, Blackholer, Z, Mangano, R, Boddy, A, Curtin, N & Plummer, R 2016, ' Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer ', Br J Cancer, vol. 114, e21 . https://doi.org/10.1038/bjc.2016.41مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Indoles, Poly (ADP-Ribose) Polymerase Inhibitor, Cohort Studies, chemistry.chemical_compound, Prostate cancer, 0302 clinical medicine, Tissue Distribution, mutation carriers, Ovarian Neoplasms, Manchester Cancer Research Centre, BRCA1 Protein, Middle Aged, Prognosis, poly(ADP-ribose) polymerase, polymerase, ovarian cancer, Oncology, 030220 oncology & carcinogenesis, Female, Corrigendum, Adult, Heterozygote, Poly ADP ribose polymerase, Breast Neoplasms, Poly(ADP-ribose) Polymerase Inhibitors, Drug Administration Schedule, Olaparib, Young Adult, 03 medical and health sciences, Germline mutation, Breast cancer, breast cancer, medicine, Humans, Rucaparib, Germ-Line Mutation, Aged, Neoplasm Staging, BRCA2 Protein, Dose-Response Relationship, Drug, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, PARP inhibition, BRCA mutation, medicine.disease, rucaparib, 030104 developmental biology, chemistry, Immunology, Cancer research, business, Follow-Up Studies
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5e00f287a35b93593ae9c8ca970c12
https://hdl.handle.net/11541.2/133063 -
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المؤلفون: Gill Matthew Iain Andrew, Nigel Ramsden, Steve Price, Christopher Higgs, Richard Hale, Dennis Norman, Dan Leggate, Hazel Joan Dyke, Soraya S. Porres, Raffaella Mangano, Pascal Savy, Alison Jones, Francis Xavier Wilson, Peter Lockey, Neil Jennings, David E. Clark, Sue Cramp, Marie Andersson
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2516-2519
مصطلحات موضوعية: Clinical Biochemistry, Histamine Antagonists, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Receptors, G-Protein-Coupled, Inhibitory Concentration 50, Drug Discovery, Animals, Inverse agonist, Potency, Histamine H4 receptor, Molecular Biology, IC50, Receptors, Histamine H4, Virtual screening, Chemistry, Organic Chemistry, Stereoisomerism, Hit to lead, Ligand (biochemistry), Rats, Macaca fascicularis, Receptors, Histamine, Molecular Medicine
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المؤلفون: Jana Kretzschmar, Giulio Superti-Furga, Stefania Gonfloni, Marina Moro, Raffaella Mangano, Daniela Barilà, Dirk Bohmann
المصدر: Scopus-Elsevier
مصطلحات موضوعية: inorganic chemicals, Proto-Oncogene Proteins c-jun, Protein tyrosine phosphatase, Biology, Transfection, SH2 domain, General Biochemistry, Genetics and Molecular Biology, SH3 domain, Cell Line, Substrate Specificity, src Homology Domains, Mice, chemistry.chemical_compound, hemic and lymphatic diseases, Animals, Humans, Amino Acid Sequence, Phosphorylation, Tyrosine, Proto-Oncogene Proteins c-abl, neoplasms, Molecular Biology, Cell Nucleus, JNK Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinases, Enzyme Activation, Recombinant Proteins, Software, ABL, General Immunology and Microbiology, General Neuroscience, Tyrosine phosphorylation, Articles, Molecular biology, Settore BIO/18 - Genetica, enzymes and coenzymes (carbohydrates), chemistry, bacteria, Tyrosine kinase
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المؤلفون: Salvatore Feo, Mike Fried, Raffaella Mangano, Trevor Duhig, Eugenia Piddini, Letizia Carramusa
المصدر: Oncogene. 17:2771-2777
مصطلحات موضوعية: Cancer Research, Oncogene Proteins, Fusion, Inverted repeat, Molecular Sequence Data, Genes, myc, HL-60 Cells, Locus (genetics), Biology, Molecular cloning, DNA sequencing, Leukemia, Promyelocytic, Acute, Gene mapping, Genetics, Humans, Cloning, Molecular, Molecular Biology, Gene, In Situ Hybridization, Fluorescence, Southern blot, Chromosome Aberrations, Recombination, Genetic, Base Sequence, Chromosome Fragility, Gene Amplification, Sequence Analysis, DNA, Amplicon, Molecular biology, Blotting, Southern, Chromosomes, Human, Pair 8
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32eb3dcb93f3e982663c20ba2e2ef5df
https://doi.org/10.1038/sj.onc.1202434 -
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المؤلفون: Paolo Albani, Arianna Ascenzi, Bozzarelli, Oriana, Maurizio, Caminito, Cecilia, Cognigni, Davide, Dalmas, Giulia Del Vecchio, Roberto Di Carlo, Valentina, Esposito, Chiara, Faggiolani, Giulio, Fortunio, Anna, Galluzzi, Giorgio, Gazzera, Anna La Ferla, Raffaella, Mangano, Beatrice, Manetti, Sara, Marchisio, Carlotta, Margarone, Luisa, Marquartdt, Marco, Muscogiuri, Enrica Pagella, Caterina Ramonda, Claudio, Rosati, Michele, Santoro, Franca, Varallo, Maurizio, Vivarelli
URL الوصول: https://explore.openaire.eu/search/publication?articleId=od_______970::987d8966a19a7604382d41e1a727315e
