المؤلفون: Ghorab Mostafa M., Alsaid Mansour S., Al-Dosari Mohammed S., Ragab Fatma A., Al-Mishari Abdullah A., Almoqbil Abdulaziz N.

المصدر: Acta Pharmaceutica, Vol 66, Iss 2, Pp 155-171 (2016)

مصطلحات موضوعية: quinolines, pyridine, thienopyridine, isoquinoline, acrylamide, thiazole, thiophene, anticancer activity, Pharmaceutical industry, HD9665-9675

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1846-9558

URL الوصول: https://doaj.org/article/07a98b69618742d9bf8209ffff752500

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المؤلفون: Zahran SS; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo 11787, Egypt., Ragab FA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, 11562, Egypt., Soliman AM; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo 11787, Egypt. Electronic address: Aiten_mahmoud@yahoo.com., El-Gazzar MG; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo 11787, Egypt., Mahmoud WR; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, 11562, Egypt., Ghorab MM; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo 11787, Egypt. Electronic address: mmsghorab@yahoo.com.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Jul; Vol. 148, pp. 107411. Date of Electronic Publication: 2024 Apr 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Apoptosis*/drug effects , Angiogenesis Inhibitors*/pharmacology , Angiogenesis Inhibitors*/chemical synthesis , Angiogenesis Inhibitors*/chemistry , Drug Screening Assays, Antitumor* , Cell Proliferation*/drug effects , Vascular Endothelial Growth Factor Receptor-2*/antagonists & inhibitors , Vascular Endothelial Growth Factor Receptor-2*/metabolism, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Pyridazines/pharmacology ; Pyridazines/chemistry ; Pyridazines/chemical synthesis ; Molecular Docking Simulation ; Cell Line, Tumor ; Cell Movement/drug effects

المؤلفون: Zahran SS; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, 11787, Egypt., Ragab FA; Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Cairo University, 11562, Egypt. Electronic address: Fatmarag@cu.edu.eg., El-Gazzar MG; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, 11787, Egypt., Soliman AM; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, 11787, Egypt., Mahmoud WR; Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Cairo University, 11562, Egypt., Ghorab MM; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, 11787, Egypt. Electronic address: mmsghorab@yahoo.com.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 05; Vol. 245 (Pt 1), pp. 114912. Date of Electronic Publication: 2022 Nov 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Quinazolines*/pharmacology , Sulfachlorpyridazine*, Humans ; Vascular Endothelial Growth Factor Receptor-2 ; Angiogenesis Inhibitors/pharmacology ; Quinazolinones

المؤلفون: Ragab FA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Eissa AAM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Fahim SH; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Salem MA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt.; School of Life and Medical Sciences, University of Hertfordshire hosted by Global Academic Foundation, Cairo, Egypt., Gamal MA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Nissan YM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt.

المصدر: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2021 Aug; Vol. 354 (8), pp. e2100029. Date of Electronic Publication: 2021 Apr 19.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Breast Neoplasms/*drug therapy , Coumarins/*pharmacology , Neoplasms/*drug therapy, A549 Cells ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Breast Neoplasms/pathology ; Coumarins/chemical synthesis ; Coumarins/chemistry ; Doxorubicin/pharmacology ; ErbB Receptors/genetics ; Erlotinib Hydrochloride/pharmacology ; HCT116 Cells ; Hep G2 Cells ; Humans ; Inhibitory Concentration 50 ; MCF-7 Cells ; Molecular Docking Simulation ; Neoplasms/genetics ; Neoplasms/pathology ; Solubility ; Structure-Activity Relationship

المؤلفون: Ragab FA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr Elini St., Cairo 11562, Egypt., Nissan YM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr Elini St., Cairo 11562, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt., Seif EM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt. Electronic address: ph.emad.seif@gmail.com., Maher A; Biochemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt., Arafa RK; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, 12578 Cairo, Egypt.

المصدر: Bioorganic chemistry [Bioorg Chem] 2020 Mar; Vol. 96, pp. 103621. Date of Electronic Publication: 2020 Jan 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemistry , Antineoplastic Agents/*pharmacology , Pyrazoles/*chemistry , Pyrazoles/*pharmacology , Pyrimidines/*chemistry , Pyrimidines/*pharmacology, Antineoplastic Agents/chemical synthesis ; Apoptosis/drug effects ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Pyrazoles/chemical synthesis ; Pyrimidines/chemical synthesis

المؤلفون: Ghorab MM; Department of Drug Radiation Research, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), PO box 29, Nasr City, Cairo, Egypt. Electronic address: mmsghorab@yahoo.com., Ragab FA; Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Heiba HI; Department of Drug Radiation Research, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), PO box 29, Nasr City, Cairo, Egypt., Elsayed MSA; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States., Ghorab WM; Department of Drug Radiation Research, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), PO box 29, Nasr City, Cairo, Egypt.

