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1دورية أكاديمية
المؤلفون: Yunhai Cui, Ralf Lotz, Hermann Rapp, Klaus Klinder, Anneke Himstedt, Achim Sauer
المصدر: Pharmaceutics, Vol 11, Iss 11, p 595 (2019)
مصطلحات موضوعية: blood–brain barrier, p-gp, bcrp, efflux, kp,uu,brain, drug partitioning, cns drug, screening, drug discovery, in vitro–in vivo correlation, Pharmacy and materia medica, RS1-441
وصف الملف: electronic resource
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2
المؤلفون: Kota Toshimoto, Yuichi Sugiyama, Renato J. Scialis, Nora Lee, Ryota Kikuchi, Hiroyuki Kusuhara, Ralf Lotz, Wooin Lee, Naoki Ishiguro, Xiaoyan Chu, Albert P. Li, Kazuya Maeda, Kiyoe Morita, Aya Kiriake, Manthena V.S. Varma, Takashi Yoshikado, Emi Kimoto, Hong Shen
المصدر: Journal of Pharmaceutical Sciences. 110:376-387
مصطلحات موضوعية: Organic Anion Transporters, Pharmaceutical Science, 02 engineering and technology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Pitavastatin, Pravastatin, Uptake study, biology, Chemistry, Biological Transport, Cerivastatin, Transporter, 021001 nanoscience & nanotechnology, Molecular biology, Organic anion-transporting polypeptide, Liver, Hepatocytes, biology.protein, Efflux, Extended time, 0210 nano-technology, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b650e5980587b146a3d1f18d3db7032d
https://doi.org/10.1016/j.xphs.2020.10.041 -
3
المؤلفون: Claudia Dallinger, Kristell Marzin, Sven Wind, Ulrike Schmid, Ralf Lotz, Matthias Freiwald, Peter Stopfer, Thomas Ebner
المصدر: Clinical Pharmacokinetics
مصطلحات موضوعية: Male, Vascular Endothelial Growth Factor A, Indoles, Lung Neoplasms, medicine.drug_class, Administration, Oral, Renal function, Review Article, Pharmacology, Tyrosine-kinase inhibitor, 03 medical and health sciences, Idiopathic pulmonary fibrosis, chemistry.chemical_compound, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Pharmacokinetics, Oral administration, Carcinoma, Non-Small-Cell Lung, medicine, Animals, Humans, Drug Interactions, Pharmacology (medical), ATP Binding Cassette Transporter, Subfamily B, Member 1, Protein Kinase Inhibitors, Aged, Platelet-Derived Growth Factor, biology, business.industry, Middle Aged, medicine.disease, Idiopathic Pulmonary Fibrosis, Rats, Fibroblast Growth Factors, Vascular endothelial growth factor, 030228 respiratory system, chemistry, Case-Control Studies, 030220 oncology & carcinogenesis, Models, Animal, biology.protein, Female, Nintedanib, business, Platelet-derived growth factor receptor
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4
المؤلفون: Kerstin Julia Schäfer, Georg Boeck, Tabea Bollmann, Ralf Lotz, Simone M. Blattner, Werner Weitschies, Michael Grimm, Mirko Koziolek
المصدر: European Journal of Pharmaceutics and Biopharmaceutics. 136:221-230
مصطلحات موضوعية: Male, medicine.medical_specialty, Administration, Oral, Pharmaceutical Science, Capsules, 02 engineering and technology, 030226 pharmacology & pharmacy, Beagle, Dosage form, 03 medical and health sciences, Dogs, 0302 clinical medicine, In vivo, Oral administration, Internal medicine, medicine, Animals, Humans, Telemetry, Gastrointestinal Transit, Cross-Over Studies, Chemistry, Stomach, digestive, oral, and skin physiology, Capsule, General Medicine, 021001 nanoscience & nanotechnology, Pentagastrin, Famotidine, medicine.anatomical_structure, Endocrinology, Gastrointestinal Absorption, Female, 0210 nano-technology, Biotechnology, medicine.drug
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5
المؤلفون: Kazuya Maeda, Nora Lee, Hong Shen, Ralf Lotz, Satoshi Koyama, Yuichi Sugiyama, Hiroyuki Kusuhara, Ryota Kikuchi, Kiyoe Morita, Naoki Ishiguro, Renato J. Scialis, Wooin Lee, Xiaoyan Chu, Larry M. Tremaine, Emi Kimoto, Aya Kiriake
المصدر: The AAPS Journal
مصطلحات موضوعية: Adult, Male, Initial uptake clearance, Human hepatocytes, media_common.quotation_subject, Primary Cell Culture, Cell, Drug Evaluation, Preclinical, Pharmaceutical Science, Organic anion transporting polypeptide (OATP), Models, Biological, Concentration ratio, medicine, Humans, Rosuvastatin, Child, Pitavastatin, Internalization, Cells, Cultured, media_common, Time course, biology, Liver-Specific Organic Anion Transporter 1, Chemistry, Statins, Cerivastatin, Culture Media, Hepatobiliary Elimination, Organic anion-transporting polypeptide, medicine.anatomical_structure, Hepatocytes, Biophysics, biology.protein, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Pravastatin, Research Article, medicine.drug
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6
