المؤلفون: Raghav JG; Center for Drug Discovery, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA., Kumar H; Center for Drug Discovery, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA., Ji L; Center for Drug Discovery, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA., Vemuri K; Center for Drug Discovery, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA., Makriyannis A; Center for Drug Discovery, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA. a.makriyannis@northeastern.edu., Suh J; Division of Depression and Anxiety Disorders, Department of Psychiatry, Harvard Medical School, Mclean Hospital, Belmont, MA, 02478, USA., Leonard MZ; Dept. of Psychology, Tufts University, 530 Boston Ave (Bacon Hall), Medford, MA, 02155, USA., Dang V; Dept. of Psychology, Tufts University, 530 Boston Ave (Bacon Hall), Medford, MA, 02155, USA., Ty C; Dept. of Psychology, Tufts University, 530 Boston Ave (Bacon Hall), Medford, MA, 02155, USA., Marandola S; Dept. of Psychology, Tufts University, 530 Boston Ave (Bacon Hall), Medford, MA, 02155, USA., Kane N; Dept. of Psychology, Tufts University, 530 Boston Ave (Bacon Hall), Medford, MA, 02155, USA., Witt AS; Dept. of Psychology, Tufts University, 530 Boston Ave (Bacon Hall), Medford, MA, 02155, USA., Shaqour S; Dept. of Psychology, Tufts University, 530 Boston Ave (Bacon Hall), Medford, MA, 02155, USA., Miczek KA; Center for Drug Discovery, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA. Klaus.Miczek@tufts.edu.; Dept. of Psychology, Tufts University, 530 Boston Ave (Bacon Hall), Medford, MA, 02155, USA. Klaus.Miczek@tufts.edu.; Dept. of Neuroscience, Tufts University, Boston, MA, 02111, USA. Klaus.Miczek@tufts.edu.

المصدر: Psychopharmacology [Psychopharmacology (Berl)] 2024 Mar; Vol. 241 (3), pp. 427-443. Date of Electronic Publication: 2023 Nov 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE

مواضيع طبية MeSH: Alcoholism*/drug therapy , Substance Withdrawal Syndrome*/drug therapy, Humans ; Mice ; Male ; Female ; Animals ; Ethanol ; Acamprosate ; Pyrazoles/pharmacology ; Alcohol Drinking/drug therapy ; Alcohol Drinking/psychology ; Mice, Inbred C57BL

المؤلفون: Jiang S, Iliopoulos-Tsoutsouvas C, Tong F, Brust CA; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, United States., Keenan CM; Hotchkiss Brain Institute and Snyder Institute for Chronic Diseases, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada., Raghav JG, Hua T; iHuman Institute, ShanghaiTech University, Shanghai 201210, China., Wu S, Ho JH; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, United States., Wu Y; iHuman Institute, ShanghaiTech University, Shanghai 201210, China., Grim TW; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, United States., Zvonok N, Thakur GA, Liu ZJ; iHuman Institute, ShanghaiTech University, Shanghai 201210, China., Sharkey KA; Hotchkiss Brain Institute and Snyder Institute for Chronic Diseases, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada., Bohn LM; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, United States., Nikas SP, Makriyannis A

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 3870-3884. Date of Electronic Publication: 2021 Mar 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cannabinoid Receptor Agonists/*pharmacology , Cannabinoids/*pharmacology , Receptor, Cannabinoid, CB1/*metabolism , Receptor, Cannabinoid, CB2/*metabolism, Analgesics/chemical synthesis ; Analgesics/metabolism ; Analgesics/pharmacology ; Animals ; Body Temperature Regulation/drug effects ; CHO Cells ; Cannabinoid Receptor Agonists/chemical synthesis ; Cannabinoid Receptor Agonists/metabolism ; Cannabinoids/chemical synthesis ; Cannabinoids/metabolism ; Cricetulus ; Humans ; Ligands ; Locomotion/drug effects ; Male ; Mice ; Molecular Docking Simulation ; Rats

المؤلفون: Malamas MS; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, United States. Electronic address: m.malamas@northeastern.edu., Raghav JG; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, United States., Ma X; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, United States., Honrao C; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, United States., Wood JT; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, United States., Benchama O; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, United States., Zhou H; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, United States., Mallipeddi S; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, United States., Makriyannis A; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, United States.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 Oct 01; Vol. 26 (18), pp. 4963-4970. Date of Electronic Publication: 2018 Aug 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Oximes/*pharmacology , Receptor, Cannabinoid, CB1/*agonists, Analgesics/chemistry ; Analgesics/pharmacokinetics ; Analgesics/pharmacology ; Animals ; Area Under Curve ; Behavior, Animal/drug effects ; Biotransformation ; HEK293 Cells ; Humans ; Hypothermia/chemically induced ; Mice ; Oximes/chemistry ; Oximes/pharmacokinetics ; Rats ; Structure-Activity Relationship

المؤلفون: Järbe TUC; Department of Pharmaceutical Sciences, Center for Drug Discovery (CDD), Northeastern University, 116 Mugar Hall, 360 Huntington Ave, Boston, MA, 02115, USA. t.jarbe@neu.edu., Raghav JG; Department of Pharmaceutical Sciences, Center for Drug Discovery (CDD), Northeastern University, 116 Mugar Hall, 360 Huntington Ave, Boston, MA, 02115, USA.