المصدر: Bioorganic chemistry [Bioorg Chem] 2018 Oct; Vol. 80, pp. 276-287. Date of Electronic Publication: 2018 Jun 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Antineoplastic Agents/*chemical synthesis , Cyclin-Dependent Kinase 2/*metabolism , Protein Kinase Inhibitors/*chemical synthesis , Sulfonamides/*chemistry , Toluene/*analogs & derivatives, Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Binding Sites ; Catalytic Domain ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclin-Dependent Kinase 2/antagonists & inhibitors ; Drug Screening Assays, Antitumor ; Gamma Rays ; Humans ; Molecular Docking Simulation ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Structure-Activity Relationship ; Sulfonamides/metabolism ; Sulfonamides/pharmacology ; Toluene/chemistry ; Toluene/metabolism ; Toluene/pharmacology

المؤلفون: Ghorab MM; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Nasr City, P.O. Box 29, Cairo, Egypt., Ragab FA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Heiba HI; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Nasr City, P.O. Box 29, Cairo, Egypt., El-Gazzar MG; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Nasr City, P.O. Box 29, Cairo, Egypt. Electronic address: marwa.galal@eaea.org.eg., El-Gazzar MGM; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Nasr City, P.O. Box 29, Cairo, Egypt.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 May 15; Vol. 28 (9), pp. 1464-1470. Date of Electronic Publication: 2018 Mar 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Amines/*pharmacology , Antineoplastic Agents/*pharmacology , Protein Kinase Inhibitors/*pharmacology , Radiation-Sensitizing Agents/*pharmacology , Sulfonamides/*pharmacology , Thiourea/*pharmacology , Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors, Amines/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Hep G2 Cells ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Radiation-Sensitizing Agents/chemical synthesis ; Radiation-Sensitizing Agents/chemistry ; Structure-Activity Relationship ; Sulfonamides/chemistry ; Thiourea/chemistry ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Benzenesulfonamides

المؤلفون: Alsaid MS; Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia., Al-Mishari AA; Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Saudi Arabia., Soliman AM; Department of Drug Radiation Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo 113701, Egypt., Ragab FA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Egypt., Ghorab MM; Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Department of Drug Radiation Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo 113701, Egypt. Electronic address: mmsghorab@yahoo.com.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2017 Dec 01; Vol. 141, pp. 84-91. Date of Electronic Publication: 2017 Sep 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Antineoplastic Agents/*pharmacology , ErbB Receptors/*antagonists & inhibitors , Protein Kinase Inhibitors/*pharmacology , Quinazolines/*pharmacology , Receptor, ErbB-2/*antagonists & inhibitors , Sulfonamides/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; ErbB Receptors/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Quinazolines/chemical synthesis ; Quinazolines/chemistry ; Receptor, ErbB-2/metabolism ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry ; Benzenesulfonamides

المؤلفون: Ghorab MM; a Department of Pharmacognosy, College of Pharmacy , King Saud University , Riyadh , Saudi Arabia.; b Department of Drug Radiation Research , National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority , Cairo , Egypt., Alsaid MS; a Department of Pharmacognosy, College of Pharmacy , King Saud University , Riyadh , Saudi Arabia., Soliman AM; b Department of Drug Radiation Research , National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority , Cairo , Egypt., Ragab FA; c Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Cairo University , Cairo , Egypt.

المصدر: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2017 Dec; Vol. 32 (1), pp. 893-907.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Apoptosis/*drug effects , Piperidines/*pharmacology , Protein Kinase Inhibitors/*chemistry , Protein Kinase Inhibitors/*pharmacology , Quinazolines/*pharmacology , Sulfonamides/*chemistry , Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Breast/cytology ; Breast/drug effects ; Caspase 3/metabolism ; Catalytic Domain ; Cell Cycle Checkpoints/drug effects ; Cell Line ; Drug Screening Assays, Antitumor ; Enzyme Activation ; Humans ; Inhibitory Concentration 50 ; MCF-7 Cells ; Molecular Docking Simulation ; Protein Kinase Inhibitors/chemical synthesis ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Quinazolines/chemical synthesis ; Quinazolines/chemistry ; Spectrum Analysis/methods ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; bcl-2-Associated X Protein/metabolism ; Benzenesulfonamides