المؤلفون: Fedoriw A; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Rajapurkar SR; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., O'Brien S; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Gerhart SV; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Mitchell LH; Epizyme, Inc, Cambridge, MA 02139, USA., Adams ND; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Rioux N; Epizyme, Inc, Cambridge, MA 02139, USA., Lingaraj T; Epizyme, Inc, Cambridge, MA 02139, USA., Ribich SA; Epizyme, Inc, Cambridge, MA 02139, USA., Pappalardi MB; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Shah N; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Laraio J; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Liu Y; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Butticello M; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Carpenter CL; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Creasy C; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Korenchuk S; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., McCabe MT; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., McHugh CF; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Nagarajan R; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Wagner C; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Zappacosta F; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Annan R; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Concha NO; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Thomas RA; Nonclinical Safety Assessment, GlaxoSmithKline, Collegeville, PA 19426, USA., Hart TK; Nonclinical Safety Assessment, GlaxoSmithKline, Collegeville, PA 19426, USA., Smith JJ; Epizyme, Inc, Cambridge, MA 02139, USA., Copeland RA; Epizyme, Inc, Cambridge, MA 02139, USA., Moyer MP; Epizyme, Inc, Cambridge, MA 02139, USA., Campbell J; Epizyme, Inc, Cambridge, MA 02139, USA., Stickland K; Epizyme, Inc, Cambridge, MA 02139, USA., Mills J; Epizyme, Inc, Cambridge, MA 02139, USA., Jacques-O'Hagan S; Epizyme, Inc, Cambridge, MA 02139, USA., Allain C; Epizyme, Inc, Cambridge, MA 02139, USA., Johnston D; Epizyme, Inc, Cambridge, MA 02139, USA., Raimondi A; Epizyme, Inc, Cambridge, MA 02139, USA., Porter Scott M; Epizyme, Inc, Cambridge, MA 02139, USA., Waters N; Epizyme, Inc, Cambridge, MA 02139, USA., Swinger K; Epizyme, Inc, Cambridge, MA 02139, USA., Boriack-Sjodin A; Epizyme, Inc, Cambridge, MA 02139, USA., Riera T; Epizyme, Inc, Cambridge, MA 02139, USA., Shapiro G; Epizyme, Inc, Cambridge, MA 02139, USA., Chesworth R; Epizyme, Inc, Cambridge, MA 02139, USA., Prinjha RK; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Kruger RG; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Barbash O; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Mohammad HP; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA. Electronic address: helai.x.mohammad@gsk.com.

المصدر: Cancer cell [Cancer Cell] 2019 Jul 08; Vol. 36 (1), pp. 100-114.e25. Date of Electronic Publication: 2019 Jun 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Enzyme Inhibitors/*pharmacology , Protein-Arginine N-Methyltransferases/*antagonists & inhibitors , Purine-Nucleoside Phosphorylase/*deficiency, Alternative Splicing ; Antineoplastic Agents/chemistry ; Biomarkers ; Cell Line, Tumor ; Drug Synergism ; Enzyme Inhibitors/chemistry ; Humans ; Methylation ; Models, Molecular ; Molecular Conformation ; Molecular Structure ; Protein Binding ; Protein-Arginine N-Methyltransferases/chemistry ; Substrate Specificity

المؤلفون: Smitheman KN; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Severson TM; Division of Molecular Carcinogenesis, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands., Rajapurkar SR; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., McCabe MT; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Karpinich N; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Foley J; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Pappalardi MB; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Hughes A; Target Sciences, GlaxoSmithKline, Collegeville, PA, USA., Halsey W; Target Sciences, GlaxoSmithKline, Collegeville, PA, USA., Thomas E; Target Sciences, GlaxoSmithKline, Collegeville, PA, USA., Traini C; Target Sciences, GlaxoSmithKline, Collegeville, PA, USA., Federowicz KE; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Laraio J; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Mobegi F; Division of Molecular Carcinogenesis, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands., Ferron-Brady G; Clinical Pharmacology and Modeling Sciences, GlaxoSmithKline, Collegeville, PA, USA., Prinjha RK; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Carpenter CL; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Kruger RG; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Wessels L; Division of Molecular Carcinogenesis, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands.; Faculty of EEMCS, Delft University of Technology, the Netherlands., Mohammad HP; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA helai.x.mohammad@gsk.com.

