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1
المؤلفون: Palucki Brenda, Patrick G. Pollard, Liangqin Guo, Tung M. Fong, Matthew J. Wyvratt, Randy R. Miller, Shuwen He, Constantin Tamvakopoulos, Iyassu K. Sebhat, Qianping Peng, Ravi P. Nargund, Zhixiong Ye, Airu S. Chen, Doreen E. Cashen, David H. Weinberg, Min K. Park, Raman K. Bakshi, D. Euan MacIntyre, Howard Y. Chen, Rui Tang, Tanya MacNeil, Qingmei Hong, Alison M. Strack, Ralph A. Stearns, Jian Liu, William J. Martin
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2330-2334
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmaceutical Science, Carboxamide, Pharmacology, Biochemistry, Partial agonist, Piperazines, Rats, Sprague-Dawley, Eating, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Oral administration, In vivo, Drug Discovery, medicine, Animals, Urea, Obesity, Receptor, Molecular Biology, Organic Chemistry, Haplorhini, Rats, Disease Models, Animal, Piperazine, chemistry, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin
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2
المؤلفون: Yingjie Lai, Ralph A. Stearns, Qianping Peng, Ravi P. Nargund, Qingmei Hong, Jian Liu, Rui Tang, Matthew J. Wyvratt, Raman K. Bakshi, Randy R. Miller, Tianying Jian, Alison M. Strack, Tanya MacNeil, Liangqin Guo, Howard Y. Chen, James Dellureficio, Iyassu K. Sebhat, Peter H. Dobbelaar, Airu S. Chen, Constantin Tamvakopoulos, David H. Weinberg, Tung M. Fong, Christopher L. Franklin, Shuwen He, Zhixiong Ye
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4399-4405
مصطلحات موضوعية: Agonist, medicine.medical_specialty, Pyrrolidines, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Anti-Obesity Agents, Internal medicine, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Spiro Compounds, Obesity, Molecular Biology, Mice, Knockout, Chemistry, Body Weight, Organic Chemistry, Amides, Rats, Endocrinology, Drug development, Anorectic, Receptor, Melanocortin, Type 4, Molecular Medicine
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3
المؤلفون: Nathan X. Yu, Thomas J. Lanza, Koppara Samuel, Sanjeev Kumar, George A. Doss, Vijay Bhasker G. Reddy, Ralph A. Stearns, Bindhu V. Karanam, Linus S. Lin, Conrad E. Raab, Andy Shiqiang Zhang
المصدر: Xenobiotica. 40:650-662
مصطلحات موضوعية: Male, Magnetic Resonance Spectroscopy, Drug Inverse Agonism, Pyridines, Stereochemistry, Health, Toxicology and Mutagenesis, Metabolite, Pharmacology, Toxicology, Biochemistry, Mass Spectrometry, Hydroxylation, chemistry.chemical_compound, Taranabant, Receptor, Cannabinoid, CB1, medicine, Animals, Humans, Inverse agonist, Receptor, Antibodies, Monoclonal, Brain, Haplorhini, General Medicine, Glutathione, Metabolism, Amides, Propanamide, Body Fluids, Rats, Ketoconazole, Radioactivity, chemistry, Microsomes, Liver, Female, medicine.drug
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4
المؤلفون: Howard Y. Chen, William J. Martin, D. Euan MacIntyre, Zhixiong Ye, Raman K. Bakshi, Alison M. Strack, Doreen E. Cashen, Jian Liu, Yingjie Lai, Tianying Jian, Constantin Tamvakopoulos, Nancy N. Tsou, Shuwen He, James Dellureficio, Tung M. Fong, Peter H. Dobbelaar, David H. Weinberg, Airu S. Chen, Qingmei Hong, Iyassu K. Sebhat, Tanya MacNeil, Christopher L. Franklin, Ravi P. Nargund, Ralph A. Stearns, Rui Tang, Richard G. Ball, Matthew J. Wyvratt, Randy R. Miller, Liangqin Guo, Qianping Peng
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2106-2110
مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, CHO Cells, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, Cricetulus, Dogs, Erectile Dysfunction, Cricetinae, Drug Discovery, medicine, Animals, Humans, Spiro Compounds, Receptor, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Haplorhini, Rats, Bioavailability, Indans, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin, Protein Binding
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5
المؤلفون: Raman K. Bakshi, Dennis C. Dean, Randy R. Miller, Wei Tang, Jason S. Ngui, Ralph A. Stearns, Ravi P. Nargund, Qing Chen, Thomas A. Baillie, Regina W. Wang
المصدر: Xenobiotica. 38:1437-1451
مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Stereochemistry, Health, Toxicology and Mutagenesis, Metabolite, Potassium cyanide, Toxicology, Biochemistry, Adduct, Rats, Sprague-Dawley, chemistry.chemical_compound, Piperidines, Tandem Mass Spectrometry, Drug Discovery, medicine, Animals, Cytochrome P-450 CYP3A, Drug Interactions, Enzyme Inhibitors, Pharmacology, Binding Sites, biology, Cytochrome P450, General Medicine, Nitroso, Rats, Potassium ferricyanide, 1-Naphthylamine, chemistry, Microsomes, Liver, Microsome, biology.protein, Cytochrome P-450 CYP3A Inhibitors, Receptor, Melanocortin, Type 4
