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1
المؤلفون: Jean-Michel Rondeau, Heinrich Rueeger, Rainer Martin Lueoend, Laura H. Jacobson, Markus Voegtle, Rainer Machauer, Grit Laue, Philipp Holzer, Konstanze Hurth, Siem Jacob Veenstra, Matthias Staufenbiel, Marina Tintelnot-Blomley, Ulf Neumann, Mathias Frederiksen
المصدر: Journal of Medicinal Chemistry. 64:4677-4696
مصطلحات موضوعية: Central nervous system, Thiazines, Molecular Dynamics Simulation, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Alzheimer Disease, Oxazines, Drug Discovery, medicine, Animals, Aspartic Acid Endopeptidases, Humans, Potency, Enzyme Inhibitors, Picolinic Acids, 030304 developmental biology, 0303 health sciences, Amyloid beta-Peptides, Binding Sites, Trifluoromethyl, Treatment regimen, Brain, Penetration (firestop), Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, chemistry, β secretase, Molecular Medicine, Efflux, Amyloid Precursor Protein Secretases, Lead compound, Half-Life
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2
المؤلفون: Ulf Neumann, Rainer Machauer, Markus Voegtle, Marina Tintelnot-Blomley, Konstanze Hurth, Grit Laue, Siem Jacob Veenstra, Rainer Martin Lueoend, Karen Beltz, Jean-Michel Rondeau, Laura H. Jacobson, Heinrich Rueeger
المصدر: Journal of medicinal chemistry. 64(20)
مصطلحات موضوعية: Male, Central nervous system, Disease, Pharmacology, Cell Line, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Dogs, Pharmacokinetics, Alzheimer Disease, Drug Discovery, Oxazines, medicine, Potency, Animals, Aspartic Acid Endopeptidases, Humans, Enzyme Inhibitors, Trifluoromethyl, Dose-Response Relationship, Drug, Molecular Structure, Rats, Mice, Inbred C57BL, medicine.anatomical_structure, chemistry, β secretase, Molecular Medicine, Efflux, Amyloid Precursor Protein Secretases, Lead compound
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3
المؤلفون: Markus Voegtle, Laura H. Jacobson, Heinrich Rueeger, Mathias Frederiksen, Ulf Neumann, Rainer Martin Lueoend, Rainer Machauer, Marina Tintelnot-Blomley, Jean-Michel Rondeau, Philipp Holzer, Siem Jacob Veenstra, Konstanze Hurth, Matthias Staufenbiel
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:2195-2200
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Oxazines, 01 natural sciences, Biochemistry, Madin Darby Canine Kidney Cells, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, Hydrolase, Animals, Aspartic Acid Endopeptidases, Potency, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, 010405 organic chemistry, Chemistry, Treatment regimen, Organic Chemistry, Cell model, Permeation, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Amyloid Precursor Protein Secretases
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4
المؤلفون: Henrik Möbitz, Rainer Machauer, Olivier Rogel, Heinrich Rueeger, Rainer Martin Lueoend, Matthias Staufenbiel, Sandrine Desrayaud, Jean-Michel Rondeau, Laura H. Jacobson, Ulf Neumann
المصدر: Journal of Medicinal Chemistry. 55:3364-3386
مصطلحات موضوعية: Models, Molecular, Indazoles, Indoles, Molecular model, Stereochemistry, Mice, Transgenic, Crystallography, X-Ray, Cell Line, Sulfone, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, Dogs, In vivo, Cricetinae, Amide, Drug Discovery, Benzene Derivatives, Ethylamines, Animals, Aspartic Acid Endopeptidases, Humans, Potency, Spiro Compounds, Sulfones, chemistry.chemical_classification, Cathepsin, Amyloid beta-Peptides, Brain, Stereoisomerism, Cyclic S-Oxides, Enzyme, chemistry, Blood-Brain Barrier, Drug Design, Molecular Medicine, Amyloid Precursor Protein Secretases, Selectivity
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5
المؤلفون: Peter Schmid, Matthias Staufenbiel, Wilfried Frieauff, Marina Tintelnot-Blomley, Rainer Machauer, Barbara Vogg, Derya R. Shimshek, Karen Beltz, Heinrich Rueeger, Rainer Martin Lueoend, Laura H. Jacobson, Grit Laue, Siem Jacob Veenstra, Ulf Neumann
المصدر: Molecular Neurodegeneration
مصطلحات موضوعية: Drug Evaluation, Preclinical, Thiazines, Pharmacology, Mice, Neuroinflammation, Cricetinae, Aspartic Acid Endopeptidases, Picolinic Acids, biology, BACE-1, Neurodegeneration, Brain, Neuroprotective Agents, Female, Microglia, Alzheimer's disease, Alzheimer’s disease, Research Article, Genetically modified mouse, Inhibitor, Amyloid, Amyloid beta, Recombinant Fusion Proteins, Transgene, Clinical Neurology, Mice, Transgenic, Nerve Tissue Proteins, CHO Cells, Cellular and Molecular Neuroscience, Cricetulus, Dogs, Alzheimer Disease, medicine, Animals, Humans, Amyloid-β, Hair Color, Molecular Biology, Amyloid beta-Peptides, medicine.disease, Peptide Fragments, Rats, Astrocytes, Mutation, biology.protein, Neurology (clinical), Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, Neuroscience
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6
المؤلفون: Marina Tintelnot-Blomley, Grit Laue, Karen Beltz, Derya R. Shimshek, Matthias Staufenbiel, Siem Jacob Veenstra, Peter Schmid, Ulf Neumann, Barbara Vogg, Wilfried Frieauff, Laura H. Jacobson, Rainer Machauer, Rainer Martin Lueoend, Heinrich Rueeger
المصدر: Alzheimer's & Dementia. 10
مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Chemistry, Health Policy, Biophysics, Neurology (clinical), Penetration (firestop), Geriatrics and Gerontology
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7
المؤلفون: Henrik Möbitz, Heinrich Rueeger, Ulf Neumann, Rainer Martin Lueoend, Jean-Michel Rondeau, Sandrine Desrayaud, Siem Jacob Veenstra, Laura H. Jacobson, Rainer Machauer, Matthias Staufenbiel
المصدر: Bioorganicmedicinal chemistry letters. 23(19)
مصطلحات موضوعية: Male, Molecular model, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Substrate Specificity, chemistry.chemical_compound, Enzyme activator, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Amide, Drug Discovery, Structure–activity relationship, Animals, Aspartic Acid Endopeptidases, Enzyme Inhibitors, Molecular Biology, Cathepsin, chemistry.chemical_classification, Brain Chemistry, Amyloid beta-Peptides, Molecular Structure, Drug discovery, Organic Chemistry, Sulfoxide, Combinatorial chemistry, Rats, Enzyme Activation, Enzyme, chemistry, Cyclization, Ethanolamines, Sulfoxides, Molecular Medicine, Female, Amyloid Precursor Protein Secretases