المصدر: Haematologica [Haematologica] 2019 Jun; Vol. 104 (6), pp. 1156-1167. Date of Electronic Publication: 2018 Dec 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Cell Differentiation/*drug effects , Histone Demethylases/*antagonists & inhibitors , Leukemia, Myeloid, Acute/*metabolism , Tretinoin/*pharmacology, Antineoplastic Agents/administration & dosage ; Apoptosis/drug effects ; Benzoates/pharmacology ; Caspases/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclopropanes/pharmacology ; Dose-Response Relationship, Drug ; Drug Synergism ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Treatment Outcome ; Tretinoin/administration & dosage

المؤلفون: Wyce A; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Matteo JJ; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Foley SW; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Felitsky DJ; Target Sciences, GlaxoSmithKline, Upper Merion, PA, USA., Rajapurkar SR; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Zhang XP; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Musso MC; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Korenchuk S; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Karpinich NO; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Keenan KM; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Stern M; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Mathew LK; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., McHugh CF; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., McCabe MT; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Tummino PJ; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.; Janssen Pharmaceuticals, Spring House, Montgomery, PA, USA., Kruger RG; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Carpenter C; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Barbash O; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA. olena.x.barbash@gsk.com.

المصدر: Oncogenesis [Oncogenesis] 2018 Apr 20; Vol. 7 (4), pp. 35. Date of Electronic Publication: 2018 Apr 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101580004 Publication Model: Electronic Cited Medium: Print ISSN: 2157-9024 (Print) Linking ISSN: 21579024 NLM ISO Abbreviation: Oncogenesis Subsets: PubMed not MEDLINE

المؤلفون: Soccio RE, Li Z, Chen ER, Foong YH, Benson KK, Dispirito JR, Mullican SE, Emmett MJ, Briggs ER, Peed LC, Dzeng RK, Medina CJ, Jolivert JF, Kissig M, Rajapurkar SR, Damle M, Lim HW, Won KJ, Seale P, Steger DJ, Lazar MA

المصدر: The Journal of clinical investigation [J Clin Invest] 2017 Apr 03; Vol. 127 (4), pp. 1451-1462. Date of Electronic Publication: 2017 Feb 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Epigenesis, Genetic*, Obesity/*metabolism , PPAR gamma/*physiology, Animals ; Diet, High-Fat/adverse effects ; Hypoglycemic Agents/pharmacology ; Intra-Abdominal Fat/metabolism ; Male ; Mice, 129 Strain ; Mice, Inbred C57BL ; Protein Binding ; Regulatory Elements, Transcriptional ; Rosiglitazone ; Subcutaneous Fat, Abdominal/metabolism ; Thiazolidinediones/pharmacology ; Transcriptional Activation ; Transcriptome ; Uncoupling Protein 1/genetics ; Uncoupling Protein 1/metabolism

المؤلفون: Soccio RE; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Chen ER; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Rajapurkar SR; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Safabakhsh P; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Marinis JM; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Dispirito JR; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Emmett MJ; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Briggs ER; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Fang B; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Everett LJ; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Lim HW; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Won KJ; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Steger DJ; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Civelek M; Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Voight BF; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics and Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Lazar MA; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: lazar@mail.med.upenn.edu.

المصدر: Cell [Cell] 2015 Jul 02; Vol. 162 (1), pp. 33-44.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Polymorphism, Single Nucleotide*, Hypoglycemic Agents/*metabolism , PPAR gamma/*genetics , PPAR gamma/*metabolism, Adipose Tissue ; Animals ; Gene Expression ; Humans ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Transcription Factors/metabolism