المصدر: Current topics in behavioral neurosciences [Curr Top Behav Neurosci] 2017; Vol. 32, pp. 263-281.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 101535383 Publication Model: Print Cited Medium: Print ISSN: 1866-3370 (Print) Linking ISSN: 18663370 NLM ISO Abbreviation: Curr Top Behav Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Behavior, Animal/*drug effects , Cannabinoids/*pharmacology , Indoles/*pharmacology , Naphthalenes/*pharmacology, Animals ; Cannabinoids/adverse effects ; Drug Tolerance ; Humans ; Hypothermia/chemically induced ; Indoles/adverse effects ; Mental Disorders/chemically induced ; Naphthalenes/adverse effects ; Seizures/chemically induced ; Substance Withdrawal Syndrome/etiology ; Substance-Related Disorders

المؤلفون: Kulkarni S; Center for Drug Discovery, Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States., Nikas SP; Center for Drug Discovery, Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States., Sharma R; Center for Drug Discovery, Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States., Jiang S; Center for Drug Discovery, Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States., Paronis CA; Center for Drug Discovery, Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States.; McLean Hospital, and Harvard Medical School, Belmont, Massachusetts 02478, United States., Leonard MZ; McLean Hospital, and Harvard Medical School, Belmont, Massachusetts 02478, United States., Zhang B; Center for Drug Discovery, Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States., Honrao C; Center for Drug Discovery, Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States., Mallipeddi S; Center for Drug Discovery, Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States., Raghav JG; Center for Drug Discovery, Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States., Benchama O; Center for Drug Discovery, Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States., Järbe TU; Center for Drug Discovery, Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States., Bergman J; McLean Hospital, and Harvard Medical School, Belmont, Massachusetts 02478, United States., Makriyannis A; Center for Drug Discovery, Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States.; King Abdulaziz University , Jeddah, 22254, Saudi Arabia.

المصدر: Journal of medicinal chemistry [J Med Chem] 2016 Jul 28; Vol. 59 (14), pp. 6903-19. Date of Electronic Publication: 2016 Jul 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cannabinoid Receptor Agonists/*pharmacology , Cannabinol/*pharmacology , Receptors, Cannabinoid/*metabolism, Animals ; Cannabinoid Receptor Agonists/administration & dosage ; Cannabinoid Receptor Agonists/chemistry ; Cannabinol/analogs & derivatives ; Cannabinol/chemistry ; Dose-Response Relationship, Drug ; Female ; HEK293 Cells ; Humans ; Male ; Mice ; Molecular Structure ; Rats ; Rats, Sprague-Dawley ; Saimiri ; Structure-Activity Relationship

المؤلفون: Nikas SP; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States., Sharma R, Paronis CA, Kulkarni S, Thakur GA, Hurst D, Wood JT, Gifford RS, Rajarshi G, Liu Y, Raghav JG, Guo JJ, Järbe TU, Reggio PH, Bergman J, Makriyannis A

المصدر: Journal of medicinal chemistry [J Med Chem] 2015 Jan 22; Vol. 58 (2), pp. 665-81. Date of Electronic Publication: 2014 Dec 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Dronabinol/*analogs & derivatives, Dronabinol/metabolism ; Drug Design ; HEK293 Cells ; Humans ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/metabolism ; Structure-Activity Relationship

المؤلفون: Sharma R; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University , Boston, Massachusetts 02115, United States., Nikas SP, Paronis CA, Wood JT, Halikhedkar A, Guo JJ, Thakur GA, Kulkarni S, Benchama O, Raghav JG, Gifford RS, Järbe TU, Bergman J, Makriyannis A

المصدر: Journal of medicinal chemistry [J Med Chem] 2013 Dec 27; Vol. 56 (24), pp. 10142-57. Date of Electronic Publication: 2013 Dec 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cannabinoids/*pharmacology , Receptor, Cannabinoid, CB1/*antagonists & inhibitors , Receptor, Cannabinoid, CB2/*antagonists & inhibitors, Animals ; Cannabinoids/chemical synthesis ; Cannabinoids/chemistry ; Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Ligands ; Mice ; Models, Molecular ; Molecular Structure ; Rats ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/metabolism ; Structure-Activity Relationship