http://hdl.handle.net/2318/1533738 -
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المؤلفون: Katie Ellard, Marcus Bantscheff, Satoko Shimamura, Kathryn Bell, Carsten Hopf, Faiza Rharbaoui, Nigel Ramsden, Mikhail M. Savitski, Gerard Drewes, Gitte Neubauer, Raffaella Mangano, Andrew Cansfield, Toby Mathieson, Ivan Plavec, Christina Rau, Friedrich B M Reinhard, Daniel Leggate, Alison O'Mahony, Thilo Werner, Carola Doce, Jessica Perrin, Katrin Müller, Giovanna Bergamini, Oliver Rausch, Emilio Hirsch
المصدر: Nature chemical biology. 8(6)
مصطلحات موضوعية: Male, Cellular differentiation, Biology, Binding, Competitive, Cell Line, Small Molecule Libraries, Mice, Structure-Activity Relationship, In vivo, Cell Movement, Drug Discovery, medicine, Structure–activity relationship, Animals, Class Ib Phosphatidylinositol 3-Kinase, Humans, Chemoproteomics, Enzyme Inhibitors, Rats, Wistar, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Molecular Structure, Drug discovery, Anti-Inflammatory Agents, Non-Steroidal, Interleukin-17, Cell Differentiation, Cell Biology, T helper cell, T-Lymphocytes, Helper-Inducer, Arthritis, Experimental, In vitro, Cell biology, Rats, Mice, Inbred C57BL, medicine.anatomical_structure, Cell culture, Mice, Inbred DBA
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المؤلفون: Bettina Huhse, Heinz Ruffner, Judith Schlegl, Karen Croughton, Anne-Claude Gavin, Martin Stein, Jens Rick, Georg Casari, Markus Schirle, Tewis Bouwmeester, Sonja Ghidelli, Bernhard Kuster, David B. Jackson, Gitte Neubauer, Giulio Superti-Furga, Raffaella Mangano, Giovanna Bergamini, Gerard Joberty, Dirk Eberhard, Markus Schwab, Angela Bauch, Pierre-Olivier Angrand, Julien Gagneur, Cristina Cruciat, Carsten Hopf, Anne-Marie Michon, Gerard Drewes, Andreas Bauer
المصدر: Nature cell biology, Vol. 6, No 2 (2004) pp. 97-105
مصطلحات موضوعية: Chaperonins, Proteome, Macromolecular Substances, medicine.medical_treatment, Cell Cycle Proteins, MAP Kinase Kinase Kinase 3, Biology, Models, Biological, Chromatography, Affinity, Mass Spectrometry, Receptors, Tumor Necrosis Factor, Cell Line, Tacrolimus Binding Proteins, Enzyme activator, RNA interference, Interaction network, medicine, Animals, Drosophila Proteins, Humans, HSP90 Heat-Shock Proteins, ddc:612, Transcription factor, Tandem affinity purification, Tumor Necrosis Factor-alpha, Tumor Suppressor Proteins, NF-kappa B, Cell Biology, NFKB1, MAP Kinase Kinase Kinases, Cell biology, Enzyme Activation, Cytokine, I-kappa B Proteins, RNA Interference, Signal transduction, Carrier Proteins, Molecular Chaperones, Signal Transduction
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مصطلحات موضوعية: inorganic chemicals, Cytoplasm, DNA Repair, Active Transport, Cell Nucleus, macromolecular substances, Protein tyrosine phosphatase, SH2 domain, environment and public health, Biochemistry, Receptor tyrosine kinase, Phosphorylation cascade, chemistry.chemical_compound, Genetic, Animals, Humans, Tyrosine, Phosphorylation, Recombination, Genetic, Pharmacology, Cell Nucleus, biology, Cell Cycle, Tyrosine phosphorylation, Protein-Tyrosine Kinases, RNA, Signal Transduction, Recombination, Active Transport, Cell biology, enzymes and coenzymes (carbohydrates), Settore BIO/18 - Genetica, chemistry, biology.protein, bacteria, Tyrosine kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ddbae7a39078a1ed66daaa8518822
http://hdl.handle.net/2108/10561 -
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المؤلفون: Carola Doce, Friedrich B M Reinhard, Thilo Werner, Raffaella Mangano, Satoko Shimamura, Katrin Müller, Nigel Ramsden, Gerard Drewes, Daniel Leggate, Gitte Neubauer, Jessica Perrin, Toby Mathieson, Alison O'Mahony, Marcus Bantscheff, Andrew Cansfield, Faiza Rharbaoui, Kathryn Bell, Carsten Hopf, Oliver Rausch, Mikhail M. Savitski, Ivan Plavec, Christina Rau, Katie Ellard, Giovanna Bergamini, Emilio Hirsch
المصدر: Nature Chemical Biology. 8:737-737
مصطلحات موضوعية: Chemistry, Nat, Cellular differentiation, Cell Biology, Molecular Biology, Molecular biology
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المؤلفون: Adele Rowley, Pierre-Olivier Angrand, Martin Stein, Eithne O'Sullivan, Jyoti S. Choudhary, Susie Thomas, Pamela Völkel, Brian Heffernan, Bernhard Kuster, Julien Gagneur, Gerard Drewes, Heinz Ruffner, Carsten Hopf, Lisa Pickard, Raffaella Mangano
المصدر: Neurobiology of Aging. 25:S37
مصطلحات موضوعية: Neuroblastoma cell, Tandem affinity purification, Aging, biology, Chemistry, General Neuroscience, Amyloid precursor protein, biology.protein, Neurology (clinical), Geriatrics and Gerontology, Molecular biology, Developmental Biology