المؤلفون: Achim Sauer, Hermann Rapp, Anneke Himstedt, Klaus Klinder, Yunhai Cui, Ralf Lotz
المصدر: Pharmaceutics, Vol 11, Iss 11, p 595 (2019)
Pharmaceutics
Volume 11
Issue 11مصطلحات موضوعية: Abcg2, Pharmaceutical Science, lcsh:RS1-441, Pharmacology, Blood–brain barrier, blood–brain barrier, 030226 pharmacology & pharmacy, Article, drug discovery, lcsh:Pharmacy and materia medica, 03 medical and health sciences, 0302 clinical medicine, in vitro–in vivo correlation, In vivo, medicine, CNS drug, biology, Chemistry, Drug discovery, Kp,uu,brain, screening, bcrp, efflux, kp,uu,brain, drug partitioning, cns drug, screening, drug discovery, in vitro–in vivo correlation, In vitro toxicology, Skeletal muscle, Transporter, p-gp, drug partitioning, efflux, medicine.anatomical_structure, biology.protein, BCRP, Efflux, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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7
المؤلفون: Frank Himmelsbach, Ralf Lotz, Moh Tadayyon, Elke Langkopf, Herbert Nar, Norbert Hauel, Leo Thomas, Matthias Eckhardt, Michael Mark, Brian Guth
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3158-3162
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Linagliptin, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Combinatorial Chemistry Techniques, Humans, Structure–activity relationship, Purine metabolism, Molecular Biology, chemistry.chemical_classification, Dipeptidyl-Peptidase IV Inhibitors, Molecular Structure, biology, DPP-4 Inhibitors, Organic Chemistry, Xanthine, Combinatorial chemistry, Pyridazines, Enzyme, chemistry, Purines, Enzyme inhibitor, Quinazolines, biology.protein, Molecular Medicine
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المؤلفون: Holger Fuchs, Moh Tadayyon, Ralf Lotz, Waldemar Pfrengle, Michael Mark, Peter Sieger, Herbert Nar, Elke Langkopf, Matthias Eckhardt, Frank Himmelsbach, Brian Guth, Leo Thomas
المصدر: Journal of Medicinal Chemistry. 50:6450-6453
مصطلحات موضوعية: Male, Models, Molecular, Stereochemistry, Dipeptidyl Peptidase 4, Administration, Oral, Linagliptin, Stereoisomerism, Crystallography, X-Ray, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Piperidines, Oral administration, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Structure–activity relationship, Rats, Wistar, Dipeptidyl-Peptidase IV Inhibitors, biology, Biological activity, Xanthine, Macaca mulatta, Rats, Macaca fascicularis, Diabetes Mellitus, Type 2, chemistry, Purines, Enzyme inhibitor, Quinazolines, biology.protein, Molecular Medicine, Caco-2 Cells, medicine.drug
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9
المؤلفون: Thorsten Lehmann, Ralf Lotz, Thorsten Oost, Mueller Stephan Georg, Klaus Rudolf, Dirk Stenkamp, Armin Heckel, Ralph Budzinski, Jörg Kley, Gerd-Michael Maier, Gerald Juergen Roth, Leo Thomas, Martin Lenter, Kirsten Arndt, Michael Markert
المصدر: Bioorganicmedicinal chemistry letters. 25(16)
مصطلحات موضوعية: medicine.medical_specialty, Pyridines, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, In Vitro Techniques, Lipidoses, Biochemistry, Part iii, Structure-Activity Relationship, Internal medicine, Appetite Depressants, Drug Discovery, medicine, Potassium Channel Blockers, Moiety, Animals, Humans, Receptors, Somatostatin, Receptor, Molecular Biology, Phospholipids, Phospholipidosis, biology, Chemistry, Organic Chemistry, Body Weight, Antagonist, Ether-A-Go-Go Potassium Channels, High-Throughput Screening Assays, Rats, Pyridazines, Endocrinology, Design synthesis, Pyrazines, biology.protein, Hepatocytes, Microsomes, Liver, Molecular Medicine, Anti-Obesity Agents, Cyclobutanes, Sibutramine, medicine.drug
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10
المؤلفون: Gerd-Michael Maier, Thorsten Lehmann, Ralf Lotz, Jörg Kley, Martin Lenter, Michael Markert, Mueller Stephan Georg, Kirsten Arndt, Philipp Lustenberger, Klaus Rudolf, Thorsten Oost, Armin Heckel, Marcus Schindler, Gerald Juergen Roth, Dirk Stenkamp
المصدر: Bioorganicmedicinal chemistry letters. 25(16)
مصطلحات موضوعية: Pyridines, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Receptors, G-Protein-Coupled, Eating, Structure-Activity Relationship, Animal model, In vivo, Drug Discovery, Potency, Animals, Cytochrome P-450 Enzyme Inhibitors, ATP Binding Cassette Transporter, Subfamily B, Member 1, Obesity, Receptors, Somatostatin, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Body Weight, Antagonist, Limiting, High-Throughput Screening Assays, Rats, Design synthesis, Cytochrome P-450 CYP2D6, Alkynes, Drug Design, Molecular Medicine, Efflux, Anti-Obesity Agents