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6
المؤلفون: Donald F. Hora, Suzanne L. Ciccotto, James R. Reed, Stella H. Vincent, Christopher J. Kochansky, David Q. Liu, Shiyao Xu, Ralph A. Stearns, Maria G. Beconi, Charles S. Elmore, Yohannes Teffera, Yuan-Qing Xia
المصدر: Drug Metabolism and Disposition. 35:525-532
مصطلحات موضوعية: Male, medicine.medical_specialty, Adenosine Deaminase, Dipeptidyl Peptidase 4, Glucuronidation, Administration, Oral, Biological Availability, Pharmaceutical Science, Dipeptidyl peptidase-4 inhibitor, In Vitro Techniques, Sulfuric Acid Esters, Hydroxylation, Kidney, Sitagliptin Phosphate, Rats, Sprague-Dawley, Excretion, Feces, Dogs, Glucuronides, Species Specificity, Pharmacokinetics, Internal medicine, Adenosine Deaminase Inhibitors, medicine, Animals, Bile, Humans, Hypoglycemic Agents, Enzyme Inhibitors, Biotransformation, Glycoproteins, Pharmacology, Volume of distribution, Dipeptidyl-Peptidase IV Inhibitors, Molecular Structure, Chemistry, Kidney metabolism, Haplorhini, Triazoles, Rats, Endocrinology, Cyclization, Pyrazines, Sitagliptin, Microsomes, Liver, Oxidation-Reduction, Protein Binding, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294ab689fa7f08ad97b8496dc34b69f8
https://doi.org/10.1124/dmd.106.013110 -
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المؤلفون: Doreen E. Cashen, Constantin Tamvakopoulos, Qianping Peng, William J. Martin, David H. Weinberg, Charles Rosenblum, Arthur A. Patchett, Tanya MacNeil, Patrick G. Pollard, Zhixiong Ye, Raman K. Bakshi, Ralph A. Stearns, Rubana N. Kalyani, Palucki Brenda, Joseph M. Metzger, Alison M. Strack, Lex H.T. Van der Ploeg, D. Euan MacIntyre, Iyassu K. Sebhat, Aurawan Vongs, Airu S. Chen, Ravi P. Nargund, Liangqin Guo, Matthew J. Wyvratt, Randy R. Miller, Rui Tang, Howard Y. Chen, Khaled J. Barakat
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:3501-3505
مصطلحات موضوعية: Male, Agonist, Quinuclidines, Time Factors, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Rodentia, Carboxamide, Biochemistry, Chemical synthesis, Piperazines, Rats, Sprague-Dawley, Eating, Structure-Activity Relationship, Piperidines, In vivo, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, Aza Compounds, Bicyclic molecule, Chemistry, Penile Erection, digestive, oral, and skin physiology, Organic Chemistry, Small molecule, Rats, Microsomes, Liver, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin, Protein Binding
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8
المؤلفون: S. Edmonson, George A. Doss, Yohannes Teffera, J. Shang, Maria G. Beconi, Shiyao Xu, Ralph A. Stearns
المصدر: Xenobiotica. 35:697-713
مصطلحات موضوعية: Male, Stereochemistry, Health, Toxicology and Mutagenesis, Reactive intermediate, In Vitro Techniques, Toxicology, Mass spectrometry, Biochemistry, Troleandomycin, Rats, Sprague-Dawley, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Nucleophile, Phenethylamines, Animals, Biotransformation, Pharmacology, chemistry.chemical_classification, biology, Cytochrome P450, General Medicine, Glutathione, In vitro, Anti-Bacterial Agents, Rats, Enzyme, chemistry, Hepatocytes, Microsomes, Liver, biology.protein, Conjugate
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9
المؤلفون: George A. Doss, Lex H.T. Van der Ploeg, Qianping Peng, Ravi P. Nargund, Charles Rosenblum, Randall R. Miller, Aurawan Vongs, Palucki Brenda, Tanya MacNeil, Ralph A. Stearns, Min K. Park, David H. Weinberg, Rui Tang, Arthur A. Patchett, Constantin Tamvakopoulos
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:1993-1996
مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Piperazines, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Receptor, Molecular Biology, biology, Chemistry, Organic Chemistry, biology.organism_classification, In vitro, Piperazine, Microsoma, Microsome, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin
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المؤلفون: William J. Martin, D. Euan MacIntyre, Ravi P. Nargund, Rubana N. Kalyani, Rui Tang, George A. Doss, Min K. Park, Alison M. Strack, Erin McGowan, Joseph M. Metzger, Charles Rosenblum, Randall R. Miller, Palucki Brenda, Qianping Peng, Arthur A. Patchett, Ralph A. Stearns, Patrick G. Pollard, Lex H.T. Van der Ploeg, Iyassu K. Sebhat, Constantin Tamvakopoulos, Cherrie Shepherd, Aurawan Vongs, Tanya MacNeil, David H. Weinberg, Zhixiong Ye
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:171-175
مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Piperazines, Mice, Dogs, Erectile Dysfunction, Piperidines, In vivo, Drug Discovery, medicine, Animals, Obesity, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Haplorhini, In vitro, Rats, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin